O81716

PR
Gene name
PPC4-2 (At2g25070, F13D4.1, F27C12)
Protein name
Probable protein phosphatase 2C 21
Names
AtPP2C21, AtPPC42
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G25070
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

301-355 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O81716

Entry ID Method Resolution Chain Position Source
AF-O81716-F1 Predicted AlphaFoldDB

22 variants for O81716

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_10665320_T_C 16 D>G No 1000Genomes
tmp_2_10665123_C_G 54 G>A No 1000Genomes
tmp_2_10664928_T_C 62 K>R No 1000Genomes
ENSVATH14549393 73 H>L No 1000Genomes
ENSVATH05585271 77 I>M No 1000Genomes
ENSVATH13392096 85 G>E No 1000Genomes
tmp_2_10664854_C_T 87 V>I No 1000Genomes
tmp_2_10664732_C_G 98 M>I No 1000Genomes
tmp_2_10664727_T_C 100 D>G No 1000Genomes
tmp_2_10664718_T_A 103 Q>L No 1000Genomes
tmp_2_10664620_C_A 136 D>Y No 1000Genomes
ENSVATH14549392 161 C>F No 1000Genomes
ENSVATH05585266 174 F>S No 1000Genomes
ENSVATH01890137 188 K>N No 1000Genomes
tmp_2_10664321_C_T 204 V>I No 1000Genomes
ENSVATH05585260 274 I>V No 1000Genomes
tmp_2_10663793_T_G 292 K>T No 1000Genomes
tmp_2_10663790_G_A 293 S>F No 1000Genomes
ENSVATH13392077 299 T>I No 1000Genomes
ENSVATH14549389 303 K>T No 1000Genomes
tmp_2_10663665_C_T 307 R>K No 1000Genomes
ENSVATH01890132 331 K>N No 1000Genomes

No associated diseases with O81716

2 regional properties for O81716

Type Name Position InterPro Accession
binding_site PPM-type phosphatase, divalent cation binding 52 - 60 IPR000222
domain PPM-type phosphatase-like domain 13 - 329 IPR001932

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.

1 GO annotations of biological process

Name Definition
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.

31 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PJZ2 PPM1L Protein phosphatase 1L Bos taurus (Bovine) PR
P49593 PPM1F Protein phosphatase 1F Homo sapiens (Human) PR
O15297 PPM1D Protein phosphatase 1D Homo sapiens (Human) PR
Q5SGD2 PPM1L Protein phosphatase 1L Homo sapiens (Human) PR
Q9ULR3 PPM1H Protein phosphatase 1H Homo sapiens (Human) PR
Q8CGA0 Ppm1f Protein phosphatase 1F Mus musculus (Mouse) PR
Q8BHN0 Ppm1l Protein phosphatase 1L Mus musculus (Mouse) PR
Q80TL0 Ppm1e Protein phosphatase 1E Mus musculus (Mouse) PR
Q3UYC0 Ppm1h Protein phosphatase 1H Mus musculus (Mouse) PR
Q5JKN1 Os01g0552300 Probable protein phosphatase 2C 5 Oryza sativa subsp japonica (Rice) PR
Q0JLP9 PP2C06 Probable protein phosphatase 2C 6 Oryza sativa subsp japonica (Rice) PR
Q5SN75 Os01g0656200 Probable protein phosphatase 2C 8 Oryza sativa subsp japonica (Rice) PR
Q7XW27 Os04g0321800 Probable protein phosphatase 2C 38 Oryza sativa subsp japonica (Rice) PR
Q6L482 Os05g0358500 Probable protein phosphatase 2C 48 Oryza sativa subsp japonica (Rice) PR
Q6L4R7 PP2C53 Protein phosphatase 2C 53 Oryza sativa subsp japonica (Rice) PR
Q6ZKL8 Os08g0500300 Probable protein phosphatase 2C 66 Oryza sativa subsp japonica (Rice) PR
Q6K5I0 Os02g0600000 Probable protein phosphatase 2C 20 Oryza sativa subsp japonica (Rice) PR
Q9LNP9 HAB2 Protein phosphatase 2C 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZN9 At1g43900 Probable protein phosphatase 2C 11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAJ0 HAB1 Protein phosphatase 2C 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRZ4 At3g16800 Probable protein phosphatase 2C 41 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GY60 At4g03415 Probable protein phosphatase 2C 52 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FG61 At5g36250 Probable protein phosphatase 2C 74 Arabidopsis thaliana (Mouse-ear cress) PR
O04719 ABI2 Protein phosphatase 2C 77 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIF5 SAG113 Probable protein phosphatase 2C 78 Arabidopsis thaliana (Mouse-ear cress) PR
Q3EAZ3 At3g27140 Putative protein phosphatase 2C-like protein 45 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AT1 At5g53140 Probable protein phosphatase 2C 76 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDA7 At3g15260 Probable protein phosphatase 2C 39 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SD02 At3g51470 Probable protein phosphatase 2C 47 Arabidopsis thaliana (Mouse-ear cress) PR
P49599 PPH1 Protein phosphatase 2C 57 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMT1 At1g18030 Probable protein phosphatase 2C 8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGTYLSSPKT EKLSEDGEND KLRFGLSSMQ GWRATMEDAH AAILDLDDKT SFFGVYDGHG
70 80 90 100 110 120
GKVVAKFCAK YLHQQVISNE AYKTGDVETS LRRAFFRMDD MMQGQRGWRE LAVLGDKMNK
130 140 150 160 170 180
FSGMIEGFIW SPRSGDTNNQ PDSWPLEDGP HSDFTGPTSG CTACVALIKD KKLFVANAGD
190 200 210 220 230 240
SRCVISRKSQ AYNLSKDHKP DLEVEKERIL KAGGFIHAGR INGSLNLTRA IGDMEFKQNK
250 260 270 280 290 300
FLPSEKQMVT ADPDINTIDL CDDDDFLVVA CDGIWDCMSS QELVDFIHEQ LKSETKLSTV
310 320 330 340 350
CEKVVDRCLA PDTATGEGCD NMTIILVQFK KPNPSETEPE DSKPEPSEDE PSSSS