P05619
Gene name |
SERPINB1 (ELANH2) |
Protein name |
Leukocyte elastase inhibitor |
Names |
LEI, Serpin B1 |
Species |
Equus caballus (Horse) |
KEGG Pathway |
ecb:100049797 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P05619
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1HLE | X-ray | 195 A | PDB | ||
| AF-P05619-F1 | Predicted | AlphaFoldDB |
No variants for P05619
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P05619 | |||||
No associated diseases with P05619
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytolytic granule | A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| serine-type endopeptidase inhibitor activity | Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of endopeptidase activity | Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. |
| negative regulation of interleukin-1 beta production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q1JPB0 | SERPINB1 | Leukocyte elastase inhibitor | Bos taurus (Bovine) | PR |
| Q9D154 | Serpinb1a | Leukocyte elastase inhibitor A | Mus musculus (Mouse) | PR |
| Q5SV42 | Serpinb1c | Leukocyte elastase inhibitor C | Mus musculus (Mouse) | PR |
| Q9ZQR6 | At2g14540 | Serpin-Z2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1T7 | At3g45220 | Serpin-Z4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48706 | At2g26390 | Serpin-Z3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEQLSTANTH | FAVDLFRALN | ESDPTGNIFI | SPLSISSALA | MIFLGTRGNT | AAQVSKALYF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DTVEDIHSRF | QSLNADINKP | GAPYILKLAN | RLYGEKTYNF | LADFLASTQK | MYGAELASVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FQQAPEDARK | EINEWVKGQT | EGKIPELLVK | GMVDNMTKLV | LVNAIYFKGN | WQEKFMKEAT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDAPFRLNKK | DTKTVKMMYQ | KKKFPYNYIE | DLKCRVLELP | YQGKELSMII | LLPDDIEDES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TGLEKIEKQL | TLEKLREWTK | PENLYLAEVN | VHLPRFKLEE | SYDLTSHLAR | LGVQDLFNRG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KADLSGMSGA | RDLFVSKIIH | KSFVDLNEEG | TEAAAATAGT | IMLAMLMPEE | NFNADHPFIF |
| 370 | |||||
| FIRHNPSANI | LFLGRFSSP |