Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2I7N2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2I7N2-F1 | Predicted | AlphaFoldDB |
No variants for A2I7N2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2I7N2 | |||||
No associated diseases with A2I7N2
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromaffin granule | Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| serine-type endopeptidase inhibitor activity | Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of endopeptidase activity | Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41361 | SERPINC1 | Antithrombin-III | Bos taurus (Bovine) | PR |
| P13909 | SERPINE1 | Plasminogen activator inhibitor 1 | Bos taurus (Bovine) | PR |
| Q9N2I2 | SERPINA5 | Plasma serine protease inhibitor | Bos taurus (Bovine) | PR |
| Q9TTE1 | SERPINA3-1 | Serpin A3-1 | Bos taurus (Bovine) | PR |
| A2I7M9 | SERPINA3-2 | Serpin A3-2 | Bos taurus (Bovine) | PR |
| A6QPQ2 | SERPINA3-8 | Serpin A3-8 | Bos taurus (Bovine) | PR |
| A2I7N1 | SERPINA3-5 | Serpin A3-5 | Bos taurus (Bovine) | PR |
| Q1JPB0 | SERPINB1 | Leukocyte elastase inhibitor | Bos taurus (Bovine) | PR |
| P01011 | SERPINA3 | Alpha-1-antichymotrypsin | Homo sapiens (Human) | PR |
| Q8BYY9 | Serpina3b | Serine protease inhibitor A3B | Mus musculus (Mouse) | PR |
| Q5I2A0 | Serpina3g | Serine protease inhibitor A3G | Mus musculus (Mouse) | PR |
| Q80X76 | Serpina3f | Serine protease inhibitor A3F | Mus musculus (Mouse) | PR |
| P05545 | Serpina3k | Serine protease inhibitor A3K | Rattus norvegicus (Rat) | PR |
| P05544 | Serpina3l | Serine protease inhibitor A3L | Rattus norvegicus (Rat) | PR |
| O48706 | At2g26390 | Serpin-Z3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1T7 | At3g45220 | Serpin-Z4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR6 | At2g14540 | Serpin-Z2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRTERVSPLL | ALGILVAGLC | SRVHCLPENV | TPEEQHKVTS | VDGHSLASSN | TDFAFSLYKQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LALKDPNKNV | IFSPLSVSIA | LAFLSLGAHG | PTVTEILEGL | KFNLTETPET | EIHQGFQHLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QTFNQPSNQL | QLSVGNAIFV | QEELKLLDKF | IEDARVLYSS | EAFPTNFRDP | EAAKSLINDY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VKNKTQGKIE | ELFKDLSPRT | ELVLVNYVYF | KAQWKTRFDP | KHTEKTEFHV | SDNKTVEVPM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MTLDLETPYF | RDEELGCTLV | ELTYTSNDSA | LFILPDKGKM | QDLEAKLTPE | MLTRWRNSLQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PRRIHELYLP | KFSIKSNYEL | NDTLSQMGIK | KIFTDADLSG | ITGTADLVVS | QVVHGAALDV |
| 370 | 380 | 390 | 400 | 410 | |
| DEEGTEGAAA | TGIGIERTFL | RIIVRVNRPF | LIAVVLKDTQ | SIIFLGKVTN | PSEA |