P09005

PR
Gene name
Protein name
Serine protease inhibitor 2.1
Names
SPI-2.1
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

50-120 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P09005

Entry ID Method Resolution Chain Position Source
AF-P09005-F1 Predicted AlphaFoldDB

No variants for P09005

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P09005

No associated diseases with P09005

2 regional properties for P09005

Type Name Position InterPro Accession
conserved_site Serpin, conserved site 186 - 196 IPR023795
domain Serpin domain 1 - 213 IPR023796

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

1 GO annotations of biological process

Name Definition
negative regulation of endopeptidase activity Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6P734 Serping1 Plasma protease C1 inhibitor Rattus norvegicus (Rat) PR
P05544 Serpina3l Serine protease inhibitor A3L Rattus norvegicus (Rat) PR
P05545 Serpina3k Serine protease inhibitor A3K Rattus norvegicus (Rat) PR
P07092 Serpine2 Glia-derived nexin Rattus norvegicus (Rat) PR
Q62975 Serpina10 Protein Z-dependent protease inhibitor Rattus norvegicus (Rat) PR
P29524 Serpinb2 Plasminogen activator inhibitor 2 type A Rattus norvegicus (Rat) PR
10 20 30 40 50 60
LVLVNYLLFK GKWKVPFNPN DTFESEFYLD EKRSVKVPMM KIKEVTTPYV RDEELSCSVL
70 80 90 100 110 120
ELKYTGNASA LFILPDQGKM QQVESSLQPE TLKKWKDSLI PSIINDLRMP KFSISTDYSL
130 140 150 160 170 180
EKEVLPELGI KKVFSQQADL SRITGTKDLY VSQVVHKAVL DVAETGTEAT AATGVATVIR
190 200 210
RQPRTLNFNQ PFMVFITDMD SQSILFVAKI TNPS