O04719

PR
Gene name
ABI2
Protein name
Protein phosphatase 2C 77
Names
AtPP2C77, Protein ABSCISIC ACID-INSENSITIVE 2, Protein phosphatase 2C ABI2, PP2C ABI2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G57050
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-138 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for O04719

Entry ID Method Resolution Chain Position Source
3NMV X-ray 210 A B 101-423 PDB
3UJK X-ray 190 A A 101-423 PDB
3UJL X-ray 250 A B 101-423 PDB
AF-O04719-F1 Predicted AlphaFoldDB

40 variants for O04719

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_23087739_C_T 7 A>V No 1000Genomes
ENSVATH07437402 33 T>S No 1000Genomes
tmp_5_23087820_T_C 34 L>S No 1000Genomes
ENSVATH07437404 35 P>S No 1000Genomes
ENSVATH07437405 36 E>Q No 1000Genomes
ENSVATH07437407 41 G>A No 1000Genomes
tmp_5_23087840_G_A 41 G>S No 1000Genomes
ENSVATH07437408 42 D>E No 1000Genomes
tmp_5_23087869_T_A 50 F>L No 1000Genomes
tmp_5_23087879_A_G 54 T>A No 1000Genomes
ENSVATH07437409 77 I>S No 1000Genomes
ENSVATH07437410 95 V>L No 1000Genomes
ENSVATH07437411 105 F>L No 1000Genomes
ENSVATH14636835 133 P>S No 1000Genomes
ENSVATH12818762 140 S>P No 1000Genomes
ENSVATH07437415 141 S>N No 1000Genomes
ENSVATH07437416 148 V>L No 1000Genomes
ENSVATH12818763 149 T>N No 1000Genomes
tmp_5_23088177_A_G 153 N>S No 1000Genomes
tmp_5_23088321_A_T 174 N>Y No 1000Genomes
ENSVATH07437417 175 Y>F No 1000Genomes
tmp_5_23088354_A_G 185 T>A No 1000Genomes
ENSVATH00738495 192 K>N No 1000Genomes
ENSVATH07437418 193 P>S No 1000Genomes
tmp_5_23088394_G_A 198 G>D No 1000Genomes
tmp_5_23088410_G_T 203 E>D No 1000Genomes
tmp_5_23088513_G_A 238 V>I No 1000Genomes
ENSVATH12818786 242 T>S No 1000Genomes
ENSVATH07437420 267 V>F No 1000Genomes
ENSVATH14636838 278 A>V No 1000Genomes
ENSVATH07437424 316 P>S No 1000Genomes
ENSVATH12818787 323 V>L No 1000Genomes
ENSVATH00738500 351 L>F No 1000Genomes
tmp_5_23089104_T_A 358 L>Q No 1000Genomes
tmp_5_23089179_C_G 383 A>G No 1000Genomes
tmp_5_23089184_A_G 385 M>V No 1000Genomes
tmp_5_23089245_G_C 405 S>T No 1000Genomes
ENSVATH03442426 419 S>T No 1000Genomes
ENSVATH07437425 421 S>A No 1000Genomes
tmp_5_23089299_A_C 423 N>T No 1000Genomes

No associated diseases with O04719

2 regional properties for O04719

Type Name Position InterPro Accession
binding_site PPM-type phosphatase, divalent cation binding 160 - 168 IPR000222
domain PPM-type phosphatase-like domain 100 - 411 IPR001932

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

9 GO annotations of biological process

Name Definition
abscisic acid-activated signaling pathway The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription.
negative regulation of protein kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
peptidyl-threonine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
photoinhibition The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II.
regulation of stomatal opening Any process that modulates the frequency, rate or extent of stomatal opening.
response to abscisic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
response to osmotic stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.

35 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PJZ2 PPM1L Protein phosphatase 1L Bos taurus (Bovine) PR
P49593 PPM1F Protein phosphatase 1F Homo sapiens (Human) PR
Q5SGD2 PPM1L Protein phosphatase 1L Homo sapiens (Human) PR
O15297 PPM1D Protein phosphatase 1D Homo sapiens (Human) PR
Q8N819 PPM1N Probable protein phosphatase 1N Homo sapiens (Human) PR
Q8CGA0 Ppm1f Protein phosphatase 1F Mus musculus (Mouse) PR
Q8BHN0 Ppm1l Protein phosphatase 1L Mus musculus (Mouse) PR
Q80TL0 Ppm1e Protein phosphatase 1E Mus musculus (Mouse) PR
Q5JKN1 Os01g0552300 Probable protein phosphatase 2C 5 Oryza sativa subsp japonica (Rice) PR
Q5SN75 Os01g0656200 Probable protein phosphatase 2C 8 Oryza sativa subsp japonica (Rice) PR
Q6K5I0 Os02g0600000 Probable protein phosphatase 2C 20 Oryza sativa subsp japonica (Rice) PR
Q7XW27 Os04g0321800 Probable protein phosphatase 2C 38 Oryza sativa subsp japonica (Rice) PR
Q6L482 Os05g0358500 Probable protein phosphatase 2C 48 Oryza sativa subsp japonica (Rice) PR
Q6ZKL8 Os08g0500300 Probable protein phosphatase 2C 66 Oryza sativa subsp japonica (Rice) PR
Q6L4R7 PP2C53 Protein phosphatase 2C 53 Oryza sativa subsp japonica (Rice) PR
Q0JLP9 PP2C06 Probable protein phosphatase 2C 6 Oryza sativa subsp japonica (Rice) PR
Q9LMT1 At1g18030 Probable protein phosphatase 2C 8 Arabidopsis thaliana (Mouse-ear cress) PR
O81716 PPC4-2 Probable protein phosphatase 2C 21 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDA7 At3g15260 Probable protein phosphatase 2C 39 Arabidopsis thaliana (Mouse-ear cress) PR
Q3EAZ3 At3g27140 Putative protein phosphatase 2C-like protein 45 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SD02 At3g51470 Probable protein phosphatase 2C 47 Arabidopsis thaliana (Mouse-ear cress) PR
P49599 PPH1 Protein phosphatase 2C 57 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AT1 At5g53140 Probable protein phosphatase 2C 76 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GY60 At4g03415 Probable protein phosphatase 2C 52 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZN9 At1g43900 Probable protein phosphatase 2C 11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FG61 At5g36250 Probable protein phosphatase 2C 74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIF5 SAG113 Probable protein phosphatase 2C 78 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNP9 HAB2 Protein phosphatase 2C 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LHJ9 PP2C38 Probable protein phosphatase 2C 38 Arabidopsis thaliana (Mouse-ear cress) PR
Q94CL8 PP2C6 Probable protein phosphatase 2C 48 Arabidopsis thaliana (Mouse-ear cress) PR
O81760 PP2C63 Probable protein phosphatase 2C 63 Arabidopsis thaliana (Mouse-ear cress) PR
Q501F9 PP2C67 Probable protein phosphatase 2C 67 Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAJ0 HAB1 Protein phosphatase 2C 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRZ4 At3g16800 Probable protein phosphatase 2C 41 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JD5 PP2C68 Probable protein phosphatase 2C 68 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDEVSPAVAV PFRPFTDPHA GLRGYCNGES RVTLPESSCS GDGAMKDSSF EINTRQDSLT
70 80 90 100 110 120
SSSSAMAGVD ISAGDEINGS DEFDPRSMNQ SEKKVLSRTE SRSLFEFKCV PLYGVTSICG
130 140 150 160 170 180
RRPEMEDSVS TIPRFLQVSS SSLLDGRVTN GFNPHLSAHF FGVYDGHGGS QVANYCRERM
190 200 210 220 230 240
HLALTEEIVK EKPEFCDGDT WQEKWKKALF NSFMRVDSEI ETVAHAPETV GSTSVVAVVF
250 260 270 280 290 300
PTHIFVANCG DSRAVLCRGK TPLALSVDHK PDRDDEAARI EAAGGKVIRW NGARVFGVLA
310 320 330 340 350 360
MSRSIGDRYL KPSVIPDPEV TSVRRVKEDD CLILASDGLW DVMTNEEVCD LARKRILLWH
370 380 390 400 410 420
KKNAMAGEAL LPAEKRGEGK DPAAMSAAEY LSKMALQKGS KDNISVVVVD LKGIRKFKSK
SLN