Q8R5A6
Gene name |
Tbc1d22a (D15Ertd781e) |
Protein name |
TBC1 domain family member 22A |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:223754 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R5A6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R5A6-F1 | Predicted | AlphaFoldDB |
32 variants for Q8R5A6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389384497 | 34 | D>E | No | EVA | |
| rs3389376616 | 42 | L>F | No | EVA | |
| rs241559829 | 42 | L>P | No | EVA | |
| rs3389384533 | 46 | P>S | No | EVA | |
| rs3389370667 | 48 | V>M | No | EVA | |
| rs3389384529 | 54 | K>T | No | EVA | |
| rs3389375143 | 67 | N>D | No | EVA | |
| rs3389351208 | 81 | L>F | No | EVA | |
| rs3389386955 | 94 | V>A | No | EVA | |
| rs3389360479 | 98 | A>T | No | EVA | |
| rs3389373622 | 110 | S>I | No | EVA | |
| rs3389391314 | 112 | P>H | No | EVA | |
| rs264782052 | 117 | T>S | No | EVA | |
| rs49115944 | 120 | E>D | No | EVA | |
| rs46079409 | 132 | P>A | No | EVA | |
| rs3389332249 | 163 | R>W | No | EVA | |
| rs3389375136 | 169 | H>N | No | EVA | |
| rs3389370640 | 169 | H>P | No | EVA | |
| rs3389395200 | 171 | A>S | No | EVA | |
| rs3389300051 | 190 | S>R | No | EVA | |
| rs3389379847 | 210 | D>H | No | EVA | |
| rs3389351235 | 224 | K>Q | No | EVA | |
| rs3389379833 | 234 | L>P | No | EVA | |
| rs3389384484 | 242 | V>I | No | EVA | |
| rs3389332237 | 244 | R>* | No | EVA | |
| rs3389370721 | 307 | I>K | No | EVA | |
| rs3389384462 | 366 | M>K | No | EVA | |
| rs3389332300 | 367 | S>R | No | EVA | |
| rs3389379832 | 384 | I>F | No | EVA | |
| rs221679117 | 404 | R>Q | No | EVA | |
| rs3389387024 | 482 | N>K | No | EVA | |
| rs3389377515 | 487 | R>L | No | EVA |
No associated diseases with Q8R5A6
4 regional properties for Q8R5A6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FAD dependent oxidoreductase | 45 - 407 | IPR006076 |
| domain | Aminomethyltransferase, folate-binding domain | 472 - 737 | IPR006222 |
| domain | Glycine cleavage T-protein, C-terminal barrel domain | 763 - 840 | IPR013977 |
| domain | FAD dependent oxidoreductase, central domain | 410 - 463 | IPR032503 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 14-3-3 protein binding | Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. |
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8WUA7 | TBC1D22A | TBC1 domain family member 22A | Homo sapiens (Human) | PR |
| Q80XC3 | Usp6nl | USP6 N-terminal-like protein | Mus musculus (Mouse) | PR |
| Q6A039 | Tbc1d12 | TBC1 domain family member 12 | Mus musculus (Mouse) | PR |
| Q8C9V1 | Tbc1d10c | Carabin | Mus musculus (Mouse) | PR |
| Q9D3N8 | Grtp1 | Growth hormone-regulated TBC protein 1 | Mus musculus (Mouse) | PR |
| Q8BYJ6 | Tbc1d4 | TBC1 domain family member 4 | Mus musculus (Mouse) | PR |
| Q60949 | Tbc1d1 | TBC1 domain family member 1 | Mus musculus (Mouse) | PR |
| A1A5B6 | Tbc1d25 | TBC1 domain family member 25 | Mus musculus (Mouse) | PR |
| Q8BYH7 | Tbc1d17 | TBC1 domain family member 17 | Mus musculus (Mouse) | PR |
| Q9Z1A9 | Tbc1d8 | TBC1 domain family member 8 | Mus musculus (Mouse) | PR |
| A3KGB4 | Tbc1d8b | TBC1 domain family member 8B | Mus musculus (Mouse) | PR |
| Q3UYK3 | Tbc1d9 | TBC1 domain family member 9 | Mus musculus (Mouse) | PR |
| P97366 | Evi5 | Ecotropic viral integration site 5 protein | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASDGARKQF | WKRSNSKVPG | SIQHVYGAQH | PPFDPLLHGT | LLKSTPKVPT | TPVKAKRVST |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FQEFESNTSD | AWDAGEDDDE | LLAMATESLN | SEVVMETAHR | VLRNHSQRQS | QPSQKTTEPE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PEPQPIAEPP | VPPSGDLRLV | KSVSESHTPC | PSESTGDTVP | LQRSQSLPHS | ATVTLSGTSD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PHALADSALS | KRETSRLDKF | KQLLAGPNTD | LEELRKLSWS | GIPKPVRPMT | WKLLSGYLPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NVDRRPATLQ | RKQKEYFAFI | EHYYSSRNDE | VHQDTYRQIH | IDIPRMSPEA | LILQPKVTEI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FERILFIWAI | RHPASGYVQG | INDLVTPFFV | VFICEYTDRE | DVDKVDVSSV | PAEVLRNIEA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DTYWCMSKLL | DGIQDNYTFA | QPGIQMKVKM | LEELVSRIDE | RVHRHLDGHE | VRYLQFAFRW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MNNLLMRELP | LRCTIRLWDT | YQSEPEGFSH | FHLYVCAAFL | VRWRREILEE | RDFQELLLFL |
| 490 | 500 | 510 | |||
| QNLPTARWDD | QDVSLLLAEA | YRLKFAFADA | PNHYKK |