Q94AT1

PR
Gene name
At5g53140 (MFH8.8)
Protein name
Probable protein phosphatase 2C 76
Names
AtPP2C76
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G53140
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

340-420 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q94AT1

Entry ID Method Resolution Chain Position Source
AF-Q94AT1-F1 Predicted AlphaFoldDB

32 variants for Q94AT1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH03419000 8 R>K No 1000Genomes
ENSVATH03419001 17 R>C No 1000Genomes
tmp_5_21549310_T_A 28 F>Y No 1000Genomes
ENSVATH07407169 33 K>N No 1000Genomes
tmp_5_21549328_C_A 34 T>N No 1000Genomes
ENSVATH12732477 59 S>N No 1000Genomes
tmp_5_21549495_G_A 90 G>S No 1000Genomes
tmp_5_21549873_A_C 99 S>R No 1000Genomes
tmp_5_21549972_A_G 132 M>V No 1000Genomes
tmp_5_21550442_A_G 165 D>G No 1000Genomes
ENSVATH03419013 183 E>K No 1000Genomes
tmp_5_21551007_G_A 250 M>I No 1000Genomes
ENSVATH03419019 294 L>I No 1000Genomes
ENSVATH12732550 320 P>L No 1000Genomes
tmp_5_21551836_G_T 323 A>S No 1000Genomes
ENSVATH12732551 330 T>S No 1000Genomes
tmp_5_21551893_T_A 342 C>S No 1000Genomes
ENSVATH00731211 357 I>T No 1000Genomes
ENSVATH00731212 369 L>M No 1000Genomes
ENSVATH12732552 371 P>S No 1000Genomes
tmp_5_21552007_A_G 380 N>D No 1000Genomes
ENSVATH07407193 381 P>S No 1000Genomes
ENSVATH12732553 382 S>R No 1000Genomes
ENSVATH03419022 384 A>E No 1000Genomes
ENSVATH03419023 385 L>M No 1000Genomes
tmp_5_21552043_A_G 392 K>E No 1000Genomes
tmp_5_21552044_A_C 392 K>T No 1000Genomes
tmp_5_21552059_C_T 397 S>F No 1000Genomes
ENSVATH03419024 397 S>P No 1000Genomes
ENSVATH14629322 404 D>N No 1000Genomes
ENSVATH00731213 406 K>I No 1000Genomes
ENSVATH07407194 411 P>Q No 1000Genomes

No associated diseases with Q94AT1

2 regional properties for Q94AT1

Type Name Position InterPro Accession
binding_site PPM-type phosphatase, divalent cation binding 132 - 140 IPR000222
domain PPM-type phosphatase-like domain 84 - 347 IPR001932

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.

1 GO annotations of biological process

Name Definition
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.

29 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PJZ2 PPM1L Protein phosphatase 1L Bos taurus (Bovine) PR
O15297 PPM1D Protein phosphatase 1D Homo sapiens (Human) PR
P49593 PPM1F Protein phosphatase 1F Homo sapiens (Human) PR
Q5SGD2 PPM1L Protein phosphatase 1L Homo sapiens (Human) PR
Q80TL0 Ppm1e Protein phosphatase 1E Mus musculus (Mouse) PR
Q8CGA0 Ppm1f Protein phosphatase 1F Mus musculus (Mouse) PR
Q8BHN0 Ppm1l Protein phosphatase 1L Mus musculus (Mouse) PR
Q5JKN1 Os01g0552300 Probable protein phosphatase 2C 5 Oryza sativa subsp japonica (Rice) PR
Q0JLP9 PP2C06 Probable protein phosphatase 2C 6 Oryza sativa subsp japonica (Rice) PR
Q5SN75 Os01g0656200 Probable protein phosphatase 2C 8 Oryza sativa subsp japonica (Rice) PR
Q6K5I0 Os02g0600000 Probable protein phosphatase 2C 20 Oryza sativa subsp japonica (Rice) PR
Q7XW27 Os04g0321800 Probable protein phosphatase 2C 38 Oryza sativa subsp japonica (Rice) PR
Q6L482 Os05g0358500 Probable protein phosphatase 2C 48 Oryza sativa subsp japonica (Rice) PR
Q6L4R7 PP2C53 Protein phosphatase 2C 53 Oryza sativa subsp japonica (Rice) PR
Q6ZKL8 Os08g0500300 Probable protein phosphatase 2C 66 Oryza sativa subsp japonica (Rice) PR
Q9LNP9 HAB2 Protein phosphatase 2C 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAJ0 HAB1 Protein phosphatase 2C 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRZ4 At3g16800 Probable protein phosphatase 2C 41 Arabidopsis thaliana (Mouse-ear cress) PR
O04719 ABI2 Protein phosphatase 2C 77 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIF5 SAG113 Probable protein phosphatase 2C 78 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GY60 At4g03415 Probable protein phosphatase 2C 52 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZN9 At1g43900 Probable protein phosphatase 2C 11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FG61 At5g36250 Probable protein phosphatase 2C 74 Arabidopsis thaliana (Mouse-ear cress) PR
O81716 PPC4-2 Probable protein phosphatase 2C 21 Arabidopsis thaliana (Mouse-ear cress) PR
Q3EAZ3 At3g27140 Putative protein phosphatase 2C-like protein 45 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDA7 At3g15260 Probable protein phosphatase 2C 39 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SD02 At3g51470 Probable protein phosphatase 2C 47 Arabidopsis thaliana (Mouse-ear cress) PR
P49599 PPH1 Protein phosphatase 2C 57 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMT1 At1g18030 Probable protein phosphatase 2C 8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVCSSFIRSF IVQAGCRIGV LAQGRHQFIH IKKTLSVGFG FRTSVIGFRT TSGIGFRTSA
70 80 90 100 110 120
KMMVDTSAGE KRISLVDMPP EKVDDGGYIG GGWKNDDGSL SCGYCSFRGK RSTMEDFYDI
130 140 150 160 170 180
KASTIEGQAV CMFGIFDGHG GSRAAEYLKE HLFNNLMKHP QFLTDTKLAL NETYKQTDVA
190 200 210 220 230 240
FLESEKDTYR DDGSTASAAV LVGNHLYVAN VGDSRTIVSK AGKAIALSDD HKPNRSDERK
250 260 270 280 290 300
RIESAGGVIM WAGTWRVGGV LAMSRAFGNR MLKQFVVAEP EIQDLEIDHE AELLVLASDG
310 320 330 340 350 360
LWDVVPNEDA VALAQSEEEP EAAARKLTDT AFSRGSADNI TCIVVKFRHD KTESPKIETN
370 380 390 400 410
AMAESEPELN PTTELEPESN PSTALETESI PKAELESEPD AIPDPKPETE PETKGEKAGE