Q6TBX7

PR
Gene name
CYP97C1 (LUT1, At3g53130, T4D2.60)
Protein name
Carotene epsilon-monooxygenase, chloroplastic
Names
Cytochrome P450 97C1, Protein LUTEIN DEFICIENT 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G53130
EC number
1.14.14.158: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q6TBX7

Entry ID Method Resolution Chain Position Source
6L8H X-ray 200 A A/B/C/D 70-539 PDB
AF-Q6TBX7-F1 Predicted AlphaFoldDB

28 variants for Q6TBX7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00416923 3 S>C No 1000Genomes
ENSVATH12737729 3 S>P No 1000Genomes
tmp_3_19692873_C_G 21 P>R No 1000Genomes
ENSVATH12737730 22 T>A No 1000Genomes
tmp_3_19692881_C_A 24 L>I No 1000Genomes
tmp_3_19692891_C_T 27 P>L No 1000Genomes
tmp_3_19692901_A_C 30 K>N No 1000Genomes
ENSVATH02498050 35 I>V No 1000Genomes
ENSVATH06305967 49 N>D No 1000Genomes
tmp_3_19692962_T_A 51 S>T No 1000Genomes
ENSVATH00416924 64 T>S No 1000Genomes
tmp_3_19693070_G_A 87 D>N No 1000Genomes
tmp_3_19693205_C_T 132 H>Y No 1000Genomes
tmp_3_19693253_G_A 148 V>I No 1000Genomes
ENSVATH12737777 330 E>V No 1000Genomes
tmp_3_19694133_T_C 332 V>A No 1000Genomes
ENSVATH02498065 366 N>H No 1000Genomes
tmp_3_19694393_C_T 386 P>L No 1000Genomes
tmp_3_19694396_C_T 387 A>V No 1000Genomes
tmp_3_19694399_T_C 388 F>S No 1000Genomes
tmp_3_19694647_G_C 448 E>Q No 1000Genomes
tmp_3_19694829_G_A 455 E>K No 1000Genomes
tmp_3_19694851_A_T 462 D>V No 1000Genomes
ENSVATH00416936 466 A>T No 1000Genomes
ENSVATH06305992 534 M>L No 1000Genomes
tmp_3_19695264_G_A 536 V>M No 1000Genomes
ENSVATH06305993 537 S>T No 1000Genomes
tmp_3_19695278_A_T 540 R>Y No 1000Genomes

No associated diseases with Q6TBX7

1 regional properties for Q6TBX7

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 480 - 489 IPR017972

Functions

Description
EC Number 1.14.14.158 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Plastid, chloroplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast envelope The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.

3 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
zeinoxanthin epsilon hydroxylase activity Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene.

1 GO annotations of biological process

Name Definition
carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail.

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VYQ5 Cyp318a1 Probable cytochrome P450 318a1 Drosophila melanogaster (Fruit fly) PR
Q9VXY0 Cyp4s3 Probable cytochrome P450 4s3 Drosophila melanogaster (Fruit fly) PR
Q9VMS7 Cyp4ac3 Probable cytochrome P450 4ac3 Drosophila melanogaster (Fruit fly) PR
Q9V559 Cyp4p3 Probable cytochrome P450 4p3 Drosophila melanogaster (Fruit fly) PR
Q9VMS8 Cyp4ac2 Probable cytochrome P450 4ac2 Drosophila melanogaster (Fruit fly) PR
Q9VVN6 Cyp312a1 Probable cytochrome P450 312a1 Drosophila melanogaster (Fruit fly) PR
Q9V7G5 Cyp4aa1 Probable cytochrome P450 4aa1 Drosophila melanogaster (Fruit fly) PR
Q02928 CYP4A11 Cytochrome P450 4A11 Homo sapiens (Human) PR
Q86W10 CYP4Z1 Cytochrome P450 4Z1 Homo sapiens (Human) PR
Q5TCH4 CYP4A22 Cytochrome P450 4A22 Homo sapiens (Human) PR
P13584 CYP4B1 Cytochrome P450 4B1 Homo sapiens (Human) PR
Q6ZWL3 CYP4V2 Cytochrome P450 4V2 Homo sapiens (Human) PR
B6SSW8 CYP714B3 Cytochrome P450 714B3 Zea mays (Maize) PR
O35728 Cyp4a14 Cytochrome P450 4A14 Mus musculus (Mouse) PR
Q91WL5 Cyp4a12a Cytochrome P450 4A12A Mus musculus (Mouse) PR
Q9GJX5 CYP4A21 Taurochenodeoxycholic 6 alpha-hydroxylase Sus scrofa (Pig) PR
Q8SPK1 CYP4A24 Cytochrome P450 4A24 Sus scrofa (Pig) PR
P24464 Cyp4a12 Cytochrome P450 4A12 Rattus norvegicus (Rat) PR
G3V7X8 Cyp26b1 Cytochrome P450 26B1 Rattus norvegicus (Rat) PR
P20816 Cyp4a2 Cytochrome P450 4A2 Rattus norvegicus (Rat) PR
Q05JG2 CYP707A5 Abscisic acid 8'-hydroxylase 1 Oryza sativa subsp japonica (Rice) PR
Q0DS59 CYP714B2 Cytochrome P450 714B2 Oryza sativa subsp japonica (Rice) PR
Q6F4F5 CYP724B1 Cytochrome P450 724B1 Oryza sativa subsp japonica (Rice) PR
Q5KQH7 CYP714D1 Cytochrome P450 714D1 Oryza sativa subsp japonica (Rice) PR
Q9SHG5 CYP72C1 Cytochrome P450 72C1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C788 CYP704B1 Cytochrome P450 704B1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZUX1 CYP94C1 Cytochrome P450 94C1 Arabidopsis thaliana (Mouse-ear cress) PR
O81077 CYP707A2 Abscisic acid 8'-hydroxylase 2 Arabidopsis thaliana (Mouse-ear cress) PR
O64698 CYP710A2 Cytochrome P450 710A2 Arabidopsis thaliana (Mouse-ear cress) PR
O64697 CYP710A1 Cytochrome P450 710A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q94IA6 CYP90D1 3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC9 CYP72A11 Cytochrome P450 72A11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC8 CYP72A13 Cytochrome P450 72A13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC6 CYP72A14 Cytochrome P450 72A14 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC5 CYP72A15 Cytochrome P450 72A15 Arabidopsis thaliana (Mouse-ear cress) PR
Q6EIG3 cyp26b1 Cytochrome P450 26B1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MESSLFSPSS SSYSSLFTAK PTRLLSPKPK FTFSIRSSIE KPKPKLETNS SKSQSWVSPD
70 80 90 100 110 120
WLTTLTRTLS SGKNDESGIP IANAKLDDVA DLLGGALFLP LYKWMNEYGP IYRLAAGPRN
130 140 150 160 170 180
FVIVSDPAIA KHVLRNYPKY AKGLVAEVSE FLFGSGFAIA EGPLWTARRR AVVPSLHRRY
190 200 210 220 230 240
LSVIVERVFC KCAERLVEKL QPYAEDGSAV NMEAKFSQMT LDVIGLSLFN YNFDSLTTDS
250 260 270 280 290 300
PVIEAVYTAL KEAELRSTDL LPYWKIDALC KIVPRQVKAE KAVTLIRETV EDLIAKCKEI
310 320 330 340 350 360
VEREGERIND EEYVNDADPS ILRFLLASRE EVSSVQLRDD LLSMLVAGHE TTGSVLTWTL
370 380 390 400 410 420
YLLSKNSSAL RKAQEEVDRV LEGRNPAFED IKELKYITRC INESMRLYPH PPVLIRRAQV
430 440 450 460 470 480
PDILPGNYKV NTGQDIMISV YNIHRSSEVW EKAEEFLPER FDIDGAIPNE TNTDFKFIPF
490 500 510 520 530
SGGPRKCVGD QFALMEAIVA LAVFLQRLNV ELVPDQTISM TTGATIHTTN GLYMKVSQR