Q8GY60
PR
Gene name |
At4g03415 (F9H3) |
Protein name |
Probable protein phosphatase 2C 52 |
Names |
AtPP2C52 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G03415 |
EC number |
3.1.3.16: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8GY60
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8GY60-F1 | Predicted | AlphaFoldDB |
45 variants for Q8GY60
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_1505473_C_A | 13 | C>F | No | 1000Genomes | |
| tmp_4_1505472_A_C | 13 | C>W | No | 1000Genomes | |
| ENSVATH06433247 | 26 | P>L | No | 1000Genomes | |
| ENSVATH10568529 | 31 | G>S | No | 1000Genomes | |
| ENSVATH00457886 | 34 | V>L | No | 1000Genomes | |
| ENSVATH06433246 | 37 | R>M | No | 1000Genomes | |
| tmp_4_1505398_G_C | 38 | A>G | No | 1000Genomes | |
| tmp_4_1505394_C_A | 39 | K>N | No | 1000Genomes | |
| tmp_4_1505303_T_C | 70 | I>V | No | 1000Genomes | |
| ENSVATH06433236 | 94 | D>N | No | 1000Genomes | |
| ENSVATH06433235 | 114 | K>R | No | 1000Genomes | |
| ENSVATH10568527 | 118 | T>K | No | 1000Genomes | |
| tmp_4_1505071_C_G | 121 | V>L | No | 1000Genomes | |
| ENSVATH06433233 | 125 | F>S | No | 1000Genomes | |
| ENSVATH00457885 | 145 | N>D | No | 1000Genomes | |
| ENSVATH06433228 | 166 | G>D | No | 1000Genomes | |
| tmp_4_1504881_C_T | 184 | R>Q | No | 1000Genomes | |
| ENSVATH06433227 | 186 | H>Y | No | 1000Genomes | |
| tmp_4_1504855_A_C | 193 | C>G | No | 1000Genomes | |
| tmp_4_1504515_T_C | 253 | K>R | No | 1000Genomes | |
| tmp_4_1504375_A_T | 300 | F>I | No | 1000Genomes | |
| tmp_4_1504371_G_A | 301 | T>I | No | 1000Genomes | |
| tmp_4_1504363_C_T | 304 | V>I | No | 1000Genomes | |
| tmp_4_1504240_A_G | 319 | V>A | No | 1000Genomes | |
| ENSVATH06433218 | 330 | D>Y | No | 1000Genomes | |
| ENSVATH06433217 | 334 | S>L | No | 1000Genomes | |
| ENSVATH06433215 | 341 | A>S | No | 1000Genomes | |
| ENSVATH02631404 | 343 | R>G | No | 1000Genomes | |
| ENSVATH02631401 | 373 | D>Y | No | 1000Genomes | |
| ENSVATH00457881 | 387 | F>L | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average leaf number at flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| tmp_4_1504033_G_A | 388 | S>F | No | 1000Genomes | |
| tmp_4_1504007_C_T | 397 | D>N | No | 1000Genomes | |
| tmp_4_1503971_T_G | 409 | N>H | No | 1000Genomes | |
| tmp_4_1503967_A_G | 410 | F>S | No | 1000Genomes | |
| ENSVATH00457880 | 425 | N>D | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| tmp_4_1503905_C_T | 431 | D>N | No | 1000Genomes | |
| tmp_4_1503887_T_C | 437 | T>A | No | 1000Genomes | |
| ENSVATH00457879 | 442 | N>K | No | 1000Genomes | |
| tmp_4_1503863_C_T | 445 | G>S | No | 1000Genomes | |
| tmp_4_1503853_C_T | 448 | G>D | No | 1000Genomes | |
| ENSVATH10568475 | 448 | G>S | No | 1000Genomes | |
| tmp_4_1503847_G_A | 450 | T>I | No | 1000Genomes | |
| ENSVATH06433213 | 464 | E>G | No | 1000Genomes | |
| tmp_4_1503799_G_A | 466 | S>L | No | 1000Genomes | |
| ENSVATH15349489 | 469 | T>R | No | 1000Genomes |
No associated diseases with Q8GY60
1 regional properties for Q8GY60
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PPM-type phosphatase-like domain | 56 - 372 | IPR001932 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.16 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| myosin phosphatase activity | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. |
| phosphoprotein phosphatase activity | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. |
| protein serine/threonine phosphatase activity | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| peptidyl-threonine dephosphorylation | The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
35 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A5PJZ2 | PPM1L | Protein phosphatase 1L | Bos taurus (Bovine) | PR |
| P49593 | PPM1F | Protein phosphatase 1F | Homo sapiens (Human) | PR |
| Q5SGD2 | PPM1L | Protein phosphatase 1L | Homo sapiens (Human) | PR |
| O15297 | PPM1D | Protein phosphatase 1D | Homo sapiens (Human) | PR |
| Q8N819 | PPM1N | Probable protein phosphatase 1N | Homo sapiens (Human) | PR |
| Q8CGA0 | Ppm1f | Protein phosphatase 1F | Mus musculus (Mouse) | PR |
| Q80TL0 | Ppm1e | Protein phosphatase 1E | Mus musculus (Mouse) | PR |
| Q8BHN0 | Ppm1l | Protein phosphatase 1L | Mus musculus (Mouse) | PR |
| Q5JKN1 | Os01g0552300 | Probable protein phosphatase 2C 5 | Oryza sativa subsp japonica (Rice) | PR |
| Q0JLP9 | PP2C06 | Probable protein phosphatase 2C 6 | Oryza sativa subsp japonica (Rice) | PR |
| Q5SN75 | Os01g0656200 | Probable protein phosphatase 2C 8 | Oryza sativa subsp japonica (Rice) | PR |
| Q6K5I0 | Os02g0600000 | Probable protein phosphatase 2C 20 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XW27 | Os04g0321800 | Probable protein phosphatase 2C 38 | Oryza sativa subsp japonica (Rice) | PR |
| Q6L482 | Os05g0358500 | Probable protein phosphatase 2C 48 | Oryza sativa subsp japonica (Rice) | PR |
| Q6L4R7 | PP2C53 | Protein phosphatase 2C 53 | Oryza sativa subsp japonica (Rice) | PR |
| Q6ZKL8 | Os08g0500300 | Probable protein phosphatase 2C 66 | Oryza sativa subsp japonica (Rice) | PR |
| Q9LMT1 | At1g18030 | Probable protein phosphatase 2C 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81716 | PPC4-2 | Probable protein phosphatase 2C 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SD02 | At3g51470 | Probable protein phosphatase 2C 47 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P49599 | PPH1 | Protein phosphatase 2C 57 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3EAZ3 | At3g27140 | Putative protein phosphatase 2C-like protein 45 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AT1 | At5g53140 | Probable protein phosphatase 2C 76 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDA7 | At3g15260 | Probable protein phosphatase 2C 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZN9 | At1g43900 | Probable protein phosphatase 2C 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FG61 | At5g36250 | Probable protein phosphatase 2C 74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIF5 | SAG113 | Probable protein phosphatase 2C 78 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LNP9 | HAB2 | Protein phosphatase 2C 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LHJ9 | PP2C38 | Probable protein phosphatase 2C 38 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94CL8 | PP2C6 | Probable protein phosphatase 2C 48 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81760 | PP2C63 | Probable protein phosphatase 2C 63 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q501F9 | PP2C67 | Probable protein phosphatase 2C 67 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O04719 | ABI2 | Protein phosphatase 2C 77 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CAJ0 | HAB1 | Protein phosphatase 2C 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRZ4 | At3g16800 | Probable protein phosphatase 2C 41 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JD5 | PP2C68 | Probable protein phosphatase 2C 68 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGGCVSTSSK | STCSSWSNGE | KPVRRPYLGI | GCCVSKRAKR | TFSDHIVSLQ | NLTSIPNRIT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSSKSRSSCI | FTQQGRKGIN | QDAMIVWEDF | MSEDVTFCGV | FDGHGPYGHL | VARKVRDTLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VKLQFFFQTL | QSKQNCSKGT | RFRRNSSKSA | VQEAVKEGSD | EDKLKGLWGE | AFLKSFKAMD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KELRSHPNLD | CFCSGSTGVT | ILKQGSNLFM | GNIGDSRAIL | GSKDSNDSMV | ATQLTVDLKP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DLPREAERIK | RCKGRVFAME | DEPEVPRVWL | PYDDAPGLAM | ARAFGDFCLK | EYGVISVPEF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| THRVLTDRDQ | FIVLASDGVW | DVLSNEEVVD | IVASATSRAS | AARTLVNSAA | REWKLKYPTS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KMDDCAVVCL | FLDGKMDSES | DYDEQGFSSA | TNAVESDDGQ | RSEPCLQRNF | TVRSSSDQEN |
| 430 | 440 | 450 | 460 | ||
| ETYGNVNTET | DAEDEKTVGD | QNWLGLQGVT | RVNSLVQLPR | FSEEKSKT |