Q501F9

PR
Gene name
PP2C67
Protein name
Probable protein phosphatase 2C 67
Names
AtPP2C67
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G02760
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q501F9

Entry ID Method Resolution Chain Position Source
AF-Q501F9-F1 Predicted AlphaFoldDB

27 variants for Q501F9

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_625424_G_C 16 K>N No 1000Genomes
ENSVATH13888074 31 L>F No 1000Genomes
tmp_5_625555_C_T 60 P>L No 1000Genomes
tmp_5_625630_C_G 85 S>C No 1000Genomes
ENSVATH03010988 103 G>S No 1000Genomes
tmp_5_625813_A_C 121 D>A No 1000Genomes
ENSVATH00602561 127 T>K No 1000Genomes
tmp_5_625846_C_G 132 T>R No 1000Genomes
ENSVATH03010989 154 Y>F No 1000Genomes
ENSVATH00602562 168 S>Y No 1000Genomes
ENSVATH06910996 196 L>M No 1000Genomes
ENSVATH06910997 198 P>S No 1000Genomes
ENSVATH10511914 206 M>T No 1000Genomes
ENSVATH00602565 210 L>M No 1000Genomes
tmp_5_626312_G_A 235 R>K No 1000Genomes
ENSVATH13888237 247 H>Y No 1000Genomes
ENSVATH00602567 261 I>M No 1000Genomes
ENSVATH00602568 273 L>F No 1000Genomes
tmp_5_626617_A_G 305 K>E No 1000Genomes
ENSVATH00602570 306 A>V No 1000Genomes
tmp_5_626714_T_G 337 I>R No 1000Genomes
tmp_5_626739_C_A,G 345 N>K No 1000Genomes
tmp_5_626747_C_A 348 P>Q No 1000Genomes
tmp_5_626762_C_T 353 S>F No 1000Genomes
ENSVATH10511926 354 W>L No 1000Genomes
tmp_5_626777_T_A 358 L>Q No 1000Genomes
tmp_5_626812_T_G 370 S>A No 1000Genomes

No associated diseases with Q501F9

2 regional properties for Q501F9

Type Name Position InterPro Accession
binding_site PPM-type phosphatase, divalent cation binding 72 - 80 IPR000222
domain PPM-type phosphatase-like domain 24 - 344 IPR001932

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
phosphatase activity Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

2 GO annotations of biological process

Name Definition
negative regulation of leaf senescence Any process that stops, prevents or reduces the frequency, rate or extent of leaf senescence.
peptidyl-threonine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O15297 PPM1D Protein phosphatase 1D Homo sapiens (Human) PR
Q8N819 PPM1N Probable protein phosphatase 1N Homo sapiens (Human) PR
Q6ZHC8 Os02g0685600 Probable protein phosphatase 2C 25 Oryza sativa subsp japonica (Rice) PR
Q10NB9 Os03g0275100 Probable protein phosphatase 2C 31 Oryza sativa subsp japonica (Rice) PR
Q7XHN8 Os07g0114000 Probable protein phosphatase 2C 61 Oryza sativa subsp japonica (Rice) PR
Q2QN36 Os12g0580900 Probable protein phosphatase 2C 78 Oryza sativa subsp japonica (Rice) PR
O81760 PP2C63 Probable protein phosphatase 2C 63 Arabidopsis thaliana (Mouse-ear cress) PR
Q94CL8 PP2C6 Probable protein phosphatase 2C 48 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LHJ9 PP2C38 Probable protein phosphatase 2C 38 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNP9 HAB2 Protein phosphatase 2C 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZN9 At1g43900 Probable protein phosphatase 2C 11 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GY60 At4g03415 Probable protein phosphatase 2C 52 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FG61 At5g36250 Probable protein phosphatase 2C 74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIF5 SAG113 Probable protein phosphatase 2C 78 Arabidopsis thaliana (Mouse-ear cress) PR
O04719 ABI2 Protein phosphatase 2C 77 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JD5 PP2C68 Probable protein phosphatase 2C 68 Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAJ0 HAB1 Protein phosphatase 2C 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRZ4 At3g16800 Probable protein phosphatase 2C 41 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVKPCWRIGA GMERSKINPT KVDGLTWYKD LGLHTFGEFS MAMIQANSVM EDQCQIESGP
70 80 90 100 110 120
LTFNNPTVQG TFVGVYDGHG GPEASRFIAD NIFPKLKKFA SEGREISEQV ISKAFAETDK
130 140 150 160 170 180
DFLKTVTKQW PTNPQMASVG SCCLAGVICN GLVYIANTGD SRAVLGRSER GGVRAVQLSV
190 200 210 220 230 240
EHNANLESAR QELWSLHPND PTILVMKHRL WRVKGVIQVT RSIGDAYLKR AEFNREPLLP
250 260 270 280 290 300
KFRLPEHFTK PILSADPSVT ITRLSPQDEF IILASDGLWE HLSNQEAVDI VHNSPRQGIA
310 320 330 340 350 360
RRLLKAALKE AAKKREMRYS DLTEIHPGVR RHFHDDITVI VVYLNPHPVK TNSWASPLSI
RGGYPMHSTS