Q5SV42

PR
Gene name
Serpinb1c
Protein name
Leukocyte elastase inhibitor C
Names
Serine protease inhibitor EIC, Serpin B1c
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:380839
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

263-335 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5SV42

Entry ID Method Resolution Chain Position Source
AF-Q5SV42-F1 Predicted AlphaFoldDB

46 variants for Q5SV42

Variant ID(s) Position Change Description Diseaes Association Provenance
rs260973677 12 A>V No EVA
rs254473750 16 F>S No EVA
rs3389269233 23 N>D No EVA
rs3389250913 56 K>M No EVA
rs3389234360 57 T>I No EVA
rs584834332 69 Q>H No EVA
rs579062123 69 Q>R No EVA
rs579247941 74 T>N No EVA
rs3389206207 79 K>R* No EVA
rs3389274370 80 R>C No EVA
rs585467803 104 Y>F No EVA
rs221449344 108 I>T No EVA
rs255790095 111 T>M No EVA
rs238799847 113 S>G No EVA
rs213476446 118 L>P No EVA
rs3404043305 142 E>V No EVA
rs29899459 148 F>L No EVA
rs3389276122 150 V>SDG* No EVA
rs3389274342 151 G>S No EVA
rs3389206162 153 V>G No EVA
rs3389250941 154 D>G No EVA
rs3389250929 156 M>L No EVA
rs240273514 157 T>I No EVA
rs3389277153 163 N>S No EVA
rs3389288802 165 T>I No EVA
rs3404093533 170 M>I No EVA
rs29899460 177 A>T No EVA
rs3404093613 178 R>W No EVA
rs235209150 186 R>Q No EVA
rs257856305 206 F>L No EVA
rs231288187 221 Y>F No EVA
rs215788320 224 G>E No EVA
rs245186523 227 S>N No EVA
rs29899461 228 M>T No EVA
rs259224104 240 T>S No EVA
rs3389277182 262 Q>R No EVA
rs29900332 278 S>N No EVA
rs3389243548 291 Q>H No EVA
rs3389234322 294 F>L No EVA
rs3389274361 294 F>L No EVA
rs261470406 312 I>V No EVA
rs235575268 315 I>T No EVA
rs29900333 339 V>D No EVA
rs3389288810 349 T>A No EVA
rs3389283636 357 F>S No EVA
rs29901235 367 L>F No EVA

No associated diseases with Q5SV42

2 regional properties for Q5SV42

Type Name Position InterPro Accession
conserved_site Serpin, conserved site 348 - 358 IPR023795
domain Serpin domain 7 - 375 IPR023796

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasmic ribonucleoprotein granule A ribonucleoprotein granule located in the cytoplasm.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
peptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

3 GO annotations of biological process

Name Definition
negative regulation of endopeptidase activity Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
negative regulation of interleukin-1 beta production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
type B pancreatic cell proliferation The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin.

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9N2I2 SERPINA5 Plasma serine protease inhibitor Bos taurus (Bovine) PR
P41361 SERPINC1 Antithrombin-III Bos taurus (Bovine) PR
A6QPQ2 SERPINA3-8 Serpin A3-8 Bos taurus (Bovine) PR
A2I7N1 SERPINA3-5 Serpin A3-5 Bos taurus (Bovine) PR
P13909 SERPINE1 Plasminogen activator inhibitor 1 Bos taurus (Bovine) PR
Q9TTE1 SERPINA3-1 Serpin A3-1 Bos taurus (Bovine) PR
Q1JPB0 SERPINB1 Leukocyte elastase inhibitor Bos taurus (Bovine) PR
O73790 SERPINB10 Heterochromatin-associated protein MENT Gallus gallus (Chicken) PR
P05619 SERPINB1 Leukocyte elastase inhibitor Equus caballus (Horse) PR
P05121 SERPINE1 Plasminogen activator inhibitor 1 Homo sapiens (Human) PR
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Homo sapiens (Human) PR
P05155 SERPING1 Plasma protease C1 inhibitor Homo sapiens (Human) PR
P08697 SERPINF2 Alpha-2-antiplasmin Homo sapiens (Human) PR
Q86WD7 SERPINA9 Serpin A9 Homo sapiens (Human) PR
P01008 SERPINC1 Antithrombin-III Homo sapiens (Human) PR
P07093 SERPINE2 Glia-derived nexin Homo sapiens (Human) PR
Q96P15 SERPINB11 Serpin B11 Homo sapiens (Human) PR
P01011 SERPINA3 Alpha-1-antichymotrypsin Homo sapiens (Human) PR
P12388 Serpinb2 Plasminogen activator inhibitor 2, macrophage Mus musculus (Mouse) PR
P32261 Serpinc1 Antithrombin-III Mus musculus (Mouse) PR
Q07235 Serpine2 Glia-derived nexin Mus musculus (Mouse) PR
Q80X76 Serpina3f Serine protease inhibitor A3F Mus musculus (Mouse) PR
Q8BYY9 Serpina3b Serine protease inhibitor A3B Mus musculus (Mouse) PR
Q9D154 Serpinb1a Leukocyte elastase inhibitor A Mus musculus (Mouse) PR
Q9JK88 Serpini2 Serpin I2 Mus musculus (Mouse) PR
Q8CDC0 Serpinb13 Serpin B13 Mus musculus (Mouse) PR
P22777 Serpine1 Plasminogen activator inhibitor 1 Mus musculus (Mouse) PR
Q5I2A0 Serpina3g Serine protease inhibitor A3G Mus musculus (Mouse) PR
P29524 Serpinb2 Plasminogen activator inhibitor 2 type A Rattus norvegicus (Rat) PR
Q6P734 Serping1 Plasma protease C1 inhibitor Rattus norvegicus (Rat) PR
P05545 Serpina3k Serine protease inhibitor A3K Rattus norvegicus (Rat) PR
P07092 Serpine2 Glia-derived nexin Rattus norvegicus (Rat) PR
Q62975 Serpina10 Protein Z-dependent protease inhibitor Rattus norvegicus (Rat) PR
O48706 At2g26390 Serpin-Z3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1T7 At3g45220 Serpin-Z4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR6 At2g14540 Serpin-Z2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGQLSSANNL FALELFHTLN ESNPTGNTIF SPVSISSALA MVYLGARGST AAQLSKTLHF
70 80 90 100 110 120
DSAEDIHSQF QSLTAEVSKR GASHTLKLAN RLYGEKTYNF LPEYLASIQK TYSADLALVD
130 140 150 160 170 180
FQHASEDARK EINQWVKGQT EEKIQELFAV GVVDSMTKLV LVNATYFKGM WQKKFMARDT
190 200 210 220 230 240
TDAPFRLSKK VTKTVKMMYL KNNLPFGYIP DLKCKVLEMP YQGGELSMVI LLPEDIEDET
250 260 270 280 290 300
TGLEEIEKQL TLEKLQECEN LQNIDVCVKL PKFKMEESYI LNSNLGQLGV QDLFSSSKAD
310 320 330 340 350 360
LSGMSGSRDL FISKIVHKSY VEVNEEGTET DAAMPGTVVG CCLMPMEFTV DHPFLFFIRH
370
NPTAHVLFLG RVCSP