P05121
PR
Gene name |
SERPINE1 (PAI1, PLANH1) |
Protein name |
Plasminogen activator inhibitor 1 |
Names |
PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5054 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
30 structures for P05121
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1A7C | X-ray | 195 A | A | 24-402 | PDB |
| 1B3K | X-ray | 299 A | A/B/C/D | 24-402 | PDB |
| 1C5G | X-ray | 260 A | A | 1-402 | PDB |
| 1DB2 | X-ray | 270 A | A/B | 26-402 | PDB |
| 1DVM | X-ray | 240 A | A/B/C/D | 24-402 | PDB |
| 1DVN | X-ray | 210 A | A | 24-402 | PDB |
| 1LJ5 | X-ray | 180 A | A | 24-402 | PDB |
| 1OC0 | X-ray | 228 A | A | 24-402 | PDB |
| 3CVM | X-ray | 202 A | A/B | 21-402 | PDB |
| 3EOX | X-ray | 261 A | A | 24-402 | PDB |
| 3PB1 | X-ray | 230 A | I | 24-402 | PDB |
| 3Q02 | X-ray | 230 A | A/B | 24-402 | PDB |
| 3Q03 | X-ray | 264 A | A/B | 24-402 | PDB |
| 3R4L | X-ray | 270 A | A | 24-402 | PDB |
| 3UT3 | X-ray | 242 A | A/B/C/D | 28-402 | PDB |
| 4AQH | X-ray | 240 A | A/B/C | 24-402 | PDB |
| 4G8O | X-ray | 271 A | A/B/C/D | 28-402 | PDB |
| 4G8R | X-ray | 219 A | A/B | 28-402 | PDB |
| 4IC0 | X-ray | 232 A | A/B/C/D | 24-402 | PDB |
| 5BRR | X-ray | 316 A | I | 24-402 | PDB |
| 5ZLZ | X-ray | 358 A | I | 29-402 | PDB |
| 6GWN | X-ray | 203 A | A | 24-402 | PDB |
| 6GWP | X-ray | 228 A | A | 24-402 | PDB |
| 6GWQ | X-ray | 232 A | A | 24-402 | PDB |
| 6I8S | X-ray | 290 A | A/B/C/D | 24-402 | PDB |
| 6ZRV | X-ray | 188 A | A | 24-402 | PDB |
| 7AQF | X-ray | 177 A | A/B | 24-402 | PDB |
| 7AQG | X-ray | 227 A | A | 24-402 | PDB |
| 9PAI | X-ray | 270 A | PDB | ||
| AF-P05121-F1 | Predicted | AlphaFoldDB |
358 variants for P05121
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
RCV001530150 RCV001723567 rs6092 VAR_007099 RCV000014541 RCV001807002 CA123260 |
15 | A>T | Susceptibility to severe coronavirus disease (COVID-19) due to an impaired coagulation process Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs6090 CA4405511 RCV001653713 VAR_011750 RCV000325357 |
17 | V>I | Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV001165029 rs1412176159 |
50 | S>C | Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinVar dbSNP |
|
COSM1446805 CA4405538 RCV000389274 rs758271488 |
64 | S>L | Variant assessed as Somatic; 0.0 impact. large_intestine Congenital plasminogen activator inhibitor type 1 deficiency [NCI-TCGA, Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
rs1554362148 RCV000577798 |
120 | I>missing | Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinVar dbSNP |
|
CA4405670 RCV001158319 rs2227669 VAR_013087 |
209 | R>H | Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA4405673 RCV000282113 rs766181190 |
217 | G>S | Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV000577196 rs1194865614 |
234 | T>missing | Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinVar dbSNP |
|
rs745829911 RCV001333537 CA4405711 |
240 | D>G | Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
CA10627850 rs750289183 RCV000337075 |
282 | I>S | Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
RCV001161522 rs1796546340 |
312 | P>S | Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinVar dbSNP |
|
CA4405769 rs192692662 RCV001161523 |
330 | T>M | Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
rs1796549628 RCV001161524 |
332 | L>P | Congenital plasminogen activator inhibitor type 1 deficiency [ClinVar] | Yes |
ClinVar dbSNP |
| TCGA novel | 2 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4405504 rs745834082 |
3 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA368593913 rs1302913603 |
5 | P>T | No |
ClinGen gnomAD |
|
|
rs1584902704 CA368593980 |
8 | T>P | No |
ClinGen Ensembl |
|
|
CA368593989 rs1156277677 |
8 | T>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA4405505 rs772178086 |
9 | C>F | No |
ClinGen ExAC gnomAD |
|
|
CA4405508 rs763507112 |
13 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA368594104 rs1411224107 |
16 | L>F | No |
ClinGen gnomAD |
|
|
CA368594123 rs1268101578 |
17 | V>A | No |
ClinGen gnomAD |
|
|
CA4405512 rs370185023 |
18 | F>S | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1178751523 CA368594159 |
19 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA368594164 rs1178751523 |
19 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
CA4405513 rs768073380 |
20 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs1418764262 CA368594259 |
23 | A>V | No |
ClinGen gnomAD |
|
|
rs753201992 CA4405514 |
24 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4405515 VAR_013086 rs2227647 |
25 | H>P | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs777658507 CA4405516 |
27 | P>H | No |
ClinGen ExAC gnomAD |
|
|
rs1163437425 CA368594325 |
27 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA368594321 rs1163437425 |
27 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1213710187 CA368594339 |
28 | P>A | No |
ClinGen TOPMed |
|
|
rs754112992 CA4405517 |
28 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754112992 CA368594345 |
28 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1562851529 CA368594350 |
29 | S>T | No |
ClinGen Ensembl |
|
|
rs969458866 CA163329382 |
30 | Y>H | No |
ClinGen Ensembl |
|
|
CA4405520 rs141347752 |
31 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4405519 rs141347752 |
31 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 36 | S>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs771977842 CA4405521 |
37 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs912771018 CA163329423 |
39 | G>E | No |
ClinGen Ensembl |
|
|
rs1246094084 CA368594551 |
39 | G>R | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 39 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1246094084 CA368594558 |
39 | G>W | No |
ClinGen TOPMed gnomAD |
|
|
CA368594579 rs1290883786 |
40 | V>A | No |
ClinGen gnomAD |
|
|
CA163329432 rs910203879 |
40 | V>L | No |
ClinGen TOPMed |
|
|
CA4405523 rs549581756 |
41 | R>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs768221689 CA4405524 |
41 | R>K | No |
ClinGen ExAC |
|
|
rs775950945 CA4405525 |
42 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA368594677 rs1174856192 |
46 | V>A | No |
ClinGen TOPMed |
|
|
rs769368888 CA4405527 |
47 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs772841880 CA4405528 |
47 | A>V | Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs767807262 CA4405530 |
48 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1183093492 CA368594707 |
48 | Q>R | No |
ClinGen gnomAD |
|
|
CA4405531 rs753220162 |
49 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA368594751 rs1412176159 |
50 | S>F | No |
ClinGen gnomAD |
|
|
rs533560118 CA163329461 |
51 | K>R | No |
ClinGen gnomAD |
|
|
CA4405532 rs761039040 |
53 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764266756 CA4405533 |
53 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA368594813 rs1562851602 |
54 | N>D | No |
ClinGen Ensembl |
|
|
rs1384573586 CA368594842 |
55 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1468978490 CA368594934 |
59 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1562851610 CA368594922 |
59 | P>T | No |
ClinGen Ensembl |
|
|
CA368594943 rs1584902848 |
60 | Y>H | No |
ClinGen Ensembl |
|
|
CA4405537 rs564909482 |
62 | V>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs781150795 CA4405542 |
65 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA4405541 rs768436491 |
65 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA368595047 rs768436491 |
65 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs867364951 CA163329511 |
67 | A>V | No |
ClinGen Ensembl |
|
|
CA163329514 rs886882915 |
68 | M>I | No |
ClinGen Ensembl |
|
|
CA4405544 rs769345666 |
68 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA368595111 rs1172504400 |
68 | M>V | No |
ClinGen gnomAD |
|
|
CA368595137 rs772860311 |
69 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4405545 rs772860311 |
69 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4405546 rs748885714 |
70 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA4405547 rs772448319 |
72 | T>K | No |
ClinGen ExAC |
|
|
rs374379570 CA4405548 |
73 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4405549 rs761071307 |
74 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764559730 COSM263592 CA4405550 |
75 | G>R | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs1407807387 CA368595284 |
76 | E>D | No |
ClinGen gnomAD |
|
|
CA4405551 rs777180184 |
76 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1584902881 CA368595288 |
77 | T>P | No |
ClinGen Ensembl |
|
|
rs1356999242 CA368595308 |
78 | Q>* | No |
ClinGen gnomAD |
|
|
rs1004257916 CA163329545 |
79 | Q>K | No |
ClinGen Ensembl |
|
|
CA163329547 rs936249320 |
80 | Q>* | No |
ClinGen TOPMed |
|
|
CA4405552 rs367935516 |
80 | Q>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1054664524 CA163329549 |
81 | I>L | No |
ClinGen TOPMed |
|
|
rs894462774 CA163329562 |
81 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA163329582 rs1056808887 |
84 | A>T | No |
ClinGen Ensembl |
|
|
rs1270639960 CA368595429 |
84 | A>V | No |
ClinGen gnomAD |
|
|
CA368595437 rs1308315286 |
85 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
rs765341520 CA4405553 |
86 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs370298461 CA163329587 |
86 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA4405554 rs750687454 |
87 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs766305135 CA4405556 |
89 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs758640987 CA4405555 |
89 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA4405557 rs751348120 |
90 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs1334796440 CA368595638 |
91 | D>N | No |
ClinGen gnomAD |
|
|
CA368597697 rs1158659403 |
91 | D>V | No |
ClinGen gnomAD |
|
|
rs1301119420 CA368597707 |
92 | K>E | No |
ClinGen gnomAD |
|
|
CA4405577 rs767288984 |
93 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA368597730 rs1379085902 |
93 | G>S | No |
ClinGen gnomAD |
|
|
CA368597750 rs1366089122 |
94 | M>K | No |
ClinGen gnomAD |
|
|
CA4405578 rs752603739 |
94 | M>L | No |
ClinGen ExAC gnomAD |
|
|
CA368597755 rs1366089122 |
94 | M>T | No |
ClinGen gnomAD |
|
|
CA4405579 rs756006462 |
95 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1321293769 CA368597784 |
96 | P>A | No |
ClinGen gnomAD |
|
|
rs1000112229 CA163331418 |
97 | A>D | No |
ClinGen Ensembl |
|
|
rs748847141 CA4405581 |
97 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748847141 CA368597802 |
97 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4405584 rs745457018 |
98 | L>P | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA368597875 rs781571389 |
99 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781571389 CA4405586 |
99 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4405585 rs144953342 |
99 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4405587 rs748629078 |
102 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA4405588 rs770461092 |
103 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 103 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA368597961 rs770461092 |
103 | K>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773829498 CA4405589 |
103 | K>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 104 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs763181047 CA4405590 |
104 | E>D | No |
ClinGen ExAC |
|
|
CA368598046 rs1439202506 |
105 | L>F | No |
ClinGen gnomAD |
|
|
rs61731296 CA163331471 |
106 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1237175559 CA368598117 |
107 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1184872386 CA368598169 |
109 | W>R | No |
ClinGen gnomAD |
|
|
CA163331484 rs3177930 |
112 | D>E | No |
ClinGen TOPMed |
|
|
rs747738685 CA4405592 |
113 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1052385929 CA163331525 |
114 | I>N | No |
ClinGen TOPMed |
|
|
rs373286742 CA4405593 |
116 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 117 | T>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1160652873 CA368598452 |
118 | D>V | No |
ClinGen TOPMed |
|
|
CA4405594 rs767250801 |
119 | A>T | No |
ClinGen ExAC gnomAD |
|
|
COSM76382 CA4405595 rs143027028 |
119 | A>V | ovary large_intestine Variant assessed as Somatic; 4.619e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA4405597 rs764077552 |
120 | I>L | No |
ClinGen ExAC gnomAD |
|
|
CA4405599 rs756762479 |
122 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA368598618 rs1315768244 |
123 | Q>P | No |
ClinGen gnomAD |
|
|
rs199790102 CA4405601 |
124 | R>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs778426934 CA4405600 |
124 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs1272429081 CA368598766 |
126 | L>P | No |
ClinGen gnomAD |
|
|
CA4405602 rs371649267 |
129 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1195570280 CA368598890 |
130 | Q>R | No |
ClinGen gnomAD |
|
|
rs779538982 CA4405603 |
131 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA368598898 rs1407805280 |
131 | G>S | No |
ClinGen gnomAD |
|
|
rs140708600 CA4405604 |
133 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA163331603 rs960899840 |
134 | P>S | No |
ClinGen TOPMed |
|
|
CA368599042 rs1325311758 |
135 | H>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 136 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs778431418 CA4405607 |
138 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778431418 CA4405606 |
138 | R>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA368599198 rs1439863093 |
138 | R>S | No |
ClinGen gnomAD |
|
|
rs771160520 CA368599260 |
140 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs145904727 CA4405610 |
141 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs377193732 CA4405609 |
141 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4405611 rs772387173 |
142 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4405612 rs775562788 |
143 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA368599377 rs1471047784 |
144 | V>I | No |
ClinGen gnomAD |
|
|
CA368599565 rs1401676588 |
147 | V>A | No |
ClinGen gnomAD |
|
|
CA368599575 rs1394354035 |
148 | D>A | No |
ClinGen gnomAD |
|
|
rs760533002 CA4405613 |
148 | D>N | No |
ClinGen ExAC |
|
|
rs181510325 CA4405615 |
151 | E>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA368599707 rs1276645231 |
155 | A>T | No |
ClinGen gnomAD |
|
|
RCV000998870 CA4405618 rs375620822 |
157 | F>L | No |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs757822025 CA4405619 |
157 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA163331709 rs375620822 |
157 | F>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs370663207 CA163331722 |
158 | I>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP NCI-TCGA TOPMed gnomAD |
| TCGA novel | 161 | D>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs756563242 CA4405622 |
163 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778237251 CA4405623 |
164 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs78007052 CA163331762 |
165 | T>K | No |
ClinGen Ensembl |
|
|
rs535214895 CA4405624 |
166 | H>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA163331771 rs557000407 |
168 | K>I | No |
ClinGen 1000Genomes |
|
|
CA368600027 rs1481295241 |
169 | G>C | No |
ClinGen gnomAD |
|
|
rs1481295241 CA368600023 |
169 | G>R | No |
ClinGen gnomAD |
|
|
CA368601511 rs1293261017 |
170 | M>I | No |
ClinGen gnomAD |
|
|
CA4405638 rs200926782 |
170 | M>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA163332962 rs1021341926 |
170 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
CA4405639 rs754641182 |
173 | N>I | No |
ClinGen ExAC gnomAD |
|
|
CA4405640 rs142959808 |
175 | L>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM1330218 CA368601696 rs538785036 |
176 | G>A | ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA368601691 rs538785036 |
176 | G>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4405641 rs372569598 |
176 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4405642 rs538785036 |
176 | G>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA163333012 rs879741706 |
177 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA368601750 rs1361456822 |
178 | G>E | No |
ClinGen TOPMed gnomAD |
|
|
rs779542683 CA4405644 |
179 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA4405643 rs779542683 |
179 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs747262372 CA4405647 |
180 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA4405646 rs553824895 |
180 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA368601954 rs1387664877 |
185 | R>Q | No |
ClinGen gnomAD |
|
|
rs371179958 CA4405649 |
185 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA163333054 rs917912294 |
186 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA4405654 rs762753334 |
187 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA4405652 rs769468957 |
187 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA4405653 rs769468957 |
187 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA368602006 rs1400537035 |
188 | L>M | No |
ClinGen TOPMed gnomAD |
|
|
CA368602005 rs1400537035 |
188 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA4405656 rs774049333 |
189 | V>G | No |
ClinGen ExAC |
|
|
CA368602039 rs1306396904 |
189 | V>L | No |
ClinGen gnomAD |
|
| TCGA novel | 190 | N>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA368602132 rs1247505082 |
191 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA368602157 rs1356660327 |
192 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA4405657 rs759099647 |
192 | L>H | No |
ClinGen ExAC gnomAD |
|
|
rs758074613 CA163333070 |
194 | F>L | No |
ClinGen Ensembl |
|
|
CA368602264 rs1228748020 |
195 | N>S | No |
ClinGen gnomAD |
|
|
rs373629815 CA368602307 |
196 | G>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs373629815 CA4405659 |
196 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4405661 rs765464397 |
201 | P>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 201 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4405664 rs138796302 |
204 | D>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs138796302 CA368602572 |
204 | D>Y | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4405665 rs751682719 |
206 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs149389532 CA4405666 |
207 | T>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA368602721 rs1584904755 |
208 | H>P | No |
ClinGen Ensembl |
|
|
CA4405669 rs769654703 |
209 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs769654703 CA368602758 |
209 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA4405671 rs139905333 |
210 | R>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs911085721 COSM1225297 CA163333200 |
210 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
rs1468734742 CA368602946 |
215 | S>P | No |
ClinGen TOPMed |
|
| TCGA novel | 216 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4405674 rs147436426 |
217 | G>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1266645675 CA368603123 |
221 | S>A | No |
ClinGen TOPMed |
|
|
CA4405677 rs551548804 |
223 | P>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 224 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 224 | M>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA163333243 rs990899872 |
225 | M>I | No |
ClinGen Ensembl |
|
|
rs750789513 CA4405679 |
225 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA4405680 rs763351020 |
226 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs766930087 CA4405681 |
227 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs560280276 CA4405682 |
228 | T>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs147003064 CA4405683 COSM1083375 |
232 | N>S | endometrium [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
rs549003197 CA4405684 |
233 | Y>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs376831061 CA163333264 |
234 | T>A | No |
ClinGen ESP |
|
|
CA368605030 rs1417668709 |
235 | E>D | No |
ClinGen gnomAD |
|
|
rs868625431 CA163334899 |
235 | E>Q | No |
ClinGen Ensembl |
|
|
rs1304682189 CA368605038 |
236 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA4405706 rs201327802 |
238 | T>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4405705 rs201327802 |
238 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA368605086 rs1459258169 |
239 | P>S | No |
ClinGen TOPMed |
|
|
rs778805248 CA4405710 |
240 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA368605133 rs1471559567 |
241 | G>C | No |
ClinGen TOPMed |
|
|
CA4405713 rs780015524 |
241 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA163335018 rs140766181 |
242 | H>R | No |
ClinGen ESP gnomAD |
|
| TCGA novel | 243 | Y>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4405714 rs13306846 |
243 | Y>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 244 | Y>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA163335034 rs925558545 |
244 | Y>N | No |
ClinGen Ensembl |
|
|
CA368605452 rs935466066 |
251 | Y>C | No |
ClinGen TOPMed |
|
|
rs935466066 CA163335046 |
251 | Y>F | No |
ClinGen TOPMed |
|
|
rs200763116 CA368605522 |
252 | H>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs771305881 CA163335073 CA4405718 |
253 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs2227685 VAR_013088 CA4405719 |
255 | T>N | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1391270191 CA368605639 |
257 | S>N | No |
ClinGen gnomAD |
|
| TCGA novel | 258 | M>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA368605747 rs1404538620 |
260 | I>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs759873081 CA4405720 |
262 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1327659431 CA368605811 |
262 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
| TCGA novel | 267 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA368605934 rs1402686368 |
267 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA368605985 rs1375343799 |
269 | P>S | No |
ClinGen gnomAD |
|
|
rs1248718701 CA368606014 |
270 | L>F | No |
ClinGen gnomAD |
|
|
CA368606022 rs1285293087 |
270 | L>P | No |
ClinGen gnomAD |
|
|
CA4405723 rs149701969 |
275 | N>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1388735914 CA368606138 |
275 | N>T | No |
ClinGen TOPMed |
|
|
CA368606184 rs1395015519 |
277 | L>P | No |
ClinGen TOPMed |
|
|
rs764180921 CA4405724 |
278 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1458782972 CA368606238 |
278 | S>T | No |
ClinGen gnomAD |
|
|
rs564553385 CA4405726 |
280 | Q>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA4405725 rs543475314 |
280 | Q>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1414138018 CA368606292 |
281 | L>V | No |
ClinGen TOPMed |
|
|
rs750289183 CA4405728 |
282 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs531963456 CA4405727 |
282 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1185403949 CA368606389 |
283 | S>G | No |
ClinGen gnomAD |
|
|
CA368606574 rs1562854376 |
287 | G>D | No |
ClinGen Ensembl |
|
|
rs140246744 CA4405730 |
289 | M>T | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1466284757 CA368606702 |
291 | R>S | No |
ClinGen gnomAD |
|
|
CA4405731 rs746896756 |
292 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA4405732 rs754458995 |
293 | P>S | No |
ClinGen ExAC gnomAD |
|
|
COSM598099 CA368606745 rs1397842827 |
294 | R>C | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs887033206 CA163335193 |
294 | R>H | No |
ClinGen gnomAD |
|
|
rs1397842827 CA368606744 |
294 | R>S | No |
ClinGen TOPMed gnomAD |
|
|
rs780703207 CA4405733 |
295 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs747628598 CA4405735 |
298 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA4405754 rs377501438 |
304 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1199684449 CA368608388 |
305 | T>S | No |
ClinGen gnomAD |
|
|
CA4405757 rs780429425 |
308 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4405758 rs780429425 |
308 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 313 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1296684862 CA368608746 |
318 | M>V | No |
ClinGen gnomAD |
|
|
CA4405766 rs145850643 |
320 | D>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4405765 rs777942007 |
320 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA163336603 rs529264179 |
321 | M>I | No |
ClinGen 1000Genomes TOPMed |
|
|
rs1231406706 CA368608837 |
321 | M>T | No |
ClinGen gnomAD |
|
|
CA4405767 rs766116768 |
322 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA163336646 rs1045857286 |
323 | R>G | No |
ClinGen TOPMed |
|
|
rs751408893 CA4405768 |
324 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1291359676 CA368608981 |
327 | A>V | No |
ClinGen TOPMed |
|
|
rs893552747 CA163336664 |
329 | F>V | No |
ClinGen TOPMed |
|
| TCGA novel | 333 | S>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs369508275 CA4405771 |
333 | S>L | No |
ClinGen ESP ExAC gnomAD |
|
|
CA4405788 rs759379433 |
334 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA368609312 rs1241850186 |
334 | D>G | No |
ClinGen TOPMed |
|
|
rs767243000 CA4405789 |
337 | P>T | No |
ClinGen ExAC |
|
|
CA163336820 rs1057408995 |
338 | L>F | No |
ClinGen TOPMed |
|
|
COSM1083378 rs760569885 CA4405791 |
340 | V>I | Variant assessed as Somatic; 0.0 impact. large_intestine central_nervous_system endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs750889471 CA4405793 |
341 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4405794 rs371573254 |
341 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs749973541 CA4405796 |
342 | Q>* | No |
ClinGen ExAC |
|
|
rs138483939 CA4405797 |
343 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 345 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA368609589 rs1421718220 |
345 | Q>L | No |
ClinGen TOPMed |
|
|
CA4405799 rs748696643 |
346 | K>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA368609630 rs1172800950 |
347 | V>L | No |
ClinGen TOPMed |
|
|
CA368609646 rs1452730496 |
348 | K>* | No |
ClinGen TOPMed gnomAD |
|
|
CA368609717 rs376197859 |
350 | E>* | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1461650727 CA368609723 |
350 | E>A | No |
ClinGen gnomAD |
|
|
rs376197859 CA4405801 |
350 | E>K | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1485291892 CA368609755 |
351 | V>G | No |
ClinGen TOPMed |
|
|
rs774647903 CA4405804 |
353 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA368609876 rs1393365660 |
355 | G>R | No |
ClinGen gnomAD |
|
|
CA368609961 rs1483835602 |
356 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
CA163336949 rs941358919 |
357 | V>L | No |
ClinGen gnomAD |
|
|
rs941358919 CA368609970 |
357 | V>M | No |
ClinGen gnomAD |
|
|
CA368609997 rs1473675544 |
358 | A>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1479001553 CA368610088 |
360 | S>L | No |
ClinGen gnomAD |
|
| TCGA novel | 361 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1021843188 CA163338132 |
364 | V>L | No |
ClinGen gnomAD |
|
|
CA4405833 rs751191243 |
365 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA4405834 rs761137404 |
366 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA163338168 rs967536478 |
367 | S>L | No |
ClinGen Ensembl |
|
|
CA368610769 rs1356324635 |
368 | A>T | No |
ClinGen TOPMed |
|
|
CA368610792 rs1478090168 |
368 | A>V | No |
ClinGen gnomAD |
|
|
CA368610799 rs1329851142 |
369 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA4405835 rs764318362 |
369 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754403277 CA4405836 |
370 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA163338186 rs52795188 |
370 | M>K | No |
ClinGen Ensembl |
|
|
rs779455068 CA4405838 |
371 | A>G | No |
ClinGen ExAC |
|
|
CA4405837 rs757748640 |
371 | A>P | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 373 | E>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs780256309 CA4405841 |
377 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA4405840 rs141469348 |
377 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA368611113 rs1262477965 |
379 | R>S | No |
ClinGen gnomAD |
|
|
CA368611138 rs1427951179 |
380 | P>L | No |
ClinGen gnomAD |
|
|
CA163338264 rs977993930 |
383 | F>S | No |
ClinGen gnomAD |
|
|
CA368611287 rs568897730 |
386 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4405845 rs568897730 |
386 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA368611279 rs1379773181 |
386 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA368611339 rs1232926937 |
387 | H>Q | No |
ClinGen TOPMed |
|
|
rs769665945 CA368611408 |
389 | P>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769665945 CA4405846 |
389 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs954649094 CA163338287 |
390 | T>R | No |
ClinGen TOPMed |
|
|
CA368612006 rs1435953393 |
391 | G>E | No |
ClinGen gnomAD |
|
|
CA4405863 rs747950403 |
393 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA4405864 rs748318160 |
394 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA368612108 rs1204456571 |
396 | M>V | No |
ClinGen TOPMed |
|
|
rs1466232798 CA368612165 |
398 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
CA4405865 rs777866453 |
402 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA4405866 rs149110965 |
403 | P>C | No |
ClinGen 1000Genomes ExAC gnomAD |
No associated diseases with P05121
6 regional properties for P05121
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PEP-utilising enzyme, C-terminal | 598 - 951 | IPR000121 |
| domain | Pyruvate phosphate dikinase, AMP/ATP-binding | 145 - 370 | IPR002192-1 |
| domain | Pyruvate phosphate dikinase, AMP/ATP-binding | 382 - 435 | IPR002192-2 |
| domain | PEP-utilising enzyme, mobile domain | 502 - 583 | IPR008279 |
| active_site | PEP-utilising enzyme, active site | 530 - 541 | IPR018274 |
| conserved_site | PEP-utilising enzyme, conserved site | 843 - 861 | IPR023151 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| peptidase inhibitor complex | A protein complex which is capable of peptidase inhibitor activity. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| platelet alpha granule lumen | The volume enclosed by the membrane of the platelet alpha granule. |
| serine protease inhibitor complex | A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| protease binding | Binding to a protease or a peptidase. |
| serine-type endopeptidase inhibitor activity | Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
27 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| cellular response to lipopolysaccharide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| defense response to Gram-negative bacterium | Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. |
| dentinogenesis | The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin. |
| fibrinolysis | A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. |
| negative regulation of blood coagulation | Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation. |
| negative regulation of cell adhesion mediated by integrin | Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin. |
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| negative regulation of endopeptidase activity | Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. |
| negative regulation of endothelial cell apoptotic process | Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. |
| negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. |
| negative regulation of fibrinolysis | Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. |
| negative regulation of plasminogen activation | Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. |
| negative regulation of smooth muscle cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. |
| negative regulation of smooth muscle cell-matrix adhesion | Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion. |
| negative regulation of vascular wound healing | Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. |
| negative regulation of wound healing | Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. |
| positive regulation of angiogenesis | Any process that activates or increases angiogenesis. |
| positive regulation of blood coagulation | Any process that activates or increases the frequency, rate or extent of blood coagulation. |
| positive regulation of inflammatory response | Any process that activates or increases the frequency, rate or extent of the inflammatory response. |
| positive regulation of interleukin-8 production | Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. |
| positive regulation of leukotriene production involved in inflammatory response | Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. |
| positive regulation of monocyte chemotaxis | Any process that increases the frequency, rate, or extent of monocyte chemotaxis. |
| positive regulation of odontoblast differentiation | Any process that activates or increases the frequency, rate or extent of odontoblast differentiation. |
| positive regulation of receptor-mediated endocytosis | Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. |
| regulation of signaling receptor activity | Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. |
| replicative senescence | A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. |
35 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9N2I2 | SERPINA5 | Plasma serine protease inhibitor | Bos taurus (Bovine) | PR |
| P41361 | SERPINC1 | Antithrombin-III | Bos taurus (Bovine) | PR |
| A6QPQ2 | SERPINA3-8 | Serpin A3-8 | Bos taurus (Bovine) | PR |
| A2I7N1 | SERPINA3-5 | Serpin A3-5 | Bos taurus (Bovine) | PR |
| Q1JPB0 | SERPINB1 | Leukocyte elastase inhibitor | Bos taurus (Bovine) | PR |
| Q9TTE1 | SERPINA3-1 | Serpin A3-1 | Bos taurus (Bovine) | PR |
| P13909 | SERPINE1 | Plasminogen activator inhibitor 1 | Bos taurus (Bovine) | PR |
| O73790 | SERPINB10 | Heterochromatin-associated protein MENT | Gallus gallus (Chicken) | PR |
| P01008 | SERPINC1 | Antithrombin-III | Homo sapiens (Human) | PR |
| P08697 | SERPINF2 | Alpha-2-antiplasmin | Homo sapiens (Human) | PR |
| P05155 | SERPING1 | Plasma protease C1 inhibitor | Homo sapiens (Human) | PR |
| Q86WD7 | SERPINA9 | Serpin A9 | Homo sapiens (Human) | PR |
| P01011 | SERPINA3 | Alpha-1-antichymotrypsin | Homo sapiens (Human) | PR |
| P07093 | SERPINE2 | Glia-derived nexin | Homo sapiens (Human) | PR |
| Q9UK55 | SERPINA10 | Protein Z-dependent protease inhibitor | Homo sapiens (Human) | PR |
| Q96P15 | SERPINB11 | Serpin B11 | Homo sapiens (Human) | PR |
| Q5SV42 | Serpinb1c | Leukocyte elastase inhibitor C | Mus musculus (Mouse) | PR |
| Q8CDC0 | Serpinb13 | Serpin B13 | Mus musculus (Mouse) | PR |
| Q5I2A0 | Serpina3g | Serine protease inhibitor A3G | Mus musculus (Mouse) | PR |
| Q9JK88 | Serpini2 | Serpin I2 | Mus musculus (Mouse) | PR |
| P12388 | Serpinb2 | Plasminogen activator inhibitor 2, macrophage | Mus musculus (Mouse) | PR |
| P32261 | Serpinc1 | Antithrombin-III | Mus musculus (Mouse) | PR |
| Q9D154 | Serpinb1a | Leukocyte elastase inhibitor A | Mus musculus (Mouse) | PR |
| Q8BYY9 | Serpina3b | Serine protease inhibitor A3B | Mus musculus (Mouse) | PR |
| Q80X76 | Serpina3f | Serine protease inhibitor A3F | Mus musculus (Mouse) | PR |
| Q07235 | Serpine2 | Glia-derived nexin | Mus musculus (Mouse) | PR |
| P22777 | Serpine1 | Plasminogen activator inhibitor 1 | Mus musculus (Mouse) | PR |
| P29524 | Serpinb2 | Plasminogen activator inhibitor 2 type A | Rattus norvegicus (Rat) | PR |
| Q6P734 | Serping1 | Plasma protease C1 inhibitor | Rattus norvegicus (Rat) | PR |
| P05545 | Serpina3k | Serine protease inhibitor A3K | Rattus norvegicus (Rat) | PR |
| P07092 | Serpine2 | Glia-derived nexin | Rattus norvegicus (Rat) | PR |
| Q62975 | Serpina10 | Protein Z-dependent protease inhibitor | Rattus norvegicus (Rat) | PR |
| Q9ZQR6 | At2g14540 | Serpin-Z2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1T7 | At3g45220 | Serpin-Z4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48706 | At2g26390 | Serpin-Z3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQMSPALTCL | VLGLALVFGE | GSAVHHPPSY | VAHLASDFGV | RVFQQVAQAS | KDRNVVFSPY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GVASVLAMLQ | LTTGGETQQQ | IQAAMGFKID | DKGMAPALRH | LYKELMGPWN | KDEISTTDAI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FVQRDLKLVQ | GFMPHFFRLF | RSTVKQVDFS | EVERARFIIN | DWVKTHTKGM | ISNLLGKGAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DQLTRLVLVN | ALYFNGQWKT | PFPDSSTHRR | LFHKSDGSTV | SVPMMAQTNK | FNYTEFTTPD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GHYYDILELP | YHGDTLSMFI | AAPYEKEVPL | SALTNILSAQ | LISHWKGNMT | RLPRLLVLPK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FSLETEVDLR | KPLENLGMTD | MFRQFQADFT | SLSDQEPLHV | AQALQKVKIE | VNESGTVASS |
| 370 | 380 | 390 | 400 | ||
| STAVIVSARM | APEEIIMDRP | FLFVVRHNPT | GTVLFMGQVM | EP |