Q9CAJ0

PR
Gene name
HAB1 (P2C-HA, At1g72770, F28P22.4)
Protein name
Protein phosphatase 2C 16
Names
AtPP2C16, AtP2C-HA, Protein HYPERSENSITIVE TO ABA 1, Protein phosphatase 2C HAB1, PP2C HAB1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G72770
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-119 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

34 structures for Q9CAJ0

Entry ID Method Resolution Chain Position Source
3KB3 X-ray 195 A B 186-506 PDB
3NMT X-ray 256 A B 172-511 PDB
3QN1 X-ray 180 A B 178-511 PDB
3RT0 X-ray 211 A A/B 172-511 PDB
3UJG X-ray 260 A B 172-511 PDB
3ZVU X-ray 210 A B 178-511 PDB
4DS8 X-ray 221 A B 169-511 PDB
4LA7 X-ray 198 A B 178-505 PDB
4LG5 X-ray 288 A B 172-511 PDB
4LGA X-ray 270 A B 172-511 PDB
4LGB X-ray 315 A B 172-511 PDB
4WVO X-ray 225 A B 178-505 PDB
5JO1 X-ray 230 A B 172-506 PDB
5JO2 X-ray 242 A B 172-506 PDB
5MN0 X-ray 200 A B 179-511 PDB
5OR2 X-ray 250 A B 178-511 PDB
5OR6 X-ray 240 A B 178-511 PDB
5VR7 X-ray 261 A B 172-511 PDB
5VRO X-ray 226 A B 172-511 PDB
5VS5 X-ray 280 A B 172-511 PDB
5VSQ X-ray 262 A B 172-511 PDB
5VSR X-ray 262 A B 172-511 PDB
5VT7 X-ray 262 A B 172-511 PDB
6ZUC X-ray 237 A B 179-505 PDB
7AVW X-ray 210 A B 179-511 PDB
7MWN X-ray 190 A B 179-511 PDB
8AY3 X-ray 190 A B 179-511 PDB
8AY6 X-ray 184 A B 179-511 PDB
8AY7 X-ray 213 A B 179-511 PDB
8AY8 X-ray 178 A B 179-511 PDB
8AY9 X-ray 228 A B 179-511 PDB
8AYA X-ray 174 A B 179-511 PDB
8EY0 X-ray 240 A B 179-511 PDB
AF-Q9CAJ0-F1 Predicted AlphaFoldDB

45 variants for Q9CAJ0

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_27391032_T_C 12 L>P No 1000Genomes
ENSVATH00139836 26 E>Q No 1000Genomes
ENSVATH00139837 28 T>I No 1000Genomes
ENSVATH01526828 46 Q>L No 1000Genomes
ENSVATH01526828 46 Q>P No 1000Genomes
ENSVATH05134295 49 C>S No 1000Genomes
ENSVATH00139838 52 G>E No 1000Genomes
tmp_1_27391168_G_A 57 M>I No 1000Genomes
ENSVATH01526829 58 E>D No 1000Genomes
tmp_1_27391172_G_A 59 D>N No 1000Genomes
ENSVATH13798740 67 G>D No 1000Genomes
ENSVATH01526830 69 Q>H No 1000Genomes
ENSVATH13798744 74 T>N No 1000Genomes
ENSVATH05134298 76 S>P No 1000Genomes
ENSVATH01526832 77 D>G No 1000Genomes
tmp_1_27391229_A_T 78 T>S No 1000Genomes
ENSVATH14474153 87 D>Y No 1000Genomes
tmp_1_27391268_G_T 91 V>L No 1000Genomes
ENSVATH00139839 97 D>H No 1000Genomes
tmp_1_27391349_T_A 118 S>T No 1000Genomes
tmp_1_27391363_G_A 122 M>I No 1000Genomes
ENSVATH13798746 127 G>V No 1000Genomes
tmp_1_27391380_G_A 128 R>Q No 1000Genomes
ENSVATH13798748 133 A>G No 1000Genomes
tmp_1_27391427_G_A 144 V>I No 1000Genomes
tmp_1_27391446_T_G 150 L>R No 1000Genomes
ENSVATH05134301 161 S>L No 1000Genomes
ENSVATH05134302 166 R>I No 1000Genomes
ENSVATH05134302 166 R>K No 1000Genomes
tmp_1_27391523_G_A 176 V>M No 1000Genomes
tmp_1_27391533_G_C 179 R>T No 1000Genomes
tmp_1_27391701_C_T 235 T>I No 1000Genomes
ENSVATH13798752 272 E>G No 1000Genomes
tmp_1_27391929_G_C 274 C>S No 1000Genomes
ENSVATH00139844 330 V>I No 1000Genomes
ENSVATH01526858 331 V>I No 1000Genomes
tmp_1_27392180_A_T 358 M>L No 1000Genomes
tmp_1_27392594_C_T 427 L>F No 1000Genomes
tmp_1_27392597_A_G 428 I>V No 1000Genomes
ENSVATH05134310 461 P>L No 1000Genomes
ENSVATH00139846 462 P>R No 1000Genomes
tmp_1_27392705_G_A 464 A>T No 1000Genomes
ENSVATH05134311 470 I>K No 1000Genomes
ENSVATH05134311 470 I>T No 1000Genomes
ENSVATH05134312 511 T>I No 1000Genomes

No associated diseases with Q9CAJ0

2 regional properties for Q9CAJ0

Type Name Position InterPro Accession
binding_site PPM-type phosphatase, divalent cation binding 238 - 246 IPR000222
domain PPM-type phosphatase-like domain 179 - 501 IPR001932

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Mainly cytoplasmic
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

2 GO annotations of biological process

Name Definition
abscisic acid-activated signaling pathway The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription.
peptidyl-threonine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.

35 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PJZ2 PPM1L Protein phosphatase 1L Bos taurus (Bovine) PR
P49593 PPM1F Protein phosphatase 1F Homo sapiens (Human) PR
Q5SGD2 PPM1L Protein phosphatase 1L Homo sapiens (Human) PR
O15297 PPM1D Protein phosphatase 1D Homo sapiens (Human) PR
Q8N819 PPM1N Probable protein phosphatase 1N Homo sapiens (Human) PR
Q8CGA0 Ppm1f Protein phosphatase 1F Mus musculus (Mouse) PR
Q8BHN0 Ppm1l Protein phosphatase 1L Mus musculus (Mouse) PR
Q80TL0 Ppm1e Protein phosphatase 1E Mus musculus (Mouse) PR
Q5JKN1 Os01g0552300 Probable protein phosphatase 2C 5 Oryza sativa subsp japonica (Rice) PR
Q5SN75 Os01g0656200 Probable protein phosphatase 2C 8 Oryza sativa subsp japonica (Rice) PR
Q6K5I0 Os02g0600000 Probable protein phosphatase 2C 20 Oryza sativa subsp japonica (Rice) PR
Q7XW27 Os04g0321800 Probable protein phosphatase 2C 38 Oryza sativa subsp japonica (Rice) PR
Q6L482 Os05g0358500 Probable protein phosphatase 2C 48 Oryza sativa subsp japonica (Rice) PR
Q6ZKL8 Os08g0500300 Probable protein phosphatase 2C 66 Oryza sativa subsp japonica (Rice) PR
Q6L4R7 PP2C53 Protein phosphatase 2C 53 Oryza sativa subsp japonica (Rice) PR
Q0JLP9 PP2C06 Probable protein phosphatase 2C 6 Oryza sativa subsp japonica (Rice) PR
Q9LMT1 At1g18030 Probable protein phosphatase 2C 8 Arabidopsis thaliana (Mouse-ear cress) PR
O81716 PPC4-2 Probable protein phosphatase 2C 21 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDA7 At3g15260 Probable protein phosphatase 2C 39 Arabidopsis thaliana (Mouse-ear cress) PR
Q3EAZ3 At3g27140 Putative protein phosphatase 2C-like protein 45 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SD02 At3g51470 Probable protein phosphatase 2C 47 Arabidopsis thaliana (Mouse-ear cress) PR
P49599 PPH1 Protein phosphatase 2C 57 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AT1 At5g53140 Probable protein phosphatase 2C 76 Arabidopsis thaliana (Mouse-ear cress) PR
O04719 ABI2 Protein phosphatase 2C 77 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GY60 At4g03415 Probable protein phosphatase 2C 52 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZN9 At1g43900 Probable protein phosphatase 2C 11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FG61 At5g36250 Probable protein phosphatase 2C 74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIF5 SAG113 Probable protein phosphatase 2C 78 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNP9 HAB2 Protein phosphatase 2C 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRZ4 At3g16800 Probable protein phosphatase 2C 41 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LHJ9 PP2C38 Probable protein phosphatase 2C 38 Arabidopsis thaliana (Mouse-ear cress) PR
Q94CL8 PP2C6 Probable protein phosphatase 2C 48 Arabidopsis thaliana (Mouse-ear cress) PR
O81760 PP2C63 Probable protein phosphatase 2C 63 Arabidopsis thaliana (Mouse-ear cress) PR
Q501F9 PP2C67 Probable protein phosphatase 2C 67 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JD5 PP2C68 Probable protein phosphatase 2C 68 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEEMTPAVAM TLSLAANTMC ESSPVEITQL KNVTDAADLL SDSENQSFCN GGTECTMEDV
70 80 90 100 110 120
SELEEVGEQD LLKTLSDTRS GSSNVFDEDD VLSVVEDNSA VISEGLLVVD AGSELSLSNT
130 140 150 160 170 180
AMEIDNGRVL ATAIIVGESS IEQVPTAEVL IAGVNQDTNT SEVVIRLPDE NSNHLVKGRS
190 200 210 220 230 240
VYELDCIPLW GTVSIQGNRS EMEDAFAVSP HFLKLPIKML MGDHEGMSPS LTHLTGHFFG
250 260 270 280 290 300
VYDGHGGHKV ADYCRDRLHF ALAEEIERIK DELCKRNTGE GRQVQWDKVF TSCFLTVDGE
310 320 330 340 350 360
IEGKIGRAVV GSSDKVLEAV ASETVGSTAV VALVCSSHIV VSNCGDSRAV LFRGKEAMPL
370 380 390 400 410 420
SVDHKPDRED EYARIENAGG KVIQWQGARV FGVLAMSRSI GDRYLKPYVI PEPEVTFMPR
430 440 450 460 470 480
SREDECLILA SDGLWDVMNN QEVCEIARRR ILMWHKKNGA PPLAERGKGI DPACQAAADY
490 500 510
LSMLALQKGS KDNISIIVID LKAQRKFKTR T