P12388

PR
Gene name
Serpinb2 (Pai2, Planh2)
Protein name
Plasminogen activator inhibitor 2, macrophage
Names
PAI-2, Serpin B2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18788
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

62-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P12388

Entry ID Method Resolution Chain Position Source
AF-P12388-F1 Predicted AlphaFoldDB

27 variants for P12388

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388493057 3 E>K No EVA
rs30537830 6 M>I No EVA
rs3410820439 6 M>R No EVA
rs3390363628 9 T>I No EVA
rs3390444187 10 M>V No EVA
rs30537829 25 T>I No EVA
rs3388490626 30 I>F No EVA
rs3388490923 55 A>G No EVA
rs30537827 55 A>T No EVA
rs3388492113 57 V>E No EVA
rs241654199 61 N>K No EVA
rs265307199 80 D>E No EVA
rs30534486 82 A>T No EVA
rs222794376 103 I>T No EVA
rs3388490574 105 S>* No EVA
rs240935165 115 N>S No EVA
rs30533632 226 S>L No EVA
rs49762164 239 A>E No EVA
rs50107183 258 H>Y No EVA
rs51523684 259 T>I No EVA
rs246528651 261 N>K No EVA
rs255059192 265 L>F No EVA
rs231671587 284 S>R No EVA
rs3388492223 311 K>M No EVA
rs235582825 377 M>T No EVA
rs30533631 386 P>S No EVA
rs261485763 399 M>I No EVA

No associated diseases with P12388

2 regional properties for P12388

Type Name Position InterPro Accession
conserved_site Serpin, conserved site 388 - 398 IPR023795
domain Serpin domain 7 - 415 IPR023796

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Secreted, extracellular space
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cornified envelope A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes).
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

3 GO annotations of biological process

Name Definition
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of endopeptidase activity Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
wound healing The series of events that restore integrity to a damaged tissue, following an injury.

35 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9N2I2 SERPINA5 Plasma serine protease inhibitor Bos taurus (Bovine) PR
P41361 SERPINC1 Antithrombin-III Bos taurus (Bovine) PR
A6QPQ2 SERPINA3-8 Serpin A3-8 Bos taurus (Bovine) PR
A2I7N1 SERPINA3-5 Serpin A3-5 Bos taurus (Bovine) PR
Q1JPB0 SERPINB1 Leukocyte elastase inhibitor Bos taurus (Bovine) PR
P13909 SERPINE1 Plasminogen activator inhibitor 1 Bos taurus (Bovine) PR
Q9TTE1 SERPINA3-1 Serpin A3-1 Bos taurus (Bovine) PR
O73790 SERPINB10 Heterochromatin-associated protein MENT Gallus gallus (Chicken) PR
P05121 SERPINE1 Plasminogen activator inhibitor 1 Homo sapiens (Human) PR
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Homo sapiens (Human) PR
P05155 SERPING1 Plasma protease C1 inhibitor Homo sapiens (Human) PR
P08697 SERPINF2 Alpha-2-antiplasmin Homo sapiens (Human) PR
Q86WD7 SERPINA9 Serpin A9 Homo sapiens (Human) PR
P01008 SERPINC1 Antithrombin-III Homo sapiens (Human) PR
P07093 SERPINE2 Glia-derived nexin Homo sapiens (Human) PR
Q96P15 SERPINB11 Serpin B11 Homo sapiens (Human) PR
P01011 SERPINA3 Alpha-1-antichymotrypsin Homo sapiens (Human) PR
P32261 Serpinc1 Antithrombin-III Mus musculus (Mouse) PR
Q07235 Serpine2 Glia-derived nexin Mus musculus (Mouse) PR
Q5SV42 Serpinb1c Leukocyte elastase inhibitor C Mus musculus (Mouse) PR
Q80X76 Serpina3f Serine protease inhibitor A3F Mus musculus (Mouse) PR
Q8BYY9 Serpina3b Serine protease inhibitor A3B Mus musculus (Mouse) PR
Q9D154 Serpinb1a Leukocyte elastase inhibitor A Mus musculus (Mouse) PR
Q9JK88 Serpini2 Serpin I2 Mus musculus (Mouse) PR
Q8CDC0 Serpinb13 Serpin B13 Mus musculus (Mouse) PR
P22777 Serpine1 Plasminogen activator inhibitor 1 Mus musculus (Mouse) PR
Q5I2A0 Serpina3g Serine protease inhibitor A3G Mus musculus (Mouse) PR
Q6P734 Serping1 Plasma protease C1 inhibitor Rattus norvegicus (Rat) PR
P05545 Serpina3k Serine protease inhibitor A3K Rattus norvegicus (Rat) PR
P07092 Serpine2 Glia-derived nexin Rattus norvegicus (Rat) PR
Q62975 Serpina10 Protein Z-dependent protease inhibitor Rattus norvegicus (Rat) PR
P29524 Serpinb2 Plasminogen activator inhibitor 2 type A Rattus norvegicus (Rat) PR
O48706 At2g26390 Serpin-Z3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1T7 At3g45220 Serpin-Z4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR6 At2g14540 Serpin-Z2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEELSMANTM FALNLLKQIE KSNSTQNIFI SPWSISSTLA IVLLGAGGNT EQQMAKVLQF
70 80 90 100 110 120
NEIGSYGITT RNPENFSGCD FAQQIQKENY PSAILQAQAG DKIHSAFSSL SSTINTPQGD
130 140 150 160 170 180
YLLESANKLF GEKSARFKEE YIQLSKKYYS TEPEAVDFLE CAEEAREKIN SWVKTQTKGE
190 200 210 220 230 240
IPNLLPEGSV DEDTKMVLVN AVYFKGKWKT PFEKKLNGLY PFRVNSHESI PVQMMFLHAK
250 260 270 280 290 300
LNIGYIKDLK TQILELPHTG NISMLLLLPD EIEDASTGLE LLESEINFAN FNKWISKDTL
310 320 330 340 350 360
DEDDVVVYIP KFKLAQSYEL KSILQSMGME DAFNKGKANF SGMSERNDLF LSEVFHQASV
370 380 390 400 410
DVTEEGTVAA GGTGAVMTGR TGHGGPQFVA DHPFLFFIMD KITHTILFVG RFSSP