AiPD: Autoinhibited Protein Database

Q8WUA7

Gene name	TBC1D22A (C22orf4)
Protein name	TBC1 domain family member 22A
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:25771
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

106-178 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

106-178 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q8WUA7

Entry ID	Method	Resolution	Chain	Position	Source
2QFZ	X-ray	210 A	A/B	191-517	PDB
AF-Q8WUA7-F1	Predicted				AlphaFoldDB

425 variants for Q8WUA7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA325202128 rs940047837	3	S>T		No	ClinGen TOPMed gnomAD
rs755020822 CA10297113	5	G>R		No	ClinGen ExAC gnomAD
rs1472328052 CA411956624	6	A>T		No	ClinGen gnomAD
CA325202139 rs1037270375	10	F>L		No	ClinGen TOPMed
CA325202141 rs972577646	13	R>C		No	ClinGen TOPMed
CA411956708 rs972577646	13	R>G		No	ClinGen TOPMed
CA325202147 rs906815129	14	S>R		No	ClinGen TOPMed gnomAD
CA411956746 rs1157852368	16	S>I		No	ClinGen gnomAD
CA10297115 rs752916321	17	K>E		No	ClinGen ExAC gnomAD
CA10297116 rs200768437	17	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA411956792 rs1375724995	20	G>A		No	ClinGen TOPMed gnomAD
rs1375724995 CA411956791	20	G>D		No	ClinGen TOPMed gnomAD
rs1280365660 CA411956784	20	G>S		No	ClinGen gnomAD
rs1601880923 CA411959347	23	Q>K		No	ClinGen Ensembl
CA411959357 rs1394023541	24	H>Y		No	ClinGen gnomAD
rs759936733 CA411959364	25	V>L		No	ClinGen TOPMed
CA325214934 rs759936733	25	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA10297143 rs569878882	26	Y>F		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	26	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769506883 CA10297144	30	H>N		No	ClinGen ExAC gnomAD
rs749629711 CA10297148	30	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs777340079 CA10297147	30	H>R		No	ClinGen ExAC
CA411959407 rs1208677696	32	P>A		No	ClinGen gnomAD
rs780242440 CA10297149	32	P>H		No	ClinGen ExAC TOPMed gnomAD
rs780242440 CA411959409	32	P>L		No	ClinGen ExAC TOPMed gnomAD
rs780242440 CA10297150	32	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1180424417 CA411959415	33	F>C		No	ClinGen gnomAD
rs771822190	33	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs760828519 CA10297155	34	D>A		No	ClinGen ExAC gnomAD
rs760828519 CA10297154	34	D>V		No	ClinGen ExAC gnomAD
CA411959429 rs1161610885	35	P>L		No	ClinGen TOPMed
rs1161610885 CA411959427	35	P>Q		No	ClinGen TOPMed
CA10297156 rs754052601	36	L>P		No	ClinGen ExAC TOPMed gnomAD
CA411959432 rs754052601	36	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA411959430 rs1419972438	36	L>V		No	ClinGen gnomAD
CA411959439 rs1293964953	37	L>F		No	ClinGen gnomAD
rs146224636 CA10297158	38	H>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs146224636 CA325214999	38	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA411959454 rs1360754684	40	T>A		No	ClinGen gnomAD
rs751292740 CA10297160	40	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs985127356 CA325215645	43	R>S		No	ClinGen TOPMed gnomAD
CA10297212 rs373533476	44	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA10297214 rs755610660	45	T>M		No	ClinGen ExAC TOPMed gnomAD
rs370891201 CA325215668	46	A>V		No	ClinGen ESP TOPMed
CA411959592 rs1472299527	48	M>I		No	ClinGen gnomAD
CA10297216 rs748273994	49	P>L		No	ClinGen ExAC TOPMed gnomAD
CA411959597 rs748273994	49	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1182410627 CA411959596	49	P>S		No	ClinGen TOPMed gnomAD
CA10297219 rs373169605	50	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs139283566 CA10297220	50	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	51	T>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760455392 CA10297222	52	P>L		No	ClinGen ExAC gnomAD
CA411959616 rs1447640878	53	V>E		No	ClinGen gnomAD
CA10297223 rs188509845	53	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411959625 rs1289169185	54	K>N		No	ClinGen gnomAD
rs1352439383 CA411959631	55	A>V		No	ClinGen gnomAD
CA10297224 rs776373828	56	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1287658736 CA411959637	56	K>R		No	ClinGen gnomAD
rs761408273 CA10297225	57	R>S		No	ClinGen ExAC gnomAD
CA10297226 rs764610953	60	T>A		No	ClinGen ExAC gnomAD
rs749915646 CA10297227	65	E>D		No	ClinGen ExAC TOPMed
rs1044797288 CA325215714	65	E>G		No	ClinGen TOPMed
CA411959715 rs1441607266	67	N>S		No	ClinGen gnomAD
CA411959724 rs1324519181	68	T>I		No	ClinGen TOPMed
CA411959733 rs1253443796 COSM3424243	70	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1481794938 CA411959754	72	W>C		No	ClinGen gnomAD
rs142628893 CA411959764	74	A>S		No	ClinGen ESP TOPMed gnomAD
rs142628893 CA325215733	74	A>T		No	ClinGen ESP TOPMed gnomAD
CA10297230 rs151001225	76	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA10297232 rs758848470	78	D>E		No	ClinGen ExAC TOPMed gnomAD
CA10297234 rs756616638	79	D>G		No	ClinGen ExAC TOPMed gnomAD
rs753108605 COSM3405723 CA10297233	79	D>N	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs375204935 CA325215759	84	M>T		No	ClinGen ESP TOPMed
CA411959829 rs1157899125	84	M>V		No	ClinGen TOPMed
CA411959841 rs1438584179	85	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs771207642 CA10297237	86	A>P		No	ClinGen ExAC TOPMed gnomAD
COSM1416917 CA411959842 rs771207642	86	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA10297238 rs779037012	86	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1185514145 CA411959848	87	E>*		No	ClinGen TOPMed
rs1339717338 CA411959852	87	E>D		No	ClinGen gnomAD
CA411959856 rs1203967471	88	S>C		No	ClinGen gnomAD
CA411959865 rs1452789652	89	L>P		No	ClinGen gnomAD
CA10297242 rs17849460	92	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA411959891 rs1213849893	93	V>A		No	ClinGen TOPMed
rs769747383 CA10297243	93	V>L		No	ClinGen ExAC gnomAD
CA10297244 rs772925609	94	V>F		No	ClinGen ExAC gnomAD
CA411959893 rs772925609	94	V>I		No	ClinGen ExAC gnomAD
CA411959899 rs1319157328	95	M>V		No	ClinGen TOPMed
CA10297245 rs141580250	97	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA411959931 rs1167533607	99	N>S		No	ClinGen gnomAD
rs1167533607 CA411959930	99	N>T		No	ClinGen gnomAD
rs147698824 CA10297248	100	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10297249 rs370656255	100	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA10297251 rs539861629	103	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778336837 COSM171051 CA10297252	103	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA411959952 rs778336837	103	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1299605071 CA411959954	104	N>D		No	ClinGen TOPMed gnomAD
rs1428177249 CA411959977	107	Q>*		No	ClinGen TOPMed
CA10297254 rs373618433	108	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10297253 rs556422849	108	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs746048534 CA411960002	111	R>G		No	ClinGen ExAC gnomAD
CA411960003 rs772304663	111	R>L		No	ClinGen ExAC TOPMed gnomAD
CA10297257 rs772304663	111	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs746048534 CA10297256	111	R>W		No	ClinGen ExAC gnomAD
CA411960009 rs1383310820	112	P>R		No	ClinGen TOPMed
TCGA novel	112	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411960012 rs1189739239	113	T>A		No	ClinGen TOPMed gnomAD
rs146025212 RCV000957767 CA10297258	113	T>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs769624699 CA411960025	115	Q>L		No	ClinGen ExAC gnomAD
rs769624699 CA10297260	115	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	118	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10297261 rs113311478	118	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA411960063 rs1221318821	121	Q>R		No	ClinGen TOPMed
rs971787175 CA325215884	122	Q>*		No	ClinGen TOPMed gnomAD
CA411960068 rs971787175	122	Q>E		No	ClinGen TOPMed gnomAD
rs1294609969 CA411960070	122	Q>R		No	ClinGen TOPMed
CA10297262 rs762574245	123	K>N		No	ClinGen ExAC gnomAD
CA411960076 rs1393791806	123	K>Q		No	ClinGen gnomAD
CA411960090 rs1386225397	125	R>T		No	ClinGen gnomAD
rs1322410409 CA411960088	125	R>W		No	ClinGen gnomAD
CA10297265 rs759162830	127	E>K		No	ClinGen ExAC gnomAD
CA411960108 rs767188708	128	A>S		No	ClinGen ExAC TOPMed gnomAD
rs767188708 CA10297266	128	A>T		No	ClinGen ExAC TOPMed gnomAD
rs189329763 CA10297268	130	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10297267 rs189329763	130	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10297271 rs757358750	132	S>L		No	ClinGen ExAC gnomAD
rs750492932 CA10297273	133	P>L		No	ClinGen ExAC gnomAD
CA10297272 rs572606763	133	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA325215916 rs572606763	133	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1318756 rs112995262 CA10297274	134	P>A	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA411960139 rs201151937	134	P>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411960140 rs201151937	134	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10297276 rs201151937	134	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411960138 rs112995262	134	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs112995262 CA10297275	134	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10297279 rs749281882	135	S>G		No	ClinGen ExAC gnomAD
CA411960143 rs1417281424	135	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA411960155 rs1386288578	136	G>D		No	ClinGen gnomAD
rs748741270 CA10297280	136	G>S		No	ClinGen ExAC TOPMed gnomAD
CA411960152 rs1386288578	136	G>V		No	ClinGen gnomAD
rs543478811 CA10297282	137	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1018052328 CA325215978	138	L>F		No	ClinGen TOPMed gnomAD
rs535972526 CA10297285	139	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10297284 rs775148519	139	R>W		No	ClinGen ExAC TOPMed gnomAD
CA325215990 rs998925166	141	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA411960204 rs998925166	141	V>G		No	ClinGen gnomAD
CA411960217 rs1484416151	142	K>R		No	ClinGen gnomAD
CA10297287 rs563554988	143	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1308707476 CA411960240	145	S>G		No	ClinGen TOPMed
CA411960244 rs1483432891	145	S>T		No	ClinGen gnomAD
CA10297289 rs765718678	147	S>N		No	ClinGen ExAC TOPMed gnomAD
CA10297290 rs375588486	149	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1343453173 CA411960296	150	S>F		No	ClinGen TOPMed
CA325215997 rs867600460	151	C>F		No	ClinGen gnomAD
CA411960307 rs867600460	151	C>Y		No	ClinGen gnomAD
rs1464321405 CA411960326	153	A>T		No	ClinGen gnomAD
CA10297309 rs762974977	155	S>I		No	ClinGen ExAC gnomAD
CA411960946 rs1271097186	156	A>D		No	ClinGen gnomAD
rs1306997716 CA411960950	157	S>G		No	ClinGen gnomAD
CA411960957 rs1267287718	158	D>N		No	ClinGen gnomAD
CA411960970 rs1467115886	159	A>V		No	ClinGen TOPMed gnomAD
CA411960972 rs759900287	160	A>S		No	ClinGen ExAC TOPMed gnomAD
CA10297312 rs759900287	160	A>T		No	ClinGen ExAC TOPMed gnomAD
CA411960981 rs1569048123	161	P>L		No	ClinGen Ensembl
CA10297313 rs547810602	162	L>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA10297315 rs561746997	168	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1424020889 CA411961028	169	P>S		No	ClinGen gnomAD
TCGA novel	170	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10297317 rs187687977	171	S>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1325759617 CA411961047	172	A>S		No	ClinGen gnomAD
rs1437638532 CA411961056	173	T>I		No	ClinGen TOPMed gnomAD
rs1389879381 CA411961053	173	T>S		No	ClinGen gnomAD
CA10297320 rs746506768	174	V>I		No	ClinGen ExAC TOPMed gnomAD
rs141698918 CA411961064	175	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000965512 CA10297322 rs141698918	175	T>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs367864102 CA10297321	175	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs773418910 CA10297325	176	L>V		No	ClinGen ExAC gnomAD
CA10297326 rs763567912	177	G>D		No	ClinGen ExAC gnomAD
CA411961078 rs1170571861	178	G>D		No	ClinGen TOPMed
rs1170571861 CA411961080	178	G>V		No	ClinGen TOPMed
CA10297327 rs146205023	179	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10297328 rs146205023	179	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139101675 CA10297329	180	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA325217927 rs748132646	181	D>H		No	ClinGen Ensembl
CA411961101 rs1175211637	182	P>R		No	ClinGen TOPMed
rs1249565988 CA411961099	182	P>S		No	ClinGen TOPMed
rs1415048979 CA411961108	183	S>N		No	ClinGen gnomAD
rs1052520953 CA325217937	186	S>G		No	ClinGen TOPMed
rs752916130 CA10297331	187	S>R		No	ClinGen ExAC gnomAD
CA10297332 rs761726540	189	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1233342682 CA411961148	190	L>M		No	ClinGen TOPMed
rs149499645 CA10297335	191	S>R		No	ClinGen ESP ExAC gnomAD
COSM1035211 rs1000073319 CA325217969	192	E>K	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1350818408 CA411961182	195	A>T		No	ClinGen gnomAD
CA411961187 rs1304770672	195	A>V		No	ClinGen gnomAD
rs372774075 CA10297338	197	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA411961194 rs1282803682	197	R>W		No	ClinGen TOPMed
rs778261467 CA10297342	199	D>E		No	ClinGen ExAC gnomAD
CA10297341 rs747838862	199	D>H		No	ClinGen ExAC gnomAD
CA411961204 rs747838862	199	D>N		No	ClinGen ExAC gnomAD
rs747838862 CA10297340	199	D>Y		No	ClinGen ExAC gnomAD
rs1305325537 CA411961224	201	F>L		No	ClinGen TOPMed
rs569400492 CA10297343	202	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs771476540 CA10297344	206	A>P		No	ClinGen ExAC gnomAD
CA325218023 rs958242168	206	A>V		No	ClinGen TOPMed gnomAD
CA10297346 rs538362760	207	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA411961264 rs1352515275	208	P>R		No	ClinGen TOPMed gnomAD
CA411961266 rs1601905353	209	N>H		No	ClinGen Ensembl
CA411961271 rs1415335800	209	N>S		No	ClinGen TOPMed gnomAD
rs1175775807 CA411961279	210	T>R		No	ClinGen gnomAD
CA10297362 rs749679165	216	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs777226130 CA10297361	216	R>W		No	ClinGen ExAC gnomAD
rs1408209617 CA411962506	219	S>R		No	ClinGen gnomAD
CA325231757 rs916918749	219	S>T		No	ClinGen TOPMed
TCGA novel	221	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1331664937 CA411962528	222	G>R		No	ClinGen gnomAD
rs1301031154 CA411962546	224	P>L		No	ClinGen gnomAD
CA10297367 rs775769635	227	V>A		No	ClinGen ExAC gnomAD
rs768924971 CA10297369	228	R>C		No	ClinGen ExAC TOPMed gnomAD
rs768924971 CA10297370	228	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1194794161 CA411962567	228	R>H		No	ClinGen gnomAD
rs1395387798 CA411962578	230	M>K		No	ClinGen TOPMed
CA10297371 rs144042293	230	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA10297372 rs563360644	231	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA325231805 rs924343238	232	W>G		No	ClinGen Ensembl
TCGA novel	233	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs529507386 CA325231809	234	L>V		No	ClinGen 1000Genomes
rs766583001 CA411962611	235	L>F		No	ClinGen TOPMed
CA325231813 rs766583001	235	L>V		No	ClinGen TOPMed
rs748255958 CA10297406	237	G>V		No	ClinGen ExAC gnomAD
rs770011457 CA10297408	238	Y>S		No	ClinGen ExAC gnomAD
rs201635788 CA10297411	241	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10297412 rs775320809	242	N>S		No	ClinGen ExAC TOPMed gnomAD
CA411962683 rs1339531459	244	D>E		No	ClinGen TOPMed
rs1227209780 CA411962679	244	D>Y		No	ClinGen TOPMed
rs776069319 CA10297415	245	R>Q		No	ClinGen ExAC gnomAD
CA10297414 COSM1495259 rs142211618	245	R>W	kidney [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA10297416 rs761339734	246	R>S		No	ClinGen ExAC gnomAD
rs1334367123 CA411962727	252	R>*		No	ClinGen gnomAD
rs764993895 CA10297417	254	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA10297418 rs750046043	254	Q>R		No	ClinGen ExAC gnomAD
COSM258146 CA411962754 rs1350377357	255	K>N	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	255	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA325225345 rs373848436	256	E>A		No	ClinGen ESP TOPMed
CA411962761 rs1208976578	256	E>D		No	ClinGen gnomAD
CA411962767 rs1406559078	257	Y>F		No	ClinGen TOPMed
rs199700764 CA10297420	260	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA411962804 rs766900008	262	E>D		No	ClinGen ExAC gnomAD
TCGA novel	262	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751940883 CA10297423	264	Y>C		No	ClinGen ExAC gnomAD
CA10297422 rs751940883	264	Y>F		No	ClinGen ExAC gnomAD
CA10297426 rs756141681 COSM1035213	266	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA10297419 rs778817994	267	S>F		No	ClinGen ExAC gnomAD
TCGA novel	269	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411962856 rs1484383950	270	D>N		No	ClinGen gnomAD
rs779768621 CA10297430 COSM1416920	271	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA325225407 rs773727543	272	V>L		No	ClinGen Ensembl
rs746812615 CA10297431	276	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1304694099 CA639667619	277	Y>*		No	ClinGen gnomAD
CA411962913 rs1238578949	278	R>G		No	ClinGen gnomAD
rs775351336 CA411963059	281	H>L		No	ClinGen ExAC TOPMed gnomAD
CA10297461 rs775351336	281	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1021808630 CA325227547	282	I>V		No	ClinGen TOPMed gnomAD
rs763218275 CA325227566	285	P>L		No	ClinGen Ensembl
rs761224095 CA10297463 COSM1535737	286	R>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs560814069 CA325227596	287	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
CA10297465 rs753916958	287	M>V		No	ClinGen ExAC TOPMed gnomAD
CA10297466 rs139839482	288	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1602353254 CA411963164	289	P>S		No	ClinGen Ensembl
rs1325701498 CA411963179	290	E>G		No	ClinGen gnomAD
rs375436361 CA10297467	291	A>V		No	ClinGen ESP ExAC gnomAD
CA325227637 rs909453412	292	L>F		No	ClinGen TOPMed gnomAD
CA10297469 rs758517657	293	I>F		No	ClinGen ExAC gnomAD
TCGA novel	295	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	297	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1332635875 CA411963262	297	K>Q		No	ClinGen gnomAD
rs147682361 CA411963295	299	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10297471 rs147682361	299	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10297473 rs777796856	300	E>K		No	ClinGen ExAC gnomAD
TCGA novel	303	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411963829 rs1380051001	305	I>T		No	ClinGen gnomAD
CA325235741 rs371872564	305	I>V		No	ClinGen Ensembl
rs1401216784 CA411963838	306	L>F		No	ClinGen TOPMed
CA10297494 rs778539219	310	A>V		No	ClinGen ExAC gnomAD
CA411963897 rs1602447008	311	I>T		No	ClinGen Ensembl
rs988342620 CA325235750	312	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs771756934 COSM189366 CA10297496	312	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs747395220 CA10297498	313	H>P		No	ClinGen ExAC gnomAD
CA10297499 rs768967302	314	P>S		No	ClinGen ExAC gnomAD
rs762431913 CA10297501	319	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10297502 rs770198561	320	Q>R		No	ClinGen ExAC gnomAD
CA411963983 rs1346541684	323	N>D		No	ClinGen gnomAD
rs548444280 CA10297505	326	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751794345 CA10297506	327	T>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	328	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759803136 CA411964027 CA10297507	329	F>L		No	ClinGen ExAC TOPMed gnomAD
rs369108625 CA10297509 COSM445140	334	I>V	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs9616149 CA325235773	335	C>G		No	ClinGen Ensembl
rs1393561622 CA411964080	337	Y>C		No	ClinGen gnomAD
rs953262044 CA325235777	337	Y>H		No	ClinGen TOPMed
rs371300371 CA325235780	338	I>V		No	ClinGen ESP TOPMed gnomAD
rs5769241 CA325235781	339	E>*		No	ClinGen Ensembl
TCGA novel	339	E>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1181280559 CA411962940	339	E>V		No	ClinGen TOPMed
rs752146755 CA10297619	341	E>K		No	ClinGen ExAC gnomAD
rs149810185 CA10297620	342	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1276229877 CA411962977	344	D>E		No	ClinGen TOPMed
CA10297621 rs767639714	345	T>M		No	ClinGen ExAC gnomAD
CA325241160 rs1026496872	345	T>P		No	ClinGen Ensembl
CA411963001 rs1398286672	348	V>A		No	ClinGen gnomAD
CA411962997 rs1403596097	348	V>I		No	ClinGen TOPMed gnomAD
CA411963007 rs1340206491	349	S>C		No	ClinGen gnomAD
CA411963004 rs1332640033	349	S>P		No	ClinGen gnomAD
rs199657694 CA10297625	350	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10297627 rs367573498	351	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs768703084 CA10297629	352	P>A		No	ClinGen ExAC TOPMed gnomAD
CA411963020 rs768703084	352	P>S		No	ClinGen ExAC TOPMed gnomAD
CA10297632 rs148990656	353	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10297631 rs148990656	353	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1378059107 CA411963041	354	E>D		No	ClinGen TOPMed
TCGA novel	354	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411963039 rs1180259997	354	E>V		No	ClinGen gnomAD
CA10297634 rs762481807	355	V>M		No	ClinGen ExAC gnomAD
CA411963072 rs1173777416	357	C>G		No	ClinGen gnomAD
rs1378817673 CA411963081	357	C>W		No	ClinGen gnomAD
CA411963074 rs1471596412	357	C>Y		No	ClinGen TOPMed
CA411963108 rs1468061528	359	I>M		No	ClinGen gnomAD
rs760099782 CA10297637	360	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10297640 rs760693157	362	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA325241232 rs775181541	363	T>S		No	ClinGen Ensembl
CA411963182 rs1333784593	365	W>*		No	ClinGen TOPMed gnomAD
rs1333784593 CA411963184	365	W>S		No	ClinGen TOPMed gnomAD
rs764259105 CA411963201	366	C>F		No	ClinGen ExAC gnomAD
CA10297641 rs764259105	366	C>S		No	ClinGen ExAC gnomAD
rs1446257680 CA411963230	368	S>N		No	ClinGen gnomAD
rs1253653736 CA411963276	372	D>N		No	ClinGen TOPMed
CA10297674 rs546110825	377	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	383	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411963725 rs1007529328	387	M>L		No	ClinGen TOPMed gnomAD
rs1007529328 CA325250258	387	M>V		No	ClinGen TOPMed gnomAD
CA10297675 rs775814845	390	K>E		No	ClinGen ExAC TOPMed gnomAD
CA10297677 rs747575625	393	E>K		No	ClinGen ExAC TOPMed gnomAD
rs776778660 CA10297679	396	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10297680 rs761744005	397	S>C		No	ClinGen ExAC gnomAD
CA10297682 rs773528818	398	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1485808665 CA411963872 COSM445141	398	R>W	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA10297683 rs763243690	399	I>L		No	ClinGen ExAC gnomAD
CA411963888 rs1164265829	399	I>T		No	ClinGen gnomAD
CA411963882 rs763243690	399	I>V		No	ClinGen ExAC gnomAD
CA10297685 rs752533977	401	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA411963359 rs755258982	402	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA411963371 rs1603106605	404	H>R		No	ClinGen Ensembl
CA10297715 rs373561956	405	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs370812561 CA10297714	405	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA411963385 rs778003136	407	L>M		No	ClinGen ExAC gnomAD
CA10297718 rs749322563	408	D>G		No	ClinGen ExAC TOPMed gnomAD
CA10297719 rs771297442	409	Q>R		No	ClinGen ExAC gnomAD
CA10297721 COSM1035215 rs759769107	411	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA411963426 rs1413659053	413	R>G		No	ClinGen gnomAD
rs1403973437 CA639677992	414	Y>*		No	ClinGen TOPMed gnomAD
CA10297724 rs776477061	414	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA10297725 rs145253414	418	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765094951 CA10297726	419	F>L		No	ClinGen ExAC gnomAD
rs1438074649 CA411963474	420	R>C		No	ClinGen TOPMed gnomAD
CA325241773 rs912846000	420	R>H		No	ClinGen TOPMed gnomAD
rs1197126354 CA411963518	426	L>Q		No	ClinGen gnomAD
rs1603106960 CA411963522	427	M>V		No	ClinGen Ensembl
rs765009698 CA325241784	429	E>D		No	ClinGen Ensembl
CA411963559 rs1188023419	432	L>P		No	ClinGen TOPMed
rs141677462 CA10297728	433	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10297729 rs766052184	433	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10297730 rs751211147	436	I>F		No	ClinGen ExAC gnomAD
CA10297732 COSM580344 rs781476335	437	R>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA10297733 COSM1416921 rs753037531	437	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs756700338 CA10297734	439	W>C		No	ClinGen ExAC gnomAD
rs778372230 CA10297735	440	D>N		No	ClinGen ExAC gnomAD
rs1391057689 CA411963614	441	T>I		No	ClinGen gnomAD
rs1208541843 CA411963609	441	T>P		No	ClinGen TOPMed
CA411963615 rs1406722017	442	Y>H		No	ClinGen gnomAD
CA10297761 rs768020083	446	P>L		No	ClinGen ExAC TOPMed gnomAD
CA411983679 rs1377904081	447	D>Y		No	ClinGen gnomAD
CA325424192 rs138576280	448	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA411983692 rs1223364922	449	F>L		No	ClinGen TOPMed
CA10297764 rs749289473	450	S>P		No	ClinGen ExAC gnomAD
CA411983707 rs1371362924	451	H>R		No	ClinGen TOPMed
rs1335105181 CA411983704	451	H>Y		No	ClinGen gnomAD
rs374905207 CA10297765	452	F>C		No	ClinGen ESP ExAC gnomAD
rs1333990859 CA411983734	455	Y>H		No	ClinGen gnomAD
rs367838104 CA10297769	456	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA411983752 rs1445715849	457	C>Y		No	ClinGen gnomAD
CA10297771 rs764607944	458	A>S		No	ClinGen ExAC gnomAD
CA411983760 rs1262223610	459	A>T		No	ClinGen gnomAD
rs1457958074 CA411983767	460	F>L		No	ClinGen gnomAD
rs1235843202 CA411983781	462	V>L		No	ClinGen gnomAD
rs757846274 CA10297773	463	R>K		No	ClinGen ExAC gnomAD
CA411983793 rs1450202904	464	W>R		No	ClinGen TOPMed
CA411983803 rs1198950585	465	R>K		No	ClinGen TOPMed gnomAD
CA411983822 COSM1308267 rs1259323519	467	E>D	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA325424239 rs989781767	469	L>I		No	ClinGen Ensembl
TCGA novel	470	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411983846 rs1405764252	471	E>G		No	ClinGen gnomAD
CA411983843 rs542380822	471	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs542380822 CA10297774	471	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411983855 rs1333549507	472	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	475	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1306585811 CA411983366	476	E>Q		No	ClinGen gnomAD
CA10297796 rs766540708	477	L>P		No	ClinGen ExAC gnomAD
rs755205214 CA10297798	478	L>P		No	ClinGen ExAC gnomAD
CA10297799 rs781343015	481	L>P		No	ClinGen ExAC gnomAD
CA10297801 rs373398596	488	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA411983488 rs1428146450	494	I>V		No	ClinGen gnomAD
CA10297802 rs778546759	495	S>T		No	ClinGen ExAC gnomAD
rs746462660 CA10297806	500	E>K		No	ClinGen ExAC gnomAD
COSM189457 CA10297808 rs776386503	503	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1601770662 CA411983547	503	R>S		No	ClinGen Ensembl
rs763586138 CA10297812	510	D>G		No	ClinGen ExAC gnomAD
CA10297811 rs773437557	510	D>N		No	ClinGen ExAC TOPMed gnomAD
CA411983598 rs1569483166 COSM3424245	511	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA10297815 rs759572384	512	P>S		No	ClinGen ExAC TOPMed gnomAD
CA10297817 rs752962513	513	N>S		No	ClinGen ExAC TOPMed gnomAD
CA10297818 rs376369955	514	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs778833309 CA10297819	515	Y>C		No	ClinGen ExAC gnomAD
rs6008057 CA325467709	516	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs542359357 CA10297821	518	K>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1380954201 CA411983646	518	K>R		No	ClinGen gnomAD

No associated diseases with Q8WUA7

1 regional properties for Q8WUA7

Type	Name	Position	InterPro Accession
domain	Rab-GAP-TBC domain	219 - 472	IPR000195

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name	Definition
14-3-3 protein binding	Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
protein homodimerization activity	Binding to an identical protein to form a homodimer.

1 GO annotations of biological process

Name	Definition
activation of GTPase activity	Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

27 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8IZP1	TBC1D3	TBC1 domain family member 3	Homo sapiens (Human)	PR
Q6IPX1	TBC1D3C	TBC1 domain family member 3C	Homo sapiens (Human)	PR
B9A6J9	TBC1D3L	TBC1 domain family member 3L	Homo sapiens (Human)	PR
A0A087WVF3	TBC1D3D	TBC1 domain family member 3D	Homo sapiens (Human)	PR
A6NER0	TBC1D3F	TBC1 domain family member 3F	Homo sapiens (Human)	PR
A0A087WXS9	TBC1D3I	TBC1 domain family member 3I	Homo sapiens (Human)	PR
Q6DHY5	TBC1D3G	TBC1 domain family member 3G	Homo sapiens (Human)	PR
A0A087X179	TBC1D3E	TBC1 domain family member 3E	Homo sapiens (Human)	PR
A0A087X1G2	TBC1D3K	TBC1 domain family member 3K	Homo sapiens (Human)	PR
P0C7X1	TBC1D3H	TBC1 domain family member 3H	Homo sapiens (Human)	PR
A6NDS4	TBC1D3B	TBC1 domain family member 3B	Homo sapiens (Human)	PR
Q8IV04	TBC1D10C	Carabin	Homo sapiens (Human)	PR
Q5TC63	GRTP1	Growth hormone-regulated TBC protein 1	Homo sapiens (Human)	PR
O60343	TBC1D4	TBC1 domain family member 4	Homo sapiens (Human)	PR
Q86TI0	TBC1D1	TBC1 domain family member 1	Homo sapiens (Human)	PR
O60447	EVI5	Ecotropic viral integration site 5 protein homolog	Homo sapiens (Human)	PR
Q3MII6	TBC1D25	TBC1 domain family member 25	Homo sapiens (Human)	PR
Q2NKQ1	SGSM1	Small G protein signaling modulator 1	Homo sapiens (Human)	PR
Q9HA65	TBC1D17	TBC1 domain family member 17	Homo sapiens (Human)	PR
Q8TC07	TBC1D15	TBC1 domain family member 15	Homo sapiens (Human)	PR
O95759	TBC1D8	TBC1 domain family member 8	Homo sapiens (Human)	PR
Q0IIM8	TBC1D8B	TBC1 domain family member 8B	Homo sapiens (Human)	PR
Q66K14	TBC1D9B	TBC1 domain family member 9B	Homo sapiens (Human)	PR
Q6ZT07	TBC1D9	TBC1 domain family member 9	Homo sapiens (Human)	PR
Q8TEA7	TBCK	TBC domain-containing protein kinase-like protein	Homo sapiens (Human)	PR
Q9UPU7	TBC1D2B	TBC1 domain family member 2B	Homo sapiens (Human)	PR
Q8R5A6	Tbc1d22a	TBC1 domain family member 22A	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MASDGARKQF	WKRSNSKLPG	SIQHVYGAQH	PPFDPLLHGT	LLRSTAKMPT	TPVKAKRVST
70	80	90	100	110	120
FQEFESNTSD	AWDAGEDDDE	LLAMAAESLN	SEVVMETANR	VLRNHSQRQG	RPTLQEGPGL
130	140	150	160	170	180
QQKPRPEAEP	PSPPSGDLRL	VKSVSESHTS	CPAESASDAA	PLQRSQSLPH	SATVTLGGTS
190	200	210	220	230	240
DPSTLSSSAL	SEREASRLDK	FKQLLAGPNT	DLEELRRLSW	SGIPKPVRPM	TWKLLSGYLP
250	260	270	280	290	300
ANVDRRPATL	QRKQKEYFAF	IEHYYDSRND	EVHQDTYRQI	HIDIPRMSPE	ALILQPKVTE
310	320	330	340	350	360
IFERILFIWA	IRHPASGYVQ	GINDLVTPFF	VVFICEYIEA	EEVDTVDVSG	VPAEVLCNIE
370	380	390	400	410	420
ADTYWCMSKL	LDGIQDNYTF	AQPGIQMKVK	MLEELVSRID	EQVHRHLDQH	EVRYLQFAFR
430	440	450	460	470	480
WMNNLLMREV	PLRCTIRLWD	TYQSEPDGFS	HFHLYVCAAF	LVRWRKEILE	EKDFQELLLF
490	500	510
LQNLPTAHWD	DEDISLLLAE	AYRLKFAFAD	APNHYKK