P49599
PR
Gene name |
PPH1 |
Protein name |
Protein phosphatase 2C 57 |
Names |
AtPP2C57, Protein phosphatase 2C PPH1, PP2C PPH1, Thylakoid-associated phosphatase of 38 kDa |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G27800 |
EC number |
3.1.3.16: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P49599
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4YZG | X-ray | 160 A | A/B | 59-351 | PDB |
| 4YZH | X-ray | 200 A | A | 59-351 | PDB |
| AF-P49599-F1 | Predicted | AlphaFoldDB |
23 variants for P49599
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_13854088_C_T | 2 | A>T | No | 1000Genomes | |
| ENSVATH02932851 | 14 | N>T | No | 1000Genomes | |
| ENSVATH02932850 | 15 | T>S | No | 1000Genomes | |
| tmp_4_13854043_G_C | 17 | R>G | No | 1000Genomes | |
| ENSVATH00541848 | 21 | Y>F | No | 1000Genomes | |
| ENSVATH00541848 | 21 | Y>S | No | 1000Genomes | |
| ENSVATH14303761 | 28 | G>S | No | 1000Genomes | |
| tmp_4_13854004_GGCCACC_AGCCACC,G | 30 | L>F | No | 1000Genomes | |
| ENSVATH06787217 | 59 | R>S | No | 1000Genomes | |
| ENSVATH02932846 | 83 | V>L | No | 1000Genomes | |
| tmp_4_13853821_C_G | 91 | V>L | No | 1000Genomes | |
| ENSVATH06787213 | 124 | G>R | No | 1000Genomes | |
| tmp_4_13853627_G_C | 130 | I>M | No | 1000Genomes | |
| ENSVATH00541846 | 167 | I>F | No | 1000Genomes | |
| ENSVATH06787208 | 184 | V>I | No | 1000Genomes | |
| ENSVATH12266299 | 208 | I>N | No | 1000Genomes | |
| tmp_4_13853063_C_T | 228 | G>R | No | 1000Genomes | |
| tmp_4_13853017_G_T | 243 | T>K | No | 1000Genomes | |
| ENSVATH02932827 | 246 | N>D | No | 1000Genomes | |
| ENSVATH06787200 | 251 | K>R | No | 1000Genomes | |
| ENSVATH06787200 | 251 | K>T | No | 1000Genomes | |
| ENSVATH02932818 | 309 | S>N | No | 1000Genomes | |
| ENSVATH00541837 | 372 | T>A | No | 1000Genomes |
No associated diseases with P49599
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.16 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| thylakoid | A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| manganese ion binding | Binding to a manganese ion (Mn). |
| myosin phosphatase activity | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. |
| phosphatase activity | Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| dephosphorylation | The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. |
| photosynthetic electron transport chain | A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. |
| photosystem stoichiometry adjustment | Adjustment of Photosystem I/Photosystem II ratio in response to light conditions. The function of photosystem stoichiometry adjustment is to compensate for any deficiency in energy conversion at either photosystem I or photosystem II by increasing the quantity the photosystem that will otherwise become the rate-limiting to overall photosynthesis. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
29 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A5PJZ2 | PPM1L | Protein phosphatase 1L | Bos taurus (Bovine) | PR |
| P49593 | PPM1F | Protein phosphatase 1F | Homo sapiens (Human) | PR |
| O15297 | PPM1D | Protein phosphatase 1D | Homo sapiens (Human) | PR |
| Q5SGD2 | PPM1L | Protein phosphatase 1L | Homo sapiens (Human) | PR |
| Q8CGA0 | Ppm1f | Protein phosphatase 1F | Mus musculus (Mouse) | PR |
| Q8BHN0 | Ppm1l | Protein phosphatase 1L | Mus musculus (Mouse) | PR |
| Q80TL0 | Ppm1e | Protein phosphatase 1E | Mus musculus (Mouse) | PR |
| Q0JLP9 | PP2C06 | Probable protein phosphatase 2C 6 | Oryza sativa subsp japonica (Rice) | PR |
| Q5SN75 | Os01g0656200 | Probable protein phosphatase 2C 8 | Oryza sativa subsp japonica (Rice) | PR |
| Q6K5I0 | Os02g0600000 | Probable protein phosphatase 2C 20 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XW27 | Os04g0321800 | Probable protein phosphatase 2C 38 | Oryza sativa subsp japonica (Rice) | PR |
| Q6L482 | Os05g0358500 | Probable protein phosphatase 2C 48 | Oryza sativa subsp japonica (Rice) | PR |
| Q6L4R7 | PP2C53 | Protein phosphatase 2C 53 | Oryza sativa subsp japonica (Rice) | PR |
| Q6ZKL8 | Os08g0500300 | Probable protein phosphatase 2C 66 | Oryza sativa subsp japonica (Rice) | PR |
| Q5JKN1 | Os01g0552300 | Probable protein phosphatase 2C 5 | Oryza sativa subsp japonica (Rice) | PR |
| Q9LNP9 | HAB2 | Protein phosphatase 2C 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZN9 | At1g43900 | Probable protein phosphatase 2C 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CAJ0 | HAB1 | Protein phosphatase 2C 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRZ4 | At3g16800 | Probable protein phosphatase 2C 41 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GY60 | At4g03415 | Probable protein phosphatase 2C 52 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FG61 | At5g36250 | Probable protein phosphatase 2C 74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O04719 | ABI2 | Protein phosphatase 2C 77 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIF5 | SAG113 | Probable protein phosphatase 2C 78 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81716 | PPC4-2 | Probable protein phosphatase 2C 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3EAZ3 | At3g27140 | Putative protein phosphatase 2C-like protein 45 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AT1 | At5g53140 | Probable protein phosphatase 2C 76 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDA7 | At3g15260 | Probable protein phosphatase 2C 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMT1 | At1g18030 | Probable protein phosphatase 2C 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SD02 | At3g51470 | Probable protein phosphatase 2C 47 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALLRPHLHR | FHSNTLRHSA | YPSADAGGGL | VVYPTYGRHR | CSAIAIDAPS | SLTGVTPIRW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GYTSVQGFRD | EMEDDIVIRS | DAVDSFSYAA | VFDGHAGSSS | VKFLREELYK | ECVGALQAGS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLNGGDFAAI | KEALIKAFES | VDRNLLKWLE | ANGDEEDESG | STATVMIIRN | DVSFIAHIGD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SCAVLSRSGQ | IEELTDYHRP | YGSSRAAIQE | VKRVKEAGGW | IVNGRICGDI | AVSRAFGDIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FKTKKNDMLK | KGVDEGRWSE | KFVSRIEFKG | DMVVATPDIF | QVPLTSDVEF | IILASDGLWD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YMKSSDVVSY | VRDQLRKHGN | VQLACESLAQ | VALDRRSQDN | ISIIIADLGR | TEWKNLPAQR |
| 370 | 380 | ||||
| QNVVVELVQA | ATTIGLVTVG | IWMSSHLS |