AiPD: Autoinhibited Protein Database

Gene name	Ppm1h (Kiaa1157)
Protein name	Protein phosphatase 1H
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:319468
EC number	3.1.3.16: Phosphoric monoester hydrolases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

79-155 (Predicted disordered autoinhibitory region) PR

79-155 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3UYC0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs49559245	111	T>I	No	EVA
rs3389135468	157	A>T	No	EVA
rs254554880	163	R>H	No	EVA
rs3401376649	188	P>Q	No	EVA
rs3401734003	191	L>R	No	EVA
rs3401376604	193	E>K	No	EVA
rs3389107493	211	L>P	No	EVA
rs3389117036	227	R>P	No	EVA
rs3389140791	238	C>R	No	EVA
rs227831195	257	R>L	No	EVA
rs3389128108	260	S>N	No	EVA
rs3389117025	297	E>D	No	EVA
rs3389135434	333	E>K	No	EVA
rs3389128111	350	R>L	No	EVA
rs3389128065	351	D>E	No	EVA
rs3389128117	375	E>*	No	EVA
rs3389135499	413	P>L	No	EVA
rs3389095092	418	Y>F	No	EVA
rs3401827149	427	A>S	No	EVA
rs3401736299	428	D>A	No	EVA
rs3401514683	428	D>Y	No	EVA
rs3401877424	429	D>A	No	EVA
rs3389102049	466	Y>D	No	EVA
rs3389122899	508	H>R	No	EVA

Type	Name	Position	InterPro Accession
domain	PPM-type phosphatase-like domain	67 - 506	IPR001932

		Description
EC Number	3.1.3.16	Phosphoric monoester hydrolases
Subcellular Localization	Nucleus Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
myosin phosphatase activity	Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
phosphoprotein phosphatase activity	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.

Name	Definition
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9ULR3	PPM1H	Protein phosphatase 1H	Homo sapiens (Human)	PR
Q8BHN0	Ppm1l	Protein phosphatase 1L	Mus musculus (Mouse)	PR
Q80TL0	Ppm1e	Protein phosphatase 1E	Mus musculus (Mouse)	PR
Q8CGA0	Ppm1f	Protein phosphatase 1F	Mus musculus (Mouse)	PR
Q6K5I0	Os02g0600000	Probable protein phosphatase 2C 20	Oryza sativa subsp japonica (Rice)	PR
O81716	PPC4-2	Probable protein phosphatase 2C 21	Arabidopsis thaliana (Mouse-ear cress)	PR