Q8BYH7

PR
Gene name
Tbc1d17
Protein name
TBC1 domain family member 17
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:233204
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

147-283 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BYH7

Entry ID Method Resolution Chain Position Source
AF-Q8BYH7-F1 Predicted AlphaFoldDB

27 variants for Q8BYH7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs219621039 3 G>E No EVA
rs3388907724 37 V>SDG* No EVA
rs3388903464 40 K>* No EVA
rs3388909860 79 T>S No EVA
rs3388898710 154 H>Q No EVA
rs3388903314 158 G>R No EVA
rs259196167 244 A>G No EVA
rs3388903238 268 E>S No EVA
rs3397081777 301 E>D No EVA
rs3397914537 302 L>F No EVA
rs3388905978 320 W>S No EVA
rs3397852328 354 W>* No EVA
rs3398011184 355 K>Q No EVA
rs3388898679 387 K>E No EVA
rs3388880522 409 M>I No EVA
rs3388907682 417 V>D No EVA
rs3388880511 431 V>A No EVA
rs3388889501 436 D>N No EVA
rs3388901046 437 A>V No EVA
rs3388910440 440 C>S No EVA
rs3388908952 460 K>M No EVA
rs31797378 461 R>Q No EVA
rs3388903455 495 W>C No EVA
rs3388880495 505 P>L No EVA
rs3397841525 587 N>I No EVA
rs3402727918 592 L>M No EVA
rs3397707568 600 P>A No EVA

No associated diseases with Q8BYH7

2 regional properties for Q8BYH7

Type Name Position InterPro Accession
domain Rab-GAP-TBC domain 307 - 545 IPR000195
domain Small G protein signalling modulator 1/2, Rab-binding domain 7 - 204 IPR021935

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, autophagosome
  • Cytoplasm
  • Recycling endosome
  • In the presence of optineurin/OPTN, may be recruited to recycling endosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

4 GO annotations of biological process

Name Definition
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P48365 GYP7 GTPase-activating protein GYP7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3MII6 TBC1D25 TBC1 domain family member 25 Homo sapiens (Human) PR
Q8TC07 TBC1D15 TBC1 domain family member 15 Homo sapiens (Human) PR
Q9HA65 TBC1D17 TBC1 domain family member 17 Homo sapiens (Human) PR
A1A5B6 Tbc1d25 TBC1 domain family member 25 Mus musculus (Mouse) PR
Q9Z1A9 Tbc1d8 TBC1 domain family member 8 Mus musculus (Mouse) PR
A3KGB4 Tbc1d8b TBC1 domain family member 8B Mus musculus (Mouse) PR
Q8R5A6 Tbc1d22a TBC1 domain family member 22A Mus musculus (Mouse) PR
Q80XC3 Usp6nl USP6 N-terminal-like protein Mus musculus (Mouse) PR
Q6A039 Tbc1d12 TBC1 domain family member 12 Mus musculus (Mouse) PR
Q8C9V1 Tbc1d10c Carabin Mus musculus (Mouse) PR
Q9D3N8 Grtp1 Growth hormone-regulated TBC protein 1 Mus musculus (Mouse) PR
Q8BYJ6 Tbc1d4 TBC1 domain family member 4 Mus musculus (Mouse) PR
Q60949 Tbc1d1 TBC1 domain family member 1 Mus musculus (Mouse) PR
Q3UYK3 Tbc1d9 TBC1 domain family member 9 Mus musculus (Mouse) PR
P97366 Evi5 Ecotropic viral integration site 5 protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MEGSSYRVVF EKGGVYLHTS ARKHQDPDSL IAGVIRVVEK DSDVFLHWAP VEEAGDPTQI
70 80 90 100 110 120
LFKKDPSRGE PSTSEEEPTF DPGYEPDWAV ISTVRPQPHL AEPRKGAEPS SSRSSWAFSV
130 140 150 160 170 180
SLGELKSIRR SKPGLSWAYL VLVTQAGGSL PALHFHRGGT RALLRVLSRY LLLASSPQDS
190 200 210 220 230 240
RLYLVFPQDP SALSDSFHHL QLFDQDSSNV VSRFLQDPYS TTFSSFSRVT NFFRGALQPH
250 260 270 280 290 300
PEGASSPNLP PLPDDEPEPG FEVISCVELG QRPTVERAPP VTEEEWNRYV GPEGRLQNVP
310 320 330 340 350 360
ELKNRIFSGG LSPGLRREAW KFLLGYLSWE SSAEEHKAHV RKKTDEYFRM KLQWKSVSAE
370 380 390 400 410 420
QERRNSLLHG YRSLIERDVS RTDRTNKFYE GPENPGLSLL HDILLTYCMY HFDLGYVQGM
430 440 450 460 470 480
SDLLSPILFV VQNEVDAFWC FCGFMELVHG NFEESQETMK RQLGQLLLLL RVLDQPLCDF
490 500 510 520 530 540
LDSQDSGSLC FCFRWLLIWF KREFPFPDVL RLWEVLWTGL PGPNLHLLVA CAILDMERDT
550 560 570 580 590 600
LMLSGFGSNE ILKHINELTM KLSVEDVLTR AEALYRQLTA CPELPHNVQE ILGLAQPEEP
610 620 630 640
SSPSPPVSPM PLSPTRAPLP PPLPEEVIPQ PDSSLEILPE DEDGA