Q1JPB0

PR
Gene name
SERPINB1
Protein name
Leukocyte elastase inhibitor
Names
LEI, Serpin B1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:507264
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

275-358 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1JPB0

Entry ID Method Resolution Chain Position Source
AF-Q1JPB0-F1 Predicted AlphaFoldDB

110 variants for Q1JPB0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs478936226 11 F>V No EVA
rs460513156 13 V>L No EVA
rs448373917 16 F>C No EVA
rs481510317 23 N>T No EVA
rs463193035 27 N>T No EVA
rs209037042 49 D>N No EVA
rs477560984 50 T>P No EVA
rs476076329 63 V>I No EVA
rs462291918 103 F>L No EVA
rs480785299 103 F>V No EVA
rs443584498 115 L>R No EVA
rs476439889 119 D>N No EVA
rs458261639 126 D>Y No EVA
rs439879875 128 R>G No EVA
rs472810793 130 T>P No EVA
rs435236906 132 N>T No EVA
rs456279809 133 A>G No EVA
rs474702783 133 A>P No EVA
rs437570946 134 W>G No EVA
rs464170680 139 T>S No EVA
rs453444609 141 G>A No EVA
rs471698158 143 I>L No EVA
rs380776177 151 M>V No EVA
rs459630334 162 N>K No EVA
rs440966853 163 A>T No EVA
rs474041545 171 Q>E No EVA
rs137073356 172 E>G No EVA
rs442966644 173 K>E No EVA
rs457337919 174 F>S No EVA
rs475749294 174 F>V No EVA
rs453568313 176 V>G No EVA
rs465674230 176 V>M No EVA
rs434963208 177 E>G No EVA
rs467961829 178 A>G No EVA
rs522327394 178 A>T No EVA
rs448870590 179 T>P No EVA
rs481730270 180 K>Q No EVA
rs469746028 181 D>E No EVA
rs444794414 182 A>G No EVA
rs477882365 184 F>L No EVA
rs441106483 187 N>D No EVA
rs453555135 189 K>T No EVA
rs435102420 202 K>E No EVA
rs467760631 203 F>Y No EVA
rs455763912 209 K>E No EVA
rs437403145 209 K>N No EVA
rs469682527 211 L>R No EVA
rs444925534 216 L>M No EVA
rs477805581 217 E>* No EVA
rs465746433 218 L>P No EVA
rs480582948 222 G>R No EVA
rs462081873 224 D>V No EVA
rs443443202 229 I>L No EVA
rs482843485 230 L>R No EVA
rs471786073 237 D>E No EVA
rs438903182 237 D>Y No EVA
rs474304226 238 E>D No EVA
rs459693409 238 E>K No EVA
rs441465416 238 E>V No EVA
rs437341649 239 A>D No EVA
rs455901064 239 A>S No EVA
rs476623707 240 T>A No EVA
rs476623707 240 T>P No EVA
rs451353885 240 T>R No EVA
rs432880013 242 L>M No EVA
rs465737475 242 L>Q No EVA
rs432880013 242 L>V No EVA
rs447189524 243 K>E No EVA
rs435225673 244 K>T No EVA
rs436111957 258 T>P No EVA
rs475411308 277 L>R No EVA
rs456900763 278 E>G No EVA
rs432209946 279 E>K No EVA
rs465233075 282 D>A No EVA
rs446741071 283 L>P No EVA
rs434524544 284 Q>R No EVA
rs467437478 285 E>D No EVA
rs448457855 286 P>S No EVA
rs481596741 287 L>R No EVA
rs450804165 289 R>P No EVA
rs459234672 290 L>R No EVA
rs382264790 290 L>V No EVA
rs473579445 293 R>P No EVA
rs461560127 296 F>L No EVA
rs475512062 310 D>A No EVA
rs442480268 310 D>Y No EVA
rs431949568 316 V>G No EVA
rs453072465 318 H>D No EVA
rs434661728 318 H>Q No EVA
rs467374076 319 K>Q No EVA
rs448997663 319 K>R No EVA
rs469445270 320 S>A No EVA
rs469445270 320 S>P No EVA
rs451020202 321 V>F No EVA
rs465401800 322 V>A No EVA
rs465401800 322 V>G No EVA
rs447139431 331 A>G No EVA
rs480135908 332 A>T No EVA
rs443008361 333 A>G No EVA
rs463418023 337 A>D No EVA
rs471174700 341 F>L No EVA
rs452810748 345 V>G No EVA
rs523726919 345 V>M No EVA
rs441019594 347 E>G No EVA
rs436973773 350 F>L No EVA
rs455659355 350 F>V No EVA
rs470024311 352 A>D No EVA
rs432475790 353 D>E No EVA
rs465338428 354 H>D No EVA
rs446867094 359 F>C No EVA

No associated diseases with Q1JPB0

2 regional properties for Q1JPB0

Type Name Position InterPro Accession
conserved_site Serpin, conserved site 350 - 360 IPR023795
domain Serpin domain 7 - 377 IPR023796

Functions

Description
EC Number
Subcellular Localization
  • Secreted
  • Cytoplasm
  • Cytolytic granule
  • Early endosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytolytic granule A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

2 GO annotations of biological process

Name Definition
negative regulation of endopeptidase activity Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
negative regulation of interleukin-1 beta production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.

38 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41361 SERPINC1 Antithrombin-III Bos taurus (Bovine) PR
Q9N2I2 SERPINA5 Plasma serine protease inhibitor Bos taurus (Bovine) PR
Q9TTE1 SERPINA3-1 Serpin A3-1 Bos taurus (Bovine) PR
P13909 SERPINE1 Plasminogen activator inhibitor 1 Bos taurus (Bovine) PR
A2I7N1 SERPINA3-5 Serpin A3-5 Bos taurus (Bovine) PR
A6QPQ2 SERPINA3-8 Serpin A3-8 Bos taurus (Bovine) PR
A2I7N2 SERPINA3-6 Serpin A3-6 Bos taurus (Bovine) PR
A2I7M9 SERPINA3-2 Serpin A3-2 Bos taurus (Bovine) PR
O73790 SERPINB10 Heterochromatin-associated protein MENT Gallus gallus (Chicken) PR
P05619 SERPINB1 Leukocyte elastase inhibitor Equus caballus (Horse) PR
P05121 SERPINE1 Plasminogen activator inhibitor 1 Homo sapiens (Human) PR
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Homo sapiens (Human) PR
P05155 SERPING1 Plasma protease C1 inhibitor Homo sapiens (Human) PR
P08697 SERPINF2 Alpha-2-antiplasmin Homo sapiens (Human) PR
Q86WD7 SERPINA9 Serpin A9 Homo sapiens (Human) PR
P01008 SERPINC1 Antithrombin-III Homo sapiens (Human) PR
P01011 SERPINA3 Alpha-1-antichymotrypsin Homo sapiens (Human) PR
P07093 SERPINE2 Glia-derived nexin Homo sapiens (Human) PR
Q96P15 SERPINB11 Serpin B11 Homo sapiens (Human) PR
Q07235 Serpine2 Glia-derived nexin Mus musculus (Mouse) PR
Q8CDC0 Serpinb13 Serpin B13 Mus musculus (Mouse) PR
P22777 Serpine1 Plasminogen activator inhibitor 1 Mus musculus (Mouse) PR
Q5I2A0 Serpina3g Serine protease inhibitor A3G Mus musculus (Mouse) PR
Q9JK88 Serpini2 Serpin I2 Mus musculus (Mouse) PR
P12388 Serpinb2 Plasminogen activator inhibitor 2, macrophage Mus musculus (Mouse) PR
P32261 Serpinc1 Antithrombin-III Mus musculus (Mouse) PR
Q8BYY9 Serpina3b Serine protease inhibitor A3B Mus musculus (Mouse) PR
Q80X76 Serpina3f Serine protease inhibitor A3F Mus musculus (Mouse) PR
Q5SV42 Serpinb1c Leukocyte elastase inhibitor C Mus musculus (Mouse) PR
Q9D154 Serpinb1a Leukocyte elastase inhibitor A Mus musculus (Mouse) PR
P29524 Serpinb2 Plasminogen activator inhibitor 2 type A Rattus norvegicus (Rat) PR
Q6P734 Serping1 Plasma protease C1 inhibitor Rattus norvegicus (Rat) PR
P05545 Serpina3k Serine protease inhibitor A3K Rattus norvegicus (Rat) PR
P07092 Serpine2 Glia-derived nexin Rattus norvegicus (Rat) PR
Q62975 Serpina10 Protein Z-dependent protease inhibitor Rattus norvegicus (Rat) PR
O48706 At2g26390 Serpin-Z3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1T7 At3g45220 Serpin-Z4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR6 At2g14540 Serpin-Z2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEQLSAANTR FAVDLFLTLT EHNPAGNIFI SPFSISSALA MVFLGARGDT AAQMSKALHF
70 80 90 100 110 120
EGVEIHSGFQ SLNADINKCG APYTLKLANR LFGEKSYDFL PEFLASTQEM YSAELASVDF
130 140 150 160 170 180
LRAPEDARKT INAWVKEQTG GKIPELLASG MVDSLTKLVL VNAIYFKGKW QEKFMVEATK
190 200 210 220 230 240
DAPFRLNKKE TKTVKMMYQK KKFPFGYIKD LKCRVLELPY EGKDLSMVIL LPDDIQDEAT
250 260 270 280 290 300
GLKKIEQQLT LEKLREWTRP ESLDLLEVRV QLPRFKLEES YDLQEPLARL GVRDLFSSKA
310 320 330 340 350 360
DLSGMSGAKD LFISKVVHKS VVDVNEEGTE AAAATGAIAE FAMLVPEEEF VADHPFIFFI
370
RHKPSSNILF LGRLSSP