Q8C9V1
PR
Gene name |
Tbc1d10c |
Protein name |
Carabin |
Names |
TBC1 domain family member 10C |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:108995 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C9V1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C9V1-F1 | Predicted | AlphaFoldDB |
25 variants for Q8C9V1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389510862 | 2 | A>S | No | EVA | |
| rs3389481242 | 13 | L>I | No | EVA | |
| rs3389525050 | 133 | I>F | No | EVA | |
| rs3389495332 | 155 | Q>R | No | EVA | |
| rs3389530479 | 183 | A>V | No | EVA | |
| rs3389495390 | 184 | V>M | No | EVA | |
| rs3389509700 | 271 | W>R | No | EVA | |
| rs3389510871 | 273 | A>T | No | EVA | |
| rs3389507761 | 284 | R>H | No | EVA | |
| rs3389530555 | 298 | E>* | No | EVA | |
| rs3389530539 | 300 | R>H | No | EVA | |
| rs3389495381 | 313 | L>I | No | EVA | |
| rs3389517246 | 322 | Q>* | No | EVA | |
| rs3389515926 | 330 | V>L | No | EVA | |
| rs3389510893 | 334 | T>A | No | EVA | |
| rs3389463960 | 337 | E>K | No | EVA | |
| rs3389517160 | 360 | P>S | No | EVA | |
| rs3389517166 | 363 | Q>* | No | EVA | |
| rs3389516707 | 413 | T>I | No | EVA | |
| rs3412162619 | 426 | I>F | No | EVA | |
| rs3389515893 | 432 | S>F | No | EVA | |
| rs3408717912 | 436 | S>C | No | EVA | |
| rs3408512225 | 436 | S>T | No | EVA | |
| rs3389525023 | 440 | L>P | No | EVA | |
| rs3389510886 | 444 | F>I | No | EVA |
No associated diseases with Q8C9V1
No regional properties for Q8C9V1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8C9V1 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| filopodium membrane | The portion of the plasma membrane surrounding a filopodium. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| B cell activation | The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
| calcineurin-NFAT signaling cascade | Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). |
| ERK1 and ERK2 cascade | An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| negative regulation of B cell activation | Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. |
| negative regulation of calcineurin-NFAT signaling cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade. |
| negative regulation of ERK1 and ERK2 cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IV04 | TBC1D10C | Carabin | Homo sapiens (Human) | PR |
| Q8R5A6 | Tbc1d22a | TBC1 domain family member 22A | Mus musculus (Mouse) | PR |
| Q80XC3 | Usp6nl | USP6 N-terminal-like protein | Mus musculus (Mouse) | PR |
| Q6A039 | Tbc1d12 | TBC1 domain family member 12 | Mus musculus (Mouse) | PR |
| Q9D3N8 | Grtp1 | Growth hormone-regulated TBC protein 1 | Mus musculus (Mouse) | PR |
| Q8BYJ6 | Tbc1d4 | TBC1 domain family member 4 | Mus musculus (Mouse) | PR |
| Q60949 | Tbc1d1 | TBC1 domain family member 1 | Mus musculus (Mouse) | PR |
| A1A5B6 | Tbc1d25 | TBC1 domain family member 25 | Mus musculus (Mouse) | PR |
| Q8BYH7 | Tbc1d17 | TBC1 domain family member 17 | Mus musculus (Mouse) | PR |
| Q9Z1A9 | Tbc1d8 | TBC1 domain family member 8 | Mus musculus (Mouse) | PR |
| A3KGB4 | Tbc1d8b | TBC1 domain family member 8B | Mus musculus (Mouse) | PR |
| Q3UYK3 | Tbc1d9 | TBC1 domain family member 9 | Mus musculus (Mouse) | PR |
| P97366 | Evi5 | Ecotropic viral integration site 5 protein | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQALGEDLL | SELQDDSSSL | GSDSELSGPS | PYRQADRYGF | IGGNSGELRL | CQPSADLIRQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| REMKWVEMTL | HWEKTMSRRY | KKVKIQCRKG | IPSALRARCW | PLLCGARMCQ | KNNPGTYQEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AAAPGDPQWM | ETIGRDLHRQ | FPLHEMFVSP | QGHGQQGLLQ | VLKAYTLYRP | EQGYCQAQGP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VAAVLLMHLP | PEEAFWCLVQ | ICEVYLPGYY | GPHMEAVQLD | AEVFMALLRR | QLPRVYKHLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QVGVGPLLYL | PEWFLCLFTR | SLPFPTVLRI | WDAFLSEGAK | VLFRVGLTLM | RLALGTVEQR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TACPGLLETL | GALRAIPPTQ | LQEEVFMSQV | HSVTLSERVL | QQEIRIQLAQ | LSKSLPGPAP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LPQARLPGAQ | AIFESQQLAG | VRESTKPEIP | RIVVQPPEEP | KPPRRKPQTR | GKTFHGLLIR |
| 430 | 440 | ||||
| ARGPPIEGPS | RSQRGSASFL | DTRF |