Q9D154
PR
Gene name |
Serpinb1a (Serpinb1) |
Protein name |
Leukocyte elastase inhibitor A |
Names |
Serine protease inhibitor EIA, Serpin B1a |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66222 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D154
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D154-F1 | Predicted | AlphaFoldDB |
37 variants for Q9D154
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs238847681 | 17 | Q>H | No | EVA | |
| rs225030757 | 28 | I>V | No | EVA | |
| rs29899922 | 43 | I>F | No | EVA | |
| rs3389279855 | 47 | K>I | No | EVA | |
| rs3404015356 | 49 | S>R | No | EVA | |
| rs244542960 | 55 | S>F | No | EVA | |
| rs29899923 | 63 | V>A | No | EVA | |
| rs3404043304 | 66 | I>F | No | EVA | |
| rs239809018 | 69 | R>G | No | EVA | |
| rs239809018 | 69 | R>S | No | EVA | |
| rs3404034281 | 71 | Q>E | No | EVA | |
| rs3403272999 | 71 | Q>R | No | EVA | |
| rs3404093227 | 73 | L>V | No | EVA | |
| rs3389288816 | 111 | M>I | No | EVA | |
| rs29900827 | 112 | Y>C | No | EVA | |
| rs3389283642 | 120 | D>G | No | EVA | |
| rs29900829 | 122 | L>Q | No | EVA | |
| rs3389243576 | 127 | D>N | No | EVA | |
| rs3389278109 | 131 | E>V | No | EVA | |
| rs16797147 | 149 | S>A | No | EVA | |
| rs3389274305 | 149 | S>C | No | EVA | |
| rs3389269197 | 169 | G>* | No | EVA | |
| rs248525168 | 178 | E>Q | No | EVA | |
| rs3389276043 | 201 | K>M | No | EVA | |
| rs3389276065 | 217 | L>V | No | EVA | |
| rs3389283632 | 223 | G>S | No | EVA | |
| rs29900833 | 228 | M>T | No | EVA | |
| rs8273594 | 256 | L>R | No | EVA | |
| rs3389288807 | 270 | H>Q | No | EVA | |
| rs3389283607 | 290 | R>C | No | EVA | |
| rs3389279869 | 296 | L>I | No | EVA | |
| rs3389250891 | 313 | L>F | No | EVA | |
| rs255613597 | 323 | F>Y | No | EVA | |
| rs1134839299 | 332 | E>K | No | EVA | |
| rs3389260596 | 340 | I>T | No | EVA | |
| rs3389243626 | 363 | R>Q | No | EVA | |
| rs3389279868 | 371 | L>F | No | EVA |
No associated diseases with Q9D154
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
| cytolytic granule | A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. |
| cytoplasmic ribonucleoprotein granule | A ribonucleoprotein granule located in the cytoplasm. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| peptidase inhibitor activity | Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. |
| serine-type endopeptidase inhibitor activity | Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular homeostasis | Any process involved in the maintenance of an internal steady state at the level of the cell. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| negative regulation of endopeptidase activity | Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. |
| negative regulation of interleukin-1 beta production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. |
| regulation of innate immune response | Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. |
| regulation of protein catabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| type B pancreatic cell proliferation | The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. |
36 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9N2I2 | SERPINA5 | Plasma serine protease inhibitor | Bos taurus (Bovine) | PR |
| P41361 | SERPINC1 | Antithrombin-III | Bos taurus (Bovine) | PR |
| A6QPQ2 | SERPINA3-8 | Serpin A3-8 | Bos taurus (Bovine) | PR |
| A2I7N1 | SERPINA3-5 | Serpin A3-5 | Bos taurus (Bovine) | PR |
| P13909 | SERPINE1 | Plasminogen activator inhibitor 1 | Bos taurus (Bovine) | PR |
| Q9TTE1 | SERPINA3-1 | Serpin A3-1 | Bos taurus (Bovine) | PR |
| Q1JPB0 | SERPINB1 | Leukocyte elastase inhibitor | Bos taurus (Bovine) | PR |
| O73790 | SERPINB10 | Heterochromatin-associated protein MENT | Gallus gallus (Chicken) | PR |
| P05619 | SERPINB1 | Leukocyte elastase inhibitor | Equus caballus (Horse) | PR |
| P05121 | SERPINE1 | Plasminogen activator inhibitor 1 | Homo sapiens (Human) | PR |
| Q9UK55 | SERPINA10 | Protein Z-dependent protease inhibitor | Homo sapiens (Human) | PR |
| P05155 | SERPING1 | Plasma protease C1 inhibitor | Homo sapiens (Human) | PR |
| P08697 | SERPINF2 | Alpha-2-antiplasmin | Homo sapiens (Human) | PR |
| Q86WD7 | SERPINA9 | Serpin A9 | Homo sapiens (Human) | PR |
| P01008 | SERPINC1 | Antithrombin-III | Homo sapiens (Human) | PR |
| P07093 | SERPINE2 | Glia-derived nexin | Homo sapiens (Human) | PR |
| Q96P15 | SERPINB11 | Serpin B11 | Homo sapiens (Human) | PR |
| P01011 | SERPINA3 | Alpha-1-antichymotrypsin | Homo sapiens (Human) | PR |
| P12388 | Serpinb2 | Plasminogen activator inhibitor 2, macrophage | Mus musculus (Mouse) | PR |
| P32261 | Serpinc1 | Antithrombin-III | Mus musculus (Mouse) | PR |
| Q07235 | Serpine2 | Glia-derived nexin | Mus musculus (Mouse) | PR |
| Q5SV42 | Serpinb1c | Leukocyte elastase inhibitor C | Mus musculus (Mouse) | PR |
| Q80X76 | Serpina3f | Serine protease inhibitor A3F | Mus musculus (Mouse) | PR |
| Q8BYY9 | Serpina3b | Serine protease inhibitor A3B | Mus musculus (Mouse) | PR |
| Q9JK88 | Serpini2 | Serpin I2 | Mus musculus (Mouse) | PR |
| Q8CDC0 | Serpinb13 | Serpin B13 | Mus musculus (Mouse) | PR |
| P22777 | Serpine1 | Plasminogen activator inhibitor 1 | Mus musculus (Mouse) | PR |
| Q5I2A0 | Serpina3g | Serine protease inhibitor A3G | Mus musculus (Mouse) | PR |
| P29524 | Serpinb2 | Plasminogen activator inhibitor 2 type A | Rattus norvegicus (Rat) | PR |
| Q6P734 | Serping1 | Plasma protease C1 inhibitor | Rattus norvegicus (Rat) | PR |
| P05545 | Serpina3k | Serine protease inhibitor A3K | Rattus norvegicus (Rat) | PR |
| P07092 | Serpine2 | Glia-derived nexin | Rattus norvegicus (Rat) | PR |
| Q62975 | Serpina10 | Protein Z-dependent protease inhibitor | Rattus norvegicus (Rat) | PR |
| O48706 | At2g26390 | Serpin-Z3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1T7 | At3g45220 | Serpin-Z4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR6 | At2g14540 | Serpin-Z2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEQLSSANTL | FALELFQTLN | ESSPTGNIFF | SPFSISSALA | MVILGAKGST | AAQLSKTFHF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DSVEDIHSRF | QSLNAEVSKR | GASHTLKLAN | RLYGEKTYNF | LPEYLASTQK | MYGADLAPVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLHASEDARK | EINQWVKGQT | EGKIPELLSV | GVVDSMTKLV | LVNAIYFKGM | WEEKFMTEDT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TDAPFRLSKK | DTKTVKMMYQ | KKKFPFGYIS | DLKCKVLEMP | YQGGELSMVI | LLPKDIEDES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TGLKKIEKQI | TLEKLLEWTK | RENLEFIDVH | VKLPRFKIEE | SYTLNSNLGR | LGVQDLFSSS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KADLSGMSGS | RDLFISKIVH | KSFVEVNEEG | TEAAAATGGI | ATFCMLLPEE | EFTVDHPFIF |
| 370 | |||||
| FIRHNPTSNV | LFLGRVCSP |