Q60949
PR
Gene name |
Tbc1d1 (Kiaa1108, Tbc1) |
Protein name |
TBC1 domain family member 1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:57915 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q60949
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q60949-F1 | Predicted | AlphaFoldDB |
69 variants for Q60949
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3395615429 | 18 | S>P | No | EVA | |
| rs3395596425 | 18 | S>Y | No | EVA | |
| rs3395596433 | 19 | V>G | No | EVA | |
| rs3388762167 | 29 | L>F | No | EVA | |
| rs3388759801 | 31 | V>E | No | EVA | |
| rs3388751722 | 108 | S>N | No | EVA | |
| rs3388758391 | 118 | I>F | No | EVA | |
| rs228745367 | 125 | R>K | No | EVA | |
| rs3388766033 | 153 | I>N | No | EVA | |
| rs3388759413 | 167 | D>N | No | EVA | |
| rs3388747613 | 176 | L>P | No | EVA | |
| rs3388762228 | 185 | H>D | No | EVA | |
| rs36968281 | 207 | R>G | No | EVA | |
| rs220373550 | 223 | P>S | No | EVA | |
| rs3388759442 | 226 | M>V | No | EVA | |
| rs244162703 | 267 | G>S | No | EVA | |
| rs3388766026 | 313 | F>I | No | EVA | |
| rs3388763194 | 314 | C>S | No | EVA | |
| rs3388762198 | 345 | V>M | No | EVA | |
| rs3388766070 | 358 | M>V | No | EVA | |
| rs3388751691 | 400 | N>K | No | EVA | |
| rs3388759471 | 441 | L>V | No | EVA | |
| rs258354609 | 477 | D>E | No | EVA | |
| rs3388759444 | 493 | R>I | No | EVA | |
| rs36510280 | 510 | N>S | No | EVA | |
| rs3388766068 | 518 | H>Y | No | EVA | |
| rs3388733900 | 521 | S>N | No | EVA | |
| rs3388759837 | 528 | T>I | No | EVA | |
| rs3388751651 | 544 | K>T | No | EVA | |
| rs264251801 | 600 | A>E | No | EVA | |
| rs264251801 | 600 | A>V | No | EVA | |
| rs3388763659 | 603 | E>Q | No | EVA | |
| rs3395500638 | 648 | S>* | No | EVA | |
| rs3388733907 | 663 | N>K | No | EVA | |
| rs3395500682 | 705 | L>I | No | EVA | |
| rs3395500664 | 705 | L>R | No | EVA | |
| rs3388744381 | 730 | A>V | No | EVA | |
| rs3388733881 | 752 | I>K | No | EVA | |
| rs3388763206 | 779 | P>L | No | EVA | |
| rs3388733902 | 781 | R>C | No | EVA | |
| rs3388768255 | 781 | R>H | No | EVA | |
| rs3388759845 | 782 | S>Y | No | EVA | |
| rs3388744403 | 793 | F>L | No | EVA | |
| rs3395428955 | 823 | R>K | No | EVA | |
| rs3388759832 | 835 | E>D | No | EVA | |
| rs3388758397 | 842 | R>C | No | EVA | |
| rs1132976665 | 849 | E>A | No | EVA | |
| rs3395598358 | 895 | E>D | No | EVA | |
| rs3388758349 | 917 | K>N | No | EVA | |
| rs3388763204 | 927 | K>M | No | EVA | |
| rs3388763167 | 949 | F>I | No | EVA | |
| rs3388751681 | 952 | Q>L | No | EVA | |
| rs3388754689 | 954 | G>V | No | EVA | |
| rs3388756370 | 977 | C>* | No | EVA | |
| rs3388744359 | 980 | L>F | No | EVA | |
| rs3388751720 | 982 | F>V | No | EVA | |
| rs3388733958 | 1036 | R>* | No | EVA | |
| rs3388756294 | 1050 | S>N | No | EVA | |
| rs3388759473 | 1064 | Q>* | No | EVA | |
| rs3388744358 | 1070 | V>E | No | EVA | |
| rs3388766084 | 1077 | I>N | No | EVA | |
| rs3388763479 | 1102 | Q>* | No | EVA | |
| rs3388759783 | 1102 | Q>L | No | EVA | |
| rs3388759466 | 1112 | F>Y | No | EVA | |
| rs3388766058 | 1146 | V>I | No | EVA | |
| rs3388759384 | 1152 | Q>H | No | EVA | |
| rs3388759437 | 1164 | N>K | No | EVA | |
| rs3388763622 | 1180 | Q>K | No | EVA | |
| rs247818153 | 1214 | Q>H | No | EVA |
No associated diseases with Q60949
4 regional properties for Q60949
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Rab-GAP-TBC domain | 884 - 1104 | IPR000195 |
| domain | PTB/PI domain | 16 - 164 | IPR006020-1 |
| domain | PTB/PI domain | 168 - 378 | IPR006020-2 |
| domain | Domain of unknown function DUF3350 | 777 - 832 | IPR021785 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| negative regulation of insulin secretion involved in cellular response to glucose stimulus | Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. |
| regulation of protein localization | Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q86TI0 | TBC1D1 | TBC1 domain family member 1 | Homo sapiens (Human) | PR |
| Q8R5A6 | Tbc1d22a | TBC1 domain family member 22A | Mus musculus (Mouse) | PR |
| Q80XC3 | Usp6nl | USP6 N-terminal-like protein | Mus musculus (Mouse) | PR |
| Q6A039 | Tbc1d12 | TBC1 domain family member 12 | Mus musculus (Mouse) | PR |
| Q8C9V1 | Tbc1d10c | Carabin | Mus musculus (Mouse) | PR |
| Q9D3N8 | Grtp1 | Growth hormone-regulated TBC protein 1 | Mus musculus (Mouse) | PR |
| Q8BYJ6 | Tbc1d4 | TBC1 domain family member 4 | Mus musculus (Mouse) | PR |
| A1A5B6 | Tbc1d25 | TBC1 domain family member 25 | Mus musculus (Mouse) | PR |
| Q8BYH7 | Tbc1d17 | TBC1 domain family member 17 | Mus musculus (Mouse) | PR |
| Q9Z1A9 | Tbc1d8 | TBC1 domain family member 8 | Mus musculus (Mouse) | PR |
| A3KGB4 | Tbc1d8b | TBC1 domain family member 8B | Mus musculus (Mouse) | PR |
| Q3UYK3 | Tbc1d9 | TBC1 domain family member 9 | Mus musculus (Mouse) | PR |
| P97366 | Evi5 | Ecotropic viral integration site 5 protein | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAITFTARK | HPFPNEVSVD | FGLQLVGSLP | VHSLTTMPML | PWVVAEVRRL | SGQCSKKEPR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TKQVRLWVSP | SGLRCEPDLE | KSQPWDPLIC | SSIFECKPQR | VHKLIHNSHD | PSYFACLIKE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DAAHRQSLCY | VFKADDQTKV | PEIISSIRQA | GKIARQEELR | CPSEFDDTFA | KKFEVLFCGR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTVAHKKAPP | ALIDECIEKF | NHVSCGRRTD | WEAPTGQPSA | PGPRPMRKSF | SQPGLRSLAF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RKEFQDASLR | SSTFSSFDND | IENHLIGGHN | VVQPTDMEEN | RTMLFTIGQS | EVYLISPDTK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KIALEKNFKE | ISFCSQGIRH | VDHFGFICRE | CSGGGSGGFH | FVCYVFQCTN | EALVDEIMMT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LKQAFTVAAV | QQTAKAPAQL | CEGCPLQGLH | KLCERIEGMN | SSKTKLELQK | HLTTLTNQEQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ATIFEEVQKL | RPRNEQRENE | LIISFLRCLY | EEKQKEHSHT | GEPKQTLQVA | AENIGSDLPP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SASRFRLDSL | KNRAKRSLTE | SLESILSRGN | KARGLQDHSA | SVDLDSSTSS | TLSNTSKELS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MGDKEAFPVS | ETSFKLLGSS | DDLSSDSEGH | IAEESALLSP | QQAFRRRANT | LSHFPVECPA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PPEPAQSSPG | VSQRKLMRYH | SVSTETPHER | NVDHLPGGES | QGCPGQPSAP | PPPRLNPSAS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SPNFFKYLKH | NSSGEQSGNA | VPKSVSYRNA | LRKKLHSSSS | VPNFLKFLAP | VDENNTCDFK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NTNRDFESKA | NHLGDTDGTP | VKTRRHSWRQ | QIFLRVATPQ | KACDSPSRYE | DYSELGELPP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RSPLEPVCED | GPFGPVQEEK | RKTSRELREL | WKKAILQQIL | LLRMEKENQK | LQASENDLLN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KRLKLDYEEI | TPCLKEVTTV | WEKMLSTPGR | SKIKFDMEKV | HSAVGQGVPR | HHRGEIWKFL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| AEQFHLKHPF | PSKQQPKDVP | YKELLKKLTS | QQHAILIDLG | RTFPTHPYFS | AQLGAGQLSL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| YNILKAYSLL | DQEVGYCQGL | SFVAGILLLH | MSEEEAFKML | KFLMFDMGLR | KQYRPDMIIL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| QIQMYQLSRL | LHDYHRDLYN | HLEEHEIGPS | LYAAPWFLTV | FASQFPLGFV | ARVFDMIFLQ |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| GSEVIFKVAL | SLLGSHKPLI | LQHENLETIV | DFIKNTLPNL | GLVQMEKTIS | QVFEMDIAKQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LQAYEVEYHV | LQEELIESSP | LSDNQRMEKL | EKTNSSLRKQ | NLDLLEQLQV | ANARIQSLEA |
| 1210 | 1220 | 1230 | 1240 | 1250 | |
| TVEKLLTSES | KLKQAALTLE | VERSALLQMV | EELRRQSARP | STPEPDCTQL | EPTGD |