A3KGB4

PR
Gene name
Tbc1d8b
Protein name
TBC1 domain family member 8B
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:245638
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

99-168 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3KGB4

Entry ID Method Resolution Chain Position Source
AF-A3KGB4-F1 Predicted AlphaFoldDB

60 variants for A3KGB4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389483478 4 K>M No EVA
rs3389533997 12 N>I No EVA
rs3412373552 28 L>V No EVA
rs3410798015 41 G>A No EVA
rs3412189542 41 G>R No EVA
rs3412569073 44 G>W No EVA
rs3389580459 48 G>V No EVA
rs3389575099 51 D>E No EVA
rs3412056379 73 Q>H No EVA
rs3412569068 84 R>F No EVA
rs3411723241 85 E>K No EVA
rs3412189559 87 I>K No EVA
rs3412056367 104 V>A No EVA
rs3412288738 104 V>L No EVA
rs3411723301 106 D>E No EVA
rs3409415820 109 E>A No EVA
rs3412374556 109 E>K No EVA
rs3412056342 139 K>R No EVA
rs3412374495 158 K>* No EVA
rs3410799654 159 L>* No EVA
rs3410799676 162 Y>N No EVA
rs3412569089 163 Y>F No EVA
rs3411956225 166 S>C No EVA
rs3412374549 166 S>T No EVA
rs3410684008 233 M>L No EVA
rs3412189493 245 E>D No EVA
rs29257517 288 K>R No EVA
rs221183202 316 S>T No EVA
rs3412097287 348 A>S No EVA
rs244245778 401 V>L No EVA
rs3389576299 404 S>R No EVA
rs3412374551 415 E>K No EVA
rs3389589183 470 G>D No EVA
rs3412190223 509 N>FSI* No EVA
rs3412058165 513 Y>* No EVA
rs3412374518 515 E>Q No EVA
rs3389526222 615 V>M No EVA
rs29255257 626 D>E No EVA
rs3410684004 633 D>H No EVA
rs3389533995 650 L>F No EVA
rs3389577001 667 D>G No EVA
rs3409417273 796 Q>K No EVA
rs3389589154 895 T>N No EVA
rs3412165758 900 L>Q No EVA
rs3412289205 902 F>L No EVA
rs29257465 945 E>K No EVA
rs3411958086 954 E>G No EVA
rs3389577044 962 I>N No EVA
rs3389483484 966 L>S No EVA
rs3412569671 967 S>R No EVA
rs29255920 1041 T>P No EVA
rs3389483483 1052 A>P No EVA
rs212431045 1055 S>R No EVA
rs29255919 1056 V>G No EVA
rs3410799647 1066 E>D No EVA
rs3412190312 1067 H>L No EVA
rs3389580477 1068 Q>H No EVA
rs3412166879 1078 A>S No EVA
rs3389576994 1102 N>I No EVA
rs3389569317 1109 R>W No EVA

No associated diseases with A3KGB4

6 regional properties for A3KGB4

Type Name Position InterPro Accession
domain Rab-GAP-TBC domain 483 - 696 IPR000195
domain EF-hand domain 857 - 892 IPR002048
domain GRAM domain 145 - 251 IPR004182-1
domain GRAM domain 285 - 377 IPR004182-2
domain TBC1D8B, PH-GRAM domain 1 156 - 254 IPR036012
domain TBC1D8B, PH-GRAM domain 2 296 - 388 IPR036015

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

3 GO annotations of biological process

Name Definition
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
glomerular filtration The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95759 TBC1D8 TBC1 domain family member 8 Homo sapiens (Human) PR
Q66K14 TBC1D9B TBC1 domain family member 9B Homo sapiens (Human) PR
Q6ZT07 TBC1D9 TBC1 domain family member 9 Homo sapiens (Human) PR
Q0IIM8 TBC1D8B TBC1 domain family member 8B Homo sapiens (Human) PR
Q9Z1A9 Tbc1d8 TBC1 domain family member 8 Mus musculus (Mouse) PR
A1A5B6 Tbc1d25 TBC1 domain family member 25 Mus musculus (Mouse) PR
Q8BYH7 Tbc1d17 TBC1 domain family member 17 Mus musculus (Mouse) PR
Q8R5A6 Tbc1d22a TBC1 domain family member 22A Mus musculus (Mouse) PR
Q80XC3 Usp6nl USP6 N-terminal-like protein Mus musculus (Mouse) PR
Q6A039 Tbc1d12 TBC1 domain family member 12 Mus musculus (Mouse) PR
Q8C9V1 Tbc1d10c Carabin Mus musculus (Mouse) PR
Q9D3N8 Grtp1 Growth hormone-regulated TBC protein 1 Mus musculus (Mouse) PR
Q8BYJ6 Tbc1d4 TBC1 domain family member 4 Mus musculus (Mouse) PR
Q60949 Tbc1d1 TBC1 domain family member 1 Mus musculus (Mouse) PR
Q3UYK3 Tbc1d9 TBC1 domain family member 9 Mus musculus (Mouse) PR
P97366 Evi5 Ecotropic viral integration site 5 protein Mus musculus (Mouse) PR
B0R0W9 tbc1d8b TBC1 domain family member 8B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MWLKPEEVLL KNALKLWLME RSNEYFVLQR RRGYGEEGGG GLTGLLVGTL DSVLDSTAKV
70 80 90 100 110 120
APFRILHQTP DSQVYLSIAC GANREEITKH WDWLEQNIMK TLSVFDSNED ITNFVQGKIR
130 140 150 160 170 180
GLIAEEGKQS FAKEDDPEKF REALLKFEKS FGLPEQEKLV TYYSCSYWRG RVPCQGWLYL
190 200 210 220 230 240
STNFLSFYSF LLGSEIKLII SWDAISKLEK TSTVILTESI HVCSQGENHY FSMFLHINET
250 260 270 280 290 300
YLLMEQLANY AIKRLFDKET FDNDPVLDDP LQITKRGLEY RAHSEQFKAF FRLPKEETLK
310 320 330 340 350 360
EVHECFLWVP FSHFSSHGKM CISENYICFA SQDGNLCSVI IPLREVLAID KTDDSNRSVI
370 380 390 400 410 420
ISIKGKTAFR FSELKDFEQL VAKLRLKCRA ASTQDDVSTE VAVSSDSTGP SENFEEQPLT
430 440 450 460 470 480
CPKECSKTVN TEALMTVFHP QNLENLDSKM LKEKMKEQSW NILFSECGRG VSMFRTKKTR
490 500 510 520 530 540
DLVVRGIPET LRGELWMLFS GAVNDMATNP GYYAEVVEQS LGTSNLATEE IERDLRRSLP
550 560 570 580 590 600
EHPAFQSDTG ISALRRVLTA YAYRNPKIGY CQAMNILTSV LLLYAKEEEA FWLLVAVCER
610 620 630 640 650 660
MLPDYFNRRI IGALVDQAVF EELIRDHLPQ LTDHMTDMTF FSSVSLSWFL TLFISVLPIE
670 680 690 700 710 720
SAVNVVDCFF YDGIKAILQL GLAILDYNLD KLLTCKDDAE AVTALNRFFD NVINKDSPLP
730 740 750 760 770 780
SNVQQGSNIS NEKSDHTKVD ITDLIKESNE KYGSIRYEDI HSMRCRNRLY VIQTLEETTK
790 800 810 820 830 840
QNVLRVVSQD VKMSLQELDE LYVIFKKELF ISCYWYLSCP GLKHHDPSLP YLEQYQIDCQ
850 860 870 880 890 900
QFRVLYHLLS PWAHSANRDS LALWTFRLLD ENSDCLINFK EFSSAIDIMY NGSFTDKLKL
910 920 930 940 950 960
LFKLHIPPAY TEVMSKTSSK GDELSTEELL YFSQLQVSKP ADEKETESGR NSPEKGKGKI
970 980 990 1000 1010 1020
DIQAYLSQWQ DELLKKEETI KDLPRMNQSQ FIQFSKTLYN LFHEDPEEES LYQAIAIVTN
1030 1040 1050 1060 1070 1080
LLLRMEEVGR KLHSPASSAS TARDSGPSEG NAESSVKKDL PSPREEHQWS FAFEQILASL
1090 1100 1110
LNEPALVRFF ERPLDLKAKL ENAKSSQLRS RTKM