O64697

PR
Gene name
CYP710A1
Protein name
Cytochrome P450 710A1
Names
C-22 sterol desaturase
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G34500
EC number
1.14.19.41: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

215-288 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O64697

Entry ID Method Resolution Chain Position Source
AF-O64697-F1 Predicted AlphaFoldDB

24 variants for O64697

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14584373 2 V>F No 1000Genomes
ENSVATH01947305 5 V>I No 1000Genomes
tmp_2_14541127_C_G 25 V>L No 1000Genomes
tmp_2_14541115_A_T 29 S>T No 1000Genomes
tmp_2_14541034_C_T 56 D>N No 1000Genomes
ENSVATH00259729 66 S>A No 1000Genomes
ENSVATH13528086 67 T>A No 1000Genomes
ENSVATH13528085 68 A>P No 1000Genomes
tmp_2_14540953_T_C 83 I>V No 1000Genomes
tmp_2_14540817_T_A 128 D>V No 1000Genomes
ENSVATH01947298 200 E>K No 1000Genomes
ENSVATH05655227 202 K>T No 1000Genomes
ENSVATH05655226 229 G>S No 1000Genomes
ENSVATH05655225 235 V>I No 1000Genomes
tmp_2_14540461_C_T 247 G>R No 1000Genomes
tmp_2_14540448_G_C 251 A>G No 1000Genomes
tmp_2_14540391_A_T 270 I>N No 1000Genomes
ENSVATH00259727 272 A>T No 1000Genomes
ENSVATH05655219 312 D>E No 1000Genomes
ENSVATH05655212 403 D>E No 1000Genomes
tmp_2_14539959_C_T 414 R>K No 1000Genomes
tmp_2_14539902_T_C 433 Q>R No 1000Genomes
tmp_2_14539867_C_T 445 V>I No 1000Genomes
ENSVATH05655209 494 F>L No 1000Genomes

No associated diseases with O64697

1 regional properties for O64697

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 427 - 436 IPR017972

Functions

Description
EC Number 1.14.19.41 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
C-22 sterol desaturase activity Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

2 GO annotations of biological process

Name Definition
sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
sterol metabolic process The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

38 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VYQ5 Cyp318a1 Probable cytochrome P450 318a1 Drosophila melanogaster (Fruit fly) PR
Q9VXY0 Cyp4s3 Probable cytochrome P450 4s3 Drosophila melanogaster (Fruit fly) PR
Q9VMS7 Cyp4ac3 Probable cytochrome P450 4ac3 Drosophila melanogaster (Fruit fly) PR
Q9V559 Cyp4p3 Probable cytochrome P450 4p3 Drosophila melanogaster (Fruit fly) PR
Q9V7G5 Cyp4aa1 Probable cytochrome P450 4aa1 Drosophila melanogaster (Fruit fly) PR
Q9VMS8 Cyp4ac2 Probable cytochrome P450 4ac2 Drosophila melanogaster (Fruit fly) PR
Q9VVN6 Cyp312a1 Probable cytochrome P450 312a1 Drosophila melanogaster (Fruit fly) PR
Q02928 CYP4A11 Cytochrome P450 4A11 Homo sapiens (Human) PR
Q86W10 CYP4Z1 Cytochrome P450 4Z1 Homo sapiens (Human) PR
Q5TCH4 CYP4A22 Cytochrome P450 4A22 Homo sapiens (Human) PR
P13584 CYP4B1 Cytochrome P450 4B1 Homo sapiens (Human) PR
Q6ZWL3 CYP4V2 Cytochrome P450 4V2 Homo sapiens (Human) PR
B6SSW8 CYP714B3 Cytochrome P450 714B3 Zea mays (Maize) PR
O35728 Cyp4a14 Cytochrome P450 4A14 Mus musculus (Mouse) PR
Q91WL5 Cyp4a12a Cytochrome P450 4A12A Mus musculus (Mouse) PR
Q9GJX5 CYP4A21 Taurochenodeoxycholic 6 alpha-hydroxylase Sus scrofa (Pig) PR
Q8SPK1 CYP4A24 Cytochrome P450 4A24 Sus scrofa (Pig) PR
P24464 Cyp4a12 Cytochrome P450 4A12 Rattus norvegicus (Rat) PR
P20816 Cyp4a2 Cytochrome P450 4A2 Rattus norvegicus (Rat) PR
G3V7X8 Cyp26b1 Cytochrome P450 26B1 Rattus norvegicus (Rat) PR
Q05JG2 CYP707A5 Abscisic acid 8'-hydroxylase 1 Oryza sativa subsp japonica (Rice) PR
Q0DS59 CYP714B2 Cytochrome P450 714B2 Oryza sativa subsp japonica (Rice) PR
Q6F4F5 CYP724B1 Cytochrome P450 724B1 Oryza sativa subsp japonica (Rice) PR
Q5KQH7 CYP714D1 Cytochrome P450 714D1 Oryza sativa subsp japonica (Rice) PR
Q9SHG5 CYP72C1 Cytochrome P450 72C1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C788 CYP704B1 Cytochrome P450 704B1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZUX1 CYP94C1 Cytochrome P450 94C1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC9 CYP72A11 Cytochrome P450 72A11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC8 CYP72A13 Cytochrome P450 72A13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC6 CYP72A14 Cytochrome P450 72A14 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC5 CYP72A15 Cytochrome P450 72A15 Arabidopsis thaliana (Mouse-ear cress) PR
Q6TBX7 CYP97C1 Carotene epsilon-monooxygenase, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
O64698 CYP710A2 Cytochrome P450 710A2 Arabidopsis thaliana (Mouse-ear cress) PR
O81077 CYP707A2 Abscisic acid 8'-hydroxylase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q94IA6 CYP90D1 3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SAA9 CYP51G1 Sterol 14-demethylase Arabidopsis thaliana (Mouse-ear cress) PR
Q96242 CYP74A Allene oxide synthase, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q6EIG3 cyp26b1 Cytochrome P450 26B1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MVFSVSIFAS LAPYLISAFL LFLLVEQLSY LFKKRNIPGP FFVPPIIGNA VALVRDPTSF
70 80 90 100 110 120
WDKQSSTANI SGLSANYLIG KFIVYIRDTE LSHQIFSNVR PDAFHLIGHP FGKKLFGDHN
130 140 150 160 170 180
LIYMFGEDHK SVRRQLAPNF TPKALSTYSA LQQLVILRHL RQWEGSTSGG SRPVSLRQLV
190 200 210 220 230 240
RELNLETSQT VFVGPYLDKE AKNRFRTDYN LFNLGSMALP IDLPGFAFGE ARRAVKRLGE
250 260 270 280 290 300
TLGICAGKSK ARMAAGEEPA CLIDFWMQAI VAENPQPPHS GDEEIGGLLF DFLFAAQDAS
310 320 330 340 350 360
TSSLLWAVTL LDSEPEVLNR VREEVAKIWS PESNALITVD QLAEMKYTRS VAREVIRYRP
370 380 390 400 410 420
PATMVPHVAA IDFPLTETYT IPKGTIVFPS VFDSSFQGFT EPDRFDPDRF SETRQEDQVF
430 440 450 460 470 480
KRNFLAFGWG PHQCVGQRYA LNHLVLFIAM FSSLLDFKRL RSDGCDEIVY CPTISPKDGC
490
TVFLSRRVAK YPNFS