Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for A0A087X179

Entry ID Method Resolution Chain Position Source
AF-A0A087X179-F1 Predicted AlphaFoldDB

197 variants for A0A087X179

Variant ID(s) Position Change Description Diseaes Association Provenance
CA398893782
rs200926967
3 V>M No ClinGen
Ensembl
CA398894043
rs1555549449
38 P>A No ClinGen
Ensembl
CA398894060
rs1205622176
40 R>L No ClinGen
gnomAD
CA398894107
rs1555549455
47 D>N No ClinGen
Ensembl
CA398894119
rs1466878291
48 H>R No ClinGen
gnomAD
CA398894222
rs1187116266
62 A>V No ClinGen
gnomAD
CA398894226
rs1255394784
63 R>W No ClinGen
gnomAD
CA398894243
rs1555549511
65 A>V No ClinGen
Ensembl
CA398894281
rs1311588126
69 R>Q No ClinGen
gnomAD
CA398894288
rs1381984298
70 R>Q No ClinGen
gnomAD
rs1555549528
CA398894313
74 R>* No ClinGen
Ensembl
rs1397218469
CA398894314
74 R>Q No ClinGen
gnomAD
CA398894348
rs1598917798
78 W>* No ClinGen
Ensembl
rs1555549529
CA398894391
84 D>E No ClinGen
Ensembl
CA398894487
rs1418457093
95 I>R No ClinGen
gnomAD
rs1418457093
CA398894486
95 I>T No ClinGen
gnomAD
CA398894483
rs1168493761
95 I>V No ClinGen
gnomAD
rs540166849
CA290675594
96 D>G No ClinGen
1000Genomes
ExAC
gnomAD
CA290675590
rs571053907
96 D>H No ClinGen
1000Genomes
ExAC
gnomAD
rs571053907
CA290675583
96 D>N No ClinGen
1000Genomes
ExAC
gnomAD
CA290675596
rs540166849
96 D>V No ClinGen
1000Genomes
ExAC
gnomAD
rs748222726
CA290675608
97 Q>* No ClinGen
ExAC
gnomAD
rs748222726
CA290675603
97 Q>E No ClinGen
ExAC
gnomAD
rs748222726
CA290675600
97 Q>K No ClinGen
ExAC
gnomAD
rs745776471
CA290675616
97 Q>L No ClinGen
ExAC
gnomAD
CA290675612
rs745776471
97 Q>R No ClinGen
ExAC
gnomAD
rs762742138
CA290675623
98 A>E No ClinGen
ExAC
gnomAD
rs775207414
CA290675619
98 A>T No ClinGen
ExAC
gnomAD
rs762742138
CA290675625
98 A>V No ClinGen
ExAC
gnomAD
CA290675634
rs761208534
99 Y>C No ClinGen
ExAC
gnomAD
rs767097126
CA290675647
100 K>* No ClinGen
ExAC
gnomAD
rs767097126
CA290675655
100 K>E No ClinGen
ExAC
gnomAD
CA290675642
rs767097126
100 K>Q No ClinGen
ExAC
gnomAD
rs1225773546
CA398894507
100 K>R No ClinGen
gnomAD
rs766812465
CA290675663
101 G>A No ClinGen
ExAC
gnomAD
CA398894512
rs1264191051
101 G>R No ClinGen
gnomAD
CA290675667
rs754246871
102 M>I No ClinGen
ExAC
gnomAD
rs1202704330
CA398894519
102 M>K No ClinGen
gnomAD
CA290675679
rs755447600
104 M>K No ClinGen
ExAC
gnomAD
CA290675683
rs755447600
104 M>T No ClinGen
ExAC
gnomAD
CA398894531
rs1193747276
104 M>V No ClinGen
gnomAD
CA290675688
rs758578457
106 I>M No ClinGen
ExAC
CA290675684
rs753004280
106 I>S No ClinGen
ExAC
gnomAD
rs569944826
CA398894552
107 R>L No ClinGen
1000Genomes
ExAC
gnomAD
rs569944826
CA290675708
107 R>Q No ClinGen
1000Genomes
ExAC
gnomAD
rs777857751
CA290675706
107 R>W No ClinGen
ExAC
gnomAD
rs1387153340
CA398894555
108 G>C No ClinGen
gnomAD
rs367571291
CA290675709
108 G>D No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA398894553
rs1387153340
108 G>S No ClinGen
gnomAD
rs371807064
CA290675712
109 P>L No ClinGen
ESP
ExAC
gnomAD
CA398894566
rs768490310
110 M>K No ClinGen
ExAC
gnomAD
CA290675726
rs768490310
110 M>T No ClinGen
ExAC
gnomAD
CA398894576
rs747799477
111 W>* No ClinGen
ExAC
gnomAD
CA290675728
rs747799477
111 W>C No ClinGen
ExAC
gnomAD
CA290675727
rs773965536
111 W>G No ClinGen
ExAC
gnomAD
rs1222451426
CA398894574
111 W>S No ClinGen
gnomAD
rs1317531836
CA398894584
113 V>I No ClinGen
TOPMed
CA290675784
rs772724880
114 L>F No ClinGen
ExAC
gnomAD
rs766975770
CA290675802
116 N>D No ClinGen
ExAC
gnomAD
rs777324564
CA290675803
117 T>A No ClinGen
ExAC
gnomAD
CA398894611
rs1567673966
117 T>I No ClinGen
Ensembl
rs1365796222
CA398894615
118 E>G No ClinGen
gnomAD
CA290675808
rs375246378
118 E>K No ClinGen
ESP
ExAC
gnomAD
rs375246378
CA290675813
118 E>Q No ClinGen
ESP
ExAC
gnomAD
rs764226411
CA290675822
CA398894632
120 M>I No ClinGen
ExAC
gnomAD
CA398894635
rs1427107070
121 K>Q No ClinGen
gnomAD
CA398894646
rs1567674003
122 L>F No ClinGen
Ensembl
CA290675826
rs11550750
122 L>M No ClinGen
ESP
ExAC
gnomAD
CA290675832
rs535666677
122 L>W No ClinGen
1000Genomes
gnomAD
CA290675834
rs757339457
123 K>E No ClinGen
ExAC
gnomAD
CA398894650
rs1309653935
123 K>T No ClinGen
gnomAD
rs1239391451
CA398894665
125 P>S No ClinGen
gnomAD
CA290675866
rs778632450
126 G>A No ClinGen
ExAC
gnomAD
rs555399383
CA290675865
126 G>R No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA290675869
rs747913076
127 R>I No ClinGen
ExAC
gnomAD
CA398894675
rs747913076
127 R>K No ClinGen
ExAC
gnomAD
CA398894678
rs1598918119
127 R>S No ClinGen
Ensembl
CA290675876
rs746502036
128 Y>* No ClinGen
ExAC
gnomAD
rs572505825
CA290675871
128 Y>C No ClinGen
1000Genomes
ExAC
gnomAD
rs771693135
CA290675870
128 Y>H No ClinGen
ExAC
gnomAD
rs770602548
CA290675882
129 Q>* No ClinGen
ExAC
gnomAD
CA398894749
rs1170348664
136 K>Q No ClinGen
gnomAD
rs199547231
CA290675986
137 K>R No ClinGen
gnomAD
CA398894805
rs1332821969
143 Q>H No ClinGen
gnomAD
CA398894809
rs1377901504
144 R>C No ClinGen
TOPMed
gnomAD
rs1400525662
CA398894812
144 R>H No ClinGen
gnomAD
CA398894832
rs1219657252
147 R>L No ClinGen
gnomAD
CA398894830
rs1219657252
147 R>Q No ClinGen
gnomAD
rs1369449689
CA398894829
147 R>W No ClinGen
TOPMed
gnomAD
CA398894841
rs1297654654
149 V>I No ClinGen
gnomAD
rs1326757827
CA398894856
151 G>R No ClinGen
gnomAD
CA398894857
rs1326757827
151 G>W No ClinGen
gnomAD
CA398894881
rs1255970597
155 K>Q No ClinGen
gnomAD
CA398894890
rs1248737778
156 H>D No ClinGen
gnomAD
CA290676013
rs200593309
157 I>M No ClinGen
gnomAD
rs1325910275
CA398894899
157 I>V No ClinGen
gnomAD
rs1260202094
CA398894912
159 F>I No ClinGen
gnomAD
CA398894938
rs1262511061
162 R>L No ClinGen
gnomAD
CA398894936
rs1262511061
162 R>Q No ClinGen
gnomAD
rs1193132219
CA398894945
163 Y>* No ClinGen
TOPMed
rs1172069919
CA398894940
163 Y>H No ClinGen
TOPMed
gnomAD
rs1236933797
CA398894986
167 Q>H No ClinGen
TOPMed
CA398895005
rs1188751068
171 L>F No ClinGen
gnomAD
CA398895013
rs1263081347
172 H>Y No ClinGen
gnomAD
rs1428486760
CA398895052
178 E>* No ClinGen
gnomAD
CA398895055
rs1191932207
178 E>A No ClinGen
gnomAD
rs1431981655
CA398895068
180 Y>N No ClinGen
gnomAD
rs1176714148
CA398895089
182 P>L No ClinGen
TOPMed
gnomAD
rs1176714148
CA398895087
182 P>Q No ClinGen
TOPMed
gnomAD
CA398895248
rs1555549669
204 E>K No ClinGen
Ensembl
CA398895452
rs1555549708
232 V>I No ClinGen
Ensembl
rs201784727
CA290676091
234 G>W No ClinGen
ExAC
gnomAD
rs1290519126
CA398895472
235 L>V No ClinGen
gnomAD
rs770728973
CA290676111
242 V>E No ClinGen
ExAC
gnomAD
CA398895547
rs1174152064
245 T>M No ClinGen
TOPMed
rs1466377945
CA398895566
248 P>R No ClinGen
TOPMed
rs1598919439
CA398895564
248 P>S No ClinGen
Ensembl
rs1198429333
CA398895592
252 G>W No ClinGen
TOPMed
rs1360878468
CA398895686
263 C>S No ClinGen
TOPMed
rs1400277098
CA398895740
271 R>Q No ClinGen
TOPMed
CA398895739
rs1299065057
271 R>W No ClinGen
TOPMed
rs1217998478
CA398895749
272 I>M No ClinGen
gnomAD
CA398895772
rs1165064625
CA398895773
276 G>R No ClinGen
TOPMed
rs745375017
CA290676122
284 R>C No ClinGen
ExAC
gnomAD
CA398895834
rs1424070716
284 R>H No ClinGen
TOPMed
gnomAD
rs1474244315
CA398895859
288 V>M No ClinGen
TOPMed
rs1248069604
CA398895885
292 E>Q No ClinGen
TOPMed
CA398895896
rs1160635169
293 G>A No ClinGen
gnomAD
CA398895898
rs1363942621
294 E>K No ClinGen
gnomAD
rs1418950355
CA398895907
295 Q>E No ClinGen
gnomAD
CA398895914
rs1450573868
296 A>T No ClinGen
TOPMed
CA398895919
rs1215474192
296 A>V No ClinGen
gnomAD
rs1405359959
CA398895937
299 P>L No ClinGen
gnomAD
CA398895942
rs1365731597
300 I>V No ClinGen
gnomAD
rs1200472700
CA398895948
301 T>A No ClinGen
TOPMed
rs1225748107
CA398895950
301 T>K No ClinGen
gnomAD
CA398895953
rs1318504038
302 R>G No ClinGen
TOPMed
rs1277404576
CA398895956
302 R>I No ClinGen
TOPMed
CA398895957
rs1277404576
302 R>K No ClinGen
TOPMed
rs1369398906
CA398895961
303 I>V No ClinGen
TOPMed
CA398895967
rs1437369258
304 A>T No ClinGen
TOPMed
CA398895995
rs1370352567
308 Q>K No ClinGen
TOPMed
CA290676185
rs774811506
310 K>N No ClinGen
ExAC
gnomAD
rs761978034
CA290676192
311 R>H No ClinGen
ExAC
gnomAD
CA398896045
rs1156720073
313 T>M No ClinGen
gnomAD
rs1425273886
CA398896058
315 T>M No ClinGen
gnomAD
CA398896068
rs550035009
317 R>K No ClinGen
1000Genomes
ExAC
gnomAD
CA290676216
rs750439941
317 R>S No ClinGen
ExAC
TOPMed
gnomAD
CA290676207
rs550035009
317 R>T No ClinGen
1000Genomes
ExAC
gnomAD
CA398896067
rs1555549780
317 R>W No ClinGen
Ensembl
CA290676218
rs760815113
320 P>L No ClinGen
ExAC
gnomAD
CA398896088
rs760815113
320 P>Q No ClinGen
ExAC
gnomAD
CA398896089
rs760815113
320 P>R No ClinGen
ExAC
gnomAD
rs765195924
CA290676222
323 R>C No ClinGen
ExAC
gnomAD
rs752612301
CA290676228
323 R>H No ClinGen
ExAC
gnomAD
CA398896105
rs765195924
323 R>S No ClinGen
ExAC
gnomAD
rs1555549786
CA398896124
325 C>W No ClinGen
Ensembl
rs777379366
CA290676253
327 R>Q No ClinGen
ExAC
gnomAD
rs1288081755
CA398896134
327 R>W No ClinGen
gnomAD
rs1354508937
CA398896145
329 V>I No ClinGen
TOPMed
CA398896147
rs1354508937
329 V>L No ClinGen
TOPMed
rs1206116867
CA398896164
331 T>I No ClinGen
gnomAD
rs751411715
CA290676259
332 W>* No ClinGen
ExAC
gnomAD
rs751411715
CA398896171
332 W>C No ClinGen
ExAC
gnomAD
CA398896179
rs1457070246
334 R>G No ClinGen
gnomAD
CA290676260
CA398896200
rs756902249
336 E>D No ClinGen
ExAC
gnomAD
CA290676263
rs781057763
337 D>N No ClinGen
ExAC
gnomAD
CA398896225
rs1358377170
340 L>P No ClinGen
gnomAD
CA290676268
rs745358254
345 A>G No ClinGen
ExAC
gnomAD
CA398896265
rs1306313403
346 S>F No ClinGen
TOPMed
rs1222622359
CA398896267
347 M>V No ClinGen
TOPMed
CA398896282
rs1598919936
348 K>N No ClinGen
Ensembl
rs1381966906
CA398896298
351 T>S No ClinGen
TOPMed
CA398896322
rs1411473769
354 K>N No ClinGen
gnomAD
rs769477682
CA290676278
354 K>Q No ClinGen
ExAC
gnomAD
rs1171348872
CA398896339
357 L>V No ClinGen
gnomAD
rs780580516
CA290676286
358 P>Q No ClinGen
ExAC
gnomAD
CA398896413
rs1555549803
366 G>V No ClinGen
Ensembl
CA398896419
rs1555549804
367 S>L No ClinGen
Ensembl
rs1364470411
CA398896462
374 P>L No ClinGen
gnomAD
rs1555549806
CA398896487
379 G>R No ClinGen
Ensembl
rs749721239
CA290676303
382 L>F No ClinGen
ExAC
gnomAD
CA290676304
rs769231287
382 L>P No ClinGen
ExAC
gnomAD
CA290676306
rs774525602
387 R>S No ClinGen
ExAC
gnomAD
rs200876653
CA290676308
390 P>S No ClinGen
1000Genomes
ExAC
gnomAD
rs1264390052
CA398896575
392 G>D No ClinGen
gnomAD
CA398896598
rs1555549809
396 R>Q No ClinGen
Ensembl
CA398896597
rs1442509951
396 R>W No ClinGen
gnomAD
rs1555549810
CA398896616
399 R>W No ClinGen
Ensembl
rs1555549811
CA398896665
406 P>L No ClinGen
Ensembl
CA398897118
rs1555549814
474 F>L No ClinGen
Ensembl
CA398897164
rs1555549816
480 V>A No ClinGen
Ensembl
CA398897189
rs1555549817
484 S>Y No ClinGen
Ensembl
CA398897308
rs1555549820
501 R>W No ClinGen
Ensembl
CA398897347
rs1555549821
507 A>T No ClinGen
Ensembl
rs200029837
CA290676313
510 S>G No ClinGen
1000Genomes
CA398897479
rs1476924229
526 Q>P No ClinGen
gnomAD

No associated diseases with A0A087X179

1 regional properties for A0A087X179

Type Name Position InterPro Accession
domain Rab-GAP-TBC domain 98 - 316 IPR000195

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor
  • Associated with lipid rafts
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

1 GO annotations of biological process

Name Definition
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

29 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5R372 RABGAP1L Rab GTPase-activating protein 1-like Homo sapiens (Human) PR
A0A087X1G2 TBC1D3K TBC1 domain family member 3K Homo sapiens (Human) PR
B9A6J9 TBC1D3L TBC1 domain family member 3L Homo sapiens (Human) PR
A0A087WVF3 TBC1D3D TBC1 domain family member 3D Homo sapiens (Human) PR
A0A087WXS9 TBC1D3I TBC1 domain family member 3I Homo sapiens (Human) PR
A6NDS4 TBC1D3B TBC1 domain family member 3B Homo sapiens (Human) PR
P0C7X1 TBC1D3H TBC1 domain family member 3H Homo sapiens (Human) PR
Q6DHY5 TBC1D3G TBC1 domain family member 3G Homo sapiens (Human) PR
Q9HA65 TBC1D17 TBC1 domain family member 17 Homo sapiens (Human) PR
Q66K14 TBC1D9B TBC1 domain family member 9B Homo sapiens (Human) PR
Q6ZT07 TBC1D9 TBC1 domain family member 9 Homo sapiens (Human) PR
Q8WUA7 TBC1D22A TBC1 domain family member 22A Homo sapiens (Human) PR
Q8IZP1 TBC1D3 TBC1 domain family member 3 Homo sapiens (Human) PR
Q6IPX1 TBC1D3C TBC1 domain family member 3C Homo sapiens (Human) PR
A6NER0 TBC1D3F TBC1 domain family member 3F Homo sapiens (Human) PR
Q8IV04 TBC1D10C Carabin Homo sapiens (Human) PR
Q5TC63 GRTP1 Growth hormone-regulated TBC protein 1 Homo sapiens (Human) PR
O60343 TBC1D4 TBC1 domain family member 4 Homo sapiens (Human) PR
Q86TI0 TBC1D1 TBC1 domain family member 1 Homo sapiens (Human) PR
O60447 EVI5 Ecotropic viral integration site 5 protein homolog Homo sapiens (Human) PR
Q3MII6 TBC1D25 TBC1 domain family member 25 Homo sapiens (Human) PR
Q2NKQ1 SGSM1 Small G protein signaling modulator 1 Homo sapiens (Human) PR
Q8TC07 TBC1D15 TBC1 domain family member 15 Homo sapiens (Human) PR
O95759 TBC1D8 TBC1 domain family member 8 Homo sapiens (Human) PR
Q0IIM8 TBC1D8B TBC1 domain family member 8B Homo sapiens (Human) PR
Q8TEA7 TBCK TBC domain-containing protein kinase-like protein Homo sapiens (Human) PR
Q9UPU7 TBC1D2B TBC1 domain family member 2B Homo sapiens (Human) PR
A6H6A9 Rabgap1l Rab GTPase-activating protein 1-like Mus musculus (Mouse) PR
Q80XC3 Usp6nl USP6 N-terminal-like protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG IVHETELPPL
70 80 90 100 110 120
TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDQAYK GMPMNIRGPM WSVLLNTEEM
130 140 150 160 170 180
KLKNPGRYQI MKEKGKKSSE HIQRIDRDVS GTLRKHIFFR DRYGTKQREL LHILLAYEEY
190 200 210 220 230 240
NPEVGYCRDL SHIAALFLLY LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE
250 260 270 280 290 300
HVVATSQPKT MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI
310 320 330 340 350 360
TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL TRKKGDLPPP
370 380 390 400 410 420
AKPEQGSSAS RPVPASRGGK TLCKGDRQAP PGPPARFPRP IWSASPPRAP RSSTPCPGGA
430 440 450 460 470 480
VREDTYPVGT QGVPSPALAQ GGPQGSWRFL QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV
490 500 510 520 530 540
RAISQEDQLA PCWQAEHPAE RVRSAFAAPS TDSDQGTPFR ARDEQQCAPT SGPCLCGLHL
ESSQFPPGF