Q3UYK3

PR
Gene name
Tbc1d9 (Kiaa0882)
Protein name
TBC1 domain family member 9
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:71310
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

236-305 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3UYK3

Entry ID Method Resolution Chain Position Source
AF-Q3UYK3-F1 Predicted AlphaFoldDB

60 variants for Q3UYK3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388987514 68 Q>H No EVA
rs3388993024 72 S>F No EVA
rs3388987046 74 V>L No EVA
rs3399335201 78 I>F No EVA
rs3388995546 83 S>P No EVA
rs51562423 111 V>I No EVA
rs216989059 126 Y>H No EVA
rs3388975134 162 N>D No EVA
rs3388992822 182 S>R No EVA
rs3388964642 214 T>P No EVA
rs3388993698 218 P>A No EVA
rs3388987078 224 S>N No EVA
rs3388993205 228 S>I No EVA
rs3388993167 287 D>N No EVA
rs3388987493 306 K>M No EVA
rs3388987056 312 D>G No EVA
rs47912899 322 M>I No EVA
rs3388993727 328 M>L No EVA
rs3388991602 350 P>T No EVA
rs3388987502 367 P>L No EVA
rs3399322811 378 M>K No EVA
rs3398427509 379 T>A No EVA
rs3399372435 379 T>I No EVA
rs3388992843 412 F>L No EVA
rs3399336721 418 S>P No EVA
rs244520402 423 V>A No EVA
rs3399164117 446 E>D No EVA
rs3388995515 458 T>K No EVA
rs3388964564 490 K>R No EVA
rs3388975176 498 Q>H No EVA
rs247663624 523 E>D No EVA
rs3388993682 528 L>R No EVA
rs3388993227 536 A>V No EVA
rs46480564 544 G>D No EVA
rs3388987104 547 E>* No EVA
rs3388993057 549 S>* No EVA
rs3388975124 586 V>I No EVA
rs3399428197 637 T>S No EVA
rs3398881786 638 R>G No EVA
rs3399057276 638 R>S No EVA
rs3388995276 697 C>F No EVA
rs3388987512 794 F>S No EVA
rs3388987073 810 R>G No EVA
rs3388997888 822 F>Y No EVA
rs3388997895 824 I>T No EVA
rs3388987465 872 K>* No EVA
rs3388997857 876 V>M No EVA
rs3388993025 885 T>I No EVA
rs3399322825 887 S>A No EVA
rs3399373521 888 D>E No EVA
rs3399404772 888 D>H No EVA
rs3388945467 956 F>L No EVA
rs1134159700 1073 Q>R No EVA
rs216108241 1075 A>V No EVA
rs3388964606 1085 C>Y No EVA
rs3399420662 1087 Q>L No EVA
rs214278472 1108 T>A No EVA
rs3388975139 1141 N>D No EVA
rs3399347752 1164 S>ALSTE* No EVA
rs3388991575 1241 A>T No EVA

No associated diseases with Q3UYK3

4 regional properties for Q3UYK3

Type Name Position InterPro Accession
domain FAD dependent oxidoreductase 45 - 407 IPR006076
domain Aminomethyltransferase, folate-binding domain 472 - 737 IPR006222
domain Glycine cleavage T-protein, C-terminal barrel domain 763 - 840 IPR013977
domain FAD dependent oxidoreductase, central domain 410 - 463 IPR032503

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

1 GO annotations of biological process

Name Definition
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95759 TBC1D8 TBC1 domain family member 8 Homo sapiens (Human) PR
Q0IIM8 TBC1D8B TBC1 domain family member 8B Homo sapiens (Human) PR
Q66K14 TBC1D9B TBC1 domain family member 9B Homo sapiens (Human) PR
Q6ZT07 TBC1D9 TBC1 domain family member 9 Homo sapiens (Human) PR
Q8R5A6 Tbc1d22a TBC1 domain family member 22A Mus musculus (Mouse) PR
Q80XC3 Usp6nl USP6 N-terminal-like protein Mus musculus (Mouse) PR
Q6A039 Tbc1d12 TBC1 domain family member 12 Mus musculus (Mouse) PR
Q8C9V1 Tbc1d10c Carabin Mus musculus (Mouse) PR
Q9D3N8 Grtp1 Growth hormone-regulated TBC protein 1 Mus musculus (Mouse) PR
Q8BYJ6 Tbc1d4 TBC1 domain family member 4 Mus musculus (Mouse) PR
Q60949 Tbc1d1 TBC1 domain family member 1 Mus musculus (Mouse) PR
A1A5B6 Tbc1d25 TBC1 domain family member 25 Mus musculus (Mouse) PR
Q8BYH7 Tbc1d17 TBC1 domain family member 17 Mus musculus (Mouse) PR
Q9Z1A9 Tbc1d8 TBC1 domain family member 8 Mus musculus (Mouse) PR
A3KGB4 Tbc1d8b TBC1 domain family member 8B Mus musculus (Mouse) PR
P97366 Evi5 Ecotropic viral integration site 5 protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MWVNPEEVLL ANALWITERA NPYFILQRRK GHGGDGGGGG GLAGLLVGTL DVVLDSSARV
70 80 90 100 110 120
APYRILYQTP DSLVYWTIAC GGSRKEVTEH WEWLEQNLLQ TLSIFENEND VTTFVRGKIQ
130 140 150 160 170 180
GIIAEYNKIN DVKEDEDTEK FKEAIVKFHR LFGMPEEEKL VNYYSCSYWK GRVPRQGWMY
190 200 210 220 230 240
LSINHLCFSS FLMGREAKLV IRWVDITQLE KNATLLLPDM IKVSTRSSEH FFSVFLNINE
250 260 270 280 290 300
TFKLMEQLAN IAMRQLLDNE GFEQDRSLPK LKKKSPKKVS ALKRDLDARA KSERYRALFR
310 320 330 340 350 360
LPKDEKLDGH TDCTLWTPFN KMHILGQMFV STNYICFTSK EENLCSLIIP LREVTIVEKA
370 380 390 400 410 420
DSCSVLPSPL SISTRNRMTF LFANLKDRDF LVQRISDFLQ QTTSRIYSDK EFSGSCNSSD
430 440 450 460 470 480
DEVYSRPSSL VSSSPQRSTS SDADGERPFN LNGNSVPTAT QTLMTMYRRR SPEEFNPKLA
490 500 510 520 530 540
KEFLKEQAWK IHFAEYGQGI CMYRTEKTRE LVLKGIPESM RGELWLLLSG AINEKATHPG
550 560 570 580 590 600
YYEGLVEKSM GKYNLATEEI ERDLHRSLPE HPAFQNEMGI AALRRVLTAY AFRNPNIGYC
610 620 630 640 650 660
QAMNIVTSVL LLYAKEEEAF WLLVALCERM LPDYYNTRVV GALVDQGVFE ELARDYVPQL
670 680 690 700 710 720
YDCMQDLGVI STISLSWFLT LFLSVMPFES AVVVVDCFFY EGIKVIFQLA LAVLDANVDK
730 740 750 760 770 780
LLNCKDDGEA MTVLGRYLDS VTNKDSTLPP IPHLHSLLSD DVGPYPAVDI FRLIGTSYEK
790 800 810 820 830 840
FGTIRADLIE QMRFKQRLKV IQTLEDTTKR NVVRTIVTET SFTIDELEEL YALFKAEHLT
850 860 870 880 890 900
SCYWGGSSNA LDRHDPSLPY LEQYRIDFEQ FKGMFVLLFP WACGTHSDVL ASRLFQLLDE
910 920 930 940 950 960
NGDSLINFRE FVSGLSAACH GDLTEKLKLL YKMHVLPEPS CDQDEPDSAF EATQYFFEDI
970 980 990 1000 1010 1020
TPECTHVVGL DSRGKQSADD GFVTVSLKQD RGKRANSQEN RNYLKLWTAE NKSKSKTAKD
1030 1040 1050 1060 1070 1080
LPKLNQGQFI ELCKTMYNMF SEDPNEQELY HATAAVTSLL LEIGEVGKFF ITQPAKEDAV
1090 1100 1110 1120 1130 1140
PGPPCGQAIP GMLFPKKGSS QSYVVESTEP LTASLAVDSE EHSLGGQMED IKLEDSSPRD
1150 1160 1170 1180 1190 1200
NGACSSMLIS DDDTKDDSSM SSYSVLSAGS HEEDKLHCED IGEDTVLVRS SQGRATLPRS
1210 1220 1230 1240 1250 1260
SSLDRDWAIT FEQFLASLLT EPALVRYFDK PVCMMARVTS AKNIRMMGKP LTSASDYEIS
ALSG