O48706

PR
Gene name
At2g26390 (T9J22.6)
Protein name
Serpin-Z3
Names
ArathZ3
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G26390
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-113 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O48706

Entry ID Method Resolution Chain Position Source
AF-O48706-F1 Predicted AlphaFoldDB

44 variants for O48706

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13413505 7 I>T No 1000Genomes
ENSVATH14555376 10 Q>K No 1000Genomes
ENSVATH01899877 29 G>D No 1000Genomes
ENSVATH05596697 72 A>T No 1000Genomes
tmp_2_11230245_C_T 83 E>K No 1000Genomes
ENSVATH05596696 86 D>Y No 1000Genomes
ENSVATH00249059 87 L>V No 1000Genomes
ENSVATH05596694 112 E>Q No 1000Genomes
ENSVATH14555375 116 K>M No 1000Genomes
tmp_2_11229867_T_A 130 E>D No 1000Genomes
ENSVATH05596688 133 D>N No 1000Genomes
tmp_2_11229842_C_T 139 A>T No 1000Genomes
ENSVATH13413491 142 H>Y No 1000Genomes
ENSVATH01899873 144 N>K No 1000Genomes
tmp_2_11229776_C_T,G 161 E>K No 1000Genomes
tmp_2_11229776_C_T,G 161 E>Q No 1000Genomes
ENSVATH13413490 166 T>I No 1000Genomes
ENSVATH05596685 178 A>P No 1000Genomes
tmp_2_11229718_C_T 180 S>N No 1000Genomes
tmp_2_11229651_T_A 202 K>N No 1000Genomes
tmp_2_11229649_A_G 203 V>A No 1000Genomes
tmp_2_11229637_A_G 207 M>T No 1000Genomes
tmp_2_11229602_C_T 219 G>S No 1000Genomes
ENSVATH01899872 226 P>H No 1000Genomes
tmp_2_11229565_T_C 231 K>R No 1000Genomes
ENSVATH05596683 237 Y>N No 1000Genomes
tmp_2_11229479_A_T 260 F>I No 1000Genomes
ENSVATH14555363 266 P>T No 1000Genomes
tmp_2_11229436_G_T 274 A>D No 1000Genomes
tmp_2_11229433_A_G 275 L>S No 1000Genomes
ENSVATH01899871 280 L>F No 1000Genomes
tmp_2_11229371_C_G 296 G>R No 1000Genomes
ENSVATH14555361 298 T>S No 1000Genomes
tmp_2_11229354_A_T 301 F>L No 1000Genomes
tmp_2_11229355_A_G 301 F>S No 1000Genomes
ENSVATH01899870 304 K>E No 1000Genomes
tmp_2_11229344_C_A 305 G>C No 1000Genomes
ENSVATH00249054 309 E>A No 1000Genomes
ENSVATH01899868 314 P>T No 1000Genomes
ENSVATH01899866 321 H>Y No 1000Genomes
tmp_2_11229293_C_T 322 V>I No 1000Genomes
tmp_2_11229220_G_A 346 A>V No 1000Genomes
tmp_2_11229133_C_T 375 G>E No 1000Genomes
ENSVATH00249053 376 V>A No 1000Genomes

No associated diseases with O48706

3 regional properties for O48706

Type Name Position InterPro Accession
conserved_site Serpin, conserved site 435 - 445 IPR023795
domain Serpin domain 87 - 462 IPR023796
domain Antithrombin-III, serpin domain 71 - 464 IPR033829

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

39 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1JPB0 SERPINB1 Leukocyte elastase inhibitor Bos taurus (Bovine) PR
Q9N2I2 SERPINA5 Plasma serine protease inhibitor Bos taurus (Bovine) PR
Q9TTE1 SERPINA3-1 Serpin A3-1 Bos taurus (Bovine) PR
P41361 SERPINC1 Antithrombin-III Bos taurus (Bovine) PR
P13909 SERPINE1 Plasminogen activator inhibitor 1 Bos taurus (Bovine) PR
A2I7N1 SERPINA3-5 Serpin A3-5 Bos taurus (Bovine) PR
A6QPQ2 SERPINA3-8 Serpin A3-8 Bos taurus (Bovine) PR
A2I7M9 SERPINA3-2 Serpin A3-2 Bos taurus (Bovine) PR
A2I7N2 SERPINA3-6 Serpin A3-6 Bos taurus (Bovine) PR
O73790 SERPINB10 Heterochromatin-associated protein MENT Gallus gallus (Chicken) PR
P05619 SERPINB1 Leukocyte elastase inhibitor Equus caballus (Horse) PR
P01008 SERPINC1 Antithrombin-III Homo sapiens (Human) PR
P08697 SERPINF2 Alpha-2-antiplasmin Homo sapiens (Human) PR
Q96P15 SERPINB11 Serpin B11 Homo sapiens (Human) PR
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Homo sapiens (Human) PR
P05121 SERPINE1 Plasminogen activator inhibitor 1 Homo sapiens (Human) PR
P05155 SERPING1 Plasma protease C1 inhibitor Homo sapiens (Human) PR
P01011 SERPINA3 Alpha-1-antichymotrypsin Homo sapiens (Human) PR
Q86WD7 SERPINA9 Serpin A9 Homo sapiens (Human) PR
P07093 SERPINE2 Glia-derived nexin Homo sapiens (Human) PR
P12388 Serpinb2 Plasminogen activator inhibitor 2, macrophage Mus musculus (Mouse) PR
P32261 Serpinc1 Antithrombin-III Mus musculus (Mouse) PR
Q07235 Serpine2 Glia-derived nexin Mus musculus (Mouse) PR
Q5SV42 Serpinb1c Leukocyte elastase inhibitor C Mus musculus (Mouse) PR
Q80X76 Serpina3f Serine protease inhibitor A3F Mus musculus (Mouse) PR
Q8BYY9 Serpina3b Serine protease inhibitor A3B Mus musculus (Mouse) PR
Q9D154 Serpinb1a Leukocyte elastase inhibitor A Mus musculus (Mouse) PR
Q9JK88 Serpini2 Serpin I2 Mus musculus (Mouse) PR
Q8CDC0 Serpinb13 Serpin B13 Mus musculus (Mouse) PR
P22777 Serpine1 Plasminogen activator inhibitor 1 Mus musculus (Mouse) PR
Q5I2A0 Serpina3g Serine protease inhibitor A3G Mus musculus (Mouse) PR
Q62975 Serpina10 Protein Z-dependent protease inhibitor Rattus norvegicus (Rat) PR
P29524 Serpinb2 Plasminogen activator inhibitor 2 type A Rattus norvegicus (Rat) PR
Q6P734 Serping1 Plasma protease C1 inhibitor Rattus norvegicus (Rat) PR
P05545 Serpina3k Serine protease inhibitor A3K Rattus norvegicus (Rat) PR
P07092 Serpine2 Glia-derived nexin Rattus norvegicus (Rat) PR
P05544 Serpina3l Serine protease inhibitor A3L Rattus norvegicus (Rat) PR
Q9M1T7 At3g45220 Serpin-Z4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR6 At2g14540 Serpin-Z2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MELGKSIENQ NNVVARLAKK VIETDVANGS NVVFSPMSIN VLLSLIAAGS NPVTKEEILS
70 80 90 100 110 120
FLMSPSTDHL NAVLAKIADG GTERSDLCLS TAHGVWIDKS SYLKPSFKEL LENSYKASCS
130 140 150 160 170 180
QVDFATKPVE VIDEVNIWAD VHTNGLIKQI LSRDCTDTIK EIRNSTLILA NAVYFKAAWS
190 200 210 220 230 240
RKFDAKLTKD NDFHLLDGNT VKVPFMMSYK DQYLRGYDGF QVLRLPYVED KRHFSMYIYL
250 260 270 280 290 300
PNDKDGLAAL LEKISTEPGF LDSHIPLHRT PVDALRIPKL NFSFEFKASE VLKDMGLTSP
310 320 330 340 350 360
FTSKGNLTEM VDSPSNGDKL HVSSIIHKAC IEVDEEGTEA AAVSVAIMMP QCLMRNPDFV
370 380
ADHPFLFTVR EDNSGVILFI GQVLDPSKH