Q6A039

PR
Gene name
Tbc1d12 (Kiaa0608)
Protein name
TBC1 domain family member 12
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:209478
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

170-241 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6A039

Entry ID Method Resolution Chain Position Source
AF-Q6A039-F1 Predicted AlphaFoldDB

No variants for Q6A039

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6A039

No associated diseases with Q6A039

1 regional properties for Q6A039

Type Name Position InterPro Accession
domain Rab-GAP-TBC domain 402 - 636 IPR000195

Functions

Description
EC Number
Subcellular Localization
  • Endosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

1 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

2 GO annotations of biological process

Name Definition
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
regulation of autophagosome assembly Any process that modulates the frequency, rate or extent of autophagosome assembly.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8R5A6 Tbc1d22a TBC1 domain family member 22A Mus musculus (Mouse) PR
Q80XC3 Usp6nl USP6 N-terminal-like protein Mus musculus (Mouse) PR
Q8C9V1 Tbc1d10c Carabin Mus musculus (Mouse) PR
Q9D3N8 Grtp1 Growth hormone-regulated TBC protein 1 Mus musculus (Mouse) PR
Q8BYJ6 Tbc1d4 TBC1 domain family member 4 Mus musculus (Mouse) PR
Q60949 Tbc1d1 TBC1 domain family member 1 Mus musculus (Mouse) PR
A1A5B6 Tbc1d25 TBC1 domain family member 25 Mus musculus (Mouse) PR
Q8BYH7 Tbc1d17 TBC1 domain family member 17 Mus musculus (Mouse) PR
Q9Z1A9 Tbc1d8 TBC1 domain family member 8 Mus musculus (Mouse) PR
A3KGB4 Tbc1d8b TBC1 domain family member 8B Mus musculus (Mouse) PR
Q3UYK3 Tbc1d9 TBC1 domain family member 9 Mus musculus (Mouse) PR
P97366 Evi5 Ecotropic viral integration site 5 protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MMGPEDAGAC SGRNAELLPV PGPMGQDGKT VPATSGFSGG AVAAEPPEEA GEEEAPPPRQ
70 80 90 100 110 120
LLQRYLAAAA GPLKPGLGGA EAEEAAAAAV PAARGSGMTN GDSGFLLRQD RRGPEEARRR
130 140 150 160 170 180
RTCGRPCLLE PADEGVDGAG GLDDWAAPLE DPLRSCCLAA GDTDDPDPAA ATPAGRAVES
190 200 210 220 230 240
AEPSLGLPDA RFGSRNTFEV SRRQSAGDLL PSAGPSAPLP AAEQGPGGTT ARARRSGGFA
250 260 270 280 290 300
DFFARNLFPK RTKELKSVVH SAPGWKLFGK VPPRENLQKT SKIIQQEYEA RTGRTCKAAP
310 320 330 340 350 360
QSSRRKSFAL EPLSTTALIL EDRPPNLPAK SVEEALRHRQ EYDEMVAEAK KREIKEAHKR
370 380 390 400 410 420
KRIMKERFKQ EESIASAMVI WINEILPNWE VMRSTRRVRE LWWQGLPPSV RGKVWSLAVG
430 440 450 460 470 480
NELNITPELY EIFLSRAKER WKSFSESSSE NDTEGLSVAD REASLELIKL DISRTFPSLY
490 500 510 520 530 540
IFQKGGPYHD VLHSILGAYT CYRPDVGYVQ GMSFIAAVLI LNLEEADAFI AFANLLNKPC
550 560 570 580 590 600
QLAFFRVDHS MMLKYFATFE VFFEENLSKL FLHFKSYNLT PDIYLIDWIF TLYSKSLPLD
610 620 630 640 650 660
LACRVWDVFC RDGEEFLFRT GLGILRLYED ILLQMDFIHI AQFLTKLPED ITSEKLFSCI
670 680 690
AAIQMQNSTK KWTQVFASVA KDIKEGDKNT SPALKS