A1A5B6

PR
Gene name
Tbc1d25
Protein name
TBC1 domain family member 25
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:209815
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

147-251 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1A5B6

Entry ID Method Resolution Chain Position Source
AF-A1A5B6-F1 Predicted AlphaFoldDB

60 variants for A1A5B6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3409338572 26 W>C No EVA
rs247336727 34 W>* No EVA
rs217785134 34 W>R No EVA
rs3409770696 65 A>P No EVA
rs229346191 65 A>V No EVA
rs3409526697 66 C>R No EVA
rs3409608846 67 S>W No EVA
rs3409467724 72 P>T No EVA
rs3408443614 73 V>G No EVA
rs3409338549 77 Q>E No EVA
rs3409431486 81 A>E No EVA
rs3389556203 107 S>P No EVA
rs3389551424 113 Q>* No EVA
rs3389562136 121 Q>L No EVA
rs3408366713 142 A>P No EVA
rs3389552797 149 E>D No EVA
rs3389551439 150 T>A No EVA
rs3409526712 174 L>W No EVA
rs3389566985 189 D>E No EVA
rs3389552837 191 D>G No EVA
rs864271140 196 K>E No EVA
rs3389459682 208 K>M No EVA
rs3389531341 213 T>M No EVA
rs3409338598 248 P>S No EVA
rs3389519410 339 R>G No EVA
rs3409769276 345 D>A No EVA
rs3408366685 345 D>Y No EVA
rs3409427311 347 L>R No EVA
rs3409126708 348 R>S No EVA
rs3389519357 361 D>E No EVA
rs3389545531 391 L>P No EVA
rs3389507502 395 I>N No EVA
rs3389507502 395 I>T No EVA
rs3389519395 411 G>D No EVA
rs3389552839 422 P>L No EVA
rs3389459664 424 G>D No EVA
rs3389562123 439 R>* No EVA
rs3389566928 471 E>K No EVA
rs3409427221 479 R>* No EVA
rs3409607652 480 M>R No EVA
rs3389531320 486 S>N No EVA
rs3389552782 502 P>H No EVA
rs243556350 513 S>G No EVA
rs3389552033 528 A>V No EVA
rs226054914 532 G>S No EVA
rs257226772 533 G>C No EVA
rs3389563711 543 A>V No EVA
rs3409653314 554 R>C No EVA
rs3389551436 567 L>H No EVA
rs264376914 585 A>V No EVA
rs3389507508 608 S>Y No EVA
rs33388897 610 R>Q No EVA
rs3389531337 639 Q>H No EVA
rs3389499472 651 V>L No EVA
rs3389562127 688 M>I No EVA
rs3389544737 700 H>R No EVA
rs3389552755 713 V>A No EVA
rs3389563693 731 D>E No EVA
rs3409526757 733 E>K No EVA
rs3409526757 733 E>Q No EVA

No associated diseases with A1A5B6

1 regional properties for A1A5B6

Type Name Position InterPro Accession
domain Rab-GAP-TBC domain 279 - 511 IPR000195

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasmic vesicle, autophagosome
  • It is dispersed in the cytoplasm under nutrient-rich conditions
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.

1 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

3 GO annotations of biological process

Name Definition
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
regulation of autophagosome maturation Any process that modulates the frequency, rate or extent of autophagosome maturation.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P48365 GYP7 GTPase-activating protein GYP7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9HA65 TBC1D17 TBC1 domain family member 17 Homo sapiens (Human) PR
Q8TC07 TBC1D15 TBC1 domain family member 15 Homo sapiens (Human) PR
Q3MII6 TBC1D25 TBC1 domain family member 25 Homo sapiens (Human) PR
Q8BYH7 Tbc1d17 TBC1 domain family member 17 Mus musculus (Mouse) PR
Q9Z1A9 Tbc1d8 TBC1 domain family member 8 Mus musculus (Mouse) PR
A3KGB4 Tbc1d8b TBC1 domain family member 8B Mus musculus (Mouse) PR
Q8R5A6 Tbc1d22a TBC1 domain family member 22A Mus musculus (Mouse) PR
Q80XC3 Usp6nl USP6 N-terminal-like protein Mus musculus (Mouse) PR
Q6A039 Tbc1d12 TBC1 domain family member 12 Mus musculus (Mouse) PR
Q8C9V1 Tbc1d10c Carabin Mus musculus (Mouse) PR
Q9D3N8 Grtp1 Growth hormone-regulated TBC protein 1 Mus musculus (Mouse) PR
Q8BYJ6 Tbc1d4 TBC1 domain family member 4 Mus musculus (Mouse) PR
Q60949 Tbc1d1 TBC1 domain family member 1 Mus musculus (Mouse) PR
Q3UYK3 Tbc1d9 TBC1 domain family member 9 Mus musculus (Mouse) PR
P97366 Evi5 Ecotropic viral integration site 5 protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MRPPAQARWE GQGPTAPLRL RSGARWGRGR PHCWVYVRVR VTIGYHLDRD DSGGMATTSA
70 80 90 100 110 120
ASDSACSAAP PPVGGAQAAA AVEEEEREVV RVRVKKCESF LSPEFRSFAV DPQITSLDVL
130 140 150 160 170 180
QHILIRAFDL NGKKNFGISY LARDRLGQET FLSLLSDWDL STAFATASKP YLQLRVDIRP
190 200 210 220 230 240
SEDSPLLEDW DIISPKDVIG SDVLLAEKRS SLTTAALPFT QSILSQVGRT LSKVQQVLSW
250 260 270 280 290 300
SYGEDVKPFK PPLSDAEFHT YLNHEGQLSR PEELRLRIYH GGVEPSLRKV VWRYLLNVYP
310 320 330 340 350 360
DGLTGRERMD YMKRKSREYE QLKSEWAQRV NPEDLEFIRS TVLKDVLRTD RAHPYYAGPE
370 380 390 400 410 420
DGPHLRALHD LLTTYAVTHP QVSYCQGMSD LASPILAVMD HEGHAFVCFC GIMKRLAANF
430 440 450 460 470 480
HPDGRAMATK FAHLKLLLRH ADPDFYQYLQ EAGADDLFFC YRWLLLELKR EFAFDDALRM
490 500 510 520 530 540
LEVTWSSLPP DPPEHEVELV GPPSQVADTG FGSHRGRPVR QRHMLRPAGG GGGAFEDAVV
550 560 570 580 590 600
HLAASSQGPS GGGRLLRQAS LDGLQQLRDN MGLRKDHLVQ LSHPATLISS KSLSEPLLNS
610 620 630 640 650 660
PDPLLSTSSR PDSPSSSSPP STQEASPSGD IAVGSPLMQE VGSPRDPGKP VPPPPPMGLP
670 680 690 700 710 720
PPQEFGRGNP FMLFLCLAIL LEHRDHIMRN GLDYNELAMH FDRLVRKHHL GRVLRRAKAL
730 740
FADYLQSEVW DSEEGAEATA PS