P05544

PR
Gene name
Serpina3l (Spin2a)
Protein name
Serine protease inhibitor A3L
Names
Serpin A3L, CPI-23, Contrapsin-like protease inhibitor 3, Serine protease inhibitor 1, SPI-1
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-175 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P05544

Entry ID Method Resolution Chain Position Source
AF-P05544-F1 Predicted AlphaFoldDB

3 variants for P05544

Variant ID(s) Position Change Description Diseaes Association Provenance
rs198864993 215 V>A No EVA
rs3320980817 244 E>G No EVA
rs3320980797 245 V>I No EVA

No associated diseases with P05544

2 regional properties for P05544

Type Name Position InterPro Accession
conserved_site Serpin, conserved site 385 - 395 IPR023795
domain Serpin domain 48 - 412 IPR023796

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

1 GO annotations of biological process

Name Definition
negative regulation of endopeptidase activity Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9TTE1 SERPINA3-1 Serpin A3-1 Bos taurus (Bovine) PR
A2I7N1 SERPINA3-5 Serpin A3-5 Bos taurus (Bovine) PR
A2I7M9 SERPINA3-2 Serpin A3-2 Bos taurus (Bovine) PR
A6QPQ2 SERPINA3-8 Serpin A3-8 Bos taurus (Bovine) PR
A2I7N2 SERPINA3-6 Serpin A3-6 Bos taurus (Bovine) PR
P01011 SERPINA3 Alpha-1-antichymotrypsin Homo sapiens (Human) PR
Q6P734 Serping1 Plasma protease C1 inhibitor Rattus norvegicus (Rat) PR
P05545 Serpina3k Serine protease inhibitor A3K Rattus norvegicus (Rat) PR
P09005 Serine protease inhibitor 2.1 Rattus norvegicus (Rat) PR
P07092 Serpine2 Glia-derived nexin Rattus norvegicus (Rat) PR
Q62975 Serpina10 Protein Z-dependent protease inhibitor Rattus norvegicus (Rat) PR
P29524 Serpinb2 Plasminogen activator inhibitor 2 type A Rattus norvegicus (Rat) PR
O48706 At2g26390 Serpin-Z3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1T7 At3g45220 Serpin-Z4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR6 At2g14540 Serpin-Z2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAFIAALGLL MAGICPAVLC DGTLGRDTLS HEDHGKGRQL HSLTLASSNT DFALSLYKKL
70 80 90 100 110 120
ALRNPDKNVV FSPLSISAAL TILSLGAKDS TMEEILEGLK FNLTEITEEE IHQGFGHLLQ
130 140 150 160 170 180
RLSQPEDQVE INTGSALFID KEQPILSEFQ EKTRALYQAE AFIADFKQPN EAKKLINDYV
190 200 210 220 230 240
SNQTQGKIAE LFSDLEERTS MVLVNYLLFK GKWKVPFNPN DTFESEFYLD EKRSVKVPMM
250 260 270 280 290 300
KIKEVTTPYV RDEELSCSVL ELKYTGNASA LFILPDQGKM QQVESSLQPE TLKKWKDSLI
310 320 330 340 350 360
PRIINDLRMP KFSISTDYSL KEVLPELGIK KVFSQQADLS RITGTKDLYV SQVVHKAVLD
370 380 390 400 410
VDETGTEATA ATGVATVIRR QPRTLNFNRP FMVVITDMDS QSILFVAKIT NPK