AiPD: Autoinhibited Protein Database

Q86WD7

Gene name	SERPINA9 (GCET1, SERPINA11, UNQ692/PRO1337)
Protein name	Serpin A9
Names	Centerin, Germinal center B-cell-expressed transcript 1 protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:327657
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-74 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q86WD7

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q86WD7-F1	Predicted				AlphaFoldDB

426 variants for Q86WD7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA390871492 rs1264137829	2	A>S		No	ClinGen gnomAD
CA7328317 rs751166625	7	G>*		No	ClinGen ExAC gnomAD
TCGA novel	9	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763654723 CA7328316	9	L>P		No	ClinGen ExAC gnomAD
TCGA novel	11	A>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1358676894 CA390871426	11	A>D		No	ClinGen TOPMed
rs758144555 CA7328315	13	G>D		No	ClinGen ExAC TOPMed gnomAD
CA390871413 rs1336000153	14	L>I		No	ClinGen gnomAD
rs1330400042 CA390871406	15	C>R		No	ClinGen TOPMed gnomAD
rs532050549 CA7328313	15	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs570822602 CA7328311	16	A>D		No	ClinGen 1000Genomes ExAC gnomAD
CA7328312 rs759442392	16	A>S		No	ClinGen ExAC gnomAD
rs570822602 CA390871398	16	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs937082940 CA265905430	17	P>L		No	ClinGen TOPMed
rs1595669184 CA390871388	18	I>T		No	ClinGen Ensembl
rs760573855 CA7328309	18	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs368995727 CA7328308	19	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1229320584 CA390871373	20	C>Y		No	ClinGen gnomAD
CA265905390 rs888124641	22	S>T		No	ClinGen TOPMed
CA7328304 rs45438398	23	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs775715515 CA7328305	23	P>S		No	ClinGen ExAC TOPMed gnomAD
CA390871355 rs1310987010	24	A>T		No	ClinGen gnomAD
CA7328302 rs4905204 VAR_047344	24	A>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs201652235 CA7328301	25	N>S		No	ClinGen ExAC TOPMed gnomAD
CA7328300 rs747466486	26	A>V		No	ClinGen ExAC TOPMed gnomAD
rs911032142 CA265905346	27	P>S		No	ClinGen TOPMed
rs1337187253 CA390871325	29	A>S		No	ClinGen gnomAD
rs777431283 CA7328298	30	Y>*		No	ClinGen ExAC gnomAD
rs1402106800 CA390871315	30	Y>C		No	ClinGen gnomAD
CA390871314 rs1402106800	30	Y>S		No	ClinGen gnomAD
CA7328297 COSM288247 rs370139069	32	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
COSM3670172 rs572746802 CA7328295	32	R>H	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
rs370139069 CA7328296	32	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA390871299 rs1410330929	33	P>R		No	ClinGen gnomAD
CA7328291 rs766049389	36	T>S		No	ClinGen ExAC gnomAD
TCGA novel	38	S>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7328289 rs372542319	38	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA390871272 rs1237412506	38	S>R		No	ClinGen gnomAD
rs45438596 CA7328288	39	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390871265 rs1595669030	39	T>P		No	ClinGen Ensembl
rs1595669012 CA390871258	40	P>H		No	ClinGen Ensembl
rs865864584 CA265905258	40	P>S		No	ClinGen TOPMed
CA265905251 rs865864584 COSM1371820	40	P>T	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs763090252 CA390871255	41	A>S		No	ClinGen ExAC gnomAD
rs763090252 CA7328287	41	A>T		No	ClinGen ExAC gnomAD
rs199717292 CA7328286	41	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA390871247 rs1350696105	42	S>L		No	ClinGen TOPMed
rs1315244213 CA390871252	42	S>T		No	ClinGen gnomAD
COSM1516174 rs1376792694 CA390871239	43	Q>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA7328284 rs746051150	44	V>M		No	ClinGen ExAC TOPMed gnomAD
rs899526373 CA265905234	45	Y>C		No	ClinGen Ensembl
CA7328283 rs777073491	46	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA390871221 rs1419116689	47	L>I		No	ClinGen TOPMed gnomAD
rs200602156 CA390871209	48	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747519683 CA7328280	49	T>I		No	ClinGen ExAC gnomAD
rs747519683 CA390871203	49	T>N		No	ClinGen ExAC gnomAD
CA7328277 rs544061591	50	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA390871201 rs544061591	50	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7328276 rs371625465	52	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs758602903 CA7328275	52	A>V		No	ClinGen ExAC TOPMed gnomAD
CA7328274 rs201522333	54	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs190620890 CA7328273	54	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755841892 CA7328272	57	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7328271 rs199573923	57	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199573923 COSM315089 CA390871156	57	R>L	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1342315242 CA390871153	58	R>G		No	ClinGen gnomAD
rs1399480601 CA390871131	61	L>W		No	ClinGen gnomAD
CA390871118 rs1047330150	63	T>I		No	ClinGen TOPMed gnomAD
rs1047330150 CA265905071	63	T>N		No	ClinGen TOPMed gnomAD
CA7328269 rs761718690	63	T>S		No	ClinGen ExAC gnomAD
rs572837692 CA7328268	64	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs59773088 CA7328266	65	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7328265 rs771270945	65	S>N		No	ClinGen ExAC TOPMed gnomAD
CA390871108 rs1411948308	65	S>R		No	ClinGen TOPMed gnomAD
rs771270945 CA7328264	65	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1338128016 CA390871094	67	N>S		No	ClinGen TOPMed gnomAD
CA390871089 rs761176457	68	I>F		No	ClinGen ExAC TOPMed gnomAD
CA390871086 rs1193660500	68	I>S		No	ClinGen gnomAD
rs761176457 CA7328263	68	I>V		No	ClinGen ExAC TOPMed gnomAD
rs575042815 CA7328261	69	F>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs748563339 CA390871082	69	F>S		No	ClinGen ExAC gnomAD
CA7328260 rs748563339	69	F>Y		No	ClinGen ExAC gnomAD
TCGA novel	70	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1566793741 CA390871067	71	S>C		No	ClinGen Ensembl
rs1566793741 CA390871065	71	S>F		No	ClinGen Ensembl
rs915932148 CA265905027	75	V>A		No	ClinGen Ensembl
rs748977210 CA390871043	75	V>F		No	ClinGen ExAC TOPMed gnomAD
rs748977210 CA7328256	75	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	76	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755752926 CA390871034	77	T>A		No	ClinGen ExAC TOPMed gnomAD
CA7328255 rs755752926	77	T>P		No	ClinGen ExAC TOPMed gnomAD
rs755752926 CA7328254	77	T>S		No	ClinGen ExAC TOPMed gnomAD
rs757220526 CA7328251	80	A>T		No	ClinGen ExAC gnomAD
rs990378863 CA265904946	80	A>V		No	ClinGen gnomAD
CA390870995 rs1389225097	83	S>C		No	ClinGen TOPMed
CA390870994 rs751390983	84	L>I		No	ClinGen ExAC gnomAD
CA7328249 rs751390983	84	L>V		No	ClinGen ExAC gnomAD
rs917893516 CA265904910	85	G>E		No	ClinGen TOPMed gnomAD
rs917893516 CA390870986	85	G>V		No	ClinGen TOPMed gnomAD
rs1170382945 CA390870982	86	A>T		No	ClinGen gnomAD
rs1295712019 CA390870979	86	A>V		No	ClinGen TOPMed
rs753937955 CA7328245	87	H>R		No	ClinGen ExAC TOPMed gnomAD
rs759598527 CA7328246	87	H>Y		No	ClinGen ExAC gnomAD
rs760946865 CA7328243	88	S>L		No	ClinGen ExAC gnomAD
CA7328244 COSM3706452 rs142619133	88	S>P	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs760492022 CA7328241	89	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1034288024 CA265904902	90	T>I		No	ClinGen TOPMed gnomAD
rs201925577 CA7328240	91	K>N		No	ClinGen ExAC gnomAD
rs12879019 CA7328238	93	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs12879019 CA7328237	93	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs12879019 CA265904879	93	Q>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7328236 rs774962208	93	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs1488031288 CA390870936	94	I>S		No	ClinGen TOPMed
rs374230953 CA265904847	97	G>D		No	ClinGen ESP TOPMed gnomAD
rs769479968 CA7328235	97	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	99	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1242649739 CA390870889	102	L>V		No	ClinGen gnomAD
rs1196518184 CA390870882	103	T>A		No	ClinGen TOPMed gnomAD
CA7328233 rs780991821	103	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1290022735 CA390870874	104	H>L		No	ClinGen TOPMed
rs1455779027 CA390870878	104	H>N		No	ClinGen TOPMed
CA390870872 rs1359337963	104	H>Q		No	ClinGen TOPMed
CA390870869 rs1331135306	105	T>A		No	ClinGen gnomAD
rs1453770363	106	P>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1273588906 CA390870857	107	E>Q		No	ClinGen TOPMed gnomAD
CA390870844 rs1232243496	109	A>T		No	ClinGen TOPMed gnomAD
rs371331582 CA7328232	109	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs377551906 CA265904818	110	I>T		No	ClinGen ESP
rs139400221 CA7328231	111	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758331597 CA7328229	112	Q>K		No	ClinGen ExAC gnomAD
rs370684428 CA7328228	112	Q>R		No	ClinGen ESP ExAC gnomAD
rs1378051469 CA390870817	113	G>A		No	ClinGen gnomAD
CA390870820 rs1442346237	113	G>S		No	ClinGen TOPMed gnomAD
CA390870798 rs1258008953	116	H>N		No	ClinGen gnomAD
rs1258008953 CA390870796	116	H>Y		No	ClinGen gnomAD
rs768000133 CA7328224	119	H>R		No	ClinGen ExAC gnomAD
rs1008169641 CA265904761	122	T>S		No	ClinGen TOPMed
CA7328222 rs377345508	123	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1218832763 CA390870756	123	V>I		No	ClinGen gnomAD
CA390870755 rs1218832763	123	V>L		No	ClinGen gnomAD
TCGA novel	124	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs35347445 CA7328221	124	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201146824 CA7328220	125	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7328219 rs202245237	126	K>*		No	ClinGen 1000Genomes ExAC gnomAD
rs202245237 CA7328218	126	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA390870733 rs1311006106	127	D>H		No	ClinGen gnomAD
CA7328216 rs776328898	129	T>N		No	ClinGen ExAC gnomAD
TCGA novel	130	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770601864 CA7328215	131	K>E		No	ClinGen ExAC gnomAD
rs1380235478 CA390870695	132	M>I		No	ClinGen TOPMed
rs1420929304 CA390870690	133	G>*		No	ClinGen gnomAD
CA265904715 rs866767080	133	G>E		No	ClinGen Ensembl
CA390870687 rs1358239157	134	S>C		No	ClinGen gnomAD
rs746825992 CA7328214	136	L>I		No	ClinGen ExAC gnomAD
rs777591835 CA7328213	136	L>R		No	ClinGen ExAC gnomAD
rs746825992 CA265904712	136	L>V		No	ClinGen ExAC gnomAD
rs562308083 CA390870664	137	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7328211 rs768342050	138	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs61740030 CA7328210	139	K>Q		No	ClinGen 1000Genomes ExAC TOPMed
CA7328208 rs756197220	139	K>R		No	ClinGen ExAC gnomAD
rs201258446 CA265904678	145	Q>*		No	ClinGen Ensembl
CA7328205 rs767692246	145	Q>R		No	ClinGen ExAC gnomAD
rs1375239336 CA390870590	148	F>L		No	ClinGen TOPMed
CA390870584 rs1223572546	149	L>F		No	ClinGen gnomAD
rs751912997 CA7328203	149	L>M		No	ClinGen ExAC TOPMed gnomAD
rs764481682 CA7328202	150	G>V		No	ClinGen ExAC gnomAD
CA7328201 rs763478766	151	N>K		No	ClinGen ExAC gnomAD
CA390870571 rs1566793282	152	V>I		No	ClinGen Ensembl
rs775921571 CA7328200	153	K>R		No	ClinGen ExAC gnomAD
rs369836270 CA7328199	154	R>G		No	ClinGen ESP ExAC gnomAD
CA390870558 rs369836270	154	R>W		No	ClinGen ESP ExAC gnomAD
CA265904649 rs992103421	156	Y>C		No	ClinGen TOPMed
CA390870522 rs1280579591	159	E>G		No	ClinGen gnomAD
TCGA novel	160	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7328198 rs759100489	160	V>F		No	ClinGen ExAC gnomAD
TCGA novel	162	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs959655925 CA265904635	163	T>A		No	ClinGen TOPMed gnomAD
CA390870495 rs1209667326	163	T>I		No	ClinGen TOPMed
CA390870490 rs1405637571	164	D>G		No	ClinGen TOPMed gnomAD
rs748943432 CA265904619	166	S>F		No	ClinGen Ensembl
CA390870459 rs1176631530	169	S>P		No	ClinGen gnomAD
TCGA novel	169	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1595668215 CA390870449	170	I>T		No	ClinGen Ensembl
CA7328191 rs771840753	171	A>S		No	ClinGen ExAC gnomAD
CA7328189 rs373122783	173	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7328190 rs748100074	173	A>T		No	ClinGen ExAC TOPMed gnomAD
COSM1225277 rs373122783 CA7328188	173	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA390870425 rs1199629879	174	R>S		No	ClinGen gnomAD
rs1453567568 CA390870419	175	I>N		No	ClinGen gnomAD
CA7328184 rs751760583	177	S>R		No	ClinGen ExAC gnomAD
CA7328183 rs572845318	178	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs753044188 CA7328181	179	V>M		No	ClinGen ExAC gnomAD
rs765779875 CA7328180	180	K>R		No	ClinGen ExAC gnomAD
rs753317420 CA7328178	181	K>R		No	ClinGen ExAC TOPMed gnomAD
CA7328177 rs371514591	183	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390870363 rs371514591	183	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs78283108 CA7328176	184	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	185	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772853992 CA7328175	186	K>R		No	ClinGen ExAC gnomAD
CA390870338 rs1368395979	187	V>A		No	ClinGen TOPMed
rs761759032 CA7328172	189	D>Y		No	ClinGen ExAC gnomAD
CA7328170 rs768756104	193	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs749200217 CA7328169	194	L>F		No	ClinGen ExAC gnomAD
CA390870286 rs1458366826	195	D>G		No	ClinGen gnomAD
CA390870280 rs1240458729	196	L>F		No	ClinGen gnomAD
rs1457730804 COSM1516178 CA390870273	197	L>P	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA7328167 rs575429531	198	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA390870264 rs1346592749	199	A>S		No	ClinGen TOPMed gnomAD
rs1346592749 CA390870266 COSM1371813	199	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA390870249 rs1456752502	201	V>F		No	ClinGen TOPMed
CA390870248 rs1216079990	201	V>G		No	ClinGen TOPMed
CA390870244 rs1247869519	202	L>V		No	ClinGen TOPMed
rs1377137276 CA390870215	205	H>P		No	ClinGen gnomAD
CA265904464 rs963782904	205	H>Y		No	ClinGen Ensembl
CA390870196 rs1333154966	206	I>T		No	ClinGen gnomAD
COSM959183 rs1421153546 CA390870179	207	F>L	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
TCGA novel	210	A>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390870151 rs1401512477	210	A>P		No	ClinGen gnomAD
CA390870150 rs1401512477	210	A>S		No	ClinGen gnomAD
TCGA novel	211	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390869215 rs1214065256	211	K>N		No	ClinGen gnomAD
rs143253931 CA7328134	212	W>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs189300483 CA7328133	212	W>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143253931 CA7328135	212	W>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs775122463 CA7328132	213	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs759349102 CA7328130	217	H>L		No	ClinGen ExAC gnomAD
CA390869109 rs1400529842	217	H>Q		No	ClinGen TOPMed gnomAD
rs17090921 CA7328129 VAR_047345	218	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs17090921 CA390869096	218	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1353940315 CA390869092	219	E>K		No	ClinGen TOPMed
rs185539688 CA7328126	220	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs185539688 CA7328127	220	Y>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7328128 rs772080455	220	Y>H		No	ClinGen ExAC gnomAD
CA390869058 rs749711646	221	T>A		No	ClinGen ExAC gnomAD
CA7328123 rs780251195	221	T>R		No	ClinGen ExAC gnomAD
CA7328124 rs749711646	221	T>S		No	ClinGen ExAC gnomAD
CA390869004 rs1281746086	224	N>S		No	ClinGen TOPMed
CA390868938 rs1190826843	228	L>V		No	ClinGen TOPMed gnomAD
CA390868923 rs1246870922	229	V>L		No	ClinGen TOPMed gnomAD
CA265902869 rs956228346	230	G>D		No	ClinGen TOPMed gnomAD
CA390868916 rs1223503981	230	G>S		No	ClinGen gnomAD
CA7328118 rs370550742	231	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1276415036 CA390868890	232	Q>K		No	ClinGen gnomAD
rs376958235 CA7328117	233	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs764890158 CA7328115	235	V>L		No	ClinGen ExAC gnomAD
CA7328114 rs764890158	235	V>M		No	ClinGen ExAC gnomAD
rs867024120 CA390868816	236	H>N		No	ClinGen gnomAD
CA390868806 rs1265046241	236	H>P		No	ClinGen TOPMed
rs28583900 VAR_047346 CA7328113	236	H>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs867024120 CA265902839	236	H>Y		No	ClinGen gnomAD
CA265902830 rs1011917518	237	V>A		No	ClinGen TOPMed
CA7328112 rs753706799	238	P>H		No	ClinGen ExAC TOPMed gnomAD
CA390868781 rs753706799	238	P>L		No	ClinGen ExAC TOPMed gnomAD
CA390868747 rs1167935139	240	M>I		No	ClinGen gnomAD
rs1566791816 CA390868702	243	K>Q		No	ClinGen Ensembl
CA390868693 rs1425250069	243	K>R		No	ClinGen gnomAD
CA7328110 rs761939141	244	E>A		No	ClinGen ExAC TOPMed gnomAD
rs539102578 CA265902816	244	E>D		No	ClinGen 1000Genomes
rs1192624890 CA390868683	244	E>Q		No	ClinGen gnomAD
CA7328108 rs376153788	245	Q>H		No	ClinGen ESP ExAC gnomAD
CA7328109 rs774392469	245	Q>P		No	ClinGen ExAC
rs774392469 CA390868659	245	Q>R		No	ClinGen ExAC
CA7328106 rs200406674	246	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390868649 rs1198992845	246	F>L		No	ClinGen gnomAD
rs61761875 CA7328105	247	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7328104 rs61761875	247	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7328103 rs781778233	247	A>V		No	ClinGen ExAC gnomAD
CA390868606 rs1312909677	249	G>R		No	ClinGen gnomAD
CA390868582 rs1362775364	251	D>N		No	ClinGen TOPMed
CA390868559 rs1217735838	252	T>A		No	ClinGen gnomAD
rs1370479292 CA390868547	253	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs193117791 CA7328101	254	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs771379037 CA265902762	255	N>S		No	ClinGen Ensembl
rs758103039 CA7328099	256	C>F		No	ClinGen ExAC TOPMed gnomAD
CA7328100 rs777372316	256	C>G		No	ClinGen ExAC gnomAD
CA390868491 rs1466990817	257	F>S		No	ClinGen gnomAD
CA7328096 rs754788111	258	V>E		No	ClinGen ExAC gnomAD
rs1315112422 CA390868456	260	Q>*		No	ClinGen TOPMed
CA7328095 rs753626112	260	Q>P		No	ClinGen ExAC gnomAD
rs761120358 CA265902734	261	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1358181806 CA390868445	261	M>L		No	ClinGen TOPMed
CA390868441 rs1358181806	261	M>V		No	ClinGen TOPMed
rs1287732141 CA390868390	263	Y>*		No	ClinGen TOPMed
CA390868359 rs1441242975	265	G>A		No	ClinGen gnomAD
CA7328094 rs766343410	265	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7328093 rs368986283	266	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs372621576 CA7328091	268	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1208056037 CA390868293	269	A>V		No	ClinGen TOPMed gnomAD
rs775515416 CA7328089	270	F>I		No	ClinGen ExAC gnomAD
rs775515416 CA390868288	270	F>L		No	ClinGen ExAC gnomAD
rs770041574 CA7328088	272	V>D		No	ClinGen ExAC TOPMed
CA7328086 rs777118123	274	P>S		No	ClinGen ExAC gnomAD
CA7328085 rs771591706	277	G>D		No	ClinGen ExAC gnomAD
CA390868177 rs1310982694	277	G>S		No	ClinGen gnomAD
rs747482522 CA7328084	278	K>R		No	ClinGen ExAC gnomAD
rs771427322 CA390868134 CA7328082	279	M>I		No	ClinGen ExAC TOPMed gnomAD
CA7328083 rs777343698	279	M>V		No	ClinGen ExAC TOPMed gnomAD
rs747682822 CA7328081	280	R>T		No	ClinGen ExAC gnomAD
rs1158942785 CA390868118	281	Q>*		No	ClinGen gnomAD
CA390868098 rs1421119943	282	L>R		No	ClinGen gnomAD
rs778497863 CA7328080	283	E>*		No	ClinGen ExAC gnomAD
CA390868095 rs778497863	283	E>Q		No	ClinGen ExAC gnomAD
rs975200178 CA265902661	284	Q>E		No	ClinGen TOPMed gnomAD
CA7328079 rs561114629	285	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs561114629 CA390868067	285	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA390868059 rs1258111947	285	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA390868044 rs1263985620	286	L>F		No	ClinGen gnomAD
rs549191408 CA7328077	286	L>S		No	ClinGen 1000Genomes ExAC gnomAD
CA265902658 rs968763111	287	S>L		No	ClinGen TOPMed
CA390868012 rs1340092516	289	R>I		No	ClinGen TOPMed gnomAD
VAR_047347 CA7328075 rs28618118	292	R>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1245918350 CA390867964	293	K>R		No	ClinGen gnomAD
CA390867942 rs758462587 TCGA novel rs1566791478 CA7328073	294	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC TOPMed gnomAD Ensembl
rs764246290 CA7328074	294	W>G		No	ClinGen ExAC gnomAD
CA390867934 rs752814721	295	S>N		No	ClinGen ExAC TOPMed gnomAD
CA7328072 rs752814721	295	S>T		No	ClinGen ExAC TOPMed gnomAD
CA390867917 rs1354334232	296	H>R		No	ClinGen gnomAD
rs1401497567 CA390867892	298	L>H		No	ClinGen gnomAD
rs777171061 CA7328069	299	Q>R		No	ClinGen ExAC gnomAD
CA390867851 rs368040594	301	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs368040594 CA7328068	301	R>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA390867855 rs1566791436	301	R>W		No	ClinGen Ensembl
rs866545816 CA265900736	302	W>*		No	ClinGen gnomAD
rs766696907 CA7328051	303	I>M		No	ClinGen ExAC gnomAD
CA265900733 rs748803342	304	E>D		No	ClinGen ExAC TOPMed gnomAD
rs767958462 CA7328048	306	F>S		No	ClinGen ExAC TOPMed gnomAD
rs1257263764 CA390867038	306	F>V		No	ClinGen TOPMed
rs1199592839 CA390867021	307	I>V		No	ClinGen TOPMed
CA7328047 rs762331920	309	R>I		No	ClinGen ExAC gnomAD
rs768085902 CA7328045	311	S>F		No	ClinGen ExAC gnomAD
CA7328046 rs773764334	311	S>P		No	ClinGen ExAC gnomAD
CA7328044 rs748951147	314	A>V		No	ClinGen ExAC gnomAD
rs1173195876 CA390866910	315	S>P		No	ClinGen gnomAD
TCGA novel	315	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390866887 rs1483943489	316	Y>C		No	ClinGen TOPMed
CA7328043 rs775178790	317	N>D		No	ClinGen ExAC gnomAD
CA7328042 COSM315091 rs769429068	317	N>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs745686158 CA7328041	318	L>P		No	ClinGen ExAC gnomAD
rs779150873 CA7328037	322	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs76159860 CA7328035	323	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs76159860 CA265900655	323	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs983686317 COSM1516184 CA265900644	325	M>I	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA390866744 rs1349611465	325	M>T		No	ClinGen TOPMed gnomAD
CA7328033 rs756338732	326	G>D		No	ClinGen ExAC TOPMed gnomAD
CA7328031 rs767884108	328	Q>*		No	ClinGen ExAC gnomAD
CA390866708 rs767884108	328	Q>K		No	ClinGen ExAC gnomAD
CA7328030 VAR_047348 rs11628722	330	V>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs752046245 CA7328029	331	F>C		No	ClinGen ExAC gnomAD
CA390866598 rs762514287	334	N>K		No	ClinGen ExAC TOPMed
rs764570314 CA7328028	334	N>S		No	ClinGen ExAC gnomAD
rs1390177721 CA390866590	335	A>T		No	ClinGen TOPMed
CA7328026 rs774947676	336	D>H		No	ClinGen ExAC gnomAD
CA7328023 rs776298818	341	A>T		No	ClinGen ExAC gnomAD
rs770704186 CA265900555	343	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs770704186 CA7328022	343	R>T		No	ClinGen ExAC TOPMed gnomAD
rs777925704 CA7328020	346	L>P		No	ClinGen ExAC
rs558575103 CA7328021	346	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA390866415 rs1254757104	347	Q>H		No	ClinGen gnomAD
rs77274019 CA7328017	348	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs77274019 CA7328016	348	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390866410 rs77274019	348	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA265900530 rs376738089	349	S>C		No	ClinGen ESP gnomAD
rs200842178 CA7328014	350	K>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1430262318 CA390865963	351	A>T		No	ClinGen gnomAD
CA7327994 rs757386494	352	T>I		No	ClinGen ExAC TOPMed gnomAD
CA390865945 rs757386494	352	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1166135543 CA390865934	353	H>Y		No	ClinGen TOPMed
rs546582038 CA265899076	355	A>G		No	ClinGen 1000Genomes
rs1163591248 CA390865901	355	A>P		No	ClinGen gnomAD
CA7327992 rs747419955	359	V>F		No	ClinGen ExAC gnomAD
rs762872752 CA265899065	360	S>R		No	ClinGen Ensembl
rs868625320 CA265899064	361	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	362	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA265899058 rs528042651	363	G>V		No	ClinGen 1000Genomes
CA7327990 rs758930818	365	E>K		No	ClinGen ExAC TOPMed gnomAD
CA390865798 rs1215285617	366	A>T		No	ClinGen gnomAD
TCGA novel	366	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1595661497 CA390865793	367	T>P		No	ClinGen Ensembl
CA7327989 rs753148839	368	A>V		No	ClinGen ExAC gnomAD
rs1385309859 CA390865759	372	T>I		No	ClinGen TOPMed
rs1320685935 CA390865757	373	K>E		No	ClinGen TOPMed
rs765652572 CA390865743	374	F>L		No	ClinGen ExAC gnomAD
rs1488911335 CA390865746	374	F>S		No	ClinGen TOPMed gnomAD
CA265899015 rs200611583	375	I>T		No	ClinGen TOPMed
CA390865729 rs1199184319	377	R>*		No	ClinGen gnomAD
CA7327987 rs199738408	377	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7327986 rs370040760	378	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1293492269 CA390865725	378	S>P		No	ClinGen TOPMed gnomAD
rs1293492269 CA390865726	378	S>T		No	ClinGen TOPMed gnomAD
CA7327984 rs760354488	380	D>A		No	ClinGen ExAC gnomAD
rs1306111241 CA390865712	380	D>N		No	ClinGen TOPMed gnomAD
CA7327983 rs773172843	381	G>S		No	ClinGen ExAC gnomAD
CA7327981 rs761855155	382	P>T		No	ClinGen ExAC TOPMed gnomAD
CA390865689 rs1355818470	384	Y>N		No	ClinGen gnomAD
rs373779363 CA7327980	385	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7327978 rs745996886	389	F>L		No	ClinGen ExAC gnomAD
rs200415975 CA265898928	390	N>D		No	ClinGen 1000Genomes gnomAD
CA390865647 rs1566788950	390	N>S		No	ClinGen Ensembl
rs200415975 CA390865648	390	N>Y		No	ClinGen 1000Genomes gnomAD
rs1259466119 CA390865642	391	R>G		No	ClinGen TOPMed
CA7327977 rs776548862	391	R>K		No	ClinGen ExAC TOPMed gnomAD
CA265898911 rs1017990188	393	F>L		No	ClinGen TOPMed
CA390865611 rs1481557321	395	M>I		No	ClinGen gnomAD
CA7327976 COSM72600 rs769630965	396	M>I	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs563120500 CA7327975	397	I>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs563120500 CA265898879	397	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA265898869 rs78420865	398	T>K		No	ClinGen Ensembl
rs758824369 CA7327973	399	N>S		No	ClinGen ExAC TOPMed gnomAD
rs544445563 CA7327972	401	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs779518053 CA7327971	402	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA390865556 rs1296752288	404	G>D		No	ClinGen TOPMed
rs371198029 CA7327969	404	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs183027056 CA7327968	405	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs750037689 CA7327966	408	L>I		No	ClinGen ExAC TOPMed gnomAD
CA390865531 rs1338243754	408	L>P		No	ClinGen TOPMed
CA265898802 rs368647334	409	G>E		No	ClinGen ESP
rs761765070 CA7327964	410	K>*		No	ClinGen ExAC
TCGA novel	410	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7327962 rs773985074	411	V>A		No	ClinGen ExAC gnomAD
rs764138245 CA7327961	412	E>*		No	ClinGen ExAC gnomAD
rs776799295 CA7327959	414	P>L		No	ClinGen ExAC gnomAD
CA7327960 rs201515358	414	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7327958 rs371000087	415	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA390865487 rs1349528009	416	K>E		No	ClinGen TOPMed
CA7327957 rs377392216	416	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs374213651 CA265898784	417	S>F		No	ClinGen ESP TOPMed gnomAD

No associated diseases with Q86WD7

2 regional properties for Q86WD7

Type	Name	Position	InterPro Accession
conserved_site	Serpin, conserved site	387 - 397	IPR023795
domain	Serpin domain	48 - 414	IPR023796

Functions

		Description
EC Number
Subcellular Localization	[Isoform 1]: Secreted ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

1 GO annotations of molecular function

Name	Definition
serine-type endopeptidase inhibitor activity	Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

1 GO annotations of biological process

Name	Definition
negative regulation of endopeptidase activity	Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

35 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9N2I2	SERPINA5	Plasma serine protease inhibitor	Bos taurus (Bovine)	PR
P41361	SERPINC1	Antithrombin-III	Bos taurus (Bovine)	PR
A6QPQ2	SERPINA3-8	Serpin A3-8	Bos taurus (Bovine)	PR
A2I7N1	SERPINA3-5	Serpin A3-5	Bos taurus (Bovine)	PR
Q1JPB0	SERPINB1	Leukocyte elastase inhibitor	Bos taurus (Bovine)	PR
P13909	SERPINE1	Plasminogen activator inhibitor 1	Bos taurus (Bovine)	PR
Q9TTE1	SERPINA3-1	Serpin A3-1	Bos taurus (Bovine)	PR
O73790	SERPINB10	Heterochromatin-associated protein MENT	Gallus gallus (Chicken)	PR
P01008	SERPINC1	Antithrombin-III	Homo sapiens (Human)	PR
P05121	SERPINE1	Plasminogen activator inhibitor 1	Homo sapiens (Human)	PR
P08697	SERPINF2	Alpha-2-antiplasmin	Homo sapiens (Human)	PR
P05155	SERPING1	Plasma protease C1 inhibitor	Homo sapiens (Human)	PR
P01011	SERPINA3	Alpha-1-antichymotrypsin	Homo sapiens (Human)	PR
P07093	SERPINE2	Glia-derived nexin	Homo sapiens (Human)	PR
Q9UK55	SERPINA10	Protein Z-dependent protease inhibitor	Homo sapiens (Human)	PR
Q96P15	SERPINB11	Serpin B11	Homo sapiens (Human)	PR
Q5SV42	Serpinb1c	Leukocyte elastase inhibitor C	Mus musculus (Mouse)	PR
Q07235	Serpine2	Glia-derived nexin	Mus musculus (Mouse)	PR
Q8CDC0	Serpinb13	Serpin B13	Mus musculus (Mouse)	PR
P22777	Serpine1	Plasminogen activator inhibitor 1	Mus musculus (Mouse)	PR
Q5I2A0	Serpina3g	Serine protease inhibitor A3G	Mus musculus (Mouse)	PR
Q9JK88	Serpini2	Serpin I2	Mus musculus (Mouse)	PR
P12388	Serpinb2	Plasminogen activator inhibitor 2, macrophage	Mus musculus (Mouse)	PR
P32261	Serpinc1	Antithrombin-III	Mus musculus (Mouse)	PR
Q9D154	Serpinb1a	Leukocyte elastase inhibitor A	Mus musculus (Mouse)	PR
Q8BYY9	Serpina3b	Serine protease inhibitor A3B	Mus musculus (Mouse)	PR
Q80X76	Serpina3f	Serine protease inhibitor A3F	Mus musculus (Mouse)	PR
P29524	Serpinb2	Plasminogen activator inhibitor 2 type A	Rattus norvegicus (Rat)	PR
Q6P734	Serping1	Plasma protease C1 inhibitor	Rattus norvegicus (Rat)	PR
P05545	Serpina3k	Serine protease inhibitor A3K	Rattus norvegicus (Rat)	PR
P07092	Serpine2	Glia-derived nexin	Rattus norvegicus (Rat)	PR
Q62975	Serpina10	Protein Z-dependent protease inhibitor	Rattus norvegicus (Rat)	PR
Q9ZQR6	At2g14540	Serpin-Z2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M1T7	At3g45220	Serpin-Z4	Arabidopsis thaliana (Mouse-ear cress)	PR
O48706	At2g26390	Serpin-Z3	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MASYLYGVLF	AVGLCAPIYC	VSPANAPSAY	PRPSSTKSTP	ASQVYSLNTD	FAFRLYRRLV
70	80	90	100	110	120
LETPSQNIFF	SPVSVSTSLA	MLSLGAHSVT	KTQILQGLGF	NLTHTPESAI	HQGFQHLVHS
130	140	150	160	170	180
LTVPSKDLTL	KMGSALFVKK	ELQLQANFLG	NVKRLYEAEV	FSTDFSNPSI	AQARINSHVK
190	200	210	220	230	240
KKTQGKVVDI	IQGLDLLTAM	VLVNHIFFKA	KWEKPFHPEY	TRKNFPFLVG	EQVTVHVPMM
250	260	270	280	290	300
HQKEQFAFGV	DTELNCFVLQ	MDYKGDAVAF	FVLPSKGKMR	QLEQALSART	LRKWSHSLQK
310	320	330	340	350	360
RWIEVFIPRF	SISASYNLET	ILPKMGIQNV	FDKNADFSGI	AKRDSLQVSK	ATHKAVLDVS
370	380	390	400	410
EEGTEATAAT	TTKFIVRSKD	GPSYFTVSFN	RTFLMMITNK	ATDGILFLGK	VENPTKS