Q9Z1A9
PR
Gene name |
Tbc1d8 (Hblp1, Vrp) |
Protein name |
TBC1 domain family member 8 |
Names |
BUB2-like protein 1, Vascular Rab-GAP/TBC-containing protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:54610 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z1A9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z1A9-F1 | Predicted | AlphaFoldDB |
63 variants for Q9Z1A9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389879433 | 45 | L>I | No | EVA | |
| rs3389879396 | 46 | V>A | No | EVA | |
| rs3388466478 | 59 | V>I | No | EVA | |
| rs3388464962 | 91 | D>E | No | EVA | |
| rs3388465434 | 97 | L>Q | No | EVA | |
| rs3388466847 | 101 | L>M | No | EVA | |
| rs3388464974 | 157 | E>* | No | EVA | |
| rs3388465031 | 159 | L>Q | No | EVA | |
| rs3412799864 | 167 | C>* | No | EVA | |
| rs3389858481 | 219 | T>I | No | EVA | |
| rs3389870675 | 220 | I>T | No | EVA | |
| rs3388467322 | 281 | R>I | No | EVA | |
| rs3388466821 | 346 | V>L | No | EVA | |
| rs3388465412 | 352 | M>L | No | EVA | |
| rs3388465433 | 362 | I>N | No | EVA | |
| rs3388465429 | 367 | R>H | No | EVA | |
| rs236170658 | 427 | G>R | No | EVA | |
| rs3388465315 | 432 | V>M | No | EVA | |
| rs3388467403 | 511 | G>R | No | EVA | |
| rs3388465506 | 564 | Q>* | No | EVA | |
| rs3388465309 | 579 | Y>* | No | EVA | |
| rs3388464930 | 599 | L>V | No | EVA | |
| rs3388465570 | 616 | C>* | No | EVA | |
| rs3388465482 | 622 | D>E | No | EVA | |
| rs3388467411 | 636 | S>* | No | EVA | |
| rs3389881931 | 674 | I>S | No | EVA | |
| rs3389783350 | 674 | I>V | No | EVA | |
| rs3389886922 | 676 | P>L | No | EVA | |
| rs3389868937 | 676 | P>T | No | EVA | |
| rs3388466193 | 690 | D>V | No | EVA | |
| rs3389878896 | 698 | L>Q | No | EVA | |
| rs3412795734 | 708 | E>D | No | EVA | |
| rs1132565570 | 731 | K>* | No | EVA | |
| rs1133854114 | 735 | S>R | No | EVA | |
| rs3388465795 | 777 | Q>* | No | EVA | |
| rs3388466838 | 795 | D>N | No | EVA | |
| rs3388465847 | 803 | R>H | No | EVA | |
| rs3388465581 | 817 | E>K | No | EVA | |
| rs3388466243 | 827 | H>Y | No | EVA | |
| rs3389887894 | 834 | E>D | No | EVA | |
| rs3389842476 | 841 | L>Q | No | EVA | |
| rs3389878684 | 842 | R>G | No | EVA | |
| rs3388465080 | 856 | D>Y | No | EVA | |
| rs3388467240 | 878 | I>V | No | EVA | |
| rs3389842443 | 905 | D>E | No | EVA | |
| rs3388465891 | 924 | I>F | No | EVA | |
| rs3388465568 | 930 | E>K | No | EVA | |
| rs3388465312 | 938 | P>S | No | EVA | |
| rs3388467360 | 946 | T>A | No | EVA | |
| rs3388466121 | 975 | K>E | No | EVA | |
| rs3388465550 | 980 | M>T | No | EVA | |
| rs3388467349 | 988 | S>N | No | EVA | |
| rs3388466167 | 989 | Q>* | No | EVA | |
| rs3388465096 | 1015 | A>V | No | EVA | |
| rs3388464728 | 1022 | L>M | No | EVA | |
| rs3388465860 | 1025 | Q>* | No | EVA | |
| rs3388466113 | 1026 | I>F | No | EVA | |
| rs3388466185 | 1035 | S>C | No | EVA | |
| rs3389876551 | 1052 | P>H | No | EVA | |
| rs3388464805 | 1056 | S>L | No | EVA | |
| rs3388465529 | 1086 | L>F | No | EVA | |
| rs13464183 | 1091 | S>P | No | EVA | |
| rs33139849 | 1122 | S>N | No | EVA |
No associated diseases with Q9Z1A9
1 regional properties for Q9Z1A9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Rab-GAP-TBC domain | 218 - 471 | IPR000195 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0IIM8 | TBC1D8B | TBC1 domain family member 8B | Homo sapiens (Human) | PR |
| Q66K14 | TBC1D9B | TBC1 domain family member 9B | Homo sapiens (Human) | PR |
| Q6ZT07 | TBC1D9 | TBC1 domain family member 9 | Homo sapiens (Human) | PR |
| O95759 | TBC1D8 | TBC1 domain family member 8 | Homo sapiens (Human) | PR |
| A3KGB4 | Tbc1d8b | TBC1 domain family member 8B | Mus musculus (Mouse) | PR |
| A1A5B6 | Tbc1d25 | TBC1 domain family member 25 | Mus musculus (Mouse) | PR |
| Q8BYH7 | Tbc1d17 | TBC1 domain family member 17 | Mus musculus (Mouse) | PR |
| Q8R5A6 | Tbc1d22a | TBC1 domain family member 22A | Mus musculus (Mouse) | PR |
| Q80XC3 | Usp6nl | USP6 N-terminal-like protein | Mus musculus (Mouse) | PR |
| Q6A039 | Tbc1d12 | TBC1 domain family member 12 | Mus musculus (Mouse) | PR |
| Q8C9V1 | Tbc1d10c | Carabin | Mus musculus (Mouse) | PR |
| Q9D3N8 | Grtp1 | Growth hormone-regulated TBC protein 1 | Mus musculus (Mouse) | PR |
| Q8BYJ6 | Tbc1d4 | TBC1 domain family member 4 | Mus musculus (Mouse) | PR |
| Q60949 | Tbc1d1 | TBC1 domain family member 1 | Mus musculus (Mouse) | PR |
| Q3UYK3 | Tbc1d9 | TBC1 domain family member 9 | Mus musculus (Mouse) | PR |
| P97366 | Evi5 | Ecotropic viral integration site 5 protein | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWLKPEEVLL | KNALKLWVTQ | KSSCYFVLQR | RRGHGEGGGR | LTGRLVGALD | AVLDSSARVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PFRILLQVPG | SQVYSPIACG | ATLEEINRHW | DWLEQNLLHT | LSVFDNKDDI | ASFVKGKVKA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LIAEETSSRL | AEQEEEPEKF | REALVKFEAR | FNFPEAEKLV | TYYSCCCWKG | RVPRQGWLYL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SINHLCFYSF | FLGKELKLVI | PWVDIQKLER | TSNVFLTDTI | RITTQNKERD | FSTFLNLDEV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FKIMEQLADV | TLRRLLDNEV | FDLDPDLQEP | SQITKRDLEA | RAQNEFFRAF | FRLPREEKLH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVADCSLWTP | FSRCHTAGRI | FSSDSYICFA | SREDGCCNVV | LPLREVVSIE | KMEDTSLLPN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PIIVSIRSKM | AFQFIELKDR | ENLVEGLLLR | LKQVHANHPV | HYETSPSDDD | MASPVFYSAS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ICTDKFGDLE | MVASQSSEER | EEKRPLPHPE | PLTAVFQQSG | SQSPDSRLSR | EQIKISLWND |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HFVEYGRTVC | MFRTEKIRKL | VAMGIPESLR | GRLWLLFSDA | VTDLASHPGY | YGNLVEQSLG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RCCLVTEEIE | RDLHRSLPEH | PAFQNETGIA | ALRRVLTAYA | HRNPKIGYCQ | SMNILTSVLL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LYAKEEEAFW | LLVAVCERML | PDYFNHRVIG | AQVDQSVFEE | LIKEQLPELA | EHMSDLSALA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SISLSWFLTL | FLSIMPLESA | VHVVDCFFYD | GIKAIFQLGL | AVLEANAEEL | CSSKDDGQAL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MVLSRFLDHI | KNEDSPGPPI | GSHHAFFSDD | QEPYPVTDIA | DLIRDSYEKF | GNQSVEQIEH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LRCKHRIRVL | QGHEDTTKQN | VLRVVIPEVS | ILPEDLEELY | DLFKRAHMMS | CYWEHHRPMA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LRHDPSRPYA | EQYRIDARQF | AHLFQLVSPW | TCGVHTEILA | ERLFRLLDDN | MDQLIEFKAF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| TSCLDIMYNG | EMNEKIKLLY | RLHIPPALTE | NDRDSQSPLK | NPLLSTSRPL | VLGKPNGDTI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DYQKQLKQMI | KDLAKEKDKM | EKELPKMSQR | EFIQFCKTLY | SMFHEDPEEN | DLYQAIATVT |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| TLLLQIGEVG | QRGSSSGSCS | QECEEPQASA | PPEQDSVFAE | AGKSPQAFPE | TEGDWTVSLE |
| 1090 | 1100 | 1110 | 1120 | 1130 | |
| HILASLLTEQ | SLVNFFEKPL | NIKSKLENAK | LNQYSLKVLE | MSHPPQAELK | LNDL |