AiPD: Autoinhibited Protein Database

Q9ULR3

Gene name	PPM1H (ARHCL1, KIAA1157, URCC2)
Protein name	Protein phosphatase 1H
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:57460
EC number	3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

70-162 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

70-162 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for Q9ULR3

Entry ID	Method	Resolution	Chain	Position	Source
7KPR	X-ray	309 A	A/B	33-514	PDB
7L4I	X-ray	258 A			PDB
7L4J	X-ray	245 A			PDB
7N0Z	X-ray	219 A			PDB
AF-Q9ULR3-F1	Predicted				AlphaFoldDB

399 variants for Q9ULR3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA385655370 rs1475093405	2	L>P		No	ClinGen gnomAD
CA6664903 rs752812136	4	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1189094166 CA385655355	5	V>A		No	ClinGen TOPMed
CA6664901 rs759809893	6	K>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6664900 rs774396082	7	S>C		No	ClinGen ExAC gnomAD
CA6664897 rs773172191	9	V>E		No	ClinGen ExAC gnomAD
rs762713478 CA6664898 CA385655332	9	V>L		No	ClinGen ExAC TOPMed gnomAD
CA238762722 rs1004682712	10	A>V		No	ClinGen TOPMed gnomAD
CA6664896 rs769712316	11	N>S		No	ClinGen ExAC TOPMed gnomAD
CA6664895 rs747712051	14	G>S		No	ClinGen ExAC gnomAD
rs1359957876 CA385655294	15	G>S		No	ClinGen gnomAD
CA385655288 rs1424585309	16	I>V		No	ClinGen gnomAD
CA385655279 rs1296930648	17	M>T		No	ClinGen gnomAD
rs539681262 CA238762721	18	A>G		No	ClinGen 1000Genomes
rs553231617 CA6664894	18	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6664892 rs746702150	21	S>L		No	ClinGen ExAC gnomAD
TCGA novel	24	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757739926 CA6664890	25	H>P		No	ClinGen ExAC TOPMed gnomAD
CA385655222 rs749669503	26	G>C		No	ClinGen ExAC TOPMed gnomAD
rs749669503 CA6664889	26	G>R		No	ClinGen ExAC TOPMed gnomAD
CA238762718 rs756704143	28	G>C		No	ClinGen ExAC TOPMed gnomAD
CA6664886 rs753080129	28	G>D		No	ClinGen ExAC TOPMed gnomAD
CA6664887 rs756704143	28	G>R		No	ClinGen ExAC TOPMed gnomAD
CA385655212 rs756704143	28	G>S		No	ClinGen ExAC TOPMed gnomAD
rs754964484 CA385655205	29	S>I		No	ClinGen ExAC TOPMed gnomAD
rs754964484 CA6664884	29	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1310207144 CA385655209	29	S>R		No	ClinGen TOPMed gnomAD
CA6664883 rs751856719	30	C>F		No	ClinGen ExAC TOPMed gnomAD
rs1332400050 CA385655202	30	C>R		No	ClinGen Ensembl
rs762801436 CA6664881	30	C>W		No	ClinGen ExAC TOPMed gnomAD
rs1296445660 CA385655193	31	G>E		No	ClinGen TOPMed gnomAD
rs570703145 CA6664878	32	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764950863 CA6664879	32	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1355461211 CA385655181	33	S>L		No	ClinGen gnomAD
rs1408726243 CA385655176	34	D>A		No	ClinGen gnomAD
CA238762717 rs866669891	34	D>E		No	ClinGen TOPMed gnomAD
CA6664877 rs776388056	34	D>N		No	ClinGen ExAC gnomAD
rs1480574379 CA385655164	36	P>L		No	ClinGen gnomAD
rs1422401823 CA385655157	38	R>C		No	ClinGen gnomAD
CA6664875 rs760074965	40	P>A		No	ClinGen ExAC TOPMed gnomAD
rs1482176576 CA385655133	41	Y>*		No	ClinGen gnomAD
rs771839014 CA6664873	41	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA6664872 rs745460816	42	G>R		No	ClinGen ExAC TOPMed gnomAD
CA385655126 rs1308029002	43	R>W		No	ClinGen gnomAD
rs770244442 CA6664870	45	E>D		No	ClinGen ExAC gnomAD
rs1276465014 CA385655095	48	G>R		No	ClinGen TOPMed gnomAD
CA6664869 rs748711490	48	G>V		No	ClinGen ExAC gnomAD
rs1276465014 CA385655094	48	G>W		No	ClinGen TOPMed gnomAD
CA238762715 rs946876608	50	S>F		No	ClinGen Ensembl
CA385655063 rs1345947458	53	E>*		No	ClinGen TOPMed
rs1312694586 CA385655061	53	E>A		No	ClinGen gnomAD
rs1312694586 CA385655060	53	E>V		No	ClinGen gnomAD
CA385655053 rs1378401970	54	V>A		No	ClinGen gnomAD
rs1378401970 CA385655052	54	V>G		No	ClinGen gnomAD
CA385655031 rs1385557285	57	S>T		No	ClinGen gnomAD
CA385655016 rs1343634343	59	D>E		No	ClinGen TOPMed
CA6664868 rs781527650	59	D>N		No	ClinGen ExAC TOPMed gnomAD
CA385655020 rs781527650	59	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs915330890 CA238762714	64	P>R		No	ClinGen Ensembl
CA238762713 rs2628035	65	I>V		No	ClinGen Ensembl
CA385654974 rs1463114037	66	L>F		No	ClinGen TOPMed gnomAD
CA385654956 rs1186177246	69	K>E		No	ClinGen gnomAD
CA385654942 rs1244832057	70	E>D		No	ClinGen gnomAD
rs1442725737 CA385654945	70	E>G		No	ClinGen gnomAD
CA6664867 rs755124939	71	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1452568695 CA385654940	71	T>P		No	ClinGen TOPMed
CA385654894 rs1271212842	79	G>S		No	ClinGen gnomAD
rs1340196480 CA385654870	82	E>G		No	ClinGen gnomAD
CA238751535 rs761701259	86	A>T		No	ClinGen Ensembl
CA6664852 rs774098569	87	G>R		No	ClinGen ExAC gnomAD
rs1419052087 CA385653894	89	S>G		No	ClinGen gnomAD
rs1405636333 CA385653881	91	H>N		No	ClinGen gnomAD
CA385653875 rs1160093536	91	H>Q		No	ClinGen gnomAD
TCGA novel	93	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	97	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385653814 rs1470389145	99	E>V		No	ClinGen gnomAD
TCGA novel	100	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6664850 rs570653055	101	L>P		No	ClinGen 1000Genomes ExAC gnomAD
rs769029280 CA6664848	103	V>M		No	ClinGen ExAC TOPMed gnomAD
CA6664847 rs747489418	106	K>E		No	ClinGen ExAC TOPMed gnomAD
rs781426313 CA238751533	106	K>M		No	ClinGen Ensembl
CA6664846 rs780109938	107	A>S		No	ClinGen ExAC
CA385653759 rs1378565200	108	G>E		No	ClinGen gnomAD
CA238751532 rs758428692	109	A>D		No	ClinGen ExAC TOPMed gnomAD
CA6664844 rs758428692	109	A>V		No	ClinGen ExAC TOPMed gnomAD
CA238751530 COSM95037 rs557575879	110	V>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6664843 rs557575879	110	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	111	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779079772 CA6664842	113	T>N		No	ClinGen ExAC TOPMed gnomAD
CA6664841 rs757145669	115	N>D		No	ClinGen ExAC gnomAD
TCGA novel	115	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385653706 rs1221268447	117	N>I		No	ClinGen gnomAD
CA385653704 rs1565803028	117	N>K		No	ClinGen Ensembl
CA385653708 rs1221268447	117	N>T		No	ClinGen gnomAD
rs1592623779 CA385653695	119	S>P		No	ClinGen Ensembl
rs773011134 CA6664840	122	R>G		No	ClinGen ExAC TOPMed gnomAD
rs756011853 CA385653675	122	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6664838 rs756011853	122	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6664839 rs773011134	122	R>W		No	ClinGen ExAC TOPMed gnomAD
rs752642318 CA6664837	124	S>F		No	ClinGen ExAC gnomAD
CA6664836 rs767159600	125	L>P		No	ClinGen ExAC gnomAD
CA6664834 rs759093804	127	N>H		No	ClinGen ExAC
rs201010099 CA6664832	127	N>K		No	ClinGen ExAC TOPMed
CA385653649 rs1326031362	127	N>S		No	ClinGen gnomAD
TCGA novel	128	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1320196044 CA385653636	129	E>G		No	ClinGen gnomAD
TCGA novel	130	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776870227 CA6664829	133	L>V		No	ClinGen ExAC TOPMed gnomAD
rs768996261 CA6664828	135	E>D		No	ClinGen ExAC
CA6664826 rs775923431	137	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6664827 rs775923431	137	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1592606625 CA385654840	140	E>G		No	ClinGen Ensembl
rs749494568 CA6664803	140	E>K		No	ClinGen ExAC TOPMed gnomAD
rs935947316 CA238748008	141	G>V		No	ClinGen gnomAD
CA238748006 rs868748234	143	S>F		No	ClinGen Ensembl
rs78522855 CA238748007	143	S>P		No	ClinGen Ensembl
rs778034507 CA6664802	144	C>S		No	ClinGen ExAC TOPMed gnomAD
rs374889057 CA6664800	146	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA238748004 rs78301701	148	S>L		No	ClinGen Ensembl
CA385654781 rs1440325360	149	L>P		No	ClinGen gnomAD
rs781335676 CA6664799	151	D>E		No	ClinGen ExAC gnomAD
CA6664798 rs754977710	152	G>R		No	ClinGen ExAC TOPMed gnomAD
CA238748003 rs1043721690	154	A>V		No	ClinGen Ensembl
rs1218166411 CA385654727	158	A>S		No	ClinGen TOPMed gnomAD
CA385654726 rs1218166411	158	A>T		No	ClinGen TOPMed gnomAD
rs750087918 CA6664794	159	A>T		No	ClinGen ExAC gnomAD
CA385654706 rs1592606550	161	V>G		No	ClinGen Ensembl
CA6664791 rs372654483	162	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs767806980 CA6664790	164	R>C		No	ClinGen ExAC gnomAD
rs767806980 CA385654693	164	R>G		No	ClinGen ExAC gnomAD
rs774874887 CA385654692	164	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs774874887 CA6664788	164	R>L		No	ClinGen ExAC TOPMed gnomAD
rs774874887 CA6664789	164	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1565792860 CA385654685	166	L>V		No	ClinGen Ensembl
CA385654672 rs1375802625	168	H>Y		No	ClinGen gnomAD
rs773373790 CA6664785	171	T>A		No	ClinGen ExAC gnomAD
CA6664784 rs201631911	171	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA385654637 rs1399256280	173	Q>K		No	ClinGen TOPMed
TCGA novel	174	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385654611 rs1347113597	176	D>E		No	ClinGen TOPMed
rs768529047 CA6664781	176	D>G		No	ClinGen ExAC TOPMed gnomAD
CA6664780 rs746963380	177	I>M		No	ClinGen ExAC gnomAD
TCGA novel	178	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385654586 rs1421248730	180	I>T		No	ClinGen gnomAD
TCGA novel	182	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385654560 rs1479847068	183	N>K		No	ClinGen gnomAD
CA6664778 rs757883510	183	N>S		No	ClinGen ExAC TOPMed gnomAD
rs757883510 CA385654565	183	N>T		No	ClinGen ExAC TOPMed gnomAD
CA6664777 rs749939955	184	S>F		No	ClinGen ExAC gnomAD
CA6664772 rs759872673	186	V>A		No	ClinGen ExAC gnomAD
CA6664773 rs767893394	186	V>F		No	ClinGen ExAC gnomAD
CA6664774 rs767893394	186	V>I		No	ClinGen ExAC gnomAD
rs752047783 CA6664771	188	P>L		No	ClinGen ExAC gnomAD
CA238748002 rs911272972	188	P>S		No	ClinGen TOPMed gnomAD
CA6664770 rs200553056	189	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6664769 rs200553056	189	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6664768 rs200553056	189	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs972029875 CA238748001	192	L>R		No	ClinGen TOPMed
CA385654479 rs1424718414	193	G>R		No	ClinGen TOPMed
CA385654473 rs1285286894	193	G>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1333679703 CA385654470	194	E>Q		No	ClinGen TOPMed gnomAD
rs776942199 CA6664765	198	N>S		No	ClinGen ExAC gnomAD
CA6664764 rs768617066	199	T>M		No	ClinGen ExAC TOPMed gnomAD
CA385654391 rs775351949	201	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6664762 rs775351949	201	A>T		No	ClinGen ExAC TOPMed gnomAD
rs772063556 CA6664761	201	A>V		No	ClinGen ExAC gnomAD
CA6664760 rs745728763	202	N>D		No	ClinGen ExAC gnomAD
CA6664759 rs778429629	203	S>C		No	ClinGen ExAC TOPMed gnomAD
rs756709628 CA6664758	204	R>G		No	ClinGen ExAC TOPMed gnomAD
rs199959694 CA6664757	204	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA238747998 rs756709628	204	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1373804294 CA385654348	205	T>N		No	ClinGen TOPMed
RCV000970870 CA6664755 rs144982343	205	T>P		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs751938700 CA6664754	206	L>V		No	ClinGen ExAC gnomAD
rs765426741 CA6664750	208	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs765426741 CA6664751	208	R>Q		No	ClinGen ExAC gnomAD
rs758947327 CA6664752	208	R>W		No	ClinGen ExAC gnomAD
TCGA novel	210	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1304457948 CA385654300	211	S>C		No	ClinGen TOPMed
CA238747997 rs373892032	211	S>T		No	ClinGen ESP gnomAD
TCGA novel	213	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA238747996 rs1014446311	215	G>E		No	ClinGen Ensembl
rs760754216 CA6664746	215	G>W		No	ClinGen ExAC TOPMed gnomAD
CA6664744 rs745843860	217	G>E		No	ClinGen ExAC TOPMed gnomAD
rs775361931 CA6664745	217	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6664743 rs745843860	217	G>V		No	ClinGen ExAC TOPMed gnomAD
CA6664739 rs777459768	219	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6664740 rs777459768	219	P>R		No	ClinGen ExAC TOPMed gnomAD
CA385654236 rs1468500377	219	P>S		No	ClinGen gnomAD
CA385654207 rs1372034741	222	P>S		No	ClinGen gnomAD
CA385654188 rs1565792693	224	T>A		No	ClinGen Ensembl
CA6664736 rs780498734	224	T>M		No	ClinGen ExAC TOPMed gnomAD
rs575495458 CA238747994	225	P>H		No	ClinGen 1000Genomes
rs765805274 CA6664733	226	P>A		No	ClinGen ExAC TOPMed gnomAD
rs776895562	227	T>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA385654153 rs760993330	228	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs760993330 CA385654151	228	R>G		No	ClinGen ExAC TOPMed gnomAD
rs911264760 CA238747993	228	R>L		No	ClinGen Ensembl
rs760993330 CA6664728	228	R>S		No	ClinGen ExAC TOPMed gnomAD
CA6664727 rs201432518	229	F>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs377044320 CA6664723	232	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs910984190 CA238747991	232	E>K		No	ClinGen TOPMed
rs370030873 CA6664724	232	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6664721 rs762817798	233	K>E		No	ClinGen ExAC gnomAD
rs1450987605 CA385654098	233	K>N		No	ClinGen gnomAD
rs1341456950 CA385654076	236	P>R		No	ClinGen TOPMed gnomAD
rs1337759925 CA385654080	236	P>S		No	ClinGen gnomAD
CA385654049 rs1283883906	240	L>V		No	ClinGen gnomAD
CA6664720 rs772711256	241	V>I		No	ClinGen ExAC
rs373606808 CA6664719	244	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs373606808 CA385654023	244	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA385653998 rs1184458741	248	A>T		No	ClinGen TOPMed
rs191415567 CA6664717	252	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1220915855 CA385653557	255	Q>K		No	ClinGen TOPMed
CA6664702 rs377085423	256	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA385653548 rs377085423	256	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs769390985 CA6664701	257	E>G		No	ClinGen ExAC TOPMed
rs761192541 CA6664700	258	R>G		No	ClinGen ExAC TOPMed gnomAD
CA6664699 rs200818178	258	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1348961598	260	R>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1277453879 CA385653513	261	S>I		No	ClinGen TOPMed gnomAD
CA385653515 rs1277453879	261	S>N		No	ClinGen TOPMed gnomAD
rs1471592097 CA385653511	261	S>R		No	ClinGen TOPMed gnomAD
CA6664698 rs189507586	263	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385653503 rs1302492925	263	Y>H		No	ClinGen TOPMed
CA385653484 rs1347390912	265	I>T		No	ClinGen gnomAD
CA238746512 rs752704956	266	S>Y		No	ClinGen Ensembl
rs1324112798 CA385653454	270	T>A		No	ClinGen gnomAD
CA6664697 rs369238249	270	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1160037178 CA385653448	271	A>V		No	ClinGen gnomAD
rs1314166426 CA385653438	273	I>V		No	ClinGen TOPMed
rs943739059 CA238746511	274	V>A		No	ClinGen TOPMed gnomAD
CA6664693 rs149789565	274	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1481454501 CA385653426	275	I>F		No	ClinGen gnomAD
CA385653411 rs1247856618	277	L>F		No	ClinGen gnomAD
CA385653397 rs1256733679	279	G>E		No	ClinGen gnomAD
rs756283774 CA6664692	281	L>V		No	ClinGen ExAC gnomAD
rs1044196400 CA238746510	282	Y>C		No	ClinGen Ensembl
CA385653381 rs1286806690	282	Y>H		No	ClinGen gnomAD
rs1209685403 CA385653361	285	N>D		No	ClinGen gnomAD
CA385653357 rs1329428613	285	N>K		No	ClinGen gnomAD
rs752708216 CA6664691	286	A>T		No	ClinGen ExAC gnomAD
rs1221215759 CA385653344	288	D>N		No	ClinGen gnomAD
rs1275405170 CA385653335	289	S>G		No	ClinGen gnomAD
TCGA novel	294	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1565773774 CA385655829	296	N>D		No	ClinGen Ensembl
CA238740876 rs368227940	296	N>K		No	ClinGen ESP TOPMed
TCGA novel	298	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1299717481 CA385655793	301	P>S		No	ClinGen gnomAD
rs892780267 CA238740875	302	M>V		No	ClinGen Ensembl
rs1186874701 CA385655770	304	S>L		No	ClinGen TOPMed
CA238740874 rs1033115757	307	T>I		No	ClinGen Ensembl
CA385655752 rs1592571449	307	T>P		No	ClinGen Ensembl
rs199521003 CA6664679	309	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs199521003 CA6664678	309	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA6664677 rs749667530	310	T>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	311	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1408268845 CA385655721	312	R>C		No	ClinGen TOPMed gnomAD
CA238740872 rs376052127	312	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA
rs1408268845 CA385655723	312	R>S		No	ClinGen TOPMed gnomAD
rs770217199 CA6664675	313	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1169756826 CA385655710	314	R>*		No	ClinGen gnomAD
CA6664674 rs748619803	314	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA385655695 rs1185752193	316	Q>H		No	ClinGen gnomAD
CA238740871 rs867182474	318	L>M		No	ClinGen Ensembl
CA6664673 rs781160115	318	L>P		No	ClinGen ExAC gnomAD
rs1490166507 CA385655648	321	M>T		No	ClinGen gnomAD
rs1336537124 CA385655651	321	M>V		No	ClinGen Ensembl
CA238738792 rs752524493	322	Q>H		No	ClinGen Ensembl
CA238738793 rs1032363753	322	Q>K		No	ClinGen TOPMed gnomAD
rs1212738584 CA385655629	324	H>Y		No	ClinGen TOPMed
CA385655601 rs1322074749	328	N>S		No	ClinGen gnomAD
CA385655596 rs758630061	329	E>*		No	ClinGen ExAC TOPMed gnomAD
rs758630061 CA6664651	329	E>K		No	ClinGen ExAC TOPMed gnomAD
CA6664649 rs778597878	331	T>A		No	ClinGen ExAC TOPMed gnomAD
rs899974028 CA238738791	331	T>I		No	ClinGen Ensembl
rs564856583 CA6664648	332	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1039933884 CA238738790	332	H>Y		No	ClinGen Ensembl
CA385655565 rs1179058881	334	E>K		No	ClinGen TOPMed
rs200127762 CA6664645	339	V>A		No	ClinGen 1000Genomes ExAC gnomAD
rs777852108 CA6664646	339	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	343	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1345008258 CA385655492	344	L>F		No	ClinGen gnomAD
CA238738788 rs531429250	348	M>L		No	ClinGen 1000Genomes
TCGA novel	349	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1265326038 CA385655454	349	L>P		No	ClinGen gnomAD
CA385655416 rs1413625108	354	N>T		No	ClinGen gnomAD
CA385655409 rs1397204616	355	M>T		No	ClinGen TOPMed
CA6664641 rs200725314	356	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs920126619 CA238738787	356	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA385655396 rs1479814358	357	G>A		No	ClinGen gnomAD
CA238735938 rs903645410	360	Y>H		No	ClinGen Ensembl
CA6664617 rs61756417	363	I>T		No	ClinGen ExAC TOPMed gnomAD
rs368717089 CA238735937	364	E>Q		No	ClinGen ESP
CA385653263 rs1592547467	365	D>G		No	ClinGen Ensembl
rs942562986 CA238735935	367	D>N		No	ClinGen Ensembl
CA385653239 rs1366335440	368	L>W		No	ClinGen gnomAD
CA6664616 rs567590288	370	F>I		No	ClinGen 1000Genomes ExAC gnomAD
rs911046951 CA238735934	377	G>A		No	ClinGen TOPMed
CA385653076 rs1162772878	380	A>D		No	ClinGen TOPMed gnomAD
rs1371022058 CA385653078	380	A>T		No	ClinGen gnomAD
rs199771693 CA6664594	381	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA385653073 rs1370465683	381	R>Q		No	ClinGen TOPMed gnomAD
CA6664595 rs199771693	381	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1487442040 CA385653039	386	I>T		No	ClinGen gnomAD
CA385653042 rs1184363308	386	I>V		No	ClinGen gnomAD
rs1565757595 CA385653029	388	V>L		No	ClinGen Ensembl
CA385653008 rs1220785093	391	G>V		No	ClinGen gnomAD
CA238735456 rs575469323	393	G>E		No	ClinGen gnomAD
CA6664588 rs776489317	394	D>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	395	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768648669 CA6664587	396	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1351096698 CA385652972	397	L>M		No	ClinGen gnomAD
CA6664585 rs779643946	400	H>R		No	ClinGen ExAC gnomAD
COSM549468 rs1399292638 CA385652944	401	D>Y	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs745562878 CA6664583	402	S>C		No	ClinGen ExAC gnomAD
rs778536082 CA6664582	403	N>D		No	ClinGen ExAC gnomAD
CA6664581 rs756532178	403	N>S		No	ClinGen ExAC TOPMed gnomAD
rs201286163 CA238735455	404	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA6664580 rs201286163	404	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs755541204 CA6664579	405	Y>C		No	ClinGen ExAC gnomAD
rs755541204 CA6664578	405	Y>S		No	ClinGen ExAC gnomAD
rs751963941 CA6664577	406	I>V		No	ClinGen ExAC gnomAD
CA385652866 rs1453785178	413	A>V		No	ClinGen gnomAD
CA238735454 rs542045521	415	E>G		No	ClinGen gnomAD
rs773635039 CA6664574	415	E>Q		No	ClinGen ExAC gnomAD
rs867760781 CA238732911	416	V>I		No	ClinGen Ensembl
rs758605916 CA6664555	417	R>S		No	ClinGen ExAC gnomAD
rs1245854354 CA385652613	417	R>T		No	ClinGen gnomAD
TCGA novel	420	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs144875947 CA6664553	420	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1216905721 CA385652558	421	L>F		No	ClinGen gnomAD
rs1216905721 CA385652561	421	L>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM1476814 rs762157400 CA6664552	424	Y>C	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs762157400 CA385652525	424	Y>F		No	ClinGen ExAC gnomAD
CA385652531 rs1565750121	424	Y>H		No	ClinGen Ensembl
rs1183451067 CA385652518	425	D>N		No	ClinGen TOPMed
rs1241869198 CA385652501	426	H>Y		No	ClinGen TOPMed
rs910600133 CA238732910	427	G>A		No	ClinGen TOPMed gnomAD
CA238732909 rs368191324	428	S>A		No	ClinGen ESP TOPMed gnomAD
TCGA novel	428	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA238732908 rs868795640	431	V>L		No	ClinGen Ensembl
rs763996259 CA6664550	433	I>V		No	ClinGen ExAC gnomAD
rs775557829 CA385652330	441	D>E		No	ClinGen ExAC TOPMed gnomAD
rs548929940 CA6664547	442	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6664546 rs759402611	443	L>S		No	ClinGen ExAC gnomAD
rs1254300068 CA385652292	446	E>Q		No	ClinGen gnomAD
rs1189544515 CA385652270	447	E>D		No	ClinGen TOPMed gnomAD
rs1449701913 CA385652258	449	A>P		No	ClinGen gnomAD
rs770382219 CA6664544	450	E>Q		No	ClinGen ExAC gnomAD
rs1443618515 CA385652234	451	A>E		No	ClinGen TOPMed gnomAD
rs1443618515 CA385652232	451	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	452	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777262702 CA6664542	453	T>A		No	ClinGen ExAC gnomAD
rs1565750051	453	T>LLKIQKLAGHGGGHL*		No	Ensembl
CA385652206 rs1339907562	454	Q>*		No	ClinGen gnomAD
CA385652205 rs1299551941	454	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs529256169 CA385652180	455	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1315866823 CA385652155	458	N>D		No	ClinGen TOPMed
CA6664538 rs371593441	458	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1026371738 CA238732907	459	C>R		No	ClinGen TOPMed gnomAD
rs560164255 CA6664536	460	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs117085639 CA6664535	461	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	461	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750920449 CA6664534	462	D>V		No	ClinGen ExAC gnomAD
rs1203458734 CA385652091	463	D>G		No	ClinGen TOPMed
CA385652081 rs1565750017	464	P>S		No	ClinGen Ensembl
CA6664521 rs371293545	468	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA238730693 rs917709579	468	T>I		No	ClinGen Ensembl
rs747764925 COSM942380 CA6664520	470	A>S	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs776028923 CA6664519	470	A>V		No	ClinGen ExAC gnomAD
CA385651632 rs1592522381	471	A>G		No	ClinGen Ensembl
rs1167307555 CA385651629	472	Q>E		No	ClinGen TOPMed
rs772515843 CA6664518	473	D>N		No	ClinGen ExAC gnomAD
rs1166515505 CA385651597 CA385651599	476	M>I		No	ClinGen TOPMed
CA385651601 rs1488086613	476	M>T		No	ClinGen gnomAD
CA6664517 rs746424088	476	M>V		No	ClinGen ExAC gnomAD
rs757417572 CA6664515 COSM431640	477	R>C	large_intestine breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM193406 rs540042623 CA6664514	477	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs757417572 CA6664516	477	R>S		No	ClinGen ExAC TOPMed gnomAD
CA385651588 rs1322620519	478	A>V		No	ClinGen gnomAD
CA385651586 rs1267726319	479	R>W		No	ClinGen TOPMed gnomAD
CA6664513 rs777843220	480	G>D		No	ClinGen ExAC gnomAD
rs925188063 CA238730692	480	G>R		No	ClinGen Ensembl
CA385651569 rs1331287054	482	L>P		No	ClinGen gnomAD
TCGA novel	485	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1289023252 CA385651549	485	R>K		No	ClinGen gnomAD
rs756322721 CA6664512	486	G>E		No	ClinGen ExAC gnomAD
COSM942379 rs376671705 CA6664510	488	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs752870905 COSM1363544 CA6664511	488	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6664509 rs754740224	493	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM942377 rs1205735334 CA385651461	499	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA385651442 rs1159119267	502	V>I		No	ClinGen gnomAD
rs954911276 CA238730688	509	H>Q		No	ClinGen Ensembl
rs370449571 CA238730689	509	H>R		No	ClinGen ESP TOPMed gnomAD
CA6664505 rs772599088	512	K>T		No	ClinGen ExAC TOPMed gnomAD
CA385651322 rs1247684810	514	S>A		No	ClinGen gnomAD
CA6664503 rs761394453	514	S>L		No	ClinGen ExAC TOPMed gnomAD
rs772603749 CA6664501	515	S>R		No	ClinGen ExAC gnomAD

No associated diseases with Q9ULR3

1 regional properties for Q9ULR3

Type	Name	Position	InterPro Accession
domain	PPM-type phosphatase-like domain	67 - 507	IPR001932

Functions

		Description
EC Number	3.1.3.16	Phosphoric monoester hydrolases
Subcellular Localization	Nucleus Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
myosin phosphatase activity	Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
phosphoprotein phosphatase activity	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.

1 GO annotations of biological process

Name	Definition
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5SGD2	PPM1L	Protein phosphatase 1L	Homo sapiens (Human)	PR
P49593	PPM1F	Protein phosphatase 1F	Homo sapiens (Human)	PR
Q3UYC0	Ppm1h	Protein phosphatase 1H	Mus musculus (Mouse)	PR
Q6K5I0	Os02g0600000	Probable protein phosphatase 2C 20	Oryza sativa subsp japonica (Rice)	PR
O81716	PPC4-2	Probable protein phosphatase 2C 21	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MLTRVKSAVA	NFMGGIMAGS	SGSEHGGGSC	GGSDLPLRFP	YGRPEFLGLS	QDEVECSADH
70	80	90	100	110	120
IARPILILKE	TRRLPWATGY	AEVINAGKST	HNEDQASCEV	LTVKKKAGAV	TSTPNRNSSK
130	140	150	160	170	180
RRSSLPNGEG	LQLKENSESE	GVSCHYWSLF	DGHAGSGAAV	VASRLLQHHI	TEQLQDIVDI
190	200	210	220	230	240
LKNSAVLPPT	CLGEEPENTP	ANSRTLTRAA	SLRGGVGAPG	SPSTPPTRFF	TEKKIPHECL
250	260	270	280	290	300
VIGALESAFK	EMDLQIERER	SSYNISGGCT	ALIVICLLGK	LYVANAGDSR	AIIIRNGEII
310	320	330	340	350	360
PMSSEFTPET	ERQRLQYLAF	MQPHLLGNEF	THLEFPRRVQ	RKELGKKMLY	RDFNMTGWAY
370	380	390	400	410	420
KTIEDEDLKF	PLIYGEGKKA	RVMATIGVTR	GLGDHDLKVH	DSNIYIKPFL	SSAPEVRIYD
430	440	450	460	470	480
LSKYDHGSDD	VLILATDGLW	DVLSNEEVAE	AITQFLPNCD	PDDPHRYTLA	AQDLVMRARG
490	500	510
VLKDRGWRIS	NDRLGSGDDI	SVYVIPLIHG	NKLS