Q8VZN9

PR
Gene name
At1g43900 (F28H19.16, F9C16.6)
Protein name
Probable protein phosphatase 2C 11
Names
AtPP2C11
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G43900
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VZN9

Entry ID Method Resolution Chain Position Source
AF-Q8VZN9-F1 Predicted AlphaFoldDB

36 variants for Q8VZN9

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_16654048_A_T 2 K>* No 1000Genomes
ENSVATH04856107 6 N>I No 1000Genomes
tmp_1_16654070_C_T 9 S>F No 1000Genomes
ENSVATH01281320 10 S>P No 1000Genomes
ENSVATH04856109 11 P>L No 1000Genomes
ENSVATH04856111 17 L>P No 1000Genomes
tmp_1_16654096_C_T 18 Q>* No 1000Genomes
ENSVATH13340312 28 S>A No 1000Genomes
ENSVATH13340313 33 L>P No 1000Genomes
tmp_1_16654153_C_T 37 Q>* No 1000Genomes
ENSVATH00079320 37 Q>P No 1000Genomes
ENSVATH04856112 48 F>Y No 1000Genomes
ENSVATH04856113 54 W>R No 1000Genomes
tmp_1_16654209_T_G 55 F>L No 1000Genomes
ENSVATH04856114 59 P>L No 1000Genomes
ENSVATH04856115 70 S>P No 1000Genomes
ENSVATH04856116 72 A>S No 1000Genomes
tmp_1_16654321_T_G 93 S>A No 1000Genomes
tmp_1_16654322_C_A 93 S>Y No 1000Genomes
tmp_1_16654355_C_A 104 A>D No 1000Genomes
ENSVATH04856124 119 T>N No 1000Genomes
ENSVATH04856125 120 V>L No 1000Genomes
ENSVATH04856126 129 L>R No 1000Genomes
ENSVATH14212498 136 M>I No 1000Genomes
ENSVATH01281325 180 S>C No 1000Genomes
tmp_1_16654765_C_T 186 S>L No 1000Genomes
tmp_1_16654770_A_C 188 T>P No 1000Genomes
ENSVATH04856134 219 A>S No 1000Genomes
ENSVATH00079321 222 F>L No 1000Genomes
ENSVATH04856135 226 D>A No 1000Genomes
tmp_1_16655335_C_G 288 A>G No 1000Genomes
ENSVATH01281329 314 F>L No 1000Genomes
tmp_1_16655706_A_G 338 I>V No 1000Genomes
ENSVATH13340357 347 K>N No 1000Genomes
tmp_1_16655754_G_A 354 A>T No 1000Genomes
tmp_1_16655758_G_A 355 R>Q No 1000Genomes

No associated diseases with Q8VZN9

2 regional properties for Q8VZN9

Type Name Position InterPro Accession
binding_site PPM-type phosphatase, divalent cation binding 154 - 162 IPR000222
domain PPM-type phosphatase-like domain 111 - 368 IPR001932

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

1 GO annotations of biological process

Name Definition
peptidyl-threonine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.

35 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PJZ2 PPM1L Protein phosphatase 1L Bos taurus (Bovine) PR
P49593 PPM1F Protein phosphatase 1F Homo sapiens (Human) PR
Q5SGD2 PPM1L Protein phosphatase 1L Homo sapiens (Human) PR
O15297 PPM1D Protein phosphatase 1D Homo sapiens (Human) PR
Q8N819 PPM1N Probable protein phosphatase 1N Homo sapiens (Human) PR
Q8BHN0 Ppm1l Protein phosphatase 1L Mus musculus (Mouse) PR
Q80TL0 Ppm1e Protein phosphatase 1E Mus musculus (Mouse) PR
Q8CGA0 Ppm1f Protein phosphatase 1F Mus musculus (Mouse) PR
Q5JKN1 Os01g0552300 Probable protein phosphatase 2C 5 Oryza sativa subsp japonica (Rice) PR
Q0JLP9 PP2C06 Probable protein phosphatase 2C 6 Oryza sativa subsp japonica (Rice) PR
Q5SN75 Os01g0656200 Probable protein phosphatase 2C 8 Oryza sativa subsp japonica (Rice) PR
Q6K5I0 Os02g0600000 Probable protein phosphatase 2C 20 Oryza sativa subsp japonica (Rice) PR
Q7XW27 Os04g0321800 Probable protein phosphatase 2C 38 Oryza sativa subsp japonica (Rice) PR
Q6L482 Os05g0358500 Probable protein phosphatase 2C 48 Oryza sativa subsp japonica (Rice) PR
Q6L4R7 PP2C53 Protein phosphatase 2C 53 Oryza sativa subsp japonica (Rice) PR
Q6ZKL8 Os08g0500300 Probable protein phosphatase 2C 66 Oryza sativa subsp japonica (Rice) PR
Q9LMT1 At1g18030 Probable protein phosphatase 2C 8 Arabidopsis thaliana (Mouse-ear cress) PR
O81716 PPC4-2 Probable protein phosphatase 2C 21 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SD02 At3g51470 Probable protein phosphatase 2C 47 Arabidopsis thaliana (Mouse-ear cress) PR
P49599 PPH1 Protein phosphatase 2C 57 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AT1 At5g53140 Probable protein phosphatase 2C 76 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDA7 At3g15260 Probable protein phosphatase 2C 39 Arabidopsis thaliana (Mouse-ear cress) PR
Q3EAZ3 At3g27140 Putative protein phosphatase 2C-like protein 45 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GY60 At4g03415 Probable protein phosphatase 2C 52 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FG61 At5g36250 Probable protein phosphatase 2C 74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIF5 SAG113 Probable protein phosphatase 2C 78 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNP9 HAB2 Protein phosphatase 2C 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LHJ9 PP2C38 Probable protein phosphatase 2C 38 Arabidopsis thaliana (Mouse-ear cress) PR
Q94CL8 PP2C6 Probable protein phosphatase 2C 48 Arabidopsis thaliana (Mouse-ear cress) PR
O81760 PP2C63 Probable protein phosphatase 2C 63 Arabidopsis thaliana (Mouse-ear cress) PR
Q501F9 PP2C67 Probable protein phosphatase 2C 67 Arabidopsis thaliana (Mouse-ear cress) PR
O04719 ABI2 Protein phosphatase 2C 77 Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAJ0 HAB1 Protein phosphatase 2C 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRZ4 At3g16800 Probable protein phosphatase 2C 41 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JD5 PP2C68 Probable protein phosphatase 2C 68 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKKTRNVASS PIECVHLQTK PTTTLVRSFF FFLFNSQTIS SFIIFYLFLC SFFWFCQSPN
70 80 90 100 110 120
LTNPSPPPLS VAPLRGDANS PPPESSSSPA TKSSLMISSR DPNALFSGGG ISFLAGVRTV
130 140 150 160 170 180
KFSYGYSSLK GKRATMEDYF ETRISDVNGQ MVAFFGVFDG HGGARTAEYL KNNLFKNLVS
190 200 210 220 230 240
HDDFISDTKK AIVEVFKQTD EEYLIEEAGQ PKNAGSTAAT AFLIGDKLIV ANVGDSRVVA
250 260 270 280 290 300
SRNGSAVPLS DDHKPDRSDE RQRIEDAGGF IIWAGTWRVG GILAVSRAFG DKQLKPYVIA
310 320 330 340 350 360
EPEIQEEDIS TLEFIVVASD GLWNVLSNKD AVAIVRDISD AETAARKLVQ EGYARGSCDN
370
ITCIVVRFEV S