Q8CDC0
PR
Gene name |
Serpinb13 |
Protein name |
Serpin B13 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:241196 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CDC0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CDC0-F1 | Predicted | AlphaFoldDB |
27 variants for Q8CDC0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs244615233 | 8 | A>T | No | EVA | |
| rs3388493526 | 15 | L>P | No | EVA | |
| rs3388494431 | 35 | S>L | No | EVA | |
| rs3390403164 | 38 | I>N | No | EVA | |
| rs3388490625 | 95 | F>I | No | EVA | |
| rs3388493074 | 128 | H>R | No | EVA | |
| rs3388494320 | 136 | F>V | No | EVA | |
| rs3388492659 | 137 | V>I | No | EVA | |
| rs3388494439 | 143 | S>G | No | EVA | |
| rs255282310 | 165 | E>D | No | EVA | |
| rs3388494357 | 176 | L>V | No | EVA | |
| rs3388493881 | 177 | I>V | No | EVA | |
| rs3388490275 | 179 | T>I | No | EVA | |
| rs3388493460 | 200 | F>I | No | EVA | |
| rs3388493893 | 202 | L>Q | No | EVA | |
| rs3388493255 | 208 | K>T | No | EVA | |
| rs3388492260 | 220 | N>K | No | EVA | |
| rs3388493482 | 242 | S>C | No | EVA | |
| rs3388494022 | 250 | D>V | No | EVA | |
| rs252455259 | 280 | V>L | No | EVA | |
| rs3388493251 | 317 | M>I | No | EVA | |
| rs3412659343 | 325 | A>T | No | EVA | |
| rs3390440956 | 345 | A>P | No | EVA | |
| rs3390424870 | 348 | G>A | No | EVA | |
| rs3390434933 | 350 | G>A | No | EVA | |
| rs3390441667 | 352 | K>N | No | EVA | |
| rs3388490907 | 382 | F>L | No | EVA |
No associated diseases with Q8CDC0
1 regional properties for Q8CDC0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Histone H2A/H2B/H3 | 1 - 132 | IPR007125 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type endopeptidase inhibitor activity | Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| protease binding | Binding to a protease or a peptidase. |
| serine-type endopeptidase inhibitor activity | Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of endopeptidase activity | Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. |
| negative regulation of keratinocyte apoptotic process | Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte apoptotic process. |
35 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9N2I2 | SERPINA5 | Plasma serine protease inhibitor | Bos taurus (Bovine) | PR |
| P41361 | SERPINC1 | Antithrombin-III | Bos taurus (Bovine) | PR |
| A6QPQ2 | SERPINA3-8 | Serpin A3-8 | Bos taurus (Bovine) | PR |
| A2I7N1 | SERPINA3-5 | Serpin A3-5 | Bos taurus (Bovine) | PR |
| Q1JPB0 | SERPINB1 | Leukocyte elastase inhibitor | Bos taurus (Bovine) | PR |
| P13909 | SERPINE1 | Plasminogen activator inhibitor 1 | Bos taurus (Bovine) | PR |
| Q9TTE1 | SERPINA3-1 | Serpin A3-1 | Bos taurus (Bovine) | PR |
| O73790 | SERPINB10 | Heterochromatin-associated protein MENT | Gallus gallus (Chicken) | PR |
| P05121 | SERPINE1 | Plasminogen activator inhibitor 1 | Homo sapiens (Human) | PR |
| Q9UK55 | SERPINA10 | Protein Z-dependent protease inhibitor | Homo sapiens (Human) | PR |
| P05155 | SERPING1 | Plasma protease C1 inhibitor | Homo sapiens (Human) | PR |
| P08697 | SERPINF2 | Alpha-2-antiplasmin | Homo sapiens (Human) | PR |
| Q86WD7 | SERPINA9 | Serpin A9 | Homo sapiens (Human) | PR |
| P01008 | SERPINC1 | Antithrombin-III | Homo sapiens (Human) | PR |
| P07093 | SERPINE2 | Glia-derived nexin | Homo sapiens (Human) | PR |
| Q96P15 | SERPINB11 | Serpin B11 | Homo sapiens (Human) | PR |
| P01011 | SERPINA3 | Alpha-1-antichymotrypsin | Homo sapiens (Human) | PR |
| P32261 | Serpinc1 | Antithrombin-III | Mus musculus (Mouse) | PR |
| Q9JK88 | Serpini2 | Serpin I2 | Mus musculus (Mouse) | PR |
| Q8BYY9 | Serpina3b | Serine protease inhibitor A3B | Mus musculus (Mouse) | PR |
| Q80X76 | Serpina3f | Serine protease inhibitor A3F | Mus musculus (Mouse) | PR |
| Q07235 | Serpine2 | Glia-derived nexin | Mus musculus (Mouse) | PR |
| P12388 | Serpinb2 | Plasminogen activator inhibitor 2, macrophage | Mus musculus (Mouse) | PR |
| Q5SV42 | Serpinb1c | Leukocyte elastase inhibitor C | Mus musculus (Mouse) | PR |
| Q9D154 | Serpinb1a | Leukocyte elastase inhibitor A | Mus musculus (Mouse) | PR |
| P22777 | Serpine1 | Plasminogen activator inhibitor 1 | Mus musculus (Mouse) | PR |
| Q5I2A0 | Serpina3g | Serine protease inhibitor A3G | Mus musculus (Mouse) | PR |
| P29524 | Serpinb2 | Plasminogen activator inhibitor 2 type A | Rattus norvegicus (Rat) | PR |
| Q6P734 | Serping1 | Plasma protease C1 inhibitor | Rattus norvegicus (Rat) | PR |
| P05545 | Serpina3k | Serine protease inhibitor A3K | Rattus norvegicus (Rat) | PR |
| P07092 | Serpine2 | Glia-derived nexin | Rattus norvegicus (Rat) | PR |
| Q62975 | Serpina10 | Protein Z-dependent protease inhibitor | Rattus norvegicus (Rat) | PR |
| Q9ZQR6 | At2g14540 | Serpin-Z2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1T7 | At3g45220 | Serpin-Z4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48706 | At2g26390 | Serpin-Z3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSLGTAATQ | FLFDLFKELN | KTNDGNVFFS | PVGISTAIGM | IILGTRGATA | SELQKVLYTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QGTESSRIKS | EEEEIEKREE | IHHQLQMLLT | EISKFSNDYD | LIISNRLFGE | KTYLFLQKYI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DYVEKYYHAS | LEPVDFVNAA | DESRKKINSW | VESQTNVKVK | DLFPEGSLNS | STKLVLINTV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YFKGLWDREF | KKEHTKEEDF | WLNKNLSKPV | QMMALCSSFN | FTFLEDLQAK | IVGIPYKNND |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ISMFVLLPND | IDGLEKIMDK | MSPEKLVEWT | SPGHLEQRRV | DLRLPRLQVE | ETYDLEPVLE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVGIHSAFSE | HADYSGMSAR | SGLHAQNFLH | RSFLVVTEEG | VEATAGTGVG | LKVSSAASCE |
| 370 | 380 | ||||
| LVHCNHPFLF | FIRHRESDSI | LFFGKFSSP |