AiPD: Autoinhibited Protein Database

Gene name	Rabgap1l
Protein name	Rab GTPase-activating protein 1-like
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:29809
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

445-522 (Predicted disordered autoinhibitory region) PR

445-522 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-A6H6A9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388512911	52	D>N	No	EVA
rs31322016	54	Q>P	No	EVA
rs3388507610	55	L>S	No	EVA
rs3388508171	64	R>K	No	EVA
rs3388507055	65	D>G	No	EVA
rs31322017	72	G>S	No	EVA
rs3388509402	75	V>D	No	EVA
rs265457793	75	V>I	No	EVA
rs254614495	81	S>N	No	EVA
rs3388509367	89	G>R	No	EVA
rs3388511146	93	A>T	No	EVA
rs48972602	97	T>N	No	EVA
rs3390891311	120	P>S	No	EVA
rs3390881543	121	S>G	No	EVA
rs3390877335	159	R>K	No	EVA
rs231872692	160	A>T	No	EVA
rs3390890472	301	F>*	No	EVA
rs3388511411	381	E>A	No	EVA
rs3388512889	381	E>D	No	EVA
rs3388512979	387	K>R	No	EVA
rs3388509806	402	V>SDG*	No	EVA
rs3388511210	421	E>K	No	EVA
rs3388509820	426	F>L	No	EVA
rs3388508537	427	S>N	No	EVA
rs3388507021	434	T>I	No	EVA
rs3388511818	448	S>N	No	EVA
rs3388511231	450	A>*	No	EVA
rs3388511409	450	A>D	No	EVA
rs3388509299	483	E>D	No	EVA
rs3390837575	503	K>T	No	EVA
rs3388508194	609	A>V	No	EVA
rs3388510870	639	A>T	No	EVA
rs3388510760	698	Q>*	No	EVA
rs3388506081	702	T>I	No	EVA
rs3388507007	718	D>G	No	EVA
rs3388509473	722	C>S	No	EVA
rs3388510772	735	L>P	No	EVA
rs3388506067	761	K>*	No	EVA
rs3388508073	763	Y>C	No	EVA
rs3388506098	798	E>V	No	EVA

Type	Name	Position	InterPro Accession
domain	Rab-GAP-TBC domain	535 - 747	IPR000195
domain	PTB/PI domain	127 - 260	IPR006020
domain	Kinesin-like	290 - 421	IPR022164

		Description
EC Number
Subcellular Localization	Early endosome Golgi apparatus	Colocalizes on endosomes partially with EEA1 (By similarity) Colocalizes and cotransports on motile vesicles with ANK2 (PubMed:27718357)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
small GTPase binding	Binding to a small monomeric GTPase.

Name	Definition
activation of GTPase activity	Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
endocytosis	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
megakaryocyte development	The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of protein localization	Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6DHY5	TBC1D3G	TBC1 domain family member 3G	Homo sapiens (Human)	PR
A0A087WVF3	TBC1D3D	TBC1 domain family member 3D	Homo sapiens (Human)	PR
A0A087WXS9	TBC1D3I	TBC1 domain family member 3I	Homo sapiens (Human)	PR
B9A6J9	TBC1D3L	TBC1 domain family member 3L	Homo sapiens (Human)	PR
Q8IZP1	TBC1D3	TBC1 domain family member 3	Homo sapiens (Human)	PR
A6NER0	TBC1D3F	TBC1 domain family member 3F	Homo sapiens (Human)	PR
P0C7X1	TBC1D3H	TBC1 domain family member 3H	Homo sapiens (Human)	PR
A0A087X179	TBC1D3E	TBC1 domain family member 3E	Homo sapiens (Human)	PR
A0A087X1G2	TBC1D3K	TBC1 domain family member 3K	Homo sapiens (Human)	PR
A6NDS4	TBC1D3B	TBC1 domain family member 3B	Homo sapiens (Human)	PR
Q5R372	RABGAP1L	Rab GTPase-activating protein 1-like	Homo sapiens (Human)	PR
Q80XC3	Usp6nl	USP6 N-terminal-like protein	Mus musculus (Mouse)	PR