Q9D3N8

PR
Gene name
Grtp1 (Tbc1d6)
Protein name
Growth hormone-regulated TBC protein 1
Names
TBC1 domain family member 6
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:66790
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-142 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D3N8

Entry ID Method Resolution Chain Position Source
AF-Q9D3N8-F1 Predicted AlphaFoldDB

21 variants for Q9D3N8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388969810 42 V>E No EVA
rs3388968517 57 G>* No EVA
rs3388971997 64 S>G No EVA
rs3388972039 67 V>L No EVA
rs3388964507 83 V>M No EVA
rs3388968592 85 M>I No EVA
rs3388968583 85 M>K No EVA
rs3388941889 130 M>T No EVA
rs3388967336 133 K>N No EVA
rs3388968563 134 T>A No EVA
rs3388923690 153 H>Y No EVA
rs3388953254 159 Y>F No EVA
rs3388967294 230 L>M No EVA
rs3388972522 232 R>G No EVA
rs3388948676 242 M>I No EVA
rs3388963354 281 G>S No EVA
rs3388963383 327 A>T No EVA
rs3388953274 336 P>L No EVA
rs3388975001 336 P>T No EVA
rs46869265 357 A>T No EVA
rs3388969839 359 S>R No EVA

No associated diseases with Q9D3N8

1 regional properties for Q9D3N8

Type Name Position InterPro Accession
domain Rab-GAP-TBC domain 71 - 304 IPR000195

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

1 GO annotations of biological process

Name Definition
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UPU7 TBC1D2B TBC1 domain family member 2B Homo sapiens (Human) PR
Q5TC63 GRTP1 Growth hormone-regulated TBC protein 1 Homo sapiens (Human) PR
Q8R5A6 Tbc1d22a TBC1 domain family member 22A Mus musculus (Mouse) PR
Q80XC3 Usp6nl USP6 N-terminal-like protein Mus musculus (Mouse) PR
Q6A039 Tbc1d12 TBC1 domain family member 12 Mus musculus (Mouse) PR
Q8C9V1 Tbc1d10c Carabin Mus musculus (Mouse) PR
Q8BYJ6 Tbc1d4 TBC1 domain family member 4 Mus musculus (Mouse) PR
Q60949 Tbc1d1 TBC1 domain family member 1 Mus musculus (Mouse) PR
A1A5B6 Tbc1d25 TBC1 domain family member 25 Mus musculus (Mouse) PR
Q8BYH7 Tbc1d17 TBC1 domain family member 17 Mus musculus (Mouse) PR
Q9Z1A9 Tbc1d8 TBC1 domain family member 8 Mus musculus (Mouse) PR
A3KGB4 Tbc1d8b TBC1 domain family member 8B Mus musculus (Mouse) PR
Q3UYK3 Tbc1d9 TBC1 domain family member 9 Mus musculus (Mouse) PR
P97366 Evi5 Ecotropic viral integration site 5 protein Mus musculus (Mouse) PR
Q4QQU7 Grtp1 Growth hormone-regulated TBC protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDPAERAQAA RARVPRIDPY GFERPEDFDY AAYEEFFSTY LVILTKRAIK WSKLLKGNGG
70 80 90 100 110 120
VRKSVTVKRY VRKGIPLEHR ARVWMAVSGA QARMDQSPGY YHRLLEGESS SSLDEAIRTD
130 140 150 160 170 180
LNRTFPDNVM FRKTADPCLQ KTLYNVLLAY GLHNPDVGYC QCCAQKPGSS AGLRSSLTGM
190 200 210 220 230 240
NFIAGYLILI TKNEEESFWL LDALVGRILP DYYSPAMLGL KTDQEVLAEL VRMKLPAVAA
250 260 270 280 290 300
LMDGHGVLWT LLVSRWFICL FVDILPVETV LRIWDCLFNE GSKIIFRVAL TLIKQHQEFI
310 320 330 340 350
LEASSIPDIC DKFKQITKGD FVTECHAFMQ KIFSEPGSLS MTTITRLRKS CRAALQAQS