Q80X76

PR
Gene name
Serpina3f
Protein name
Serine protease inhibitor A3F
Names
Serpin A3F
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:238393
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q80X76

Entry ID Method Resolution Chain Position Source
AF-Q80X76-F1 Predicted AlphaFoldDB

51 variants for Q80X76

Variant ID(s) Position Change Description Diseaes Association Provenance
rs249721786 4 V>I No EVA
rs29138924 10 G>V No EVA
rs3403006943 11 C>F No EVA
rs3403241020 11 C>S No EVA
rs214061443 17 G>E No EVA
rs3389216816 17 G>R No EVA
rs3389271772 28 N>S No EVA
rs236759664 29 I>V No EVA
rs3413093340 32 V>G No EVA
rs3403674063 38 A>V No EVA
rs262800569 50 K>R No EVA
rs587106051 51 E>K No EVA
rs224642426 69 C>S No EVA
rs29491238 73 A>T No EVA
rs580685307 92 K>R No EVA
rs3403584919 98 T>N No EVA
rs582925938 101 P>L No EVA
rs581620618 119 N>D No EVA
rs29154535 124 S>N No EVA
rs3403654390 131 I>V No EVA
rs3389271692 142 K>E No EVA
rs3389231489 161 P>H No EVA
rs3403674061 165 T>R No EVA
rs387326142 175 H>Q No EVA
rs49422322 200 Y>* No EVA
rs230213466 221 L>V No EVA
rs580072326 243 R>Q No EVA
rs582621852 257 T>R No EVA
rs222821869 271 K>R No EVA
rs3389266304 279 L>* No EVA
rs33106418 286 N>K No EVA
rs3389266366 288 K>M No EVA
rs585724254 289 D>N No EVA
rs33104349 297 N>D No EVA
rs3389231505 330 D>E No EVA
rs3389266318 341 R>K No EVA
rs3389249914 346 V>I No EVA
rs3389266346 356 T>A No EVA
rs234773148 362 A>V No EVA
rs3389258833 363 G>S No EVA
rs3389255857 375 V>L No EVA
rs1133153174 376 I>M No EVA
rs1133958055 378 S>F No EVA
rs1132433080 379 M>L No EVA
rs33108777 384 D>N No EVA
rs29194568 406 S>T No EVA
rs237402497 417 V>G No EVA
rs3389231518 424 V>M No EVA
rs3389231522 429 P>L No EVA
rs215219207 443 T>P No EVA
rs387538769 444 R>T No EVA

No associated diseases with Q80X76

3 regional properties for Q80X76

Type Name Position InterPro Accession
conserved_site Serpin, conserved site 435 - 445 IPR023795
domain Serpin domain 87 - 462 IPR023796
domain Antithrombin-III, serpin domain 71 - 464 IPR033829

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

4 GO annotations of biological process

Name Definition
negative regulation of endopeptidase activity Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
response to cytokine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
response to peptide hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9N2I2 SERPINA5 Plasma serine protease inhibitor Bos taurus (Bovine) PR
P41361 SERPINC1 Antithrombin-III Bos taurus (Bovine) PR
Q1JPB0 SERPINB1 Leukocyte elastase inhibitor Bos taurus (Bovine) PR
P13909 SERPINE1 Plasminogen activator inhibitor 1 Bos taurus (Bovine) PR
Q9TTE1 SERPINA3-1 Serpin A3-1 Bos taurus (Bovine) PR
A2I7N1 SERPINA3-5 Serpin A3-5 Bos taurus (Bovine) PR
A6QPQ2 SERPINA3-8 Serpin A3-8 Bos taurus (Bovine) PR
A2I7N2 SERPINA3-6 Serpin A3-6 Bos taurus (Bovine) PR
A2I7M9 SERPINA3-2 Serpin A3-2 Bos taurus (Bovine) PR
O73790 SERPINB10 Heterochromatin-associated protein MENT Gallus gallus (Chicken) PR
P05121 SERPINE1 Plasminogen activator inhibitor 1 Homo sapiens (Human) PR
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Homo sapiens (Human) PR
P05155 SERPING1 Plasma protease C1 inhibitor Homo sapiens (Human) PR
P08697 SERPINF2 Alpha-2-antiplasmin Homo sapiens (Human) PR
Q86WD7 SERPINA9 Serpin A9 Homo sapiens (Human) PR
P01008 SERPINC1 Antithrombin-III Homo sapiens (Human) PR
P07093 SERPINE2 Glia-derived nexin Homo sapiens (Human) PR
Q96P15 SERPINB11 Serpin B11 Homo sapiens (Human) PR
P01011 SERPINA3 Alpha-1-antichymotrypsin Homo sapiens (Human) PR
P12388 Serpinb2 Plasminogen activator inhibitor 2, macrophage Mus musculus (Mouse) PR
P32261 Serpinc1 Antithrombin-III Mus musculus (Mouse) PR
Q07235 Serpine2 Glia-derived nexin Mus musculus (Mouse) PR
Q5SV42 Serpinb1c Leukocyte elastase inhibitor C Mus musculus (Mouse) PR
Q8BYY9 Serpina3b Serine protease inhibitor A3B Mus musculus (Mouse) PR
Q9D154 Serpinb1a Leukocyte elastase inhibitor A Mus musculus (Mouse) PR
Q9JK88 Serpini2 Serpin I2 Mus musculus (Mouse) PR
Q8CDC0 Serpinb13 Serpin B13 Mus musculus (Mouse) PR
P22777 Serpine1 Plasminogen activator inhibitor 1 Mus musculus (Mouse) PR
Q5I2A0 Serpina3g Serine protease inhibitor A3G Mus musculus (Mouse) PR
P29524 Serpinb2 Plasminogen activator inhibitor 2 type A Rattus norvegicus (Rat) PR
Q6P734 Serping1 Plasma protease C1 inhibitor Rattus norvegicus (Rat) PR
P05545 Serpina3k Serine protease inhibitor A3K Rattus norvegicus (Rat) PR
P07092 Serpine2 Glia-derived nexin Rattus norvegicus (Rat) PR
Q62975 Serpina10 Protein Z-dependent protease inhibitor Rattus norvegicus (Rat) PR
O48706 At2g26390 Serpin-Z3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1T7 At3g45220 Serpin-Z4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR6 At2g14540 Serpin-Z2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAGVSPAVFG CPDVTLGRNT AVREVQENIT SVDSLTLASS NTDFAFSLYK ELVLKNPDEN
70 80 90 100 110 120
VVFSPFSICT ALALLSLGAK SNTLKEILEG LKFNLTETPE PDIHQGFRYL LDLLSQPGNQ
130 140 150 160 170 180
VQISTGSALF IEKHLQILAE FKEKARALYQ AEAFTADFQQ PLEATKLIND YVSNHTQGKI
190 200 210 220 230 240
KELISDLDKR TLMVLVNYIY FKGKWEMPFD PDDTCKSEFY LDENRSVKVP MMKINNLTTP
250 260 270 280 290 300
YFRDEELSCT VVELKYTGNA SAMFILPDQG KMQQVEASLQ PETLRNWKDS LKPRLINELC
310 320 330 340 350 360
LPKFSISTDY SLEHILPELG IRELFSTQAD LSAITGTKDL RTSQVVHKAV LDVAETGTEA
370 380 390 400 410 420
AAGTGYQNLQ CCQGVIYSMK IYFDRPFLMI ISDTNTHIAL FMAKVSNPES DENFLNVEYA
430 440
FPQVLEIMPE YRSVCTCCLP CLTRQ