A0A087WVF3

PR
Gene name
TBC1D3D
Protein name
TBC1 domain family member 3D
Names
Species
Homo sapiens (Human)
KEGG Pathway
hsa:101060389
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0A087WVF3

Entry ID Method Resolution Chain Position Source
AF-A0A087WVF3-F1 Predicted AlphaFoldDB

29 variants for A0A087WVF3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1209188260
CA398862526
 327 R>W No ClinGen
TOPMed
rs1354118412
CA398862557
 331 T>I No ClinGen
TOPMed
rs1252859114
CA398862567
 333 A>T No ClinGen
TOPMed
rs1227962917
CA398862595
 336 E>D No ClinGen
TOPMed
CA398862662
rs1341192147
 346 S>C No ClinGen
TOPMed
rs1485870703
CA398863162
 422 R>Q No ClinGen
TOPMed
rs1279682471
CA398863226
 431 Q>H No ClinGen
TOPMed
CA398863257
rs1281302460
 436 P>L No ClinGen
TOPMed
CA398863275
rs1350333604
 439 A>V No ClinGen
TOPMed
rs1417072881
CA398863488
 470 R>H No ClinGen
TOPMed
CA398863567
rs1341416387
 480 V>A No ClinGen
TOPMed
CA398863571
rs1333154516
 481 R>C No ClinGen
TOPMed
rs1412353805
CA398863572
 481 R>H No ClinGen
TOPMed
CA398863587
rs1386541392
 483 I>M No ClinGen
TOPMed
rs1159177292
CA398863591
 484 S>Y No ClinGen
TOPMed
CA398863664
rs1456655967
 494 Q>R No ClinGen
TOPMed
CA398863682
rs1409746189
 497 H>Y No ClinGen
TOPMed
CA398863715
rs1473025001
 502 V>M No ClinGen
TOPMed
rs1236655637
CA398863733
 504 S>L No ClinGen
TOPMed
CA398863748
rs1187132172
 507 A>T No ClinGen
TOPMed
CA398863767
rs1440867532
 510 S>G No ClinGen
TOPMed
CA398863794
rs1209374252
 514 D>N No ClinGen
TOPMed
CA398863864
rs1328558758
 524 E>K No ClinGen
TOPMed
CA398863891
rs1266825715
 527 C>Y No ClinGen
TOPMed
rs1235658030
CA398863901
 528 A>V No ClinGen
TOPMed
CA398863904
rs1380379726
 529 P>S No ClinGen
TOPMed
rs1283934072
CA398863954
 537 G>S No ClinGen
TOPMed
CA398863973
rs1445366284
 539 H>Q No ClinGen
TOPMed
CA398863988
rs1327775641
 541 E>D No ClinGen
TOPMed

No associated diseases with A0A087WVF3

1 regional properties for A0A087WVF3

Type Name Position InterPro Accession
domain Rab-GAP-TBC domain 98 - 316 IPR000195

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor
  • Associated with lipid rafts
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

1 GO annotations of biological process

Name Definition
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

29 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5R372 RABGAP1L Rab GTPase-activating protein 1-like Homo sapiens (Human) PR
A0A087X1G2 TBC1D3K TBC1 domain family member 3K Homo sapiens (Human) PR
B9A6J9 TBC1D3L TBC1 domain family member 3L Homo sapiens (Human) PR
A0A087WXS9 TBC1D3I TBC1 domain family member 3I Homo sapiens (Human) PR
A0A087X179 TBC1D3E TBC1 domain family member 3E Homo sapiens (Human) PR
A6NDS4 TBC1D3B TBC1 domain family member 3B Homo sapiens (Human) PR
P0C7X1 TBC1D3H TBC1 domain family member 3H Homo sapiens (Human) PR
Q6DHY5 TBC1D3G TBC1 domain family member 3G Homo sapiens (Human) PR
Q9HA65 TBC1D17 TBC1 domain family member 17 Homo sapiens (Human) PR
Q66K14 TBC1D9B TBC1 domain family member 9B Homo sapiens (Human) PR
Q6ZT07 TBC1D9 TBC1 domain family member 9 Homo sapiens (Human) PR
Q8WUA7 TBC1D22A TBC1 domain family member 22A Homo sapiens (Human) PR
Q8IZP1 TBC1D3 TBC1 domain family member 3 Homo sapiens (Human) PR
Q6IPX1 TBC1D3C TBC1 domain family member 3C Homo sapiens (Human) PR
A6NER0 TBC1D3F TBC1 domain family member 3F Homo sapiens (Human) PR
Q8IV04 TBC1D10C Carabin Homo sapiens (Human) PR
Q5TC63 GRTP1 Growth hormone-regulated TBC protein 1 Homo sapiens (Human) PR
O60343 TBC1D4 TBC1 domain family member 4 Homo sapiens (Human) PR
Q86TI0 TBC1D1 TBC1 domain family member 1 Homo sapiens (Human) PR
O60447 EVI5 Ecotropic viral integration site 5 protein homolog Homo sapiens (Human) PR
Q3MII6 TBC1D25 TBC1 domain family member 25 Homo sapiens (Human) PR
Q2NKQ1 SGSM1 Small G protein signaling modulator 1 Homo sapiens (Human) PR
Q8TC07 TBC1D15 TBC1 domain family member 15 Homo sapiens (Human) PR
O95759 TBC1D8 TBC1 domain family member 8 Homo sapiens (Human) PR
Q0IIM8 TBC1D8B TBC1 domain family member 8B Homo sapiens (Human) PR
Q8TEA7 TBCK TBC domain-containing protein kinase-like protein Homo sapiens (Human) PR
Q9UPU7 TBC1D2B TBC1 domain family member 2B Homo sapiens (Human) PR
A6H6A9 Rabgap1l Rab GTPase-activating protein 1-like Mus musculus (Mouse) PR
Q80XC3 Usp6nl USP6 N-terminal-like protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG IVHETELPPL
70 80 90 100 110 120
TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK GMPMNIRGPM WSVLLNTEEM
130 140 150 160 170 180
KLKNPGRYQI MKEKGKRSSE HIQRIDRDVS GTLRKHIFFR DRYGTKQREL LHILLAYEEY
190 200 210 220 230 240
NPEVGYCRDL SHIAALFLLY LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE
250 260 270 280 290 300
HVVATSQPKT MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI
310 320 330 340 350 360
TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL TRKQGDLPPP
370 380 390 400 410 420
AKPEQGSSAS RPVPASRGGK TLCKGDRQAP PGPPARFPRP IWSASPPRAP RSSTPCPGGA
430 440 450 460 470 480
VREDTYPVGT QGVPSPALAQ GGPQGSWRFL QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV
490 500 510 520 530 540
RAISQEDQLA PCWQAEHPAE RVRSAFAAPS TDSDQGTPFR ARDEQQCAPT SGPCLCGLHL
ESSQFPPGF