Q9M1T7

PR
Gene name
At3g45220 (T14D3.160)
Protein name
Serpin-Z4
Names
ArathZ4
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G45220
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

276-347 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9M1T7

Entry ID Method Resolution Chain Position Source
AF-Q9M1T7-F1 Predicted AlphaFoldDB

158 variants for Q9M1T7

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_16566320_C_G 4 G>A No 1000Genomes
ENSVATH02431927 7 M>R No 1000Genomes
tmp_3_16566309_C_T 8 E>K No 1000Genomes
ENSVATH12501224 11 T>I No 1000Genomes
tmp_3_16566285_A_C 16 L>V No 1000Genomes
ENSVATH00399566 23 P>A No 1000Genomes
tmp_3_16566261_T_C 24 T>A No 1000Genomes
ENSVATH02431926 32 V>I No 1000Genomes
ENSVATH06225618 36 M>K No 1000Genomes
ENSVATH06225618 36 M>T No 1000Genomes
ENSVATH12501222 38 I>V No 1000Genomes
tmp_3_16566195_C_G 46 A>P No 1000Genomes
ENSVATH06225616 49 S>C No 1000Genomes
tmp_3_16566179_C_T 51 C>Y No 1000Genomes
ENSVATH06225615 53 T>S No 1000Genomes
ENSVATH06225614 61 I>L No 1000Genomes
ENSVATH06225613 63 L>S No 1000Genomes
ENSVATH12501220 64 P>R No 1000Genomes
ENSVATH06225612 64 P>S No 1000Genomes
tmp_3_16566127_G_T 68 Y>* No 1000Genomes
ENSVATH00399565 68 Y>H No 1000Genomes
tmp_3_16566112_T_G 73 L>F No 1000Genomes
ENSVATH06225611 78 S>Y No 1000Genomes
ENSVATH02431925 80 A>S No 1000Genomes
ENSVATH06225610 82 N>Y No 1000Genomes
ENSVATH02431924 83 D>E No 1000Genomes
tmp_3_16566064_G_C 89 D>E No 1000Genomes
ENSVATH06225608 90 L>F No 1000Genomes
ENSVATH14365033 91 H>L No 1000Genomes
tmp_3_16566047_G_A 95 A>V No 1000Genomes
tmp_3_16566028_G_T 101 D>E No 1000Genomes
ENSVATH14365032 101 D>G No 1000Genomes
ENSVATH12501216 102 K>N No 1000Genomes
ENSVATH14365031 106 F>L No 1000Genomes
tmp_3_16566012_T_G 107 K>Q No 1000Genomes
tmp_3_16566011_T_C 107 K>R No 1000Genomes
ENSVATH06225605 111 K>* No 1000Genomes
ENSVATH06225602 119 N>D No 1000Genomes
ENSVATH06225602 119 N>Y No 1000Genomes
ENSVATH14365030 121 T>S No 1000Genomes
ENSVATH02431921 123 N>S No 1000Genomes
ENSVATH14365029 130 K>E No 1000Genomes
ENSVATH00399564 130 K>T No 1000Genomes
tmp_3_16565672_G_T 131 P>T No 1000Genomes
ENSVATH02431911 134 V>A No 1000Genomes
ENSVATH14365025 136 N>K No 1000Genomes
tmp_3_16565648_T_C 139 N>D No 1000Genomes
ENSVATH14365024 140 A>S No 1000Genomes
ENSVATH02431910 142 A>T No 1000Genomes
ENSVATH06225587 144 V>A No 1000Genomes
ENSVATH06225586 148 G>E No 1000Genomes
ENSVATH06225586 148 G>V No 1000Genomes
tmp_3_16565609_C_A 152 E>* No 1000Genomes
ENSVATH06225585 152 E>D No 1000Genomes
ENSVATH12501177 159 I>S No 1000Genomes
ENSVATH06225584 159 I>V No 1000Genomes
ENSVATH12501176 160 K>* No 1000Genomes
tmp_3_16565579_T_C 162 I>V No 1000Genomes
tmp_3_16565573_C_T 164 E>K No 1000Genomes
tmp_3_16565566_A_G 166 M>T No 1000Genomes
ENSVATH06225581 169 L>P No 1000Genomes
tmp_3_16565530_G_A 178 A>V No 1000Genomes
tmp_3_16565526_C_T 179 W>* No 1000Genomes
ENSVATH12501152 179 W>R No 1000Genomes
tmp_3_16565524_C_T,A 180 S>I No 1000Genomes
tmp_3_16565524_C_T,A 180 S>N No 1000Genomes
tmp_3_16565520_T_A 181 K>N No 1000Genomes
ENSVATH12501151 182 K>I No 1000Genomes
ENSVATH06225580 182 K>N No 1000Genomes
ENSVATH12501151 182 K>T No 1000Genomes
tmp_3_16565516_A_T 183 F>I No 1000Genomes
ENSVATH12501150 186 K>R No 1000Genomes
ENSVATH12501149 187 L>F No 1000Genomes
ENSVATH06225579 189 K>T No 1000Genomes
tmp_3_16565490_G_T 191 Y>* No 1000Genomes
ENSVATH12501148 192 D>Y No 1000Genomes
ENSVATH12501147 196 L>H No 1000Genomes
ENSVATH02431908 198 G>A No 1000Genomes
ENSVATH02431907 200 M>I No 1000Genomes
ENSVATH12501146 201 V>G No 1000Genomes
ENSVATH14365021 203 V>D No 1000Genomes
ENSVATH02431905 213 Y>D No 1000Genomes
ENSVATH02431905 213 Y>N No 1000Genomes
ENSVATH02431904 215 E>K No 1000Genomes
ENSVATH14365020 216 Y>* No 1000Genomes
ENSVATH06225576 218 D>N No 1000Genomes
tmp_3_16565399_C_G 222 V>L No 1000Genomes
ENSVATH06225574 224 R>G No 1000Genomes
ENSVATH14365019 228 V>L No 1000Genomes
tmp_3_16565371_TG_CG,T 231 Q>R No 1000Genomes
tmp_3_16565355_C_G 236 M>I No 1000Genomes
ENSVATH12501111 238 I>T No 1000Genomes
ENSVATH06225573 239 Y>H No 1000Genomes
tmp_3_16565336_C_T 243 D>N No 1000Genomes
ENSVATH12501110 245 D>N No 1000Genomes
ENSVATH12501109 246 G>* No 1000Genomes
ENSVATH12501109 246 G>R No 1000Genomes
tmp_3_16565318_T_A 249 T>S No 1000Genomes
tmp_3_16565314_A_G 250 L>P No 1000Genomes
tmp_3_16565306_C_T 253 E>K No 1000Genomes
tmp_3_16565293_T_G 257 K>T No 1000Genomes
ENSVATH06225572 258 P>T No 1000Genomes
ENSVATH02431900 259 R>* No 1000Genomes
tmp_3_16565281_A_G 261 L>P No 1000Genomes
tmp_3_16565274_G_T 263 N>K No 1000Genomes
ENSVATH14365018 263 N>S No 1000Genomes
ENSVATH00399561 266 P>Q No 1000Genomes
ENSVATH06225571 267 R>C No 1000Genomes
ENSVATH06225570 268 Q>K No 1000Genomes
ENSVATH06225569 268 Q>P No 1000Genomes
ENSVATH12501108 269 R>H No 1000Genomes
ENSVATH06225568 271 L>* No 1000Genomes
tmp_3_16565230_G_A 278 P>L No 1000Genomes
ENSVATH02431898 280 F>L No 1000Genomes
ENSVATH08135921 281 K>* No 1000Genomes
tmp_3_16565220_C_A 281 K>N No 1000Genomes
ENSVATH12501107 284 F>V No 1000Genomes
ENSVATH06225567 287 K>E No 1000Genomes
ENSVATH06225566 288 A>T No 1000Genomes
tmp_3_16565192_C_T 291 V>I No 1000Genomes
tmp_3_16565178_C_T 295 M>I No 1000Genomes
tmp_3_16565174_G_T 297 L>M No 1000Genomes
ENSVATH06225565 298 T>S No 1000Genomes
ENSVATH14365016 308 E>V No 1000Genomes
ENSVATH06225563 311 E>K No 1000Genomes
ENSVATH14365015 315 I>T No 1000Genomes
tmp_3_16565108_G_T 319 L>I No 1000Genomes
ENSVATH12501106 321 V>F No 1000Genomes
ENSVATH06225560 326 F>I No 1000Genomes
ENSVATH02431897 326 F>Y No 1000Genomes
ENSVATH06225559 327 V>I No 1000Genomes
ENSVATH06225558 330 V>I No 1000Genomes
ENSVATH06225557 332 H>L No 1000Genomes
ENSVATH06225557 332 H>R No 1000Genomes
ENSVATH12501105 339 D>H No 1000Genomes
ENSVATH12501105 339 D>N No 1000Genomes
ENSVATH12501064 339 D>V No 1000Genomes
tmp_3_16565038_C_T 342 G>E No 1000Genomes
ENSVATH06225556 348 V>F No 1000Genomes
tmp_3_16565003_T_A 354 T>S No 1000Genomes
ENSVATH06225555 356 D>N No 1000Genomes
ENSVATH02431896 357 M>I No 1000Genomes
tmp_3_16564990_A_G 358 L>S No 1000Genomes
ENSVATH00399559 361 G>R No 1000Genomes
tmp_3_16564979_C_A 362 D>Y No 1000Genomes
tmp_3_16564976_A_G 363 F>L No 1000Genomes
tmp_3_16564973_C_T 364 V>I No 1000Genomes
ENSVATH12501061 365 A>P No 1000Genomes
ENSVATH12501061 365 A>T No 1000Genomes
tmp_3_16564948_G_A 372 T>I No 1000Genomes
ENSVATH06225553 373 V>A No 1000Genomes
ENSVATH12501059 373 V>M No 1000Genomes
ENSVATH14364984 384 M>I No 1000Genomes
ENSVATH12501057 384 M>V No 1000Genomes
ENSVATH12501056 385 G>R No 1000Genomes
tmp_3_16564909_C_A 385 G>V No 1000Genomes
ENSVATH06225551 392 I>K No 1000Genomes
ENSVATH14364983 394 H>K No 1000Genomes

No associated diseases with Q9M1T7

2 regional properties for Q9M1T7

Type Name Position InterPro Accession
conserved_site Serpin, conserved site 363 - 373 IPR023795
domain Serpin domain 11 - 390 IPR023796

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

39 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1JPB0 SERPINB1 Leukocyte elastase inhibitor Bos taurus (Bovine) PR
Q9N2I2 SERPINA5 Plasma serine protease inhibitor Bos taurus (Bovine) PR
Q9TTE1 SERPINA3-1 Serpin A3-1 Bos taurus (Bovine) PR
P41361 SERPINC1 Antithrombin-III Bos taurus (Bovine) PR
P13909 SERPINE1 Plasminogen activator inhibitor 1 Bos taurus (Bovine) PR
A2I7N1 SERPINA3-5 Serpin A3-5 Bos taurus (Bovine) PR
A6QPQ2 SERPINA3-8 Serpin A3-8 Bos taurus (Bovine) PR
A2I7M9 SERPINA3-2 Serpin A3-2 Bos taurus (Bovine) PR
A2I7N2 SERPINA3-6 Serpin A3-6 Bos taurus (Bovine) PR
O73790 SERPINB10 Heterochromatin-associated protein MENT Gallus gallus (Chicken) PR
P05619 SERPINB1 Leukocyte elastase inhibitor Equus caballus (Horse) PR
P01008 SERPINC1 Antithrombin-III Homo sapiens (Human) PR
P08697 SERPINF2 Alpha-2-antiplasmin Homo sapiens (Human) PR
Q96P15 SERPINB11 Serpin B11 Homo sapiens (Human) PR
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Homo sapiens (Human) PR
P05121 SERPINE1 Plasminogen activator inhibitor 1 Homo sapiens (Human) PR
P05155 SERPING1 Plasma protease C1 inhibitor Homo sapiens (Human) PR
P01011 SERPINA3 Alpha-1-antichymotrypsin Homo sapiens (Human) PR
Q86WD7 SERPINA9 Serpin A9 Homo sapiens (Human) PR
P07093 SERPINE2 Glia-derived nexin Homo sapiens (Human) PR
P12388 Serpinb2 Plasminogen activator inhibitor 2, macrophage Mus musculus (Mouse) PR
P32261 Serpinc1 Antithrombin-III Mus musculus (Mouse) PR
Q07235 Serpine2 Glia-derived nexin Mus musculus (Mouse) PR
Q5SV42 Serpinb1c Leukocyte elastase inhibitor C Mus musculus (Mouse) PR
Q80X76 Serpina3f Serine protease inhibitor A3F Mus musculus (Mouse) PR
Q8BYY9 Serpina3b Serine protease inhibitor A3B Mus musculus (Mouse) PR
Q9D154 Serpinb1a Leukocyte elastase inhibitor A Mus musculus (Mouse) PR
Q9JK88 Serpini2 Serpin I2 Mus musculus (Mouse) PR
Q8CDC0 Serpinb13 Serpin B13 Mus musculus (Mouse) PR
P22777 Serpine1 Plasminogen activator inhibitor 1 Mus musculus (Mouse) PR
Q5I2A0 Serpina3g Serine protease inhibitor A3G Mus musculus (Mouse) PR
Q62975 Serpina10 Protein Z-dependent protease inhibitor Rattus norvegicus (Rat) PR
P29524 Serpinb2 Plasminogen activator inhibitor 2 type A Rattus norvegicus (Rat) PR
Q6P734 Serping1 Plasma protease C1 inhibitor Rattus norvegicus (Rat) PR
P05545 Serpina3k Serine protease inhibitor A3K Rattus norvegicus (Rat) PR
P07092 Serpine2 Glia-derived nexin Rattus norvegicus (Rat) PR
P05544 Serpina3l Serine protease inhibitor A3L Rattus norvegicus (Rat) PR
O48706 At2g26390 Serpin-Z3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR6 At2g14540 Serpin-Z2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MELGKSMENQ TDVMVLLAKH VIPTVANGSN LVFSPMSINV LLCLIAAGSN CVTKEQILSF
70 80 90 100 110 120
IMLPSSDYLN AVLAKTVSVA LNDGMERSDL HLSTAYGVWI DKSLSFKPSF KDLLENSYNA
130 140 150 160 170 180
TCNQVDFATK PAEVINEVNA WAEVHTNGLI KEILSDDSIK TIRESMLILA NAVYFKGAWS
190 200 210 220 230 240
KKFDAKLTKS YDFHLLDGTM VKVPFMTNYK KQYLEYYDGF KVLRLPYVED QRQFAMYIYL
250 260 270 280 290 300
PNDRDGLPTL LEEISSKPRF LDNHIPRQRI LTEAFKIPKF KFSFEFKASD VLKEMGLTLP
310 320 330 340 350 360
FTHGSLTEMV ESPSIPENLC VAENLFVSNV FHKACIEVDE EGTEAAAVSV ASMTKDMLLM
370 380 390
GDFVADHPFL FTVREEKSGV ILFMGQVLDP SIH