Q80XC3
PR
Gene name |
Usp6nl (Kiaa0019) |
Protein name |
USP6 N-terminal-like protein |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:98910 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80XC3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80XC3-F1 | Predicted | AlphaFoldDB |
44 variants for Q80XC3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388527292 | 9 | L>F | No | EVA | |
| rs3388526053 | 52 | H>D | No | EVA | |
| rs3388526809 | 99 | K>* | No | EVA | |
| rs3388524840 | 248 | K>R | No | EVA | |
| rs3388523938 | 251 | Q>E | No | EVA | |
| rs3388527266 | 265 | M>I | No | EVA | |
| rs3388528811 | 266 | K>N | No | EVA | |
| rs3388529710 | 289 | I>F | No | EVA | |
| rs3388528686 | 294 | R>* | No | EVA | |
| rs3388528874 | 308 | K>N | No | EVA | |
| rs3391238303 | 312 | M>I | No | EVA | |
| rs3388527289 | 312 | M>R | No | EVA | |
| rs3388527289 | 312 | M>T | No | EVA | |
| rs3388523511 | 384 | S>N | No | EVA | |
| rs3388525585 | 455 | M>L | No | EVA | |
| rs3388526079 | 465 | A>V | No | EVA | |
| rs3388529762 | 475 | S>* | No | EVA | |
| rs3388529197 | 482 | M>L | No | EVA | |
| rs3388528895 | 484 | K>R | No | EVA | |
| rs3388525666 | 488 | P>L | No | EVA | |
| rs27065358 | 502 | V>I | No | EVA | |
| rs3388525601 | 504 | G>V | No | EVA | |
| rs3388529755 | 510 | L>P | No | EVA | |
| rs581828902 | 516 | A>T | No | EVA | |
| rs1132176355 | 523 | T>I | No | EVA | |
| rs3388525649 | 525 | L>W | No | EVA | |
| rs227694757 | 526 | P>S | No | EVA | |
| rs3388525584 | 553 | P>S | No | EVA | |
| rs1133233997 | 555 | G>S | No | EVA | |
| rs216427991 | 557 | S>N | No | EVA | |
| rs3391217531 | 623 | N>T | No | EVA | |
| rs3388530465 | 629 | G>E | No | EVA | |
| rs235101389 | 634 | H>Q | No | EVA | |
| rs3388525583 | 673 | A>V | No | EVA | |
| rs3391000919 | 690 | L>P | No | EVA | |
| rs3391238269 | 693 | D>E | No | EVA | |
| rs245136715 | 694 | M>I | No | EVA | |
| rs3388526781 | 741 | T>A | No | EVA | |
| rs215945801 | 745 | H>N | No | EVA | |
| rs3388523925 | 779 | Y>F | No | EVA | |
| rs236180802 | 783 | A>P | No | EVA | |
| rs262416111 | 791 | P>H | No | EVA | |
| rs3391105009 | 809 | E>G | No | EVA | |
| rs3391178006 | 810 | G>R | No | EVA |
No associated diseases with Q80XC3
1 regional properties for Q80XC3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Rab-GAP-TBC domain | 97 - 315 | IPR000195 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| small GTPase binding | Binding to a small monomeric GTPase. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| plasma membrane to endosome transport | Transport of a vesicle from the plasma membrane to the endosome. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| regulation of Golgi organization | Any process that modulates the frequency, rate or extent of Golgi organization. |
| retrograde transport, plasma membrane to Golgi | The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles. |
| virion assembly | A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. |
25 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5R372 | RABGAP1L | Rab GTPase-activating protein 1-like | Homo sapiens (Human) | PR |
| A0A087WVF3 | TBC1D3D | TBC1 domain family member 3D | Homo sapiens (Human) | PR |
| A0A087WXS9 | TBC1D3I | TBC1 domain family member 3I | Homo sapiens (Human) | PR |
| B9A6J9 | TBC1D3L | TBC1 domain family member 3L | Homo sapiens (Human) | PR |
| A0A087X179 | TBC1D3E | TBC1 domain family member 3E | Homo sapiens (Human) | PR |
| A0A087X1G2 | TBC1D3K | TBC1 domain family member 3K | Homo sapiens (Human) | PR |
| A6NDS4 | TBC1D3B | TBC1 domain family member 3B | Homo sapiens (Human) | PR |
| A6NER0 | TBC1D3F | TBC1 domain family member 3F | Homo sapiens (Human) | PR |
| P0C7X1 | TBC1D3H | TBC1 domain family member 3H | Homo sapiens (Human) | PR |
| Q6DHY5 | TBC1D3G | TBC1 domain family member 3G | Homo sapiens (Human) | PR |
| Q8IZP1 | TBC1D3 | TBC1 domain family member 3 | Homo sapiens (Human) | PR |
| Q6IPX1 | TBC1D3C | TBC1 domain family member 3C | Homo sapiens (Human) | PR |
| A6H6A9 | Rabgap1l | Rab GTPase-activating protein 1-like | Mus musculus (Mouse) | PR |
| Q8R5A6 | Tbc1d22a | TBC1 domain family member 22A | Mus musculus (Mouse) | PR |
| Q6A039 | Tbc1d12 | TBC1 domain family member 12 | Mus musculus (Mouse) | PR |
| Q8C9V1 | Tbc1d10c | Carabin | Mus musculus (Mouse) | PR |
| Q9D3N8 | Grtp1 | Growth hormone-regulated TBC protein 1 | Mus musculus (Mouse) | PR |
| Q8BYJ6 | Tbc1d4 | TBC1 domain family member 4 | Mus musculus (Mouse) | PR |
| Q60949 | Tbc1d1 | TBC1 domain family member 1 | Mus musculus (Mouse) | PR |
| A1A5B6 | Tbc1d25 | TBC1 domain family member 25 | Mus musculus (Mouse) | PR |
| Q8BYH7 | Tbc1d17 | TBC1 domain family member 17 | Mus musculus (Mouse) | PR |
| Q9Z1A9 | Tbc1d8 | TBC1 domain family member 8 | Mus musculus (Mouse) | PR |
| A3KGB4 | Tbc1d8b | TBC1 domain family member 8B | Mus musculus (Mouse) | PR |
| Q3UYK3 | Tbc1d9 | TBC1 domain family member 9 | Mus musculus (Mouse) | PR |
| P97366 | Evi5 | Ecotropic viral integration site 5 protein | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNSDQDVALK | LAQERAEIVA | KYDRGREGAE | IEPWEDADYL | VYKVTDRFGF | LHEEELPYHN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AAADRQKQLE | IERTSKWLKM | LKKWERYKNT | EKFHRRIYKG | IPLQLRGEVW | ALLLEIPKMK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EETRDLYSKL | KHRARGCSPD | IRQIDLDVNR | TFRDHIMFRD | RYGVKQQSLF | HVLAAYSIYN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TEVGYCQGMS | QITALLLMYM | NEEDAFWALV | KLFSGPKHAM | HGFFVQGFPK | LLRFQEHHEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ILNKFLSKLK | QHLDSQEIYT | SFYTMKWFFQ | CFLDRTPFRL | NLRIWDIYIF | EGERVLTAMS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YTILKLHKKH | LMKLSMEELV | EFLQETLAKD | FFFEDDFVIE | QLQVSMAELK | RAKLDLPEPG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KEDEYPKKPL | GQLPPESACV | NHLSNGQRSV | GRPSPKTSSR | REDGSPRKNH | EHSPVHHSRN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GTPERAGQSR | RKSVDEGSKN | LKHEAESQRK | PSPGMQDSSR | HYNHAAANQN | SNAISNVRKE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FMPKWRKPSD | ASAIERTTKY | AVEGKSHSAL | PALPVAIPGS | AETRLPNSRQ | KMKALDGGEG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KRGSNASQYD | NVPGGESEHG | ASAEEGPERT | HPHSPRKHPE | PSPSPPKVPN | KFTFKVQPPS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HVRYPPQLPE | EDHRAAYPPS | YSNPPVYHGN | SPKHVPTAHS | GFVSTQISPR | PQINPSRRPY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GSSLSVDTSP | EKAYSRPTPV | VLPSSRIEVL | PIDMGARGYG | SSGSPKNGQF | ILPPVDYLPE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NRKWSEVSYT | YRPEMHGQSW | TRDAHRSHLS | NLPNYAAFQH | IPFQAHGLPE | VSVDSPVRYK |
| 790 | 800 | 810 | |||
| MSAAVEDASP | PGYPYAGPSP | SAHHYRNGEG | LSVQESVLL |