Q9ZQR6

PR
Gene name
At2g14540 (T13P21.8)
Protein name
Serpin-Z2
Names
ArathZ2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G14540
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZQR6

Entry ID Method Resolution Chain Position Source
AF-Q9ZQR6-F1 Predicted AlphaFoldDB

167 variants for Q9ZQR6

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05462563 2 D>N No 1000Genomes
tmp_2_6199377_C_T 5 R>K No 1000Genomes
ENSVATH01787940 7 N>K No 1000Genomes
tmp_2_6199366_C_A 9 E>* No 1000Genomes
ENSVATH05462562 11 S>I No 1000Genomes
ENSVATH01787939 12 T>I No 1000Genomes
ENSVATH14450278 13 S>L No 1000Genomes
tmp_2_6199347_G_T 15 T>N No 1000Genomes
ENSVATH13092832 16 A>T No 1000Genomes
ENSVATH14450277 28 K>R No 1000Genomes
tmp_2_6199302_T_A 30 D>V No 1000Genomes
ENSVATH14450276 34 A>T No 1000Genomes
tmp_2_6199285_T_A 36 K>* No 1000Genomes
tmp_2_6199276_T_C 39 N>D No 1000Genomes
ENSVATH14450275 39 N>I No 1000Genomes
ENSVATH05462559 40 E>D No 1000Genomes
tmp_2_6199254_A_C 46 V>G No 1000Genomes
ENSVATH05462558 47 G>R No 1000Genomes
ENSVATH05462557 52 A>T No 1000Genomes
ENSVATH05462555 63 P>L No 1000Genomes
tmp_2_6199200_G_T 64 A>E No 1000Genomes
ENSVATH01787937 65 S>F No 1000Genomes
tmp_2_6199191_T_G 67 N>T No 1000Genomes
ENSVATH00228730 69 V>F No 1000Genomes
ENSVATH00228730 69 V>I No 1000Genomes
tmp_2_6199180_T_G 71 T>P No 1000Genomes
ENSVATH00228729 76 N>T No 1000Genomes
tmp_2_6199161_G_A 77 T>I No 1000Genomes
ENSVATH05462553 79 N>S No 1000Genomes
ENSVATH05462552 87 L>F No 1000Genomes
ENSVATH14450243 92 S>F No 1000Genomes
tmp_2_6199113_G_A 93 S>F No 1000Genomes
ENSVATH13092826 95 T>I No 1000Genomes
ENSVATH05462549 107 S>F No 1000Genomes
ENSVATH05462549 107 S>Y No 1000Genomes
ENSVATH07863470 112 D>A No 1000Genomes
ENSVATH05462548 112 D>E No 1000Genomes
ENSVATH05462546 113 G>E No 1000Genomes
ENSVATH05462547 113 G>R No 1000Genomes
ENSVATH05462545 116 T>I No 1000Genomes
ENSVATH05462545 116 T>R No 1000Genomes
ENSVATH05462543 124 V>F No 1000Genomes
tmp_2_6199014_C_G 126 G>A No 1000Genomes
tmp_2_6198985_T_C 136 N>D No 1000Genomes
ENSVATH14450242 137 P>L No 1000Genomes
ENSVATH05462541 139 W>R No 1000Genomes
ENSVATH05462538 144 L>P No 1000Genomes
ENSVATH05462538 144 L>R No 1000Genomes
ENSVATH05462536 152 A>P No 1000Genomes
ENSVATH13092804 154 V>F No 1000Genomes
ENSVATH13092804 154 V>I No 1000Genomes
tmp_2_6198928_C_G 155 D>H No 1000Genomes
ENSVATH05462535 157 R>* No 1000Genomes
ENSVATH05462534 159 K>T No 1000Genomes
ENSVATH05462514 165 L>M No 1000Genomes
ENSVATH05462514 165 L>V No 1000Genomes
ENSVATH05462512 166 D>E No 1000Genomes
tmp_2_6198640_G_A 169 T>M No 1000Genomes
ENSVATH01787933 173 R>C No 1000Genomes
tmp_2_6198622_G_C 175 T>S No 1000Genomes
ENSVATH13092798 176 N>Y No 1000Genomes
ENSVATH05462510 177 D>N No 1000Genomes
tmp_2_6198613_A_C 178 L>R No 1000Genomes
ENSVATH13092797 185 R>H No 1000Genomes
ENSVATH05462509 188 V>A No 1000Genomes
ENSVATH01787932 189 T>R No 1000Genomes
tmp_2_6198564_C_T 194 W>* No 1000Genomes
tmp_2_6198554_T_G 198 N>H No 1000Genomes
ENSVATH05462507 211 D>N No 1000Genomes
ENSVATH13092796 214 M>T No 1000Genomes
ENSVATH05462506 215 T>K No 1000Genomes
ENSVATH05462506 215 T>R No 1000Genomes
ENSVATH05462505 217 D>H No 1000Genomes
ENSVATH05462505 217 D>N No 1000Genomes
ENSVATH05462503 219 P>Q No 1000Genomes
ENSVATH05462502 220 F>S No 1000Genomes
ENSVATH05462500 225 G>D No 1000Genomes
tmp_2_6198460_G_A 229 S>F No 1000Genomes
ENSVATH05462499 229 S>T No 1000Genomes
tmp_2_6198450_G_T 232 F>L No 1000Genomes
ENSVATH05462498 234 R>G No 1000Genomes
ENSVATH01787931 234 R>I No 1000Genomes
tmp_2_6198439_T_A,G 236 Y>F No 1000Genomes
tmp_2_6198439_T_A,G 236 Y>S No 1000Genomes
ENSVATH05462497 237 E>K No 1000Genomes
ENSVATH05462497 237 E>Q No 1000Genomes
ENSVATH13092795 238 K>N No 1000Genomes
ENSVATH01787930 238 K>R No 1000Genomes
ENSVATH05462496 242 E>Q No 1000Genomes
ENSVATH13092774 243 A>T No 1000Genomes
ENSVATH05462495 246 G>S No 1000Genomes
tmp_2_6198395_G_A 251 R>C No 1000Genomes
ENSVATH05462494 252 L>F No 1000Genomes
ENSVATH05462493 257 G>R No 1000Genomes
ENSVATH13092772 260 D>E No 1000Genomes
ENSVATH14450236 263 R>C No 1000Genomes
ENSVATH14450236 263 R>S No 1000Genomes
ENSVATH00228726 264 E>K No 1000Genomes
tmp_2_6198349_GA_GAA,AA,G 266 S>L No 1000Genomes
ENSVATH13092771 271 L>F No 1000Genomes
ENSVATH05462489 272 P>H No 1000Genomes
ENSVATH05462489 272 P>L No 1000Genomes
tmp_2_6198332_G_A 272 P>S No 1000Genomes
ENSVATH01787928 277 E>G No 1000Genomes
ENSVATH14450235 281 L>F No 1000Genomes
tmp_2_6198295_C_A 284 R>I No 1000Genomes
ENSVATH01787925 285 I>M No 1000Genomes
ENSVATH01787926 285 I>V No 1000Genomes
ENSVATH01787924 288 N>T No 1000Genomes
ENSVATH01787923 289 P>S No 1000Genomes
tmp_2_6198278_C_A 290 G>* No 1000Genomes
ENSVATH01787922 292 L>F No 1000Genomes
ENSVATH01787921 295 H>D No 1000Genomes
tmp_2_6198260_T_C 296 I>V No 1000Genomes
tmp_2_6198257_G_C,A 297 P>A No 1000Genomes
ENSVATH01787920 297 P>L No 1000Genomes
ENSVATH01787920 297 P>Q No 1000Genomes
tmp_2_6198257_G_C,A 297 P>S No 1000Genomes
ENSVATH01787919 298 E>K No 1000Genomes
ENSVATH05462488 298 E>V No 1000Genomes
tmp_2_6198248_G_A,C 300 R>C No 1000Genomes
tmp_2_6198248_G_A,C 300 R>G No 1000Genomes
ENSVATH13092769 300 R>H No 1000Genomes
ENSVATH13092769 300 R>L No 1000Genomes
ENSVATH00228725 301 V>I No 1000Genomes
tmp_2_6198233_C_T 305 D>N No 1000Genomes
ENSVATH01787917 308 I>F No 1000Genomes
ENSVATH01787916 308 I>N No 1000Genomes
tmp_2_6198220_G_A 309 P>L No 1000Genomes
tmp_2_6198221_G_A 309 P>S No 1000Genomes
ENSVATH13092768 312 K>Q No 1000Genomes
tmp_2_6198194_C_G 318 E>Q No 1000Genomes
ENSVATH05462485 319 A>V No 1000Genomes
ENSVATH05462484 331 S>L No 1000Genomes
ENSVATH05462483 333 H>L No 1000Genomes
tmp_2_6198147_G_T 333 H>Q No 1000Genomes
ENSVATH00228724 334 Q>H No 1000Genomes
ENSVATH05462482 343 E>D No 1000Genomes
ENSVATH05462481 348 A>T No 1000Genomes
ENSVATH13092766 349 A>G No 1000Genomes
tmp_2_6198101_C_T 349 A>T No 1000Genomes
ENSVATH05462480 351 T>S No 1000Genomes
ENSVATH01787911 353 V>I No 1000Genomes
tmp_2_6198083_C_T 355 V>I No 1000Genomes
ENSVATH00228723 357 T>I No 1000Genomes
ENSVATH07863467 358 G>D No 1000Genomes
tmp_2_6198067_C_A 360 C>F No 1000Genomes
tmp_2_6198041_C_T 369 D>N No 1000Genomes
ENSVATH05462477 371 V>M No 1000Genomes
tmp_2_6198012_A_T 378 F>L No 1000Genomes
ENSVATH01787909 378 F>Y No 1000Genomes
ENSVATH05462476 379 L>F No 1000Genomes
ENSVATH01787908 382 E>V No 1000Genomes
ENSVATH13092743 386 G>E No 1000Genomes
tmp_2_6197990_C_T 386 G>R No 1000Genomes
ENSVATH01787907 389 L>F No 1000Genomes
ENSVATH05462472 391 A>V No 1000Genomes
ENSVATH05462471 392 G>R No 1000Genomes
ENSVATH13092741 399 E>* No 1000Genomes
ENSVATH05462470 401 S>F No 1000Genomes
ENSVATH05462469 402 S>F No 1000Genomes
ENSVATH01787905 403 A>P No 1000Genomes
ENSVATH01787905 403 A>T No 1000Genomes
ENSVATH05462468 403 A>V No 1000Genomes
ENSVATH05462467 406 R>Q No 1000Genomes
ENSVATH00228722 406 R>W No 1000Genomes
ENSVATH01787903 407 A>S No 1000Genomes

No associated diseases with Q9ZQR6

2 regional properties for Q9ZQR6

Type Name Position InterPro Accession
conserved_site Serpin, conserved site 370 - 380 IPR023795
domain Serpin domain 40 - 397 IPR023796

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

2 GO annotations of biological process

Name Definition
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

39 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1JPB0 SERPINB1 Leukocyte elastase inhibitor Bos taurus (Bovine) PR
Q9N2I2 SERPINA5 Plasma serine protease inhibitor Bos taurus (Bovine) PR
Q9TTE1 SERPINA3-1 Serpin A3-1 Bos taurus (Bovine) PR
P41361 SERPINC1 Antithrombin-III Bos taurus (Bovine) PR
P13909 SERPINE1 Plasminogen activator inhibitor 1 Bos taurus (Bovine) PR
A2I7N1 SERPINA3-5 Serpin A3-5 Bos taurus (Bovine) PR
A6QPQ2 SERPINA3-8 Serpin A3-8 Bos taurus (Bovine) PR
A2I7M9 SERPINA3-2 Serpin A3-2 Bos taurus (Bovine) PR
A2I7N2 SERPINA3-6 Serpin A3-6 Bos taurus (Bovine) PR
O73790 SERPINB10 Heterochromatin-associated protein MENT Gallus gallus (Chicken) PR
P05619 SERPINB1 Leukocyte elastase inhibitor Equus caballus (Horse) PR
P01008 SERPINC1 Antithrombin-III Homo sapiens (Human) PR
P08697 SERPINF2 Alpha-2-antiplasmin Homo sapiens (Human) PR
Q96P15 SERPINB11 Serpin B11 Homo sapiens (Human) PR
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Homo sapiens (Human) PR
P05121 SERPINE1 Plasminogen activator inhibitor 1 Homo sapiens (Human) PR
P05155 SERPING1 Plasma protease C1 inhibitor Homo sapiens (Human) PR
P01011 SERPINA3 Alpha-1-antichymotrypsin Homo sapiens (Human) PR
Q86WD7 SERPINA9 Serpin A9 Homo sapiens (Human) PR
P07093 SERPINE2 Glia-derived nexin Homo sapiens (Human) PR
P12388 Serpinb2 Plasminogen activator inhibitor 2, macrophage Mus musculus (Mouse) PR
P32261 Serpinc1 Antithrombin-III Mus musculus (Mouse) PR
Q07235 Serpine2 Glia-derived nexin Mus musculus (Mouse) PR
Q5SV42 Serpinb1c Leukocyte elastase inhibitor C Mus musculus (Mouse) PR
Q80X76 Serpina3f Serine protease inhibitor A3F Mus musculus (Mouse) PR
Q8BYY9 Serpina3b Serine protease inhibitor A3B Mus musculus (Mouse) PR
Q9D154 Serpinb1a Leukocyte elastase inhibitor A Mus musculus (Mouse) PR
Q9JK88 Serpini2 Serpin I2 Mus musculus (Mouse) PR
Q8CDC0 Serpinb13 Serpin B13 Mus musculus (Mouse) PR
P22777 Serpine1 Plasminogen activator inhibitor 1 Mus musculus (Mouse) PR
Q5I2A0 Serpina3g Serine protease inhibitor A3G Mus musculus (Mouse) PR
Q62975 Serpina10 Protein Z-dependent protease inhibitor Rattus norvegicus (Rat) PR
P29524 Serpinb2 Plasminogen activator inhibitor 2 type A Rattus norvegicus (Rat) PR
Q6P734 Serping1 Plasma protease C1 inhibitor Rattus norvegicus (Rat) PR
P05545 Serpina3k Serine protease inhibitor A3K Rattus norvegicus (Rat) PR
P07092 Serpine2 Glia-derived nexin Rattus norvegicus (Rat) PR
P05544 Serpina3l Serine protease inhibitor A3L Rattus norvegicus (Rat) PR
O48706 At2g26390 Serpin-Z3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1T7 At3g45220 Serpin-Z4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDSKRKNQEL STSETADPSL SKTNKKQKID MQEAMKNQNE VSLLLVGKVI SAVAKNSNCV
70 80 90 100 110 120
FSPASINAVL TVTAANTDNK TLRSFILSFL KSSSTEETNA IFHELASVVF KDGSETGGPK
130 140 150 160 170 180
IAAVNGVWME QSLSCNPDWE DLFLNFFKAS FAKVDFRHKA EEVRLDVNTW ASRHTNDLIK
190 200 210 220 230 240
EILPRGSVTS LTNWIYGNAL YFKGAWEKAF DKSMTRDKPF HLLNGKSVSV PFMRSYEKQF
250 260 270 280 290 300
IEAYDGFKVL RLPYRQGRDD TNREFSMYLY LPDKKGELDN LLERITSNPG FLDSHIPEYR
310 320 330 340 350 360
VDVGDFRIPK FKIEFGFEAS SVFNDFELNV SLHQKALIEI DEEGTEAAAA TTVVVVTGSC
370 380 390 400
LWEPKKKIDF VADHPFLFLI REDKTGTLLF AGQIFDPSEL SSALDRA