P48365
Gene name |
GYP7 (YDL234C) |
Protein name |
GTPase-activating protein GYP7 |
Names |
GAP for YPT7 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDL234C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P48365
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P48365-F1 | Predicted | AlphaFoldDB |
15 variants for P48365
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-36418 | 21 | D>N | No | SGRP | |
| s04-36106 | 125 | T>A | No | SGRP | |
| s04-35808 | 224 | L>P | No | SGRP | |
| s04-35499 | 327 | N>T | No | SGRP | |
| s04-35401 | 360 | S>P | No | SGRP | |
| s04-35379 | 367 | G>E | No | SGRP | |
| s04-35317 | 388 | D>N | No | SGRP | |
| s04-35164 | 439 | E>K | No | SGRP | |
| s04-35038 | 481 | L>F | No | SGRP | |
| s04-35031 | 483 | A>E | No | SGRP | |
| s04-35026 | 485 | E>K | No | SGRP | |
| s04-35013 | 489 | T>I | No | SGRP | |
| s04-34948 | 511 | I>V | No | SGRP | |
| s04-34339 | 714 | T>A | No | SGRP | |
| s04-34306 | 725 | T>A | No | SGRP |
No associated diseases with P48365
No regional properties for P48365
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P48365 | |||
2 GO annotations of cellular component
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| regulation of vacuole fusion, non-autophagic | Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MII6 | TBC1D25 | TBC1 domain family member 25 | Homo sapiens (Human) | PR |
| Q9HA65 | TBC1D17 | TBC1 domain family member 17 | Homo sapiens (Human) | PR |
| Q8TC07 | TBC1D15 | TBC1 domain family member 15 | Homo sapiens (Human) | PR |
| A1A5B6 | Tbc1d25 | TBC1 domain family member 25 | Mus musculus (Mouse) | PR |
| Q8BYH7 | Tbc1d17 | TBC1 domain family member 17 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKILFCKSK | VFLHPTSDAR | DNIAGFLLLT | LEANKLSHQA | ILQYIPESGL | STLEISKLLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HEAKVGTCPT | STPFVIENSI | NFSNLVNTSL | GQAFEISLSQ | IYCIQFRPPS | PNGWYVGSLV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IYPLTEQFTG | FQPPVLFFHD | QLCPSTTDKL | KRLRKSMNPF | DDSDELYWGG | VDLRNKINEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MELKKSNLEP | EFWLVNPSLN | DLRNFVSKDL | LESYNNSKKD | TTELATAGVK | LNEKFQEWKW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NVMSKIADVT | TKSTNFIDSW | LTNNSPIQKS | QIDNEYLQKL | LNNEKVKQIE | QDYDSARVYL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ANWSLGVKQE | AERYQKQNKL | FDSYRNNIFN | DLNLTDELSD | TEINNALQRQ | FPLTEAKWNS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LWDENDGRLR | VTVNEVKDFI | FHGGLENDSL | RGKVWGFLLE | IYPWDSSQDE | RVQIDQTLAA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EYDQLKLTWS | KDFLQFDDED | EEEYWNDQLF | RISKDVRRCD | RNLEIFQYNT | IDGLPPPPQQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LPANENNSTS | PESANDESDD | ADDGVRNPHL | IHLQNILITY | NVYNTNLGYV | QGMTDLLSPI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YVIMKEEWKT | FWCFTHFMDI | MERNFLRDQS | GIHEQMLTLV | ELVQLMLPEL | SEHLNKCDSG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NLFFCFRMLL | VWFKREFEME | DIMHIWENFW | TFYYSSQFQL | FFMLAILQKN | SQAILQHLNQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FDQILKFFNE | LNGKLDWNDL | MVRAELLFKK | FEKMMHVMER | DLQNVSSSSS | SSSTGVLPCQ |
| 730 | 740 | ||||
| SERLTLLLSK | KPIIRHEGQR | SKNSVK |