Q9LHJ9

PR
Gene name
PP2C38
Protein name
Probable protein phosphatase 2C 38
Names
AtPP2C38
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G12620
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

167-237 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9LHJ9

Entry ID Method Resolution Chain Position Source
AF-Q9LHJ9-F1 Predicted AlphaFoldDB

27 variants for Q9LHJ9

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_4010977_G_A 6 T>I No 1000Genomes
ENSVATH00319479 10 M>I No 1000Genomes
ENSVATH05816855 12 A>T No 1000Genomes
tmp_3_4010936_C_G 20 V>L No 1000Genomes
ENSVATH10635161 24 H>R No 1000Genomes
ENSVATH00319478 42 S>F No 1000Genomes
ENSVATH00319478 42 S>Y No 1000Genomes
tmp_3_4010867_C_A 43 G>C No 1000Genomes
ENSVATH05816853 72 V>I No 1000Genomes
tmp_3_4010755_T_A 80 Q>L No 1000Genomes
tmp_3_4010747_A_T 83 F>I No 1000Genomes
tmp_3_4010745_A_C 83 F>L No 1000Genomes
ENSVATH05816852 97 R>C No 1000Genomes
ENSVATH05816851 101 K>N No 1000Genomes
ENSVATH10635159 108 R>K No 1000Genomes
tmp_3_4010554_C_T 117 M>I No 1000Genomes
ENSVATH05816850 140 Q>H No 1000Genomes
tmp_3_4010340_C_T 189 V>I No 1000Genomes
tmp_3_4010303_G_C 201 S>C No 1000Genomes
ENSVATH13905048 257 V>I No 1000Genomes
tmp_3_4009980_C_T 259 E>K No 1000Genomes
ENSVATH10635133 260 V>I No 1000Genomes
ENSVATH10635132 263 K>E No 1000Genomes
tmp_3_4009856_G_A 300 A>V No 1000Genomes
tmp_3_4009699_C_G 323 E>D No 1000Genomes
ENSVATH05816843 343 R>W No 1000Genomes
tmp_3_4009520_G_C 383 P>R No 1000Genomes

No associated diseases with Q9LHJ9

2 regional properties for Q9LHJ9

Type Name Position InterPro Accession
binding_site PPM-type phosphatase, divalent cation binding 83 - 91 IPR000222
domain PPM-type phosphatase-like domain 46 - 357 IPR001932

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

2 GO annotations of biological process

Name Definition
negative regulation of defense response to bacterium Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.
peptidyl-threonine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O15297 PPM1D Protein phosphatase 1D Homo sapiens (Human) PR
Q8N819 PPM1N Probable protein phosphatase 1N Homo sapiens (Human) PR
Q6ZHC8 Os02g0685600 Probable protein phosphatase 2C 25 Oryza sativa subsp japonica (Rice) PR
Q10NB9 Os03g0275100 Probable protein phosphatase 2C 31 Oryza sativa subsp japonica (Rice) PR
Q7XHN8 Os07g0114000 Probable protein phosphatase 2C 61 Oryza sativa subsp japonica (Rice) PR
Q2QN36 Os12g0580900 Probable protein phosphatase 2C 78 Oryza sativa subsp japonica (Rice) PR
O81760 PP2C63 Probable protein phosphatase 2C 63 Arabidopsis thaliana (Mouse-ear cress) PR
Q501F9 PP2C67 Probable protein phosphatase 2C 67 Arabidopsis thaliana (Mouse-ear cress) PR
Q94CL8 PP2C6 Probable protein phosphatase 2C 48 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNP9 HAB2 Protein phosphatase 2C 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZN9 At1g43900 Probable protein phosphatase 2C 11 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GY60 At4g03415 Probable protein phosphatase 2C 52 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FG61 At5g36250 Probable protein phosphatase 2C 74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIF5 SAG113 Probable protein phosphatase 2C 78 Arabidopsis thaliana (Mouse-ear cress) PR
O04719 ABI2 Protein phosphatase 2C 77 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JD5 PP2C68 Probable protein phosphatase 2C 68 Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAJ0 HAB1 Protein phosphatase 2C 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRZ4 At3g16800 Probable protein phosphatase 2C 41 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVSSATILRM VAPCWRRPSV KGDHSTRDAN GRCDGLLWYK DSGNHVAGEF SMSVIQANNL
70 80 90 100 110 120
LEDHSKLESG PVSMFDSGPQ ATFVGVYDGH GGPEAARFVN KHLFDNIRKF TSENHGMSAN
130 140 150 160 170 180
VITKAFLATE EDFLSLVRRQ WQIKPQIASV GACCLVGIIC SGLLYIANAG DSRVVLGRLE
190 200 210 220 230 240
KAFKIVKAVQ LSSEHNASLE SVREELRSLH PNDPQIVVLK HKVWRVKGII QVSRSIGDAY
250 260 270 280 290 300
LKKAEFNREP LLAKFRVPEV FHKPILRAEP AITVHKIHPE DQFLIFASDG LWEHLSNQEA
310 320 330 340 350 360
VDIVNTCPRN GIARKLIKTA LREAAKKREM RYSDLKKIDR GVRRHFHDDI TVIVVFLDSH
370 380
LVSRSTSRRP LLSISGGGDL AGPST