Q9V7G5

PR
Gene name
Cyp4aa1 (CG8302)
Protein name
Probable cytochrome P450 4aa1
Names
CYPIVAA1
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG8302
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

229-303 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9V7G5

Entry ID Method Resolution Chain Position Source
AF-Q9V7G5-F1 Predicted AlphaFoldDB

No variants for Q9V7G5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9V7G5

No associated diseases with Q9V7G5

1 regional properties for Q9V7G5

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 443 - 452 IPR017972

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Peripheral membrane protein
  • Microsome membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.

4 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

1 GO annotations of biological process

Name Definition
ecdysone biosynthetic process The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects.

38 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VYQ5 Cyp318a1 Probable cytochrome P450 318a1 Drosophila melanogaster (Fruit fly) PR
Q9V559 Cyp4p3 Probable cytochrome P450 4p3 Drosophila melanogaster (Fruit fly) PR
Q9VMS7 Cyp4ac3 Probable cytochrome P450 4ac3 Drosophila melanogaster (Fruit fly) PR
Q9VMS8 Cyp4ac2 Probable cytochrome P450 4ac2 Drosophila melanogaster (Fruit fly) PR
Q9VVN6 Cyp312a1 Probable cytochrome P450 312a1 Drosophila melanogaster (Fruit fly) PR
Q9VXY0 Cyp4s3 Probable cytochrome P450 4s3 Drosophila melanogaster (Fruit fly) PR
Q6ZWL3 CYP4V2 Cytochrome P450 4V2 Homo sapiens (Human) PR
Q5TCH4 CYP4A22 Cytochrome P450 4A22 Homo sapiens (Human) PR
Q02928 CYP4A11 Cytochrome P450 4A11 Homo sapiens (Human) PR
P13584 CYP4B1 Cytochrome P450 4B1 Homo sapiens (Human) PR
Q86W10 CYP4Z1 Cytochrome P450 4Z1 Homo sapiens (Human) PR
B6SSW8 CYP714B3 Cytochrome P450 714B3 Zea mays (Maize) PR
O35728 Cyp4a14 Cytochrome P450 4A14 Mus musculus (Mouse) PR
Q91WL5 Cyp4a12a Cytochrome P450 4A12A Mus musculus (Mouse) PR
Q8SPK1 CYP4A24 Cytochrome P450 4A24 Sus scrofa (Pig) PR
Q9GJX5 CYP4A21 Taurochenodeoxycholic 6 alpha-hydroxylase Sus scrofa (Pig) PR
Q8SPK0 CYP4A25 Cytochrome P450 4A25 Sus scrofa (Pig) PR
G3V7X8 Cyp26b1 Cytochrome P450 26B1 Rattus norvegicus (Rat) PR
P20817 Cyp4a14 Cytochrome P450 4A14 Rattus norvegicus (Rat) PR
P20816 Cyp4a2 Cytochrome P450 4A2 Rattus norvegicus (Rat) PR
P24464 Cyp4a12 Cytochrome P450 4A12 Rattus norvegicus (Rat) PR
Q05JG2 CYP707A5 Abscisic acid 8'-hydroxylase 1 Oryza sativa subsp japonica (Rice) PR
Q6F4F5 CYP724B1 Cytochrome P450 724B1 Oryza sativa subsp japonica (Rice) PR
Q0DS59 CYP714B2 Cytochrome P450 714B2 Oryza sativa subsp japonica (Rice) PR
Q5KQH7 CYP714D1 Cytochrome P450 714D1 Oryza sativa subsp japonica (Rice) PR
Q9C788 CYP704B1 Cytochrome P450 704B1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZUX1 CYP94C1 Cytochrome P450 94C1 Arabidopsis thaliana (Mouse-ear cress) PR
O81077 CYP707A2 Abscisic acid 8'-hydroxylase 2 Arabidopsis thaliana (Mouse-ear cress) PR
O64698 CYP710A2 Cytochrome P450 710A2 Arabidopsis thaliana (Mouse-ear cress) PR
O64697 CYP710A1 Cytochrome P450 710A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q94IA6 CYP90D1 3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1 Arabidopsis thaliana (Mouse-ear cress) PR
Q6TBX7 CYP97C1 Carotene epsilon-monooxygenase, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC5 CYP72A15 Cytochrome P450 72A15 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC6 CYP72A14 Cytochrome P450 72A14 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC8 CYP72A13 Cytochrome P450 72A13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC9 CYP72A11 Cytochrome P450 72A11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SHG5 CYP72C1 Cytochrome P450 72C1 Arabidopsis thaliana (Mouse-ear cress) PR
Q6EIG3 cyp26b1 Cytochrome P450 26B1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MFVEKVLERT TNLELCSILI LLVISLSIYT FYATLNTYLR SVLLSLRLTG PPSLPFLGNC
70 80 90 100 110 120
MLVTDKDLMR RCAGKAFDLY GSLVRIWVLL FPFFAVLEPE DLQVILSSKK HTNKVFFYRL
130 140 150 160 170 180
MHNFLGDGLI TSSGSKWSNH RRLIQPAFHH NLLEKFIDTF VDASQSLYEN LDAEAVGTEI
190 200 210 220 230 240
NIAKYVNNCV LDILNEAVLG VPIKKRGQDV AMMEDSPFRQ GKIMMPARFT QPWLLLDGIY
250 260 270 280 290 300
HWTKMANDEL NQKKRLNDFT RKMIQRRRQI QNNNNGNSER KCLLDHMIEI SESNRDFTEE
310 320 330 340 350 360
DIVNEACTFM LAGQDSVGAA VAFTLFLLTQ NPECQDRCVL ELATIFEDSN RAPTMTDLHE
370 380 390 400 410 420
MRYMEMCIKE ALRLYPSVPL IARKLGEEVR LAKHTLPAGS NVFICPYATH RLAHIYPDPE
430 440 450 460 470 480
KFQPERFSPE NSENRHPYAF LPFSAGPRYC IGNRFAIMEI KTIVSRLLRS YQLLPVTGKT
490 500
TIAATFRITL RASGGLWVRL KERDHPLIAH