Q8BYY9

PR
Gene name
Serpina3b
Protein name
Serine protease inhibitor A3B
Names
Serpin A3B
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:271047
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-111 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BYY9

Entry ID Method Resolution Chain Position Source
AF-Q8BYY9-F1 Predicted AlphaFoldDB

58 variants for Q8BYY9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs254409947 13 E>G No EVA
rs3403442368 18 V>A No EVA
rs3403681335 21 C>N No EVA
rs33096095 58 F>L No EVA
rs3389271708 61 E>* No EVA
rs3389243433 70 N>S No EVA
rs232756296 76 F>V No EVA
rs253481732 81 A>S No EVA
rs33096098 85 L>F No EVA
rs243808646 111 A>S No EVA
rs46608050 118 K>E No EVA
rs47107255 118 K>R No EVA
rs262573443 178 I>V No EVA
rs224234950 186 T>I No EVA
rs33096896 197 M>L No EVA
rs252591946 203 M>V No EVA
rs3403238499 205 I>M No EVA
rs45861189 208 D>E No EVA
rs3403984048 209 L>I No EVA
rs49284200 210 F>L No EVA
rs3403005862 212 K>T No EVA
rs3389260695 214 E>G No EVA
rs3389190271 214 E>Q No EVA
rs29145410 216 M>K No EVA
rs3389252913 217 V>M No EVA
rs213899934 222 D>N No EVA
rs238969757 230 I>K No EVA
rs252289450 236 H>R No EVA
rs3389255790 261 V>M No EVA
rs3389255650 266 Y>* No EVA
rs3413093363 271 K>M No EVA
rs3403737775 271 K>N No EVA
rs3403681350 271 K>Q No EVA
rs3389216794 279 Q>L No EVA
rs254997094 291 P>S No EVA
rs254997094 291 P>T No EVA
rs217969040 292 G>E No EVA
rs3389258754 298 R>K No EVA
rs3402301496 305 K>M No EVA
rs3403442394 307 K>E No EVA
rs3389271710 307 K>N No EVA
rs3403845242 310 H>Y No EVA
rs3389255648 320 Y>* No EVA
rs3403681340 354 E>Q No EVA
rs1133575800 355 M>I No EVA
rs3389243426 355 M>L No EVA
rs1134846152 356 I>V No EVA
rs1133889307 359 T>A No EVA
rs1132360762 360 E>V No EVA
rs1132689656 366 K>Q No EVA
rs1133949084 366 K>T No EVA
rs1132423058 370 G>A No EVA
rs1134949776 377 G>E No EVA
rs1133063608 379 N>D No EVA
rs1135267838 381 M>L No EVA
rs3389249951 392 F>I No EVA
rs214768149 409 H>Y No EVA
rs232426754 410 V>L No EVA

No associated diseases with Q8BYY9

2 regional properties for Q8BYY9

Type Name Position InterPro Accession
domain Rotavirus VP4 helical domain 485 - 776 IPR035329
domain Rotavirus VP4, membrane interaction domain 250 - 474 IPR035330

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

1 GO annotations of biological process

Name Definition
negative regulation of endopeptidase activity Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9N2I2 SERPINA5 Plasma serine protease inhibitor Bos taurus (Bovine) PR
P41361 SERPINC1 Antithrombin-III Bos taurus (Bovine) PR
Q1JPB0 SERPINB1 Leukocyte elastase inhibitor Bos taurus (Bovine) PR
P13909 SERPINE1 Plasminogen activator inhibitor 1 Bos taurus (Bovine) PR
Q9TTE1 SERPINA3-1 Serpin A3-1 Bos taurus (Bovine) PR
A2I7N1 SERPINA3-5 Serpin A3-5 Bos taurus (Bovine) PR
A6QPQ2 SERPINA3-8 Serpin A3-8 Bos taurus (Bovine) PR
A2I7N2 SERPINA3-6 Serpin A3-6 Bos taurus (Bovine) PR
A2I7M9 SERPINA3-2 Serpin A3-2 Bos taurus (Bovine) PR
O73790 SERPINB10 Heterochromatin-associated protein MENT Gallus gallus (Chicken) PR
P05121 SERPINE1 Plasminogen activator inhibitor 1 Homo sapiens (Human) PR
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Homo sapiens (Human) PR
P05155 SERPING1 Plasma protease C1 inhibitor Homo sapiens (Human) PR
P08697 SERPINF2 Alpha-2-antiplasmin Homo sapiens (Human) PR
Q86WD7 SERPINA9 Serpin A9 Homo sapiens (Human) PR
P01008 SERPINC1 Antithrombin-III Homo sapiens (Human) PR
P07093 SERPINE2 Glia-derived nexin Homo sapiens (Human) PR
Q96P15 SERPINB11 Serpin B11 Homo sapiens (Human) PR
P01011 SERPINA3 Alpha-1-antichymotrypsin Homo sapiens (Human) PR
P12388 Serpinb2 Plasminogen activator inhibitor 2, macrophage Mus musculus (Mouse) PR
P32261 Serpinc1 Antithrombin-III Mus musculus (Mouse) PR
Q07235 Serpine2 Glia-derived nexin Mus musculus (Mouse) PR
Q5SV42 Serpinb1c Leukocyte elastase inhibitor C Mus musculus (Mouse) PR
Q80X76 Serpina3f Serine protease inhibitor A3F Mus musculus (Mouse) PR
Q9D154 Serpinb1a Leukocyte elastase inhibitor A Mus musculus (Mouse) PR
Q9JK88 Serpini2 Serpin I2 Mus musculus (Mouse) PR
Q8CDC0 Serpinb13 Serpin B13 Mus musculus (Mouse) PR
P22777 Serpine1 Plasminogen activator inhibitor 1 Mus musculus (Mouse) PR
Q5I2A0 Serpina3g Serine protease inhibitor A3G Mus musculus (Mouse) PR
P29524 Serpinb2 Plasminogen activator inhibitor 2 type A Rattus norvegicus (Rat) PR
Q6P734 Serping1 Plasma protease C1 inhibitor Rattus norvegicus (Rat) PR
P05545 Serpina3k Serine protease inhibitor A3K Rattus norvegicus (Rat) PR
P07092 Serpine2 Glia-derived nexin Rattus norvegicus (Rat) PR
Q62975 Serpina10 Protein Z-dependent protease inhibitor Rattus norvegicus (Rat) PR
O48706 At2g26390 Serpin-Z3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1T7 At3g45220 Serpin-Z4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR6 At2g14540 Serpin-Z2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAFIAALGLL MAEICPAVIC CSDGTLGMHN AVQKGQDTQK QLDSLTLASI NTDFAFSFYK
70 80 90 100 110 120
ELALKNPHKN IAFSPFGIAT ALNSLTLGAK GNTLEEILEV LKFNLTETSE ADIHQGFKHL
130 140 150 160 170 180
LQRLSHPGDQ VQIRTGNALF VEKHLQILAE FKEKARALYH TEVFTANFQQ PHEAMKLINS
190 200 210 220 230 240
YMSNQTQGKI KELVSDMDGN TSMVIVNDLF FKAEWMVPFN SDDTFMGKFI VDRSRHVKVP
250 260 270 280 290 300
MMKTKNLRTP YFRDEELKCT VVELNYKGNG KAMFILPDQG KMQQVEASLQ PGTLKKWRKS
310 320 330 340 350 360
LRPRKIKELH LPKFSLSQHY NLEDILPELG IRELFSTQAD LSGITGVKNI TVSEMIHSTE
370 380 390 400 410
LDMTEKGTEG DAITIVGYNF MSAKLKPVFV KFEDQFLYIV LDQGDLWIHV MGKVINPSEK