P13909

PR
Gene name
SERPINE1 (PAI1)
Protein name
Plasminogen activator inhibitor 1
Names
PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281375
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P13909

Entry ID Method Resolution Chain Position Source
AF-P13909-F1 Predicted AlphaFoldDB

No variants for P13909

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P13909

No associated diseases with P13909

2 regional properties for P13909

Type Name Position InterPro Accession
conserved_site Serpin, conserved site 388 - 398 IPR023795
domain Serpin domain 7 - 415 IPR023796

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

3 GO annotations of molecular function

Name Definition
enzyme inhibitor activity Binds to and stops, prevents or reduces the activity of an enzyme.
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
zymogen binding Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.

4 GO annotations of biological process

Name Definition
negative regulation of endopeptidase activity Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
negative regulation of plasminogen activation Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.
negative regulation of vascular wound healing Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.
replicative senescence A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41361 SERPINC1 Antithrombin-III Bos taurus (Bovine) PR
Q1JPB0 SERPINB1 Leukocyte elastase inhibitor Bos taurus (Bovine) PR
Q9N2I2 SERPINA5 Plasma serine protease inhibitor Bos taurus (Bovine) PR
Q9TTE1 SERPINA3-1 Serpin A3-1 Bos taurus (Bovine) PR
A2I7N1 SERPINA3-5 Serpin A3-5 Bos taurus (Bovine) PR
A6QPQ2 SERPINA3-8 Serpin A3-8 Bos taurus (Bovine) PR
A2I7N2 SERPINA3-6 Serpin A3-6 Bos taurus (Bovine) PR
A2I7M9 SERPINA3-2 Serpin A3-2 Bos taurus (Bovine) PR
O73790 SERPINB10 Heterochromatin-associated protein MENT Gallus gallus (Chicken) PR
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Homo sapiens (Human) PR
P05155 SERPING1 Plasma protease C1 inhibitor Homo sapiens (Human) PR
P08697 SERPINF2 Alpha-2-antiplasmin Homo sapiens (Human) PR
Q86WD7 SERPINA9 Serpin A9 Homo sapiens (Human) PR
P01008 SERPINC1 Antithrombin-III Homo sapiens (Human) PR
P01011 SERPINA3 Alpha-1-antichymotrypsin Homo sapiens (Human) PR
P07093 SERPINE2 Glia-derived nexin Homo sapiens (Human) PR
Q96P15 SERPINB11 Serpin B11 Homo sapiens (Human) PR
P05121 SERPINE1 Plasminogen activator inhibitor 1 Homo sapiens (Human) PR
Q5SV42 Serpinb1c Leukocyte elastase inhibitor C Mus musculus (Mouse) PR
Q07235 Serpine2 Glia-derived nexin Mus musculus (Mouse) PR
Q8CDC0 Serpinb13 Serpin B13 Mus musculus (Mouse) PR
Q5I2A0 Serpina3g Serine protease inhibitor A3G Mus musculus (Mouse) PR
Q9JK88 Serpini2 Serpin I2 Mus musculus (Mouse) PR
P12388 Serpinb2 Plasminogen activator inhibitor 2, macrophage Mus musculus (Mouse) PR
P32261 Serpinc1 Antithrombin-III Mus musculus (Mouse) PR
Q9D154 Serpinb1a Leukocyte elastase inhibitor A Mus musculus (Mouse) PR
Q8BYY9 Serpina3b Serine protease inhibitor A3B Mus musculus (Mouse) PR
Q80X76 Serpina3f Serine protease inhibitor A3F Mus musculus (Mouse) PR
P22777 Serpine1 Plasminogen activator inhibitor 1 Mus musculus (Mouse) PR
P29524 Serpinb2 Plasminogen activator inhibitor 2 type A Rattus norvegicus (Rat) PR
Q6P734 Serping1 Plasma protease C1 inhibitor Rattus norvegicus (Rat) PR
P05545 Serpina3k Serine protease inhibitor A3K Rattus norvegicus (Rat) PR
P07092 Serpine2 Glia-derived nexin Rattus norvegicus (Rat) PR
Q62975 Serpina10 Protein Z-dependent protease inhibitor Rattus norvegicus (Rat) PR
O48706 At2g26390 Serpin-Z3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1T7 At3g45220 Serpin-Z4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR6 At2g14540 Serpin-Z2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRMSPVFACL ALGLALIFGE GSASYQPQSA AASLATDFGV KVFQQVVRAS KDRNVVFSPY
70 80 90 100 110 120
GVASVLAMLQ LTTGGETRQQ IQEAMQFKIE EKGMAPAFHR LYKELMGPWN KDEISTADAI
130 140 150 160 170 180
FVQRDLELVH GFMPNFFRLF RTTVKQVDFS EVERARFIVN DWVKRHTKGM ISDLLGEGAV
190 200 210 220 230 240
DQLTRLVLVN ALYFNGQWKM PFPESNTHHR LFHKSDGSTI SVPMMAQTNK FNYTEFTTPD
250 260 270 280 290 300
GRYYDILELP YHGNTLSMLI AAPYEKEVPL SALTSILDAE LISQWKGNMT RLTRLLVLPK
310 320 330 340 350 360
FSLETEIDLR RPLENLGMTD MFRPSQADFS SFSDQEFLYV SQALQKVKIE VNESGTLASS
370 380 390 400
STALVVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP