Q8BYJ6
Gene name |
Tbc1d4 (As160, Kiaa0603) |
Protein name |
TBC1 domain family member 4 |
Names |
Akt substrate of 160 kDa, AS160 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:210789 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BYJ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BYJ6-F1 | Predicted | AlphaFoldDB |
No variants for Q8BYJ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8BYJ6 | |||||
No associated diseases with Q8BYJ6
1 regional properties for Q8BYJ6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Luciferase-like domain | 4 - 326 | IPR011251 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| vesicle | Any small, fluid-filled, spherical organelle enclosed by membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| cellular response to insulin stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| negative regulation of vesicle fusion | Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O60343 | TBC1D4 | TBC1 domain family member 4 | Homo sapiens (Human) | PR |
| Q8R5A6 | Tbc1d22a | TBC1 domain family member 22A | Mus musculus (Mouse) | PR |
| Q80XC3 | Usp6nl | USP6 N-terminal-like protein | Mus musculus (Mouse) | PR |
| Q6A039 | Tbc1d12 | TBC1 domain family member 12 | Mus musculus (Mouse) | PR |
| Q8C9V1 | Tbc1d10c | Carabin | Mus musculus (Mouse) | PR |
| Q9D3N8 | Grtp1 | Growth hormone-regulated TBC protein 1 | Mus musculus (Mouse) | PR |
| Q60949 | Tbc1d1 | TBC1 domain family member 1 | Mus musculus (Mouse) | PR |
| A1A5B6 | Tbc1d25 | TBC1 domain family member 25 | Mus musculus (Mouse) | PR |
| Q8BYH7 | Tbc1d17 | TBC1 domain family member 17 | Mus musculus (Mouse) | PR |
| Q9Z1A9 | Tbc1d8 | TBC1 domain family member 8 | Mus musculus (Mouse) | PR |
| A3KGB4 | Tbc1d8b | TBC1 domain family member 8B | Mus musculus (Mouse) | PR |
| Q3UYK3 | Tbc1d9 | TBC1 domain family member 9 | Mus musculus (Mouse) | PR |
| P97366 | Evi5 | Ecotropic viral integration site 5 protein | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESPSCIQDE | PFPHPLEPEP | SAPAQPGATK | PGDKRFRLWY | VGGSCLDRRT | TLPMLPWLMA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EIRRRSQKPD | AGGCGAPAAR | EVILVLSAPF | LRCVPAPGAG | VGGGAGSGAV | QPNTGVFIFE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HKAQHISRFI | HNSHDLTYFA | YLIKAQPDDP | ESQMACHVFR | ATDPNQVPDV | ISSIRQLSKA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AMKEDSKPSK | DNEDAFYNSQ | KFEVLYCGRV | IVTHKKAPSS | LIDDCKDKFS | LHEQQRLKLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GERGGDPGDE | MGVLEVESPV | SPDDSLPEKA | DGTVNSPRAL | PSLASLPALA | SQPALASSRV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CFPERILEDC | GFDEQQEFRS | RCSSVTGVMQ | KKVHENNQKT | QPRRRHASAP | SHVQPSDSEK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NRTMLFQVGR | FEINLISPDT | KSVVLEKNFK | DISSCSQGIK | HVDHFGFICR | ESPEPGLSQY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ICYVFQCANE | SLVDEVMLTL | KQAFSTAAAL | QSAKTQIKLC | ETCPMHSLHK | LCERIEGLYP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PRAKLVIQRH | LSSLTDNEQA | DIFERVQKMK | PISDQEENEL | VILHLRQLCE | AKQRTHVHIG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EGPAIISNST | IPENVTSGGR | FKLDVLKNKA | KRSLTSSLEN | IFSRGANRMR | GRLGSMDSFE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RANSLASEKD | FSPGDSPPGT | PPASPLSSAW | HAFPEEDSDS | PQFRRRAHTF | SHPPSSSRRK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LNLQDGKAHG | LRSPLLRQSS | SEQCSIVPSA | RRMYKESNSS | CSLPSLHTSF | SAPSFTAPSF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LKSFYQNSGR | LSPQYENEIR | QDTASESSDG | EGRKRTSSTC | SNESLNAGGT | PVTPRRVSWR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QRIFLRVASP | VNKSPSAMQQ | QKDGLDRTEL | LPLSPLSPTM | EEEPLIIFLS | GDEDTEKVEE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KKKSKELKSL | WKKAIHQQIL | LLRMEKENQK | LEEARRDELQ | SRKVKLDYEE | VGTCQKEILI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| AWDKKLLNCR | TKIRCDMEDI | HTSLKEGVPK | SRRGEIWQFL | ALQYRLRHRL | PNKHQPPDTS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| YKELLKQLTA | QQHAILVDLG | RTFPTHPYFS | VQLGAGQLSL | FNLLKAYSLL | DKEVGYCQGI |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SFVAGVLLLH | MSEEQAFEML | KFLMYDLGFR | KQYRPDMMSL | QIQMYQLSRL | LHDYHRELYN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| HLEENEISPS | LYAAPWFLTL | FASQFPLGFV | ARVFDIIFLQ | GTEVIFKVAL | SLLSSQEALI |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| MECENFENIV | EFLKSTLPDM | NTTEMEKIIT | QVFEMDISKQ | LHAYEVEYHV | LQDELLESSY |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| ACEDNESLEK | LERANNQLKR | QNMDLLEKLQ | VAHAKIQALE | SNLETLLTRE | TKMKALIRTL |
| 1270 | 1280 | 1290 | 1300 | ||
| EQDKMAYQKT | VEQIRKLLPA | DALANCELLL | KDLTHPTNDK | AKAGNKP |