P49593
PR
Gene name |
PPM1F (KIAA0015, POPX2) |
Protein name |
Protein phosphatase 1F |
Names |
Ca(2+)/calmodulin-dependent protein kinase phosphatase, CaM-kinase phosphatase, CaMKPase, Partner of PIX 2, Protein fem-2 homolog, hFem-2 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:9647 |
EC number |
3.1.3.16: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P49593
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P49593-F1 | Predicted | AlphaFoldDB |
360 variants for P49593
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA10125231 rs770042220 |
2 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs746224746 CA10125230 |
3 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10125229 rs781470132 |
4 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs565255163 CA10125227 |
5 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1601792827 CA410833890 |
6 | P>S | No |
ClinGen Ensembl |
|
|
rs144742048 CA322348762 |
7 | Q>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs144742048 CA10125226 |
7 | Q>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10125225 rs545350752 |
8 | K>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA10125224 rs752308850 |
9 | S>R | No |
ClinGen ExAC |
|
|
CA410833864 rs1569132342 |
10 | S>N | No |
ClinGen Ensembl |
|
|
CA10125223 rs140871633 |
10 | S>R | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1357070275 CA410833861 |
10 | S>R | No |
ClinGen gnomAD |
|
|
rs753626964 CA10125221 |
12 | M>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10125222 rs762076150 |
12 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1601792798 CA410833842 |
13 | A>G | No |
ClinGen Ensembl |
|
|
CA10125219 rs760617515 |
14 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA410833838 rs139013152 |
14 | S>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1362028759 CA410833835 |
14 | S>R | No |
ClinGen gnomAD |
|
|
rs139013152 CA10125218 |
14 | S>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10125217 rs142002832 |
15 | G>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs142002832 CA322348707 |
15 | G>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs762988140 CA10125216 |
16 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA410833813 rs1309828256 |
18 | E>A | No |
ClinGen TOPMed |
|
|
CA322348691 rs765430160 |
18 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs148178922 CA10125213 |
19 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 21 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10125210 rs747505604 |
25 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772748986 CA10125208 |
26 | L>I | No |
ClinGen ExAC gnomAD |
|
|
rs747660424 CA10125207 |
26 | L>R | No |
ClinGen ExAC gnomAD |
|
|
CA322348680 rs983865755 |
27 | L>R | No |
ClinGen TOPMed |
|
|
rs1292700838 CA410833742 |
30 | F>L | No |
ClinGen gnomAD |
|
| TCGA novel | 32 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1222963672 CA410833722 |
33 | L>V | No |
ClinGen gnomAD |
|
|
rs542661043 CA322348672 |
39 | P>S | No |
ClinGen gnomAD |
|
|
CA322348670 rs200899033 |
41 | P>L | No |
ClinGen Ensembl |
|
|
CA410833661 rs1301040765 |
42 | W>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1372867749 CA410833667 |
42 | W>R | No |
ClinGen gnomAD |
|
|
rs1226578947 CA410833655 |
43 | K>R | No |
ClinGen gnomAD |
|
|
rs778576584 CA10125206 |
44 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs754608593 CA10125205 |
45 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1279581572 CA410833645 |
45 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA10125203 rs145130250 |
46 | G>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1303308142 CA410833635 |
47 | T>A | No |
ClinGen gnomAD |
|
|
rs142942577 CA10125202 |
47 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA410833623 rs1167894723 |
49 | L>F | No |
ClinGen gnomAD |
|
|
CA410833616 rs1462916965 |
50 | S>I | No |
ClinGen gnomAD |
|
|
CA410833583 rs1601792657 |
54 | V>G | No |
ClinGen Ensembl |
|
|
CA10125200 rs142387650 |
55 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA410833568 rs1227120857 |
57 | E>K | No |
ClinGen TOPMed |
|
|
rs1269958189 CA410833528 |
63 | M>T | No |
ClinGen gnomAD |
|
|
CA322348560 rs376410604 |
63 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
CA10125196 rs752717352 |
69 | R>T | No |
ClinGen ExAC |
|
|
rs1045152874 CA322342133 |
71 | A>V | No |
ClinGen Ensembl |
|
|
CA322342132 rs554795895 |
72 | P>L | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA10125184 rs376022548 |
77 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs954965582 CA322342129 |
78 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1384527715 CA410833001 |
78 | A>V | No |
ClinGen gnomAD |
|
|
CA410832986 rs1381911837 |
80 | A>T | No |
ClinGen gnomAD |
|
|
CA10125181 rs745634939 |
81 | H>R | No |
ClinGen ExAC gnomAD |
|
|
rs1211622826 CA410832944 |
82 | E>D | No |
ClinGen gnomAD |
|
|
rs200384965 CA10125179 |
82 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA410832915 rs1258495309 |
85 | S>A | No |
ClinGen TOPMed |
|
|
rs1569130406 CA410832902 COSM182771 |
86 | Q>* | large_intestine [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs765252377 CA10125177 |
86 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753994387 CA10125175 |
89 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1601788410 CA410832822 |
92 | L>F | No |
ClinGen Ensembl |
|
|
rs761018228 CA10125173 |
94 | E>K | Variant assessed as Somatic; 6.039e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA10125172 rs137892679 |
96 | R>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA410832761 rs1477140753 |
96 | R>S | No |
ClinGen TOPMed |
|
|
rs768022793 CA10125171 |
97 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA410832737 rs1325915016 |
98 | L>F | No |
ClinGen gnomAD |
|
|
CA410832733 rs1319282784 |
99 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA410832728 rs1363899842 |
100 | R>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1479046327 CA410832723 |
101 | E>K | No |
ClinGen TOPMed |
|
|
rs774973812 CA10125169 |
102 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs370601228 CA322342098 |
103 | E>K | No |
ClinGen TOPMed |
|
|
rs1020204015 CA322342087 |
104 | E>K | No |
ClinGen gnomAD |
|
|
CA410832689 rs1474170519 |
105 | E>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs138566201 CA10125165 |
107 | E>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1297215552 CA410832677 |
107 | E>K | No |
ClinGen gnomAD |
|
|
rs769270846 CA10125159 |
109 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769270846 CA322342070 |
109 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780926684 CA10125157 |
111 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1322687888 CA410832635 |
112 | E>D | No |
ClinGen gnomAD |
|
|
CA10125156 rs770735567 |
113 | E>D | No |
ClinGen ExAC TOPMed |
|
|
rs746856265 CA10125154 |
116 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA410832611 rs1292710678 |
116 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA10125153 rs368293453 |
117 | V>E | No |
ClinGen ESP ExAC gnomAD |
|
|
CA322342050 rs924700437 |
117 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1343887846 CA410832599 |
118 | T>I | No |
ClinGen gnomAD |
|
| TCGA novel | 119 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs756191806 CA10125132 |
120 | L>P | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 123 | Q>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA322338959 rs530107747 |
125 | L>V | No |
ClinGen 1000Genomes gnomAD |
|
|
rs1264854449 CA410832166 |
126 | A>V | No |
ClinGen gnomAD |
|
|
rs750567170 CA410832164 |
127 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10125131 rs750567170 |
127 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA410832153 rs1323390628 |
128 | S>N | No |
ClinGen gnomAD |
|
|
CA410832144 rs1292853417 |
129 | F>L | No |
ClinGen gnomAD |
|
|
CA410832134 rs1340751283 |
131 | N>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1601783801 CA410832131 |
131 | N>T | No |
ClinGen Ensembl |
|
|
VAR_050620 rs9610645 CA10125129 |
132 | R>C | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs751912661 CA10125128 |
132 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs918663158 CA322338951 |
133 | L>F | No |
ClinGen Ensembl |
|
|
rs1390443465 CA410832106 |
135 | E>* | No |
ClinGen gnomAD |
|
|
rs1164378866 CA410832102 |
135 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
rs1390443465 CA410832108 |
135 | E>K | No |
ClinGen gnomAD |
|
|
CA410832094 rs550518307 |
137 | A>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM1682134 CA10125127 rs550518307 |
137 | A>T | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA10125126 rs377163282 |
138 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs372671040 CA10125125 |
140 | W>* | No |
ClinGen ESP ExAC gnomAD |
|
|
CA410832059 rs1601783751 |
142 | K>E | No |
ClinGen Ensembl |
|
|
rs530815427 CA322338944 |
143 | Q>L | No |
ClinGen 1000Genomes gnomAD |
|
|
CA410832042 rs1601783741 |
144 | V>G | No |
ClinGen Ensembl |
|
|
rs1165941679 CA410832044 |
144 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA410832035 rs1197521905 |
145 | P>R | No |
ClinGen gnomAD |
|
|
CA410832016 rs1266445872 |
148 | A>G | No |
ClinGen gnomAD |
|
|
CA10125123 rs759016459 |
149 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765713884 CA10125124 |
149 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA410832011 rs1249477981 |
150 | A>T | No |
ClinGen gnomAD |
|
|
rs971123078 CA322338916 |
150 | A>V | No |
ClinGen TOPMed |
|
|
rs760336731 CA410831992 |
153 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10125119 rs564984837 |
153 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10125120 rs760336731 |
153 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 155 | W>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs747940041 CA10125117 |
157 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs1324646912 CA410831967 |
157 | V>I | No |
ClinGen gnomAD |
|
|
CA410831958 rs1394975490 |
158 | S>C | No |
ClinGen gnomAD |
|
|
CA10125116 rs774309318 |
161 | A>T | No |
ClinGen ExAC |
|
|
CA410831930 rs1466261892 |
162 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
CA410831932 rs1601783682 |
162 | I>T | No |
ClinGen Ensembl |
|
|
CA410831928 rs1174317216 |
163 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs745928402 CA10125114 |
163 | R>W | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 165 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1569128633 CA410831909 |
166 | R>C | No |
ClinGen Ensembl |
|
|
CA10125113 rs781432214 |
166 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA10125112 rs757487890 |
167 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs1199309249 CA410831902 |
167 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1199309249 CA410831903 |
167 | R>P | No |
ClinGen TOPMed gnomAD |
|
|
rs747264218 CA10125111 |
168 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA410831888 rs1236341697 |
169 | M>I | No |
ClinGen gnomAD |
|
|
CA410831876 rs1457851790 |
171 | D>N | No |
ClinGen gnomAD |
|
|
rs577103268 CA10125109 |
172 | R>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA410831869 rs1201182279 |
172 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA10125107 rs765770907 |
173 | H>D | No |
ClinGen ExAC gnomAD |
|
|
rs1309237568 CA410831855 |
174 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1309237568 CA410831857 |
174 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
CA410831847 rs1448208975 |
175 | S>C | No |
ClinGen gnomAD |
|
|
rs1334804390 CA410831835 |
177 | P>R | No |
ClinGen gnomAD |
|
|
rs1403259806 CA410831830 |
178 | S>C | No |
ClinGen gnomAD |
|
|
CA410831832 rs1413911365 |
178 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1174519092 CA410831826 |
179 | F>L | No |
ClinGen gnomAD |
|
| TCGA novel | 179 | F>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA322338836 rs560067214 |
183 | F>C | No |
ClinGen 1000Genomes |
|
|
CA10125105 rs753291754 |
184 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs147032523 CA10125082 |
187 | D>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1340129426 CA410831670 |
188 | P>S | No |
ClinGen gnomAD |
|
|
rs1249200143 CA410831625 |
190 | N>H | No |
ClinGen TOPMed |
|
|
rs1055314607 CA322338334 |
191 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs936716075 CA322338328 |
191 | R>H | No |
ClinGen Ensembl |
|
|
rs371052460 CA10125081 |
193 | Y>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs762934268 CA10125080 |
194 | F>I | No |
ClinGen ExAC gnomAD |
|
|
CA410831568 rs762934268 |
194 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA10125079 rs775546838 |
195 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs925362483 CA322338319 |
198 | D>V | No |
ClinGen Ensembl |
|
|
rs760806504 CA10125077 |
201 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10125076 rs553631089 |
203 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10125075 rs772282135 |
204 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 205 | A>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA410831467 rs1245372501 |
206 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1452710879 CA410831460 |
207 | R>K | No |
ClinGen gnomAD |
|
|
rs1292571037 CA410831452 |
207 | R>S | No |
ClinGen gnomAD |
|
|
CA410831436 rs1317363863 COSM379685 |
209 | A>S | lung [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
CA410831434 rs1317363863 |
209 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA10125072 rs768983378 |
210 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA410831413 rs1343832171 |
211 | V>F | No |
ClinGen gnomAD |
|
| TCGA novel | 213 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs369868805 CA410831386 |
213 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs369868805 CA10125070 |
213 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs756668925 CA10125069 |
215 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA410831348 rs1463649020 |
216 | N>H | No |
ClinGen gnomAD |
|
|
CA10125068 rs375506131 |
216 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1371480209 CA410831329 |
217 | A>T | No |
ClinGen TOPMed |
|
|
rs373955365 CA10125065 |
219 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10125064 rs763888472 |
219 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 220 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs762810315 CA10125063 |
224 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1205135195 CA410831212 |
226 | D>H | No |
ClinGen gnomAD |
|
|
CA410831189 rs1457403907 |
228 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA10125060 rs765253739 |
229 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA410831164 rs1200553660 |
229 | G>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1310669846 CA410831161 |
230 | A>T | No |
ClinGen gnomAD |
|
|
rs958510014 CA322338243 |
230 | A>V | No |
ClinGen TOPMed |
|
|
rs773278865 CA10125058 |
234 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773278865 CA410831103 |
234 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1305585180 CA410831087 |
235 | F>L | No |
ClinGen gnomAD |
|
|
CA10125057 rs772079351 |
235 | F>S | No |
ClinGen ExAC |
|
|
rs774522572 CA10125055 |
236 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs762050247 CA10125056 |
236 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10125054 rs144678508 |
237 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10125053 rs140855421 |
237 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1357141521 CA410831065 |
238 | T>A | No |
ClinGen gnomAD |
|
|
CA410831042 rs1325164458 |
239 | D>E | No |
ClinGen TOPMed |
|
|
CA10125052 rs780407448 |
239 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10125051 rs537126643 |
240 | Q>* | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs746390865 CA10125050 |
241 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs780703480 CA10125049 |
244 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA410830983 rs780703480 |
244 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1239249768 CA410830954 |
248 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1239249768 CA410830955 |
248 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs993840823 CA322338225 |
248 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs754710375 CA10125024 |
250 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10125025 rs778725091 |
250 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10125023 rs753730476 |
252 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA10125022 rs766208962 |
252 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA10125020 rs751568857 |
254 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10125019 rs764188200 |
255 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA10125015 rs759814828 |
258 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs759814828 CA10125016 |
258 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs775666012 CA10125017 |
258 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA10125013 rs61730100 |
260 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs867121892 CA322336894 |
261 | L>F | No |
ClinGen Ensembl |
|
|
rs759966864 CA10125010 |
262 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1206624886 CA410830742 |
264 | G>E | No |
ClinGen gnomAD |
|
|
CA410830734 rs1487472647 |
265 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs748974534 CA10125006 |
267 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA10125005 rs779901052 |
269 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750380798 COSM1415089 CA10125003 |
270 | A>T | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA410830690 rs1181147575 |
273 | G>R | No |
ClinGen TOPMed |
|
|
CA410830684 rs1294621028 |
274 | D>N | No |
ClinGen gnomAD |
|
| TCGA novel | 276 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 276 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1601781256 CA410830658 |
277 | V>G | No |
ClinGen Ensembl |
|
|
rs139401156 CA10125000 |
277 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 278 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10124999 rs376795506 |
278 | I>V | No |
ClinGen ESP ExAC gnomAD |
|
|
rs759818451 CA10124998 |
281 | Q>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs754086706 CA10124997 |
282 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
CA410830541 rs1601781233 |
286 | V>G | No |
ClinGen Ensembl |
|
|
rs1191673557 CA410830491 |
290 | E>K | No |
ClinGen gnomAD |
|
|
CA410830457 rs1469732067 |
292 | H>R | No |
ClinGen gnomAD |
|
|
CA410830436 rs1255629330 |
293 | R>S | No |
ClinGen gnomAD |
|
|
COSM32999 CA410830411 VAR_036520 rs1318162463 |
296 | R>Q | large_intestine a colorectal cancer sample; somatic mutation [Cosmic, UniProt] | No |
ClinGen cosmic curated UniProt TOPMed dbSNP gnomAD |
|
CA10124993 rs772750930 |
296 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769502731 CA10124970 |
301 | A>E | No |
ClinGen ExAC gnomAD |
|
|
rs1447672877 CA410829994 |
301 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1395693423 CA410829983 VAR_086701 |
302 | R>C | Variant assessed as Somatic; 0.0 impact. found in a patient with sclerosing cholangitis short stature hypothyroidism and abnormal tongue pigmentation; unknown pathological significance [NCI-TCGA, UniProt] | No |
ClinGen UniProt NCI-TCGA TOPMed dbSNP gnomAD |
|
CA322332633 rs549205418 |
302 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA410829958 COSM1307993 rs1174030342 |
304 | E>K | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA410829867 rs1601777465 |
312 | H>D | No |
ClinGen Ensembl |
|
|
CA10124967 rs374278330 |
313 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1274845384 CA410829842 |
315 | C>G | No |
ClinGen TOPMed |
|
|
CA322332612 rs981011575 |
316 | W>* | No |
ClinGen TOPMed |
|
|
rs746999477 CA10124966 |
319 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs573839921 CA10124964 |
320 | G>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10124963 rs749371622 |
321 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10124960 rs750746998 |
322 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 323 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs755692988 CA322332557 |
324 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
CA322332539 rs4050961 |
325 | S>C | No |
ClinGen Ensembl |
|
|
rs752082994 CA10124957 |
329 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA410829005 rs1335371010 |
330 | D>H | No |
ClinGen TOPMed |
|
|
CA10124898 rs747218234 |
330 | D>V | No |
ClinGen ExAC gnomAD |
|
|
CA10124897 rs778158817 |
331 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA410828986 rs1206856529 |
332 | F>L | No |
ClinGen gnomAD |
|
|
CA10124895 rs779376709 |
335 | P>A | No |
ClinGen ExAC gnomAD |
|
|
CA10124894 rs779376709 |
335 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs755542293 CA10124893 |
336 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10124891 rs779457408 |
337 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs552638029 CA10124890 |
338 | S>F | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1601775758 CA410828937 |
339 | G>A | No |
ClinGen Ensembl |
|
|
COSM3842261 rs1443956182 CA410828900 |
342 | D>N | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA410828894 rs1357017980 |
342 | D>V | No |
ClinGen gnomAD |
|
|
rs199861570 CA10124886 |
346 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10124887 rs114630807 |
346 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs764057762 CA10124885 |
347 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10124883 rs144940091 COSM1565996 |
349 | T>M | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs760847369 CA10124881 |
350 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs369233514 CA10124880 |
351 | S>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs369233514 CA410828785 |
351 | S>F | No |
ClinGen ESP ExAC gnomAD |
|
|
CA410828770 rs1282432275 |
352 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
rs1485861558 CA410828780 |
352 | E>K | No |
ClinGen gnomAD |
|
|
rs1316221957 CA410828753 |
353 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
CA410828766 rs1237907416 |
353 | D>N | No |
ClinGen gnomAD |
|
|
CA322330838 rs906498869 |
357 | L>F | No |
ClinGen TOPMed |
|
|
CA410828703 rs1569124947 |
358 | A>P | No |
ClinGen Ensembl |
|
| TCGA novel | 362 | F>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1397879871 CA410828652 |
363 | F>S | No |
ClinGen TOPMed gnomAD |
|
|
rs774698640 CA10124877 |
365 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs749829790 CA10124875 |
366 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1296697502 CA410828622 |
368 | H>Y | No |
ClinGen gnomAD |
|
|
rs1324283360 CA410828615 |
369 | Q>E | No |
ClinGen TOPMed |
|
|
CA10124872 rs745443715 |
372 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs1422119262 CA410828584 |
373 | G>V | No |
ClinGen gnomAD |
|
|
rs143120845 CA10124871 |
376 | Q>E | No |
ClinGen ESP ExAC gnomAD |
|
|
CA410828563 rs1461683083 |
377 | S>C | No |
ClinGen gnomAD |
|
|
rs377507736 CA10124870 |
378 | H>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1476285320 CA410828529 |
382 | Q>R | No |
ClinGen gnomAD |
|
|
rs1259380102 CA410828520 |
383 | Q>R | No |
ClinGen gnomAD |
|
|
rs149519614 CA322330784 |
384 | G>S | No |
ClinGen ESP TOPMed |
|
|
rs1177548949 CA410828514 |
384 | G>V | No |
ClinGen TOPMed |
|
|
rs1214110514 CA410828510 |
385 | S>G | No |
ClinGen gnomAD |
|
|
CA10124867 rs758369684 |
386 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764002847 CA10124868 |
386 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA10124864 rs541801402 |
388 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs149886262 CA10124863 |
388 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA410828489 rs1276701681 |
389 | V>I | No |
ClinGen gnomAD |
|
|
CA10124861 rs373611791 |
390 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10124859 rs147873434 |
391 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1299120264 CA410828467 |
392 | E>G | No |
ClinGen TOPMed |
|
|
rs146460819 CA322330692 |
395 | A>S | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA410828444 rs770401420 |
396 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs775850661 CA10124857 |
396 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770401420 CA10124856 |
396 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA10124854 rs201217825 |
398 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10124855 rs745310134 |
398 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs746689848 CA10124852 |
399 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs200753279 CA322330639 |
400 | R>Q | No |
ClinGen 1000Genomes gnomAD |
|
|
CA410828426 rs1213701733 |
400 | R>W | No |
ClinGen gnomAD |
|
|
rs1255744164 CA410828420 |
401 | G>D | No |
ClinGen gnomAD |
|
|
rs777608532 CA10124851 |
403 | H>P | No |
ClinGen ExAC gnomAD |
|
|
rs369252135 CA10124849 |
404 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1003542794 CA410828378 |
407 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA322330615 rs1003542794 |
407 | T>R | No |
ClinGen TOPMed |
|
|
rs761925185 CA10124842 |
409 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs559659083 CA322330592 |
410 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
CA410828355 rs1373467397 |
411 | V>D | No |
ClinGen gnomAD |
|
|
rs372015251 CA322330590 |
411 | V>I | No |
ClinGen gnomAD |
|
|
CA322330588 rs1036587806 |
413 | L>F | No |
ClinGen Ensembl |
|
|
CA410828330 rs1321180760 |
415 | D>G | No |
ClinGen gnomAD |
|
|
CA10124840 rs764361815 |
415 | D>N | No |
ClinGen ExAC gnomAD |
|
| VAR_036521 | 417 | Q>K | a breast cancer sample; somatic mutation [UniProt] | No | UniProt |
|
VAR_024580 rs2070507 CA10124839 |
420 | L>R | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA10124838 rs775929790 |
421 | E>* | No |
ClinGen ExAC |
|
|
CA410828291 rs1469398160 |
421 | E>G | No |
ClinGen gnomAD |
|
|
rs1194903845 COSM1484098 CA410828279 |
423 | G>R | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs1339601174 CA410828264 |
425 | Q>P | No |
ClinGen TOPMed gnomAD |
|
|
CA10124835 CA10124836 rs776240342 |
428 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs929230830 CA322330551 |
428 | G>V | No |
ClinGen TOPMed |
|
|
CA10124833 rs746565007 |
429 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs1236655160 CA410828238 |
429 | D>E | No |
ClinGen gnomAD |
|
|
rs770532927 CA10124834 |
429 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA410828239 rs746565007 |
429 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs374898094 CA10124832 |
430 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10124831 rs771821959 |
431 | Q>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1438820084 CA410828221 |
432 | A>E | No |
ClinGen TOPMed |
|
|
rs1398840318 CA410828207 |
434 | G>E | No |
ClinGen gnomAD |
|
|
rs139119123 CA10124828 |
437 | Q>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10124827 rs754818649 |
438 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA10124826 rs753786937 |
439 | L>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 440 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1455502051 CA410828156 |
442 | S>C | No |
ClinGen gnomAD |
|
|
CA410828154 rs1361583215 |
442 | S>T | No |
ClinGen gnomAD |
|
|
CA410828144 rs1180388157 |
444 | P>T | No |
ClinGen gnomAD |
|
|
CA410828138 rs1215102478 |
445 | E>Q | No |
ClinGen TOPMed |
|
|
rs780020474 CA10124825 COSM1327319 |
448 | T>I | ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA10124823 rs74525416 |
449 | Q>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA410828101 rs1441189538 |
450 | A>D | No |
ClinGen gnomAD |
|
|
CA10124822 rs764235417 |
451 | P>A | No |
ClinGen ExAC gnomAD |
|
|
CA10124820 rs148553069 |
454 | S>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
1 associated diseases with P49593
Without disease ID
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.16 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| calmodulin-dependent protein phosphatase activity | Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin. |
| metal ion binding | Binding to a metal ion. |
| myosin phosphatase activity | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. |
| protein serine/threonine phosphatase activity | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
| protein tyrosine/serine/threonine phosphatase activity | Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| intrinsic apoptotic signaling pathway | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). |
| negative regulation of cell-cell adhesion mediated by cadherin | Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of peptidyl-serine phosphorylation | Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
| negative regulation of protein kinase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. |
| negative regulation of protein kinase activity by regulation of protein phosphorylation | The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase. |
| negative regulation of protein transport | Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| peptidyl-serine dephosphorylation | The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine. |
| peptidyl-threonine dephosphorylation | The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of cell-substrate adhesion | Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. |
| positive regulation of chemotaxis | Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process. |
| positive regulation of epithelial cell migration | Any process that activates or increases the frequency, rate or extent of epithelial cell migration. |
| positive regulation of focal adhesion assembly | Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of growth | Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. |
| positive regulation of stress fiber assembly | Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
| regulation of protein localization | Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. |
30 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A5PJZ2 | PPM1L | Protein phosphatase 1L | Bos taurus (Bovine) | PR |
| O15297 | PPM1D | Protein phosphatase 1D | Homo sapiens (Human) | PR |
| Q9ULR3 | PPM1H | Protein phosphatase 1H | Homo sapiens (Human) | PR |
| Q5SGD2 | PPM1L | Protein phosphatase 1L | Homo sapiens (Human) | PR |
| Q8BHN0 | Ppm1l | Protein phosphatase 1L | Mus musculus (Mouse) | PR |
| Q80TL0 | Ppm1e | Protein phosphatase 1E | Mus musculus (Mouse) | PR |
| Q8CGA0 | Ppm1f | Protein phosphatase 1F | Mus musculus (Mouse) | PR |
| Q5JKN1 | Os01g0552300 | Probable protein phosphatase 2C 5 | Oryza sativa subsp japonica (Rice) | PR |
| Q0JLP9 | PP2C06 | Probable protein phosphatase 2C 6 | Oryza sativa subsp japonica (Rice) | PR |
| Q5SN75 | Os01g0656200 | Probable protein phosphatase 2C 8 | Oryza sativa subsp japonica (Rice) | PR |
| Q6K5I0 | Os02g0600000 | Probable protein phosphatase 2C 20 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XW27 | Os04g0321800 | Probable protein phosphatase 2C 38 | Oryza sativa subsp japonica (Rice) | PR |
| Q6L482 | Os05g0358500 | Probable protein phosphatase 2C 48 | Oryza sativa subsp japonica (Rice) | PR |
| Q6L4R7 | PP2C53 | Protein phosphatase 2C 53 | Oryza sativa subsp japonica (Rice) | PR |
| Q6ZKL8 | Os08g0500300 | Probable protein phosphatase 2C 66 | Oryza sativa subsp japonica (Rice) | PR |
| Q9LNP9 | HAB2 | Protein phosphatase 2C 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMT1 | At1g18030 | Probable protein phosphatase 2C 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CAJ0 | HAB1 | Protein phosphatase 2C 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81716 | PPC4-2 | Probable protein phosphatase 2C 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRZ4 | At3g16800 | Probable protein phosphatase 2C 41 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3EAZ3 | At3g27140 | Putative protein phosphatase 2C-like protein 45 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SD02 | At3g51470 | Probable protein phosphatase 2C 47 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GY60 | At4g03415 | Probable protein phosphatase 2C 52 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P49599 | PPH1 | Protein phosphatase 2C 57 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FG61 | At5g36250 | Probable protein phosphatase 2C 74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O04719 | ABI2 | Protein phosphatase 2C 77 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIF5 | SAG113 | Probable protein phosphatase 2C 78 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZN9 | At1g43900 | Probable protein phosphatase 2C 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AT1 | At5g53140 | Probable protein phosphatase 2C 76 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDA7 | At3g15260 | Probable protein phosphatase 2C 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSGAPQKSS | PMASGAEETP | GFLDTLLQDF | PALLNPEDPL | PWKAPGTVLS | QEEVEGELAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LAMGFLGSRK | APPPLAAALA | HEAVSQLLQT | DLSEFRKLPR | EEEEEEEDDD | EEEKAPVTLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DAQSLAQSFF | NRLWEVAGQW | QKQVPLAARA | SQRQWLVSIH | AIRNTRRKME | DRHVSLPSFN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QLFGLSDPVN | RAYFAVFDGH | GGVDAARYAA | VHVHTNAARQ | PELPTDPEGA | LREAFRRTDQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MFLRKAKRER | LQSGTTGVCA | LIAGATLHVA | WLGDSQVILV | QQGQVVKLME | PHRPERQDEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ARIEALGGFV | SHMDCWRVNG | TLAVSRAIGD | VFQKPYVSGE | ADAASRALTG | SEDYLLLACD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GFFDVVPHQE | VVGLVQSHLT | RQQGSGLRVA | EELVAAARER | GSHDNITVMV | VFLRDPQELL |
| 430 | 440 | 450 | |||
| EGGNQGEGDP | QAEGRRQDLP | SSLPEPETQA | PPRS |