Q5TCH4
PR
Gene name |
CYP4A22 |
Protein name |
Cytochrome P450 4A22 |
Names |
CYPIVA22, Fatty acid omega-hydroxylase, Lauric acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:284541 |
EC number |
1.14.14.80: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5TCH4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5TCH4-F1 | Predicted | AlphaFoldDB |
514 variants for Q5TCH4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs765156370 CA840836 |
2 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs762999985 CA340235310 |
3 | V>F | No |
ClinGen ExAC |
|
|
rs762999985 CA840838 |
3 | V>I | No |
ClinGen ExAC |
|
|
CA340235324 rs1251560374 |
4 | S>A | No |
ClinGen gnomAD |
|
|
rs764185261 CA840839 |
4 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1046358292 CA22026409 |
7 | S>N | No |
ClinGen TOPMed |
|
|
rs546712111 CA22026410 |
8 | P>S | No |
ClinGen 1000Genomes TOPMed |
|
|
rs546712111 CA340235383 |
8 | P>T | No |
ClinGen 1000Genomes TOPMed |
|
|
CA840841 rs571296678 |
9 | S>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs199572592 CA840843 |
9 | S>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs76011927 VAR_044349 CA840844 |
11 | R>C | allele CYP4A22*2 and CYP4A22*3 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA840845 rs200538871 |
11 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA340235450 rs200538871 |
11 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs200121806 CA22026468 |
14 | G>A | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs749856086 CA840846 |
14 | G>C | No |
ClinGen ExAC gnomAD |
|
|
CA22026467 rs200121806 |
14 | G>D | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs200121806 CA22026469 |
14 | G>V | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA340235515 rs1366799781 |
15 | V>I | No |
ClinGen gnomAD |
|
|
CA736320232 rs1201595916 |
16 | S>* | No |
ClinGen TOPMed |
|
|
rs1309271312 CA340235560 |
16 | S>F | No |
ClinGen gnomAD |
|
|
CA840853 rs770606110 |
17 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA22026495 CA840851 rs369829008 |
17 | G>R | No |
ClinGen 1000Genomes TOPMed |
|
|
CA840855 rs759296620 |
18 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA340235654 rs1205509549 |
20 | Q>R | No |
ClinGen TOPMed |
|
|
CA22026512 rs1018478866 |
21 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
CA340235673 rs1018478866 |
21 | V>G | No |
ClinGen TOPMed gnomAD |
|
|
CA22026524 rs964360299 |
22 | T>A | No |
ClinGen TOPMed |
|
|
CA840856 rs769626452 |
23 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs1263254350 CA340235735 |
26 | I>M | No |
ClinGen gnomAD |
|
| TCGA novel | 28 | L>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs762906910 CA840858 |
32 | I>F | No |
ClinGen ExAC gnomAD |
|
|
CA840860 rs141897799 |
33 | K>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA840861 rs761854619 |
34 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs767845138 CA840862 |
35 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340235872 rs1297201537 |
40 | H>N | No |
ClinGen gnomAD |
|
|
rs368458255 CA840867 |
45 | L>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs779348753 CA840868 |
46 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs534701920 CA840871 |
47 | A>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA840870 rs534701920 |
47 | A>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA840869 rs137980355 |
47 | A>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs137980355 CA340236019 |
47 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA340236037 rs1485938745 COSM1321007 |
48 | L>F | ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs745474045 CA840872 |
49 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs1245883076 CA340236067 |
50 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1245883076 CA340236065 |
50 | Q>E | No |
ClinGen TOPMed gnomAD |
|
|
CA840873 rs769468020 |
50 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA840874 rs775199086 |
52 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs144569653 CA840876 |
54 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA340236175 rs774220009 |
55 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA840877 rs774220009 |
55 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
COSM3944152 CA340236201 rs1319978192 |
56 | S>F | ovary [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA840880 rs148805480 |
57 | H>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1461947382 CA340236224 |
57 | H>Q | No |
ClinGen TOPMed |
|
|
CA840879 rs148805480 |
57 | H>Y | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA840882 rs766725560 |
58 | W>C | No |
ClinGen ExAC gnomAD |
|
|
rs760916578 CA840881 |
58 | W>R | No |
ClinGen ExAC gnomAD |
|
|
rs1226947560 CA340236252 |
59 | L>V | No |
ClinGen gnomAD |
|
|
CA340236267 rs1309863995 |
60 | F>L | No |
ClinGen gnomAD |
|
|
CA340236289 rs112604161 CA840884 |
61 | G>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs765744521 CA840885 |
63 | I>F | No |
ClinGen ExAC gnomAD |
|
|
TCGA novel rs1215996583 CA340236811 |
66 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen TOPMed gnomAD NCI-TCGA |
|
rs370585374 CA840920 CA340236854 |
68 | H>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA340236867 rs763365225 |
69 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs373881337 CA840921 |
69 | D>N | No |
ClinGen ESP ExAC gnomAD |
|
|
CA840923 rs764578626 |
70 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs56258513 CA840924 |
72 | L>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA22028445 rs993202547 |
72 | L>P | No |
ClinGen TOPMed |
|
|
COSM243946 rs765755173 CA840926 |
74 | R>Q | Variant assessed as Somatic; 4.62e-05 impact. prostate [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA840925 rs377043739 |
74 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs568254542 CA840927 |
77 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM291802 rs201122681 CA840929 |
78 | R>Q | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs200383147 CA840928 |
78 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA840930 rs547934003 |
80 | K>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA840931 rs192345500 |
81 | T>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs777833770 CA840933 |
85 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs746895963 CA840934 |
85 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA340237110 rs1364009914 |
88 | Y>H | No |
ClinGen TOPMed gnomAD |
|
|
CA340237137 rs1316905071 |
89 | W>C | No |
ClinGen gnomAD |
|
|
rs745974402 CA840938 |
90 | I>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA840936 rs781066663 |
90 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA840937 rs745974402 |
90 | I>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA22028518 rs866281074 |
91 | W>* | No |
ClinGen gnomAD |
|
|
CA340237150 CA840939 rs775848300 |
91 | W>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1210654743 CA340237168 |
93 | G>D | No |
ClinGen gnomAD |
|
|
rs756314227 CA22028523 |
94 | K>* | No |
ClinGen Ensembl |
|
|
rs780190981 COSM1343194 CA840940 |
96 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs564518259 CA840942 |
96 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs564518259 CA840941 |
96 | R>P | No |
ClinGen ExAC gnomAD |
|
|
CA340237850 rs1186857512 |
97 | V>A | No |
ClinGen gnomAD |
|
|
rs768070119 CA840944 |
98 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs759156135 CA840946 |
100 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340237940 rs1320650403 |
101 | D>E | No |
ClinGen gnomAD |
|
|
CA340237947 rs1387198359 |
102 | P>A | No |
ClinGen gnomAD |
|
|
CA840947 rs61507155 VAR_061045 |
104 | Y>F | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA22028565 rs61507155 |
104 | Y>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA340238017 rs1340883775 |
105 | M>T | No |
ClinGen gnomAD |
|
|
CA840948 rs752449954 |
110 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1282414705 CA340238138 |
111 | R>K | No |
ClinGen gnomAD |
|
|
CA840949 rs758148526 |
112 | S>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA840967 rs762627393 |
113 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA340238185 rs1211272692 |
113 | D>H | No |
ClinGen TOPMed |
|
|
COSM1627101 rs570043566 CA840968 |
114 | P>L | liver [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC gnomAD |
|
CA340238358 rs1557646140 |
115 | K>* | No |
ClinGen Ensembl |
|
|
rs549333757 CA840970 |
117 | H>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1183583918 CA340238384 |
117 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA340238443 rs1463573354 |
119 | S>C | No |
ClinGen TOPMed |
|
|
VAR_044350 CA840972 rs2758717 |
121 | K>R | No |
ClinGen UniProt ExAC dbSNP gnomAD |
|
|
CA840973 CA840974 rs756026269 |
122 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749372717 CA840975 |
123 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340238522 rs749372717 |
123 | L>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA840976 rs368794910 |
124 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA340238559 rs1372223535 |
125 | P>R | No |
ClinGen gnomAD |
|
|
rs748432726 CA840978 |
126 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs12564525 CA840977 VAR_044351 |
126 | R>W | allele CYP4A22*8, allele CYP4A22*9, allele CYP4A22*11, allele CYP4A22*12, allele CYP4A22*13, allele CYP4A22*14 and allele CYP4A22*15 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA841009 rs2056900 |
130 | G>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs753825027 CA841010 |
130 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA340238906 rs2056900 |
130 | G>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA841008 rs2056900 VAR_044352 |
130 | G>S | allele CYP4A22*4, allele CYP4A22*10, allele CYP4A22*12, allele CYP4A22*13, allele CYP4A22*14 and allele CYP4A22*15 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA841011 CA340238942 rs759496666 |
131 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs897652439 CA22029373 |
131 | L>V | No |
ClinGen TOPMed |
|
|
rs1231938047 CA340239085 |
137 | Q>* | No |
ClinGen gnomAD |
|
|
rs752724599 CA841013 |
137 | Q>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs758588354 CA841014 |
138 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1049441295 CA22029408 |
139 | W>* | No |
ClinGen TOPMed |
|
|
rs371221965 CA841015 |
139 | W>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA340239226 rs1245790459 |
141 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1484143980 CA340239242 |
142 | H>P | No |
ClinGen gnomAD |
|
|
CA340239239 rs1557646663 |
142 | H>Y | No |
ClinGen Ensembl |
|
|
CA340239254 rs1182232056 |
143 | R>* | No |
ClinGen gnomAD |
|
|
COSM122467 CA841016 rs138940178 |
143 | R>Q | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA841018 rs781758484 |
144 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781758484 CA22029414 |
144 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs147010308 CA841017 |
144 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA841019 rs746327819 CA841020 |
145 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs778416551 CA841021 |
147 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1569803710 CA340239336 |
147 | T>P | No |
ClinGen Ensembl |
|
|
rs2056899 CA340239456 |
152 | N>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA841023 rs771740217 |
152 | N>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
VAR_044353 rs2056899 CA841022 |
152 | N>Y | allele CYP4A22*2, allele CYP4A22*3, allele CYP4A22*4, allele CYP4A22*5, allele CYP4A22*6, allele CYP4A22*7, allele CYP4A22*8, allele CYP4A22*9, allele CYP4A22*10, allele CYP4A22*11, allele CYP4A22*12, allele CYP4A22*13, allele CYP4A22*14 and allele CYP4A22*15 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs200279801 CA841024 |
153 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
CA340239487 rs1290717985 |
154 | I>N | No |
ClinGen gnomAD |
|
|
CA340239552 rs2758715 CA841029 |
158 | Y>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA841028 rs759406647 |
158 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
rs751777511 CA841033 |
159 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs763011921 CA841032 COSM3700747 |
159 | V>L | liver [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA841031 rs763011921 |
159 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757574338 CA841034 |
160 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA22029502 rs376345723 |
161 | L>R | No |
ClinGen Ensembl |
|
|
rs189269010 CA22029503 |
162 | M>I | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA340239626 rs1405806751 |
163 | A>V | No |
ClinGen gnomAD |
|
| TCGA novel | 165 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340239671 rs1298383816 |
166 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs771031011 CA841035 |
167 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA841036 rs201496093 |
167 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs571262150 CA841055 |
173 | W>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA340240388 rs1476775415 |
173 | W>R | No |
ClinGen gnomAD |
|
|
CA841056 rs377172013 |
176 | L>F | No |
ClinGen ESP ExAC gnomAD |
|
|
CA340240436 rs1221295385 |
177 | L>I | No |
ClinGen TOPMed |
|
|
CA841057 rs754252488 |
177 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs755543244 CA841058 |
178 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs777084778 CA841060 |
180 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs777084778 CA841059 |
180 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs886098830 CA22030150 |
181 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
rs201572429 CA22030161 |
182 | P>L | No |
ClinGen Ensembl |
|
|
rs780889935 CA841062 |
184 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs4926581 CA841063 VAR_044354 |
185 | V>F | allele CYP4A22*10, allele CYP4A22*11, allele CYP4A22*12, allele CYP4A22*13, allele CYP4A22*14 and allele CYP4A22*15 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs4926581 CA340240549 |
185 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs769528188 CA841064 |
186 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs775375934 CA841065 |
187 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs749138787 CA841066 |
189 | V>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
CA841067 rs768642561 |
190 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA340240696 rs1475274017 |
191 | L>V | No |
ClinGen gnomAD |
|
|
rs1166712716 CA340240708 |
191 | L>W | No |
ClinGen gnomAD |
|
|
rs1416583656 CA340240754 |
193 | T>A | No |
ClinGen gnomAD |
|
|
CA841069 rs774514132 |
195 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841070 rs762037223 |
196 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772416181 CA841071 |
198 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA841073 rs761075456 |
200 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340240927 rs1224945328 |
200 | S>R | No |
ClinGen gnomAD |
|
|
CA841074 rs200757417 |
201 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841075 rs754237745 |
203 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs1272653870 CA340240983 |
203 | S>I | No |
ClinGen gnomAD |
|
|
CA340240991 rs1210867872 |
204 | H>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs575378698 CA841076 |
205 | Q>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
CA22030283 rs1015934282 |
205 | Q>P | No |
ClinGen TOPMed gnomAD |
|
|
rs765792185 CA841078 |
208 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765792185 CA22030311 |
208 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751065012 CA841079 |
209 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
CA841080 rs756801439 |
210 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340241151 rs756801439 |
210 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 211 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA841082 rs780802083 |
212 | R>K | No |
ClinGen ExAC gnomAD |
|
|
CA841081 rs780802083 |
212 | R>T | No |
ClinGen ExAC gnomAD |
|
|
CA340241425 rs1286885581 |
216 | S>P | No |
ClinGen TOPMed |
|
|
CA340241468 rs1276803164 |
218 | I>L | No |
ClinGen gnomAD |
|
|
rs748046944 CA841106 |
218 | I>N | No |
ClinGen ExAC gnomAD |
|
|
CA22030676 rs199792812 |
219 | Q>* | No |
ClinGen 1000Genomes gnomAD |
|
|
CA841111 rs369774561 |
221 | I>F | No |
ClinGen ESP ExAC gnomAD |
|
|
rs369774561 CA841110 |
221 | I>V | No |
ClinGen ESP ExAC gnomAD |
|
|
CA340241582 rs1352230697 |
222 | S>N | No |
ClinGen TOPMed |
|
|
rs1416762133 CA340241606 |
223 | D>A | No |
ClinGen TOPMed gnomAD |
|
|
rs146477822 CA841112 |
223 | D>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1249248656 COSM1343196 CA340241594 |
223 | D>N | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA340241625 rs776953073 |
224 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841115 VAR_044355 rs35202523 |
226 | S>N | No |
ClinGen UniProt ExAC dbSNP gnomAD |
|
|
CA841116 rs775861962 |
226 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs763383232 CA841117 |
227 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs772583047 CA841119 |
228 | V>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 230 | C>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1389725991 CA340241764 |
230 | C>G | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 230 | C>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs35156123 CA22030728 VAR_044356 |
230 | C>S | No |
ClinGen UniProt TOPMed dbSNP gnomAD |
|
|
rs765912026 CA340241803 |
231 | C>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841120 rs10789501 VAR_044357 |
231 | C>R | allele CYP4A22*2, allele CYP4A22*3, allele CYP4A22*4, allele CYP4A22*5, allele CYP4A22*6, allele CYP4A22*7, allele CYP4A22*8, allele CYP4A22*9, allele CYP4A22*10, allele CYP4A22*11, allele CYP4A22*12, allele CYP4A22*13, allele CYP4A22*14 and allele CYP4A22*15 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA340241788 rs10789501 |
231 | C>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs765912026 CA841121 |
231 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340241821 rs191687330 |
232 | M>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA841122 rs191687330 |
232 | M>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs765059748 CA841124 |
234 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs752556492 CA841125 |
235 | A>T | No |
ClinGen ExAC TOPMed |
|
|
CA841126 rs183880611 |
236 | F>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA841127 rs777837250 |
237 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340241919 rs1479406516 |
237 | H>Y | No |
ClinGen gnomAD |
|
|
CA340241947 rs1191318638 |
238 | E>D | No |
ClinGen gnomAD |
|
|
CA841129 rs757407453 |
238 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs143425502 CA841130 |
240 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
|
rs746052339 CA841131 |
240 | D>V | No |
ClinGen ExAC gnomAD |
|
|
CA340241983 rs1569808408 |
241 | T>P | No |
ClinGen Ensembl |
|
|
CA340241991 rs1283583411 |
241 | T>S | No |
ClinGen TOPMed |
|
|
CA841133 rs199906672 |
242 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770005682 CA841132 |
242 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749710175 CA841134 |
243 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 243 | Y>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA841135 rs769147059 |
244 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841136 rs550279903 |
245 | L>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs550279903 CA22030825 |
245 | L>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs760078696 CA841137 |
246 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA340242055 rs1569808521 |
246 | T>P | No |
ClinGen Ensembl |
|
|
rs1557647941 CA340242152 |
249 | G>D | No |
ClinGen Ensembl |
|
|
rs765043322 CA841141 |
250 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841142 rs569148380 |
250 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA340242173 rs569148380 |
250 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA841143 rs758308317 |
251 | W>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs138579860 CA841144 |
252 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1569808671 CA340242244 |
253 | H>P | No |
ClinGen Ensembl |
|
|
rs1333483063 CA340242266 |
254 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA841145 rs536116490 |
254 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs781263992 CA340242286 |
255 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340242275 rs376758503 |
255 | A>P | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA22030876 rs376758503 |
255 | A>T | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA841147 rs781263992 |
255 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841149 rs756315173 |
256 | C>R | No |
ClinGen ExAC gnomAD |
|
|
rs1290048673 CA340242347 |
257 | Q>L | No |
ClinGen TOPMed gnomAD |
|
|
CA340242340 rs1290048673 |
257 | Q>P | No |
ClinGen TOPMed gnomAD |
|
|
CA22030892 rs554345540 |
259 | A>P | No |
ClinGen 1000Genomes |
|
|
CA340242389 rs1359389946 |
259 | A>V | No |
ClinGen TOPMed |
|
|
CA22030893 rs982039925 |
260 | H>L | No |
ClinGen TOPMed |
|
|
CA841151 rs147311489 |
261 | Q>K | No |
ClinGen ESP ExAC |
|
|
rs779166657 CA841153 |
263 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841176 rs778465891 |
264 | D>A | No |
ClinGen ExAC gnomAD |
|
|
CA340242553 rs745354214 |
264 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs769383660 CA841178 |
265 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs1484659308 CA522612590 |
266 | V>* | No |
ClinGen gnomAD |
|
|
CA841180 rs375004222 |
270 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA841181 rs768203901 |
270 | R>K | No |
ClinGen ExAC gnomAD |
|
|
CA340242606 rs1174666948 |
271 | K>* | No |
ClinGen gnomAD |
|
|
CA841184 rs570937997 |
275 | Q>* | No |
ClinGen 1000Genomes ExAC |
|
|
CA340242642 rs1310359568 |
275 | Q>P | No |
ClinGen gnomAD |
|
|
CA841186 rs6661132 |
276 | K>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
VAR_044358 CA841185 rs6661132 |
276 | K>T | allele CYP4A22*8, allele CYP4A22*11, allele CYP4A22*14 and allele CYP4A22*15 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA841188 rs760627269 |
277 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA841189 CA340242663 rs766404686 |
278 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs556570340 CA841190 |
284 | K>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1438532970 CA340242720 |
284 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA340242719 rs556570340 |
284 | K>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA340242726 rs1203915857 |
285 | R>K | No |
ClinGen gnomAD |
|
|
CA340242736 rs1342426426 |
286 | K>R | No |
ClinGen gnomAD |
|
|
rs755217084 CA841192 |
287 | R>G | No |
ClinGen ExAC |
|
|
rs200832137 CA841194 |
288 | H>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1394900118 CA340242765 |
289 | L>F | No |
ClinGen gnomAD |
|
| TCGA novel | 290 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs753076403 CA841195 |
290 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1182344907 CA340242777 |
291 | F>S | No |
ClinGen TOPMed |
|
|
CA841196 rs758739769 |
292 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841197 rs778308717 |
293 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340242799 rs1167722685 |
294 | I>V | No |
ClinGen gnomAD |
|
|
rs1557648525 CA340242819 |
296 | L>H | No |
ClinGen Ensembl |
|
|
CA340242817 rs1351068577 |
296 | L>V | No |
ClinGen gnomAD |
|
|
rs1285432563 CA340242973 |
300 | M>I | No |
ClinGen gnomAD |
|
|
CA841224 rs747714590 |
301 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA841226 rs772931089 |
305 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841227 rs746874675 |
306 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776482741 CA841229 |
307 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA841231 rs765195499 |
308 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759540673 CA841230 |
308 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA340243132 rs1158753349 |
310 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
rs1384033286 CA340243136 |
311 | L>F | No |
ClinGen gnomAD |
|
|
rs775647945 CA841232 |
312 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA841233 rs140149915 |
312 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA841234 rs764470979 |
313 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA841235 rs751965673 |
314 | E>* | No |
ClinGen ExAC gnomAD |
|
|
rs762306533 CA841236 |
314 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs1353601040 CA340243162 |
315 | V>M | No |
ClinGen gnomAD |
|
|
rs768112609 CA841238 |
317 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841237 rs768112609 |
317 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 318 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340243250 rs1282841765 |
319 | M>I | No |
ClinGen gnomAD |
|
|
CA841241 rs752263315 |
319 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA841240 rs778219609 |
319 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs758031619 CA841242 |
321 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA340243304 rs1296184837 |
322 | G>S | No |
ClinGen gnomAD |
|
|
rs1254825012 CA340243311 |
322 | G>V | No |
ClinGen gnomAD |
|
|
CA340243331 rs968322 CA340243334 |
323 | H>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA841246 rs770664416 |
324 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs375999051 CA841245 |
324 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA340243351 rs1260551974 |
324 | D>V | No |
ClinGen TOPMed |
|
|
rs781073103 CA841247 |
325 | T>P | No |
ClinGen ExAC gnomAD |
|
|
rs745730799 CA841248 |
326 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA340243383 rs1234402325 |
326 | T>R | No |
ClinGen TOPMed |
|
|
rs1395405207 CA340243398 |
327 | A>V | No |
ClinGen gnomAD |
|
|
CA22031508 rs769786424 |
329 | G>E | No |
ClinGen ExAC TOPMed |
|
|
COSM3360939 CA841250 rs769786424 |
329 | G>V | kidney [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed |
|
CA841251 rs369645508 |
330 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs768964816 CA841253 |
331 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA841252 rs763189351 |
331 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA340243500 CA841254 rs774759365 |
332 | W>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340243535 rs1344350397 |
334 | L>F | No |
ClinGen TOPMed |
|
|
rs762145254 CA841255 |
334 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340243549 rs762145254 |
334 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767733132 CA841256 |
335 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
CA340243565 rs1306121257 |
335 | Y>C | No |
ClinGen gnomAD |
|
|
rs546435756 CA841257 |
336 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1195880580 CA340243639 |
338 | A>T | No |
ClinGen gnomAD |
|
|
rs752173609 CA841260 |
338 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs756911556 CA841264 |
340 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
CA841263 rs751173345 |
340 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777286981 CA841262 |
340 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340243721 rs1480208945 |
341 | P>H | No |
ClinGen TOPMed |
|
|
CA841265 rs369004314 |
341 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 341 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA841266 rs745735706 |
343 | H>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1195383964 CA340243794 |
345 | E>K | No |
ClinGen TOPMed |
|
|
rs1168590646 CA340243820 COSM910396 |
347 | C>* | Variant assessed as Somatic; 9.24e-05 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs201521465 CA841270 |
348 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841268 rs372905572 |
348 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 349 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1395812815 CA340243833 |
349 | E>Q | No |
ClinGen gnomAD |
|
|
CA340243883 rs56085413 |
352 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs377127501 CA22031576 |
353 | G>C | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA340243897 rs1328141052 |
353 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
rs377127501 CA340243888 |
353 | G>S | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs370559458 CA841273 |
355 | L>P | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1299565403 CA340243949 |
356 | G>D | No |
ClinGen gnomAD |
|
|
CA841274 rs532237456 |
358 | G>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA841275 rs773433358 |
359 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340243989 rs773433358 |
359 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA22031583 rs200956466 |
361 | I>T | No |
ClinGen TOPMed |
|
|
rs761167111 CA841276 |
362 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1215230960 CA340244022 |
362 | T>P | No |
ClinGen gnomAD |
|
|
rs761167111 CA340244025 |
362 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1557649090 CA340244318 |
363 | W>C | No |
ClinGen Ensembl |
|
|
rs773849395 CA841299 |
365 | H>N | No |
ClinGen ExAC gnomAD |
|
|
CA340244340 rs1162907688 |
366 | L>P | No |
ClinGen gnomAD |
|
|
CA841300 rs761428966 |
366 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA841301 rs570554271 |
368 | Q>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA340244365 rs1454620087 |
369 | M>I | No |
ClinGen gnomAD |
|
|
rs1288867081 CA340244373 |
370 | P>L | No |
ClinGen gnomAD |
|
|
rs1227057139 CA340244385 |
372 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA841302 rs750042028 |
374 | M>R | No |
ClinGen ExAC gnomAD |
|
|
rs1226305369 CA340244410 |
376 | I>L | No |
ClinGen gnomAD |
|
|
rs755749594 CA841303 |
376 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA22031664 rs967716185 |
378 | E>D | No |
ClinGen TOPMed |
|
|
CA340244431 rs1317364810 |
379 | A>T | No |
ClinGen gnomAD |
|
|
rs1447033815 CA340244444 |
381 | R>K | No |
ClinGen TOPMed |
|
|
rs1283547573 CA340244451 |
382 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA841305 rs377641755 |
382 | L>R | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1557649162 CA340244470 |
385 | P>A | No |
ClinGen Ensembl |
|
|
rs61736431 CA841307 |
385 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1485375524 CA340244473 |
386 | V>M | No |
ClinGen gnomAD |
|
| TCGA novel | 387 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1180401559 CA340244488 |
388 | G>D | No |
ClinGen gnomAD |
|
|
CA340244485 rs1481167725 |
388 | G>S | No |
ClinGen TOPMed |
|
|
rs926412144 CA22031691 |
389 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA340244523 rs1158861005 |
393 | L>R | No |
ClinGen gnomAD |
|
|
CA841310 rs758456855 |
394 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA340244528 rs1378807264 |
394 | S>T | No |
ClinGen gnomAD |
|
|
rs1313994102 CA340244532 |
395 | T>A | No |
ClinGen gnomAD |
|
|
rs141856283 CA841312 COSM1474050 |
397 | V>I | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD |
|
rs939106012 CA22031699 |
401 | D>G | No |
ClinGen TOPMed |
|
|
rs1361582544 CA340244568 |
401 | D>N | No |
ClinGen TOPMed |
|
|
rs148459778 CA841313 |
402 | G>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs148459778 CA340244579 |
402 | G>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs371439568 CA841314 |
403 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA841315 rs375392496 |
403 | R>H | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs371439568 CA340244580 |
403 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA841318 rs770257448 |
405 | L>* | No |
ClinGen ExAC gnomAD |
|
|
rs1306848505 CA340244597 |
405 | L>F | No |
ClinGen gnomAD |
|
| TCGA novel | 406 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340244599 rs1569812830 |
406 | P>T | No |
ClinGen Ensembl |
|
|
rs776023387 CA841319 |
407 | K>* | No |
ClinGen ExAC gnomAD |
|
|
rs1234996955 CA340244608 |
407 | K>R | No |
ClinGen gnomAD |
|
|
rs765059695 CA841344 |
409 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA340244643 rs1427069828 |
410 | M>I | No |
ClinGen TOPMed |
|
|
rs752448693 CA841345 |
410 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA841347 rs764009214 |
413 | L>I | No |
ClinGen ExAC gnomAD |
|
|
rs112631646 CA841348 |
414 | S>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs750600674 CA841351 |
417 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs756331644 CA841352 |
418 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780404999 CA841353 CA340244698 |
419 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA22032397 rs200686099 |
421 | N>H | No |
ClinGen gnomAD |
|
|
CA340244712 rs1289669941 |
421 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1450216767 CA340244729 |
424 | V>L | No |
ClinGen gnomAD |
|
|
rs369051627 CA841354 |
426 | P>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 426 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340244749 rs1243200583 |
427 | N>D | No |
ClinGen TOPMed gnomAD |
|
|
rs143777632 CA340244751 |
427 | N>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1162624609 CA340244754 |
427 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
CA841355 rs143777632 |
427 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
VAR_044359 rs2405599 CA841356 |
428 | L>P | allele CYP4A22*6, allele CYP4A22*9, allele CYP4A22*10, allele CYP4A22*12, allele CYP4A22*13 and allele CYP4A22*15 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA340244757 rs2405599 |
428 | L>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs2405599 CA340244758 |
428 | L>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1457976430 CA340244765 |
429 | E>D | No |
ClinGen gnomAD |
|
|
CA841357 rs746495343 |
429 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs1366357088 CA340244780 |
430 | V>G | No |
ClinGen gnomAD |
|
|
CA340244777 rs557697033 CA841373 |
430 | V>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA340244790 rs1569815388 |
432 | D>A | No |
ClinGen Ensembl |
|
|
CA841376 rs780837392 |
432 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs748598921 CA841375 |
432 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs748598921 CA841374 |
432 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs138826010 CA841377 |
434 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA841379 rs199782847 |
435 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs150794228 CA841380 COSM3771765 |
435 | R>H | pancreas [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA841378 rs199782847 |
435 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841381 rs149509404 |
436 | F>Y | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA841383 rs148627284 |
438 | P>L | No |
ClinGen 1000Genomes ESP TOPMed |
|
|
rs774132925 CA841382 |
438 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767498373 CA841386 |
439 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA340244828 rs767498373 |
439 | G>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 442 | Q>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1569815513 CA340244855 |
443 | H>P | No |
ClinGen Ensembl |
|
|
CA841388 CA841387 rs147763791 |
443 | H>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 443 | H>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340244869 rs753957494 |
445 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841389 rs766602047 |
445 | H>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs139469516 CA841391 |
446 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA841392 rs765462401 |
446 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA340244886 rs1199400859 |
448 | L>P | No |
ClinGen gnomAD |
|
|
rs267598634 CA22032809 |
453 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs267598633 CA22032808 |
453 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1237395045 CA340244918 |
454 | S>T | No |
ClinGen gnomAD |
|
|
rs1557650086 CA340244924 |
455 | R>G | No |
ClinGen Ensembl |
|
|
rs746864745 CA841422 |
458 | I>N | No |
ClinGen ExAC gnomAD |
|
|
CA841424 COSM3705912 rs554623281 |
459 | G>R | liver [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs776244724 CA841425 |
460 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs1355438790 CA340245181 |
461 | Q>R | No |
ClinGen gnomAD |
|
| TCGA novel | 463 | A>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA841427 rs145355751 |
464 | M>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA841426 rs145355751 |
464 | M>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 465 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs763303000 CA841428 |
465 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA841429 rs764489470 |
466 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764489470 CA340245328 |
466 | Q>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841430 rs751963169 |
467 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340245339 rs751963169 |
467 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA841431 rs145063739 |
470 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs753253715 CA841433 |
471 | R>G | No |
ClinGen ExAC |
|
|
CA841434 rs192410694 |
471 | R>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA22034219 rs540636031 |
472 | A>G | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA22034226 rs540636031 |
472 | A>V | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs1182558951 CA340245432 |
473 | L>P | No |
ClinGen TOPMed |
|
|
rs752306468 CA841436 |
474 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752306468 CA340245447 |
474 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777531624 CA841438 |
477 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs377247931 COSM910398 CA841439 |
477 | R>H | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs377247931 CA340245500 |
477 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 479 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340245619 rs1401096218 |
482 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1297082427 CA340245636 |
483 | D>E | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 483 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs757113433 CA841442 |
484 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340245657 rs1454022502 |
485 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs781241287 CA841443 |
486 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA841444 rs745818783 |
486 | R>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1242355263 CA340245734 |
489 | I>V | No |
ClinGen gnomAD |
|
|
rs1317225997 CA340245750 |
490 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs2758714 CA841448 VAR_044360 |
491 | M>I | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs774570898 CA841449 |
492 | A>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA340245819 rs762274692 |
493 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs767886913 CA340245827 |
493 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1343199 rs767886913 CA841451 |
493 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs773718162 CA841452 |
495 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1163152118 CA340245973 |
498 | S>C | No |
ClinGen gnomAD |
|
|
CA841453 rs761201440 |
498 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1420880520 CA340246018 |
500 | N>S | No |
ClinGen gnomAD |
|
|
rs1358145451 CA340246070 |
502 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1569820249 CA340246094 |
503 | H>P | No |
ClinGen Ensembl |
|
|
CA841456 rs758042184 |
503 | H>Y | No |
ClinGen ExAC TOPMed |
|
|
CA841457 COSM1343201 rs148057835 |
505 | R>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA841458 rs375990198 COSM1249602 |
505 | R>H | oesophagus haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs61736430 CA841460 COSM3747000 |
506 | L>F | liver [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
rs4926600 VAR_044361 CA841462 |
509 | L>F | allele CYP4A22*7, allele CYP4A22*10, allele CYP4A22*11, allele CYP4A22*13, allele CYP4A22*14 and allele CYP4A22*15 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA340246212 rs4926600 |
509 | L>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA841465 rs376754437 |
511 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA841466 rs143878521 |
512 | P>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs772441252 CA841468 |
513 | C>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM414878 rs1232464242 CA340246332 |
514 | E>K | urinary_tract [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA841469 rs773451936 |
515 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs142987331 CA841470 |
515 | D>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs369656798 CA841471 |
516 | K>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs762499977 CA841473 |
517 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA340246406 rs1557651275 |
517 | D>N | No |
ClinGen Ensembl |
|
|
rs774950099 CA841472 |
517 | D>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 518 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340246459 rs1557651287 |
519 | L>F | No |
ClinGen Ensembl |
No associated diseases with Q5TCH4
1 regional properties for Q5TCH4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 450 - 459 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.80 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| 16-hydroxypalmitate dehydrogenase activity | Catalysis of the reaction: 16-hydroxypalmitate + NADP <=> H+ + 16-oxo-palmitate + NADPH. |
| alkane 1-monooxygenase activity | Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. |
| arachidonic acid monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| laurate hydroxylase activity | Catalysis of the reaction: dodecanoate + NADPH + O2 + H+ <=> 11-hydroxylaurate + NADP + H2O. |
| long-chain fatty acid omega-hydroxylase activity | Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| arachidonic acid metabolic process | The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. |
| icosanoid biosynthetic process | The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. |
| kidney development | The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. |
| lauric acid metabolic process | The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources. |
| linoleic acid metabolic process | The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. |
| lipid hydroxylation | The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid. |
38 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VYQ5 | Cyp318a1 | Probable cytochrome P450 318a1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9V7G5 | Cyp4aa1 | Probable cytochrome P450 4aa1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VVN6 | Cyp312a1 | Probable cytochrome P450 312a1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VXY0 | Cyp4s3 | Probable cytochrome P450 4s3 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VMS8 | Cyp4ac2 | Probable cytochrome P450 4ac2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VMS7 | Cyp4ac3 | Probable cytochrome P450 4ac3 | Drosophila melanogaster (Fruit fly) | PR |
| Q9V559 | Cyp4p3 | Probable cytochrome P450 4p3 | Drosophila melanogaster (Fruit fly) | PR |
| Q6ZWL3 | CYP4V2 | Cytochrome P450 4V2 | Homo sapiens (Human) | PR |
| Q86W10 | CYP4Z1 | Cytochrome P450 4Z1 | Homo sapiens (Human) | PR |
| Q02928 | CYP4A11 | Cytochrome P450 4A11 | Homo sapiens (Human) | PR |
| P13584 | CYP4B1 | Cytochrome P450 4B1 | Homo sapiens (Human) | PR |
| B6SSW8 | CYP714B3 | Cytochrome P450 714B3 | Zea mays (Maize) | PR |
| O35728 | Cyp4a14 | Cytochrome P450 4A14 | Mus musculus (Mouse) | PR |
| Q91WL5 | Cyp4a12a | Cytochrome P450 4A12A | Mus musculus (Mouse) | PR |
| Q9GJX5 | CYP4A21 | Taurochenodeoxycholic 6 alpha-hydroxylase | Sus scrofa (Pig) | PR |
| Q8SPK1 | CYP4A24 | Cytochrome P450 4A24 | Sus scrofa (Pig) | PR |
| Q8SPK0 | CYP4A25 | Cytochrome P450 4A25 | Sus scrofa (Pig) | PR |
| G3V7X8 | Cyp26b1 | Cytochrome P450 26B1 | Rattus norvegicus (Rat) | PR |
| P20816 | Cyp4a2 | Cytochrome P450 4A2 | Rattus norvegicus (Rat) | PR |
| P20817 | Cyp4a14 | Cytochrome P450 4A14 | Rattus norvegicus (Rat) | PR |
| P24464 | Cyp4a12 | Cytochrome P450 4A12 | Rattus norvegicus (Rat) | PR |
| Q05JG2 | CYP707A5 | Abscisic acid 8'-hydroxylase 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q6F4F5 | CYP724B1 | Cytochrome P450 724B1 | Oryza sativa subsp japonica (Rice) | PR |
| Q0DS59 | CYP714B2 | Cytochrome P450 714B2 | Oryza sativa subsp japonica (Rice) | PR |
| Q5KQH7 | CYP714D1 | Cytochrome P450 714D1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9C788 | CYP704B1 | Cytochrome P450 704B1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZUX1 | CYP94C1 | Cytochrome P450 94C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81077 | CYP707A2 | Abscisic acid 8'-hydroxylase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64698 | CYP710A2 | Cytochrome P450 710A2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64697 | CYP710A1 | Cytochrome P450 710A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94IA6 | CYP90D1 | 3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6TBX7 | CYP97C1 | Carotene epsilon-monooxygenase, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC5 | CYP72A15 | Cytochrome P450 72A15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC6 | CYP72A14 | Cytochrome P450 72A14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC8 | CYP72A13 | Cytochrome P450 72A13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC9 | CYP72A11 | Cytochrome P450 72A11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHG5 | CYP72C1 | Cytochrome P450 72C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6EIG3 | cyp26b1 | Cytochrome P450 26B1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVSVLSPSR | RLGGVSGILQ | VTSLLILLLL | LIKAAQLYLH | RQWLLKALQQ | FPCPPSHWLF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GHIQEFQHDQ | ELQRIQERVK | TFPSACPYWI | WGGKVRVQLY | DPDYMKVILG | RSDPKSHGSY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KFLAPRIGYG | LLLLNGQTWF | QHRRMLTPAF | HNDILKPYVG | LMADSVRVML | DKWEELLGQD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SPLEVFQHVS | LMTLDTIMKS | AFSHQGSIQV | DRNSQSYIQA | ISDLNSLVFC | CMRNAFHEND |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TIYSLTSAGR | WTHRACQLAH | QHTDQVIQLR | KAQLQKEGEL | EKIKRKRHLD | FLDILLLAKM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ENGSILSDKD | LRAEVDTFMF | EGHDTTASGI | SWILYALATH | PKHQERCREE | IHGLLGDGAS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ITWNHLDQMP | YTTMCIKEAL | RLYPPVPGIG | RELSTPVTFP | DGRSLPKGIM | VLLSIYGLHH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NPKVWPNLEV | FDPSRFAPGS | AQHSHAFLPF | SGGSRNCIGK | QFAMNQLKVA | RALTLLRFEL |
| 490 | 500 | 510 | |||
| LPDPTRIPIP | MARLVLKSKN | GIHLRLRRLP | NPCEDKDQL |